Elizabeth A Grice

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Associate Professor of Dermatology
Department: Dermatology

Contact information
421 Curie Blvd
1015 BRB II/III
Philadelphia, PA 19104
Office: 215-898-3179
Fax: 215-573-2033
Lab: 215-573-1095
Education:
B.A. (Biology)
Luther College, 2001.
Ph.D. (Human Genetics)
Johns Hopkins University, 2006.
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Description of Research Expertise

Research Interests:
Genomic and metagenomic approaches to understand cutaneous host-microbe interactions in health and disease.

Keywords:
host-microbe interactions, skin microbiome, metagenomics, wound healing, chronic wounds

Research Description:
The skin is a formidable barrier and the first line of defense against the external environment. The skin is also host to myriad microbes (the "microbiome") including diverse communities of bacteria, fungi, viruses, and even arthropods. Our research uses an interdisciplinary approach to understand how these microbial communities coexist and interact with the host at the skin surface, in health and disease. We hypothesize that disruptions in the dynamic interplay between the skin barrier, the microbiome, and the cutaneous defense response may in part be responsible for inflammatory and infectious skin disorders. One area of particular focus is impaired wound healing, especially in the context of diabetes, and how microbes modulate wound repair processes and clinical outcomes. To address these questions, our lab uses multiple approaches, including genomic and metagenomic sequencing of clinical specimens (16S ribosomal RNA gene sequencing, shotgun metagenomic sequencing, whole genome sequencing, RNA-seq), microbiological and skin tissue culture, and in vivo murine and porcine skin and wound models.

Selected Publications

Uberoi A, Bartow-McKenney C, Zheng Q, Flowers L, Campbell A, Knight SAB, Chan N, Wei M, Lovins V, Bugayev J, Horwinski J, Bradley C, Meyer J, Crumrine D, Sutter CH, Elias P, Mauldin E, Sutter TR, Grice EA.: Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor. Cell Host Microbe 29: 1235-1248, Aug 2021.

Dalton KR, Ruble K, Redding LE, Morris DO, Mueller NT, Thorpe RJ Jr, Agnew J, Carroll KC, Planet PJ, Rubenstein RC, Chen AR, Grice EA, Davis MF.: Microbial Sharing between Pediatric Patients and Therapy Dogs during Hospital Animal-Assisted Intervention Programs. Microorganisms 9: 1054, May 2021.

Wang G, Sweren E, Liu H, Wier E, Alphonse MP, Chen R, Islam N, Li A, Xue Y, Chen J, Park S, Chen Y, Lee S, Wang Y, Wang S, Archer NK, Andrews W, Kane MA, Dare E, Reddy SK, Hu Z, Grice EA, Miller LS, Garza LA.: Bacteria induce skin regeneration via IL-1β signaling. Cell Host Microbe 29: 777-791, May 2021.

Byeon J, Blizinsky KD, Persaud A, Findley K, Lee JJ, Buscetta AJ, You S, Bittinger K, Minniti CP, Bonham VL, Grice EA.: Insights into the skin microbiome of sickle cell disease leg ulcers. Wound Repair Regen ound Repair Regen, May 2021.

Zheng Q, Capell BC, Parekh V, O'Day C, Atillasoy C, Bashir HM, Yeh C, Shim EH, Prouty SM, Dentchev T, Lee V, Wushanley L, Kweon Y, Suzuki-Horiuchi Y, Pear W, Grice EA, Seykora JT.: Whole-Exome and Transcriptome Analysis of UV-Exposed Epidermis and Carcinoma In Situ Reveals Early Drivers of Carcinogenesis. J Invest Dermatol 141: 295-307, Feb 2021.

Bradley Charles W, Lee Fiona F, Rankin Shelley C, Kalan Lindsay R, Horwinski Joseph, Morris Daniel O, Grice Elizabeth A, Cain Christine L: The otic microbiota and mycobiota in a referral population of dogs in eastern USA with otitis externa. Veterinary dermatology 31: 225-e49, Jan 2020.

Deusenbery Carly B, Kalan Lindsay, Meisel Jacquelyn S, Gardner Sue E, Grice Elizabeth A, Spiller Kara L: Human macrophage response to microbial supernatants from diabetic foot ulcers. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 27(6): 598-608, Jul 2019.

Beck James Peter, Grogan Max, Bennett Brian T, Jeyapalina Sujee, Agarwal Jay, Bartow-McKenney Casey, Bugayev Julia, Kubiak Erik, Sinclair Sarina, Grice Elizabeth: Analysis of the Stomal Microbiota of a Percutaneous Osseointegrated Prosthesis: A Longitudinal Prospective Cohort Study. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 37(12): 2645-2654, Jul 2019.

Kalan Lindsay R, Meisel Jacquelyn S, Loesche Michael A, Horwinski Joseph, Soaita Ioana, Chen Xiaoxuan, Uberoi Aayushi, Gardner Sue E, Grice Elizabeth A: Strain- and Species-Level Variation in the Microbiome of Diabetic Wounds Is Associated with Clinical Outcomes and Therapeutic Efficacy. Cell Host & Microbe 25(5): 641-655.e5, May 2019.

Zheng Qi, Bartow-McKenney Casey, Meisel Jacquelyn S, Grice Elizabeth A: HmmUFOtu: An HMM and phylogenetic placement based ultra-fast taxonomic assignment and OTU picking tool for microbiome amplicon sequencing studies. Genome Biology 19(1): 82, June 2018.

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Last updated: 08/24/2021
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