Elizabeth A Grice
The Sandra J. Lazarus Associate Professor in Dermatology
Department: Dermatology
Graduate Group Affiliations
Contact information
421 Curie Blvd
1015 BRB II/III
Philadelphia, PA 19104
1015 BRB II/III
Philadelphia, PA 19104
Office: 215-898-3179
Lab: 215-573-1095
Lab: 215-573-1095
Publications
Education:
B.A. (Biology)
Luther College, 2001.
Ph.D. (Human Genetics)
Johns Hopkins University, 2006.
Permanent linkB.A. (Biology)
Luther College, 2001.
Ph.D. (Human Genetics)
Johns Hopkins University, 2006.
Description of Research Expertise
Research Interests:Skin microbiome; cutaneous host-microbe interactions; wound healing
Research Description:
The skin is a formidable barrier and the first line of defense against the external environment. The skin is also colonized with microbial communities, which we hypothesize have critical functions in cutaneous health and disease. These functions may include but are not limited to colonization resistance to block invasion by opportunistic or pathogenic microbiota and regulation of immunity and inflammation. Various cutaneous disorders and infections are hypothesized to in part result from dysregulation of microbiota-host interactions. The Grice lab applies a variety of different approaches, model systems, and human tissues and isolates to elucidate mechanisms regulating such interactions.
Currently, research in the laboratory is divided into the following focus areas:
(1) Skin microbiome regulation of epithelial defense
(2) Microbial regulation of tissue repair and inflammation in chronic wounds
(3) Skin microbiota-driven mechanisms of colonization resistance to pathogens
Selected Publications
Singh TP, Farias Amorim C, Lovins VM, Bradley CW, Carvalho LP, Carvalho EM, Grice EA, Scott P.: Regulatory T cells control Staphylococcus aureus and disease severity of cutaneous leishmaniasis. J Exp Med 220: e20230558, Dec 2023.Hajfathalian M, de Vries CR, Hsu JC, Amirshaghaghi A, Dong YC, Ren Z, Liu Y, Huang Y, Li Y, Knight SA, Jonnalagadda P, Zlitni A, Grice EA, Bollyky PL, Koo H, Cormode DP.: Theranostic gold-in-gold cage nanoparticles enable photothermal ablation and photoacoustic imaging in biofilm-associated infection models. J Clin Invest 133: e168485, Nov 2023.
Wei M, Knight SAB, Flowers L, Walsh J, Grice E.: Complete genome sequence of the bacterium Desemzia incerta isolated from the dorsal skin of a Yucatan pig. Microbiol Resour Announc Nov 2023.
Campbell AE, McCready-Vangi AR, Uberoi A, Murga-Garrido SM, Lovins VM, White EK, Pan JT, Knight SAB, Morgenstern AR, Bianco C, Planet PJ, Gardner SE, Grice EA.: Variable staphyloxanthin production by Staphylococcus aureus drives strain-dependent effects on diabetic wound-healing outcomes. Cell Rep 42: 113281, Oct 2023.
Farias Amorim C, Lovins VM, Singh TP, Novais FO, Harris JC, Lago AS, Carvalho LP, Carvalho EM, Beiting DP, Scott P, Grice EA.: Multiomic profiling of cutaneous leishmaniasis infections reveals microbiota-driven mechanisms underlying disease severity. Sci Transl Med 15: eadh1469, Oct 2023.
Margolis DJ, Chiesa Fuxench ZC, Hoffstad OJ, Grice EA, Mitra N.: Pregnant Females with Atopic Dermatitis Are More Likely to be Colonized with Group B Streptococci. J Invest Dermatol Aug 2023.
Wei M, Flowers L, Knight SAB, Zheng Q, Murga-Garrido S, Uberoi A, Pan JT, Walsh J, Schroeder E, Chu EW, Campbell A, Shin D, Bradley CW, Duran-Struuck R, Grice EA.: Harnessing diversity and antagonism within the pig skin microbiota to identify novel mediators of colonization resistance to methicillin-resistant Staphylococcus aureus. mSphere 8: e0017723, Aug 2023.
Sutter CH, Azim S, Wang A, Bhuju J, Simpson AS, Uberoi A, Grice EA, Sutter TR.: Ligand-activation of the aryl hydrocarbon receptor up-regulates epidermal UDP-glucose ceramide glucosyltransferase and glucosylceramides. J Invest Dermatol Mar 2023.
Schmidt AD, Miciano C, Zheng Q, Mathyer ME, Grice EA, de Guzman Strong C.: Involucrin Modulates Vitamin D Receptor Activity in the Epidermis. J Invest Dermatol Jan 2023.
Wang G, Sweren E, Andrews W, Li Y, Chen J, Xue Y, Wier E, Alphonse MP, Luo L, Miao Y, Chen R, Zeng D, Lee S, Li A, Dare E, Kim D, Archer NK, Reddy SK, Resar L, Hu Z, Grice EA, Kane MA, Garza LA.: Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1α signaling and glutamine metabolism. Sci Adv 9: eabo7555, Jan 2023.