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Aime T. Franco
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Associate Professor of Pediatrics (Endocrinology and Diabetes)
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Department: Pediatrics
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Graduate Group Affiliations
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Contact information
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Children's Hospital of Philadelphia
13 ARC 803-Lab
32 ARC 816C-Office
Philadelphia, PA 19104
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13 ARC 803-Lab
32 ARC 816C-Office
Philadelphia, PA 19104
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Office: 215-590-1066
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Email:
francoa1@email.chop.edu
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francoa1@email.chop.edu
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Education:
21 e B.S./B.A. 45 (B.S. Sports Medicine and Athletic Training; B.A. Biology) c
32 University of Connecticut, 2000.
21 9 M.S. 21 (Nutritional Sciences) c
32 University of Connecticut, 2002.
21 a Ph.D. 1b (Cancer Biology) c
2e Vanderbilt University, 2007.
21 9 M.S. 1a (Social Policy) c
33 University of Pennsylvania, 2023.
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Permanent link21 e B.S./B.A. 45 (B.S. Sports Medicine and Athletic Training; B.A. Biology) c
32 University of Connecticut, 2000.
21 9 M.S. 21 (Nutritional Sciences) c
32 University of Connecticut, 2002.
21 a Ph.D. 1b (Cancer Biology) c
2e Vanderbilt University, 2007.
21 9 M.S. 1a (Social Policy) c
33 University of Pennsylvania, 2023.
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Description of Research Expertise
67 Thyroid Cancer, Tumor Microenvironment, mouse models of cancer, transgenic mouse modelse 29
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12a Jana A, Nookaew I, Singh J, Behkam B, Franco AT, Nain AS: Crosshatch nanofiber networks of tunable interfiber spacing induce plasticity in cell migration and cytoskeletal response. FASEB Journal 33(10): 10618-10632, Oct 2019.
180 Jolly Lee Ann, Novitskiy Sergey, Owens Phillip, Massoll Nicole, Cheng Nikki, Fang Wei, Moses Harold L, Franco Aime T: Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss. Cancer Research 76(7): 1804-13, Apr 2016.
17f Jolly Lee Ann, Massoll Nicole, Franco Aime T: Immune Suppression Mediated by Myeloid and Lymphoid Derived Immune Cells in the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by Hras and Pten Loss. Journal of clinical & cellular immunology 7(5): doi: 10.4172/ Sep 2016 Notes: Epub only.
116 Hinson AM, Massoll NA, Jolly LA, Stack BC, Bodenner D, Franco AT: Structural Alterations in Tumor-Draining Lymph Nodes Before Papillary Thyroid Carcinoma Metastasis. Head & Neck 39(8): 1639-1646, Aug 2017.
1fe Franco Aime T, Malaguarnera Roberta, Refetoff Samuel, Liao Xiao-Hui, Lundsmith Emma, Kimura Shioko, Pritchard Catrin, Marais Richard, Davies Terry F, Weinstein Lee S, Chen Min, Rosen Neal, Ghossein Ronald, Knauf Jeffrey A, Fagin James A: Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice. Proceedings of the National Academy of Sciences of the United States of America 108(4): 1615-20, Jan 2011.
207 Chen Xu, Mitsutake Norisato, LaPerle Krista, Akeno Nagako, Zanzonico Pat, Longo Valerie A, Mitsutake Shin, Kimura Edna T, Geiger Hartmut, Santos Eugenio, Wendel Hans G, Franco Aime, Knauf Jeffrey A, Fagin James A: Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene. Proceedings of the National Academy of Sciences of the United States of America 106(19): 7979-84, May 2009.
e9 Ciccarella A, Staley AC, Franco AT: Transforming Research: Engaging patient advocates at all stages of cancer research. Ann Transl Medicine 6(9): 167, May 2018.
d3 Franco Aime T, Corken Adam, Ware Jerry: Platelets at the interface of thrombosis, inflammation, and cancer. Blood 126(5): 582-8, Jul 2015.
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Selected Publications
15e Franco AT, Labourier E, Adlordeppey KK, Surrey LF, Mostoufi-Moab S, Isaac A, Adzick NS, Kazahaya K, Kumar G, Bauer AJ: "miRNA expression can classify pediatric thyroid lesions and increases the diagnostic yield of mutation testing" Pediatr Blood Cancer 67(6): e28276, Jun 2020.12a Jana A, Nookaew I, Singh J, Behkam B, Franco AT, Nain AS: Crosshatch nanofiber networks of tunable interfiber spacing induce plasticity in cell migration and cytoskeletal response. FASEB Journal 33(10): 10618-10632, Oct 2019.
180 Jolly Lee Ann, Novitskiy Sergey, Owens Phillip, Massoll Nicole, Cheng Nikki, Fang Wei, Moses Harold L, Franco Aime T: Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss. Cancer Research 76(7): 1804-13, Apr 2016.
17f Jolly Lee Ann, Massoll Nicole, Franco Aime T: Immune Suppression Mediated by Myeloid and Lymphoid Derived Immune Cells in the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by Hras and Pten Loss. Journal of clinical & cellular immunology 7(5): doi: 10.4172/ Sep 2016 Notes: Epub only.
116 Hinson AM, Massoll NA, Jolly LA, Stack BC, Bodenner D, Franco AT: Structural Alterations in Tumor-Draining Lymph Nodes Before Papillary Thyroid Carcinoma Metastasis. Head & Neck 39(8): 1639-1646, Aug 2017.
1fe Franco Aime T, Malaguarnera Roberta, Refetoff Samuel, Liao Xiao-Hui, Lundsmith Emma, Kimura Shioko, Pritchard Catrin, Marais Richard, Davies Terry F, Weinstein Lee S, Chen Min, Rosen Neal, Ghossein Ronald, Knauf Jeffrey A, Fagin James A: Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice. Proceedings of the National Academy of Sciences of the United States of America 108(4): 1615-20, Jan 2011.
207 Chen Xu, Mitsutake Norisato, LaPerle Krista, Akeno Nagako, Zanzonico Pat, Longo Valerie A, Mitsutake Shin, Kimura Edna T, Geiger Hartmut, Santos Eugenio, Wendel Hans G, Franco Aime, Knauf Jeffrey A, Fagin James A: Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene. Proceedings of the National Academy of Sciences of the United States of America 106(19): 7979-84, May 2009.
e9 Ciccarella A, Staley AC, Franco AT: Transforming Research: Engaging patient advocates at all stages of cancer research. Ann Transl Medicine 6(9): 167, May 2018.
d3 Franco Aime T, Corken Adam, Ware Jerry: Platelets at the interface of thrombosis, inflammation, and cancer. Blood 126(5): 582-8, Jul 2015.
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