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Laura Vella
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Assistant Professor of Pediatrics (Infectious Diseases)
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Department: Pediatrics
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Graduate Group Affiliations
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- Immunology e
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Contact information
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Children's Hospital of Philadelphia
3a 3615 Civic Center Blvd.
Philadelphia, PA 19104
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3a 3615 Civic Center Blvd.
Philadelphia, PA 19104
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Publications
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Education:
21 7 BA 2b (Major: Biology, Minor: English) c
2f University of Delaware, 2002.
21 8 PhD 17 (Immunology) c
44 University of Pittsburgh School of Medicine, 2008.
21 7 MD c
44 University of Pittsburgh School of Medicine, 2010.
21 9 MSTR 23 (Translational Research) c
33 University of Pennsylvania, 2019.
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Permanent link21 7 BA 2b (Major: Biology, Minor: English) c
2f University of Delaware, 2002.
21 8 PhD 17 (Immunology) c
44 University of Pittsburgh School of Medicine, 2008.
21 7 MD c
44 University of Pittsburgh School of Medicine, 2010.
21 9 MSTR 23 (Translational Research) c
33 University of Pennsylvania, 2019.
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2fd Q Gong, M Sharma, E Kuan, M Glass, A Chander, M Singh, L Graybuck, Z Thomson, C La France, SR Zaim, T Peng, L Okada, P Genge, K Henderson, E Dornisch, E Layton, P Wittig, A Heubeck, N Mukuka, J Reading, C Roll, V Hernandez, V Parthasarathy, T Stuckey, B Musgrove, E Swanson, C Lord, M Weiss, C Phalen, R Mettey, K Lee, J Johanneson, E Kawelo, J Garber, U Krishnan, M Smithmeyer, E Wherry, L Vella, S Henrickson, M Kopp, A Savage, L Becker, P Meijer, E Coffey, J Goronzy, C Speake, T Bumol, A Goldrath, T Torgerson, X Li, P Skene, J Buckner, G Strawn, T Titus-Adewunmi, K Abadie, M Sigvardsson: Multi-omic Profiling Reveals Age-Related Immune Dynamics in Healthy Adults. Nature In Press, 2025.
1a5 Vella LA#*, Berna AZ*, Blatz AM, Logan J, Sharma P, Liu Y, Tedesco J, Toland C, Babiker L, Hafertepe K, Kammerman S, Novacek J, Akaho E, Gonzalez AK, Taylor D, Diorio C, Balamuth F, Bassiri H, Odom John AR#. : Metabolomic and Immunologic Discriminators of MIS-C at Emergency Room Presentation. medRxiv January 2024 Notes: #Co-corresponding author.
1b6 Guruprasad P, Carturan A, Zhang Y, Cho JH, Kumashie KG, Patel RP, Kim K-H, Lee J-S, Lee Y, Kim JH, Chung J, Joshi A, Cohen I, Shestov M, Ghilardi G, Harris J, Pajarillo, Angelos M, Lee YG, Liu S, Rodriguez J, Wang M, Ballard HJ, Gupta A, Ugwuanyi OH, Hong SJA, Bochi-Layec AC, Sauter CT, Chen L, Paruzzo L, Kammerman S, Shestova O, Liu D, Vella LA, Schuster SJ, Svoboda J, Porazzi P, Ruella M 79 : The BTLA-HVEM axis restricts CAR T cell efficacy in cancer. Nature Immunology June 2024.
2bd Chong EA, Kumashie KG, Chong ER, Fabrizio J, Gupta A, Svoboda J, Barta SK, Walsh KM, Napier EB, Lundberg RK, Nasta SD, Gerson JN, Landsburg DJ, Gonzalez J, Gaano A, Weirick ME , McAllister CM, Awofolaju M, John GN, Kammerman SC, Novaceck J, Pajarillo R, Lundgreen KA, Tanenbaum N, Gouma S, Drapeau EM, Adamski A, D’Andrea K, Pattekar A, Hicks A, Korte S, Sharma H, Herring S, Williams JC, Hamilton JT, Bates P, Hensley SE, Luning Prak ET, Greenplate AR, Wherry EJ, Schuster SJ*, Ruella M* and Vella LA* : Immunologic predictors of vaccine readiness in patients with lymphoma and CLL. Journal of Infectious Diseases March 2024.
29e Thomson Z, He Z, Swanson E, Henderson K, Phalen C, Zaim SR, Pebworth MP, Okada LY, Heubeck AT, Roll CR, Hernandez V, Weiss M, Genge PC, Reading J, Giles JR, Manne S, Dougherty J, Jasen CJ, Greenplate AR, Becker LA, Graybuck LT, Vasaikar SV, Szeto GL, Savage AK, Speake C, Buckner JH, Li X-j, Bumol TF, Wherry EJ, Torgerson TR, Vella LA,‡ Henrickson SE,‡ Skene PJ,†* Gustafson CE†* : Tri-modal single cell profiling reveals a novel pediatric CD8aa T cell subset and broad age-related molecular reprogramming across the T cell compartment. Nature Immunology 24: 1947-1959, November 2023.
7f Conrey PE, Denu L, O'Boyle KC, Rozich I, Green J, Maslanka J, Lubin JB, Duranova T, 69 Haltzman BL, Gianchett L, Oldridge DA, De Luna N, Vella LA, Allman D, Spergel J, Tanes C, Bittinger K, d9 Henrickson SE, Silverman MA: IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation. Science Immunology 8(83): eade2335, May 2023.
1c5 Wu VH, Nguyen S, Nordin JML, Joy J, Mampe F, del Rio Estrada PM, Torres-Ruiz F, González-Navarro M, Luna-Villalobos YA, Ávila-Ríos S, Reyes-Terán G, Tebas P, Montaner LJ, Bar KJ, Vella LA#, Betts MR#: Profound phenotypic and epigenetic heterogeneity of the HIV-1 infected CD4+ T cell reservoir. Nature Immunology 24(2): 359-370, December 2022 Notes: #Co-corresponding author.
21a Herati RS#*, Knorr DA#, Vella LA, Silva LV, Chilukuri L, Apostolidis SA, Huang AC, Muselman A, Manne S, Kuthuru O, Staupe RP, Adamski SA, Kannan S, Kurupati RK, Ertl HCJ, Wong JLL, Bournazos S, McGettigan S, Schuchter LM, Kotecha RR, Funt S, Voss MH, Motzer RJ, Lee CH, Bajorin DF, Mitchell TC, Ravetch JV, Wherry EJ*: PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine. Nature Immunology 23(8): 1183-1192, July 2022.
295 Apostolidis SA, Sarkar A, Giannini HM, Goel RR, Mathew D, Suzuki A, Baxter AE, Greenplate AR, Alanio C, Abdel-Hakeem M, Oldridge DA, Giles JR, Wu JE, Chen Z, Huang YJ, Ajinkya, P, Manne S, Kuthuru O, Dougherty J, Weiderhold B, Weisman, AR, Ittner CAG, Dunbar D, Frank I, Huang AC, Vella LA, The UPenn COVID Processing Unit, Reilly JP, Hensley SE, Rauova L, Zhao L, Meyer NJ, Poncz M, Abrams CA, Wherry EJ: Signaling through FcgRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19. Frontiers in Immunology 13 : DOI: 10.3389/fimmu.2022.834988, March 2022 Notes: epub.
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Selected Publications
20b Dubensky, S. B., Zhu, Y., Gallagher, M., Kumashie, K. G., Lu, T., Tedesco, J., De Luna, N., Premo, K., Qi, Y., Rachimi, S., Cabrera, E. C., Fulmer, B., Meremikwu, I. C., Carter, A., Henrickson, S. E., Romberg, N., Baxter, A. E., Oldridge, D. A., & Vella, L. A.: "Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans" BioRxiv: doi:10.64898/2025.12.10.693235. December 2025.2fd Q Gong, M Sharma, E Kuan, M Glass, A Chander, M Singh, L Graybuck, Z Thomson, C La France, SR Zaim, T Peng, L Okada, P Genge, K Henderson, E Dornisch, E Layton, P Wittig, A Heubeck, N Mukuka, J Reading, C Roll, V Hernandez, V Parthasarathy, T Stuckey, B Musgrove, E Swanson, C Lord, M Weiss, C Phalen, R Mettey, K Lee, J Johanneson, E Kawelo, J Garber, U Krishnan, M Smithmeyer, E Wherry, L Vella, S Henrickson, M Kopp, A Savage, L Becker, P Meijer, E Coffey, J Goronzy, C Speake, T Bumol, A Goldrath, T Torgerson, X Li, P Skene, J Buckner, G Strawn, T Titus-Adewunmi, K Abadie, M Sigvardsson: Multi-omic Profiling Reveals Age-Related Immune Dynamics in Healthy Adults. Nature In Press, 2025.
1a5 Vella LA#*, Berna AZ*, Blatz AM, Logan J, Sharma P, Liu Y, Tedesco J, Toland C, Babiker L, Hafertepe K, Kammerman S, Novacek J, Akaho E, Gonzalez AK, Taylor D, Diorio C, Balamuth F, Bassiri H, Odom John AR#. : Metabolomic and Immunologic Discriminators of MIS-C at Emergency Room Presentation. medRxiv January 2024 Notes: #Co-corresponding author.
