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Kyle Bittinger
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Kyle Bittinger, Ph.D.
9eAssistant Professor of Pediatrics (Gastroenterology, Hepatology and Nutrition) at the Children's Hospital of Philadelphia
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Bioinformatics Laboratory Director, Microbiome Center, Children's Hospital of Philadelphia
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Director of Analytics, Center for Microbial Medicine, Children's Hospital of Philadelphia
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Department: Pediatrics
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Contact information
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Children's Hospital of Philadelphia
19 Microbiome Center
2d Roberts Center for Pediatric Research
45 2716 South Street, 14th Floor
Philadelphia, PA 19146-2305
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19 Microbiome Center
2d Roberts Center for Pediatric Research
45 2716 South Street, 14th Floor
Philadelphia, PA 19146-2305
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Office: 267-425-1641
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Email:
bittingerk@chop.edu
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bittingerk@chop.edu
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Graduate Group Affiliations
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Education:
21 9 B.S. 16 (Chemistry) c
31 University of Pittsburgh, 2001.
21 a Ph.D. 1f (Physical Chemistry) c
3e Massachusetts Institute of Technology, 2008.
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Permanent link21 9 B.S. 16 (Chemistry) c
31 University of Pittsburgh, 2001.
21 a Ph.D. 1f (Physical Chemistry) c
3e Massachusetts Institute of Technology, 2008.
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14e Hantsoo L, Ford E, Friedman ES, Hao F, Patterson AD, Bittinger K, Wu GD, Zemel BS, Tanes C: The impact of adverse childhood experiences on gut microbiota and markers of inflammation is mediated by obesity and depression. Brain Behav Immun 134: 106479, Feb 2026.
1d4 Barekat K, Ghosh S, Herrmann C, Keat K, Assenmacher CA, Tanes C, Wilson N, Lordan R, Mrčela A, Rauova L, Sengupta A, Das US, Joshi R, Friedman E, Ritchie MD, Bittinger K, Weljie A, Cadwell K, Bushman FD, Wu GD, FitzGerald GA, Ricciotti E: Concomitant COX-1 and COX-2 suppression is not sufficient to induce enteropathy associated with chronic NSAID use. J Clin Invest 136(6): e190575, Jan 2026.
4b0 Stanton TD, Keegan SP, Abdulahi JA, Amulele AV, Bates M, Heinz E, Hooda Y, Hu W, Jain K, Kanwar S, Magobo R, Olwagen CP, Tembo JM, Sonda T, Strysko J, Tigoi CC, Amin SA, Bittinger K, Cornick J, Foster-Nyarko E, Gumbi W, Hotwani A, Iqbal N, Jones SM, Kabir F, Khan W, Musyani CL, McGann CM, Mittal V, Moustafa AM, Musicha P, Mwansa JCL, Ndumba ML, Odih EE, Omuoyo DO, Pearse O, Phillips LT, Planet PJ, Rasool AA, Rodrigues CMC, Sands K, Tanmoy AM, Theiller E, Zuza AM, Basu S, Chan GJ, Iregbu KC, Mazarati JB, Alemayehu SS, Walsh TR, Zahra R, Dramowski A, Fwoloshi S, Labi AK, Madrid L, Obeng-Nkrumah N, Ojok D, Wadugu BD, Whitelaw AC, Bethou A, Bhargava A, Jindal A, Nanavati RN, Prasad PS, Sastry A, Farooqi JQ, Ghanchi N, Jehan F, Khan E, Agarwal RK, Aiken AM, Berkley JA, Coffin SE, Feasey NA, Govender NP, Hamer DH, Madhi SA, Nisar MI, Saha SK, Saha S, Sankar MJ, Wyres KL, Holt KE: Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: A meta-analysis of genome-predicted serotype prevalence to inform potential vaccine coverage. PLoS Med 23(1): e1004879, Jan 2026.
16b Hoffmann Sardá FA, Giuntini EB, Oliveira A, Souza GS, Prado SBR, Taddei CR, Tadini CC, Bittinger K, Bushman FD, Menezes EW, Hoffmann C: Baseline intestinal microbiota composition influences response to a real-world dietary fiber intervention. NPJ Biofilms Microbiomes 11(1): 203, Nov 2025.
166 Hewlett KK, PeBenito A, Hecht AL, Tiffany C, Tanes C, Glover RC, Fawad JA, Friedman ES, Reynolds JC, Bittinger K, Lewis JD, Wu GD, Ahuja NK, Zackular JP: Dietary fiber modulates the window of susceptibility to Clostridioides difficile infection. Gastroenterology 169(5): 970, Oct 2025.
105 Tanes C, Hu W, Friedman E, Hecht A, Daniel S, Clish C, Lewis JD, Wu GD, Bittinger K: Distinguishing diet- and microbe-derived metabolites in the human gut. Microbiome 13(1): 206, Oct 2025.
1e9 McGann CM, Strysko J, Bayani O, Moorad B, Ntlhako N, Nwako N, Hu W, Tanes C, Moustafa AM, Jones SM, Nakstad B, Gezmu AM, Arscott-Mills T, Goldfarb DM, Steenhoff AP, Richard-Greenblatt M, Machiya T, Thela T, Mokomane M, Paganotti GM, Vurayai M, Zalot M, Boustany M, Planet PJ, Coffin S, Bittinger K: Effect of maternal HIV status on the early neonatal microbiome. J Pediatric Infect Dis Soc 14(10): piaf076, Oct 2025.
