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Carla R Scanzello, MD, PhD
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Associate Professor of Medicine (Rheumatology) at the Hospital of the University of Pennsylvania
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Department: Medicine
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Graduate Group Affiliations
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- Immunology e
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Contact information
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Division of Rheumatology
36 University of Pennsylvania, School of Medicine
1c 5th Floor White Bldg
1a 3400 Spruce Street
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1d CMC VA Medical Center
1a 3900 Woodland Ave.
33 Bldg 21, Rm A215
Philadelphia, PA 19104
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36 University of Pennsylvania, School of Medicine
1c 5th Floor White Bldg
1a 3400 Spruce Street
9 &
1d CMC VA Medical Center
1a 3900 Woodland Ave.
33 Bldg 21, Rm A215
Philadelphia, PA 19104
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Office: 215-823-5800 x205666
46 Lab: 215-823-5800 x207776
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46 Lab: 215-823-5800 x207776
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Publications
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Education:
21 9 B.S. 19 (Biochemistry) c
3b University of Delaware, Newark, DE, 1991.
21 9 M.D. c
50 Temple University, School of Medicine, Philadelphia, PA, 2001.
21 9 Ph.D 26 (Immunology & Microbiology) c
50 Temple University, School of Medicine, Philadelphia, PA, 2001.
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Permanent link21 9 B.S. 19 (Biochemistry) c
3b University of Delaware, Newark, DE, 1991.
21 9 M.D. c
50 Temple University, School of Medicine, Philadelphia, PA, 2001.
21 9 Ph.D 26 (Immunology & Microbiology) c
50 Temple University, School of Medicine, Philadelphia, PA, 2001.
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Description of Research Expertise
2a4 My research focuses on understanding the molecular stimuli and clinical consequences of synovial inflammation in osteoarthritis (OA) and meniscal injury. We have identified specific inflammatory pathways that are over-expressed in patients with early-stage knee OA, including Toll-like receptor pathways and chemokine-mediated pathways. We are now exploring how these pathways impact OA development and progression after joint injury in animal models, incorporating pain-related outcomes with with translational relevance. The ultimate goal of our laboratory's work is to develop novel anti-inflammatory strategies to reduce pain and disability from OA.e 29
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13e Nair A, Gan J, Bush-Joseph C, Verma N, Tetreault MW, Saha K, Margulis A, Fogg L, Scanzello CR.: Synovial chemokine expression and relationship with knee symptoms in patients with meniscal tears. Osteoarthritis Cartilage 23(7): 1158-64, Jul 2015.
1ae Sambamurthy Nisha, Nguyen Vu, Smalley Ryan, Xiao Rui, Hankenson Kurt, Gan Justin, Miller Rachel E, Malfait Anne-Marie, Dodge George R, Scanzello Carla R: Chemokine receptor-7 (CCR7) deficiency leads to delayed development of joint damage and functional deficits in a murine model of osteoarthritis. Journal of orthopaedic research 36(3): 864-87, March 2018.
16b Sambamurthy Nisha, Zhou Cheng, Nguyen Vu, Smalley Ryan, Hankenson Kurt D, Dodge George R, Scanzello Carla R: Deficiency of the pattern-recognition receptor CD14 protects against joint pathology and functional decline in a murine model of osteoarthritis. PloS One 13(11): e0206217, Nov 2018.
272 S Kolasinski, T Neogi, M Hochberg, C Oatis, GH Guyatt, J Block, L Callahan, C Copenhaver, C Dodge, D Felson, K Geller, W Harvey, G Hawker, E Herzig, K Kwoh, A Nelson, J Samuels, C Scanzello, D White, B Wise, R Altman, D DiRenzo, J Fontanarosa, G Giradi, M Ishimori, D Misra, A Shah, A Shmagel, L Thoma, M Turgunbaev, A Turner, J Reston.: 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip and Knee. Arthritis & Rheumatology 72(2): 220-233 Feb 2020 Notes: DOI 10.1002/art.41142.
187 S Bansal, KD Meadows,LM Miller, KS Saleh, JM Patel, BD Stoeckl, EA Lemmon, MW Hast, MH Zgonis,CR Scanzello, DM Elliott,RL Mauck: Six Month Outcomes of Clinically Relevant Meniscal Injury in a Large Animal Model. Orthopaedic Journal of Sports Medicine 9(11): 23259671211035444, Nov 2021 Notes: Accepted for publication.
1b8 CR Scanzello, KA Hasty, CB Chung, TM Griffin, NJ Willet, H Krug, Cong-Qiu Chu, D Ewart, S Jerban, JF Baker, CL Duvall, JM Brunger, JA Burdick, KP Spindler, H Drissi. : Teaming Up to Overcome Challenges in the Clinical Translation of New Therapeutics for Osteoarthritis. J Ortho Res. Online ahead of print, 42(12): 2659-2672. Dec 2024 Notes: doi: 10.1002/jor.25944.