1b6 Guruprasad P, Carturan A, Zhang Y, Cho JH, Kumashie KG, Patel RP, Kim K-H, Lee J-S, Lee Y, Kim JH, Chung J, Joshi A, Cohen I, Shestov M, Ghilardi G, Harris J, Pajarillo, Angelos M, Lee YG, Liu S, Rodriguez J, Wang M, Ballard HJ, Gupta A, Ugwuanyi OH, Hong SJA, Bochi-Layec AC, Sauter CT, Chen L, Paruzzo L, Kammerman S, Shestova O, Liu D, Vella LA, Schuster SJ, Svoboda J, Porazzi P, Ruella M 79 : The BTLA-HVEM axis restricts CAR T cell efficacy in cancer. Nature Immunology June 2024.
2bd Chong EA, Kumashie KG, Chong ER, Fabrizio J, Gupta A, Svoboda J, Barta SK, Walsh KM, Napier EB, Lundberg RK, Nasta SD, Gerson JN, Landsburg DJ, Gonzalez J, Gaano A, Weirick ME , McAllister CM, Awofolaju M, John GN, Kammerman SC, Novaceck J, Pajarillo R, Lundgreen KA, Tanenbaum N, Gouma S, Drapeau EM, Adamski A, D’Andrea K, Pattekar A, Hicks A, Korte S, Sharma H, Herring S, Williams JC, Hamilton JT, Bates P, Hensley SE, Luning Prak ET, Greenplate AR, Wherry EJ, Schuster SJ*, Ruella M* and Vella LA* : Immunologic predictors of vaccine readiness in patients with lymphoma and CLL. Journal of Infectious Diseases March 2024.
29e Thomson Z, He Z, Swanson E, Henderson K, Phalen C, Zaim SR, Pebworth MP, Okada LY, Heubeck AT, Roll CR, Hernandez V, Weiss M, Genge PC, Reading J, Giles JR, Manne S, Dougherty J, Jasen CJ, Greenplate AR, Becker LA, Graybuck LT, Vasaikar SV, Szeto GL, Savage AK, Speake C, Buckner JH, Li X-j, Bumol TF, Wherry EJ, Torgerson TR, Vella LA,‡ Henrickson SE,‡ Skene PJ,†* Gustafson CE†* : Tri-modal single cell profiling reveals a novel pediatric CD8aa T cell subset and broad age-related molecular reprogramming across the T cell compartment. Nature Immunology 24: 1947-1959, November 2023.
7f Conrey PE, Denu L, O'Boyle KC, Rozich I, Green J, Maslanka J, Lubin JB, Duranova T, 69 Haltzman BL, Gianchett L, Oldridge DA, De Luna N, Vella LA, Allman D, Spergel J, Tanes C, Bittinger K, d9 Henrickson SE, Silverman MA: IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation. Science Immunology 8(83): eade2335, May 2023.
1c5 Wu VH, Nguyen S, Nordin JML, Joy J, Mampe F, del Rio Estrada PM, Torres-Ruiz F, González-Navarro M, Luna-Villalobos YA, Ávila-Ríos S, Reyes-Terán G, Tebas P, Montaner LJ, Bar KJ, Vella LA#, Betts MR#: Profound phenotypic and epigenetic heterogeneity of the HIV-1 infected CD4+ T cell reservoir. Nature Immunology 24(2): 359-370, December 2022 Notes: #Co-corresponding author.
21a Herati RS#*, Knorr DA#, Vella LA, Silva LV, Chilukuri L, Apostolidis SA, Huang AC, Muselman A, Manne S, Kuthuru O, Staupe RP, Adamski SA, Kannan S, Kurupati RK, Ertl HCJ, Wong JLL, Bournazos S, McGettigan S, Schuchter LM, Kotecha RR, Funt S, Voss MH, Motzer RJ, Lee CH, Bajorin DF, Mitchell TC, Ravetch JV, Wherry EJ*: PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine. Nature Immunology 23(8): 1183-1192, July 2022.
295 Apostolidis SA, Sarkar A, Giannini HM, Goel RR, Mathew D, Suzuki A, Baxter AE, Greenplate AR, Alanio C, Abdel-Hakeem M, Oldridge DA, Giles JR, Wu JE, Chen Z, Huang YJ, Ajinkya, P, Manne S, Kuthuru O, Dougherty J, Weiderhold B, Weisman, AR, Ittner CAG, Dunbar D, Frank I, Huang AC, Vella LA, The UPenn COVID Processing Unit, Reilly JP, Hensley SE, Rauova L, Zhao L, Meyer NJ, Poncz M, Abrams CA, Wherry EJ: Signaling through FcgRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19. Frontiers in Immunology 13 : DOI: 10.3389/fimmu.2022.834988, March 2022 Notes: epub.
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