115 Drake MJ, Pierdon M, DeMers G, Daniel SG, Bittinger K, Redding LE: The effect of dietary zinc on the microbiome and resistome of the gestating sow and neonatal piglets. Anim Microbiome 7(1): 71, Jul 2025.
242 Feigenberg SJ, Costabile F, Tanes C, Bittinger K, O'Connor R, Agarwal D, Skoufos G, Salaris S, Hatzigeorgiou A, Kostopoulos N, Lloyd S, Friedes C, Chen L, Yegya-Raman N, Cengel K, Levin W, Valentić B, Quarton T, Shestov AA, Berman A, Bradley J, Maity A, Koumenis C, Ben-Josef E, Facciabene A: Enhancing outcomes in medically inoperable early-stage NSCLC with gut-targeted antibiotics and stereotactic body radiotherapy: results from a randomized pilot study. J Immunother Cancer 13(6): e011356, Jul 2025.
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Selected Publications
11e Southwood LL, Long A, Perez J, Daniel S, Bittinger K, Aitken M, Redding L: Effect of surgical antimicrobial prophylaxis duration for colic surgery on complications and resistome. Equine Vet J 58(2): 390, Mar 2026.14e Hantsoo L, Ford E, Friedman ES, Hao F, Patterson AD, Bittinger K, Wu GD, Zemel BS, Tanes C: The impact of adverse childhood experiences on gut microbiota and markers of inflammation is mediated by obesity and depression. Brain Behav Immun 134: 106479, Feb 2026.
1d4 Barekat K, Ghosh S, Herrmann C, Keat K, Assenmacher CA, Tanes C, Wilson N, Lordan R, Mrčela A, Rauova L, Sengupta A, Das US, Joshi R, Friedman E, Ritchie MD, Bittinger K, Weljie A, Cadwell K, Bushman FD, Wu GD, FitzGerald GA, Ricciotti E: Concomitant COX-1 and COX-2 suppression is not sufficient to induce enteropathy associated with chronic NSAID use. J Clin Invest 136(6): e190575, Jan 2026.
4b0 Stanton TD, Keegan SP, Abdulahi JA, Amulele AV, Bates M, Heinz E, Hooda Y, Hu W, Jain K, Kanwar S, Magobo R, Olwagen CP, Tembo JM, Sonda T, Strysko J, Tigoi CC, Amin SA, Bittinger K, Cornick J, Foster-Nyarko E, Gumbi W, Hotwani A, Iqbal N, Jones SM, Kabir F, Khan W, Musyani CL, McGann CM, Mittal V, Moustafa AM, Musicha P, Mwansa JCL, Ndumba ML, Odih EE, Omuoyo DO, Pearse O, Phillips LT, Planet PJ, Rasool AA, Rodrigues CMC, Sands K, Tanmoy AM, Theiller E, Zuza AM, Basu S, Chan GJ, Iregbu KC, Mazarati JB, Alemayehu SS, Walsh TR, Zahra R, Dramowski A, Fwoloshi S, Labi AK, Madrid L, Obeng-Nkrumah N, Ojok D, Wadugu BD, Whitelaw AC, Bethou A, Bhargava A, Jindal A, Nanavati RN, Prasad PS, Sastry A, Farooqi JQ, Ghanchi N, Jehan F, Khan E, Agarwal RK, Aiken AM, Berkley JA, Coffin SE, Feasey NA, Govender NP, Hamer DH, Madhi SA, Nisar MI, Saha SK, Saha S, Sankar MJ, Wyres KL, Holt KE: Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: A meta-analysis of genome-predicted serotype prevalence to inform potential vaccine coverage. PLoS Med 23(1): e1004879, Jan 2026.
16b Hoffmann Sardá FA, Giuntini EB, Oliveira A, Souza GS, Prado SBR, Taddei CR, Tadini CC, Bittinger K, Bushman FD, Menezes EW, Hoffmann C: Baseline intestinal microbiota composition influences response to a real-world dietary fiber intervention. NPJ Biofilms Microbiomes 11(1): 203, Nov 2025.
166 Hewlett KK, PeBenito A, Hecht AL, Tiffany C, Tanes C, Glover RC, Fawad JA, Friedman ES, Reynolds JC, Bittinger K, Lewis JD, Wu GD, Ahuja NK, Zackular JP: Dietary fiber modulates the window of susceptibility to Clostridioides difficile infection. Gastroenterology 169(5): 970, Oct 2025.
105 Tanes C, Hu W, Friedman E, Hecht A, Daniel S, Clish C, Lewis JD, Wu GD, Bittinger K: Distinguishing diet- and microbe-derived metabolites in the human gut. Microbiome 13(1): 206, Oct 2025.
1e9 McGann CM, Strysko J, Bayani O, Moorad B, Ntlhako N, Nwako N, Hu W, Tanes C, Moustafa AM, Jones SM, Nakstad B, Gezmu AM, Arscott-Mills T, Goldfarb DM, Steenhoff AP, Richard-Greenblatt M, Machiya T, Thela T, Mokomane M, Paganotti GM, Vurayai M, Zalot M, Boustany M, Planet PJ, Coffin S, Bittinger K: Effect of maternal HIV status on the early neonatal microbiome. J Pediatric Infect Dis Soc 14(10): piaf076, Oct 2025.
115 Drake MJ, Pierdon M, DeMers G, Daniel SG, Bittinger K, Redding LE: The effect of dietary zinc on the microbiome and resistome of the gestating sow and neonatal piglets. