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Hao Shen
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Hao Shen, Ph.D.
3eProfessor of Microbiology
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Department: Microbiology
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Contact information
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303C Johnson Pavilion
36 3610 Hamilton Walk
Philadelphia, PA 19104
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36 3610 Hamilton Walk
Philadelphia, PA 19104
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Office: (215) 573-5259
34 Fax: (215) 573-9068
32 Lab: 215-898-6586
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34 Fax: (215) 573-9068
32 Lab: 215-898-6586
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Email:
hshen@mail.med.upenn.edu
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hshen@mail.med.upenn.edu
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Graduate Group Affiliations
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- Immunology e
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Publications
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Education:
21 9 B.S. c
36 Jiangxi Agr University, China, 1983.
21 a Ph.D. c
3e University of California at Riverside, 1992.
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21 9 B.S. c
36 Jiangxi Agr University, China, 1983.
21 a Ph.D. c
3e University of California at Riverside, 1992.
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Links
e5 Search PubMed for articles
43 Cell and Molecular Biology graduate group faculty webpage.
5d Primary Work Website
54 Parasitology graduate group faculty webpage.
40 Immunology graduate group faculty webpage.
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Permanent linke5 Search PubMed for articles
43 Cell and Molecular Biology graduate group faculty webpage.
5d Primary Work Website
54 Parasitology graduate group faculty webpage.
40 Immunology graduate group faculty webpage.
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5e
4a Immunity against intracellular, emerging and co-infecting agents.
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57 Key words: T cell responses and memory, bacterial pathogenesis, vaccine.
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26 Description of Research
5c5 We have a long-standing interest in basic questions related to generation of effective immune responses, mechanisms of protective immunity, and the establishment of long-term immunological memory. For these basic studies, we have used two well-characterized murine models of infection with lymphocytic choriomeningitis virus (LCMV) and Listeria monocytogenes. More recently, we have become interested in viral/bacterial co-infections, which occur frequently in clinics and often result in more severe disease than infection by an individual pathogen. A striking example of this is the high mortality caused by secondary bacterial pneumonia following flu infection. We are: 1) studying how inflammation induced by a bacterial pathogen may affect the host response to a co-infecting viral pathogen and vice versa, 2) investigating the mechanisms of bacterial pathogenesis that contribute to lethal secondary bacterial pneumonia following flu infection, 3) identifying immune mechanisms and protective antigens that provide immunity against co-infection, and 4) examining how these protective mechanisms may be inhibited during co-infection that leads to high mortality and inadequate immunological memory. Through these studies, we have gained new insights into complexity of tripartite interactions between the virus, bacterium and host immune system. Based on our new findings, we are developing novel, combinational vaccine approaches tailored towards co-infection.
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Description of Research Expertise
2b Research Interests4a Immunity against intracellular, emerging and co-infecting agents.
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57 Key words: T cell responses and memory, bacterial pathogenesis, vaccine.
8
26 Description of Research
5c5 We have a long-standing interest in basic questions related to generation of effective immune responses, mechanisms of protective immunity, and the establishment of long-term immunological memory. For these basic studies, we have used two well-characterized murine models of infection with lymphocytic choriomeningitis virus (LCMV) and Listeria monocytogenes. More recently, we have become interested in viral/bacterial co-infections, which occur frequently in clinics and often result in more severe disease than infection by an individual pathogen. A striking example of this is the high mortality caused by secondary bacterial pneumonia following flu infection. We are: 1) studying how inflammation induced by a bacterial pathogen may affect the host response to a co-infecting viral pathogen and vice versa, 2) investigating the mechanisms of bacterial pathogenesis that contribute to lethal secondary bacterial pneumonia following flu infection, 3) identifying immune mechanisms and protective antigens that provide immunity against co-infection, and 4) examining how these protective mechanisms may be inhibited during co-infection that leads to high mortality and inadequate immunological memory. Through these studies, we have gained new insights into complexity of tripartite interactions between the virus, bacterium and host immune system. Based on our new findings, we are developing novel, combinational vaccine approaches tailored towards co-infection.
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