Perelman School of Medicine at the University of Pennsylvania

Penn Institute for Immunology

Kellie Ann Jurado

faculty photo
Assistant Professor of Microbiology
Department: Microbiology
Graduate Group Affiliations

Contact information
3450 Hamilton Walk
Stemmler Hall 474A
Philadelphia, PA 19123
Office: 215-573-6378
Lab: 215-573-7459
Education:
B.S. (Biology, Microbiology)
New Mexico State University, 2011.
Ph.D. (Medical Sciences)
Harvard University, 2015.
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Description of Research Expertise

Our research group focuses on delineating disease pathogenesis of emerging viruses in order to uncover mechanisms of immune control. We primarily focus on emerging viral pathogens that present with unknown mechanisms of disease in the nervous system or placenta. Both regions of infection have interfaces (maternal-fetal and blood-brain) that provide extra protection to an essential organ or allogenic fetus. These interfaces necessitate a delicate balance of initiating an effective antiviral response while also ensuring that there is limited damage and tolerance is maintained. In order to achieve this balance, immune responses in these regions have evolved intricate layers of distinct control which are only now beginning to be fully appreciated.

As we are a newly formed group, we are currently recruiting motivated students and postdocs. Please feel free to contact us if interested!

Selected Publications

Orzalli MH, Smith A, Jurado KA, Iwasaki A, Garlick JA, Kagan JC: An antiviral branch of the IL-1 signaling pathway restricts immune-evasion virus replication. Mol. Cell. 71(5): 825-840, September 2018.

Yockey LJ, Jurado KA, Arora N, Millet A, Rakib T, Milano KM, Hastings AK, Fikrig E, Kong Y: Type I interferons instigate fetal demise after Zika virus infection. Science Immunology 3(19): 1680, August 2018.

Jurado KA, Yockey LJ, Wong PW, Lee S, Hutner A, Iwasaki A: Antiviral CD8 T cells underlie Zika virus associated paralysis in mice. Nature Microbiology 3(2): 141-147, February 2018.

Jurado KA and Iwasaki A: Zika virus targets blood monocytes Nature Microbiology 2(11): 1460-1, November 2017.

Zhu S, DDing S, Wang P, Wei Z, Yang Y, Li H, Pan W, Wang G, Lei X, Yu H, Palm NW, Zoete M, Zheng Y, Zhao J, Chen H, Zhao Y, Jurado KA, Feng N, Shan L,, Kulger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA: Nlrp9b inflammasome recognized an restricts rotavirus infection in intestinal epithelial cells. Nature 546(7660): 667-670, June 2017.

Uraki R, Jurado KA, Hwang J, Szigeti-Buck K, Horvath TL, Iwasaki A, Fikrig E.: Fetal growth restriction caused by sexual transmission of Zika virus in mice. J. Infect Dis 215(11): 1720 - 1724, June 2017.

Wang W, Zhou J, Halambage Y, Jurado KA, Jamin A, Wang Y, Engelman A: Inhibition of HIV-1 maturation via small molecule targeting of the amino-terminal domain in the viral capsid protein. J. Virol. 13(91): e02155-16, April 2017.

Uraki R, Hwang J, Jurado KA, Householer S, Yockey L, Hastings A, Homer R, Iwasaki A, Fikrig E: Zika virus causes testicular atrophy. Science Advances 3(2): e1602899, February 2017.

Simoni MK, Jurado KA, Abrahams VM, Fikrig E, Guller S: Zika virus productively infects primary human placenta-specific macrophages. JCI Insight 1(13): e88461, August 2016.

Hwang J, Jurado KA, Fikrig E: Genetics of war and truce between mosquiots and emerging viruses. Cell Host Microbe 19(5): 583-7, May 2016.

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Last updated: 10/02/2019
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