19c AM Obeidat, SY Kim, KG Burt, B Hu, J Li, S Ishihara, R Xiao, RE Miller, C Little, AM Malfait, CR Scanzello: A standardized approach to evaluation and reporting of synovial histopathology in two surgically induced murine models of osteoarthritis. Osteoarthritis Cartilage. 32(10): 1273-1282, Oct 2024 Notes: doi: 10.1016/j.joca.2024.05.006.
e0 SY Kim, CR Scanzello: When “Synovitis” isn’t Synovitis. Osteoarthritis Cartilage 33(1): 1-4, Jan 2025 Notes: doi: 10.1016/j.joca.2024.09.005.
103 LA Murphy, CR Scanzello. : Cellular and molecular mechanisms underlying subchondral bone remodeling and associated pain in osteoarthritis. Connect Tissue Res. 66(5): 435-441, Aug 2025
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Selected Publications
1ac Q Wang, AL Rozelle, CM Lepus, CR Scanzello, JJ Song, DM Larsen, JF Crish, G Bebek, SY Ritter, TM Lindstrom, I Hwang, HH Wong, L Punzi, A Encarnacion, M Shamloo, SB Goodman, T Wyss-Coray, SR Goldring, R Gobezie, MK Crow, VM Holers DM Lee, WH Robinson: Identification of a central role for complement in osteoarthritis. Nature Medicine 17(12): 1674-9, 2011.13e Nair A, Gan J, Bush-Joseph C, Verma N, Tetreault MW, Saha K, Margulis A, Fogg L, Scanzello CR.: Synovial chemokine expression and relationship with knee symptoms in patients with meniscal tears. Osteoarthritis Cartilage 23(7): 1158-64, Jul 2015.
1ae Sambamurthy Nisha, Nguyen Vu, Smalley Ryan, Xiao Rui, Hankenson Kurt, Gan Justin, Miller Rachel E, Malfait Anne-Marie, Dodge George R, Scanzello Carla R: Chemokine receptor-7 (CCR7) deficiency leads to delayed development of joint damage and functional deficits in a murine model of osteoarthritis. Journal of orthopaedic research 36(3): 864-87, March 2018.
16b Sambamurthy Nisha, Zhou Cheng, Nguyen Vu, Smalley Ryan, Hankenson Kurt D, Dodge George R, Scanzello Carla R: Deficiency of the pattern-recognition receptor CD14 protects against joint pathology and functional decline in a murine model of osteoarthritis. PloS One 13(11): e0206217, Nov 2018.
272 S Kolasinski, T Neogi, M Hochberg, C Oatis, GH Guyatt, J Block, L Callahan, C Copenhaver, C Dodge, D Felson, K Geller, W Harvey, G Hawker, E Herzig, K Kwoh, A Nelson, J Samuels, C Scanzello, D White, B Wise, R Altman, D DiRenzo, J Fontanarosa, G Giradi, M Ishimori, D Misra, A Shah, A Shmagel, L Thoma, M Turgunbaev, A Turner, J Reston.: 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip and Knee. Arthritis & Rheumatology 72(2): 220-233 Feb 2020 Notes: DOI 10.1002/art.41142.
187 S Bansal, KD Meadows,LM Miller, KS Saleh, JM Patel, BD Stoeckl, EA Lemmon, MW Hast, MH Zgonis,CR Scanzello, DM Elliott,RL Mauck: Six Month Outcomes of Clinically Relevant Meniscal Injury in a Large Animal Model. Orthopaedic Journal of Sports Medicine 9(11): 23259671211035444, Nov 2021 Notes: Accepted for publication.
1b8 CR Scanzello, KA Hasty, CB Chung, TM Griffin, NJ Willet, H Krug, Cong-Qiu Chu, D Ewart, S Jerban, JF Baker, CL Duvall, JM Brunger, JA Burdick, KP Spindler, H Drissi. : Teaming Up to Overcome Challenges in the Clinical Translation of New Therapeutics for Osteoarthritis. J Ortho Res. Online ahead of print, 42(12): 2659-2672. Dec 2024 Notes: doi: 10.1002/jor.25944.
19c AM Obeidat, SY Kim, KG Burt, B Hu, J Li, S Ishihara, R Xiao, RE Miller, C Little, AM Malfait, CR Scanzello: A standardized approach to evaluation and reporting of synovial histopathology in two surgically induced murine models of osteoarthritis. Osteoarthritis Cartilage. 32(10): 1273-1282, Oct 2024 Notes: doi: 10.1016/j.joca.2024.05.006.
e0 SY Kim, CR Scanzello: When “Synovitis” isn’t Synovitis. Osteoarthritis Cartilage 33(1): 1-4, Jan 2025 Notes: doi: 10.1016/j.joca.2024.09.005.
103 LA Murphy, CR Scanzello. : Cellular and molecular mechanisms underlying subchondral bone remodeling and associated pain in osteoarthritis. Connect Tissue Res. 66(5): 435-441, Aug 2025
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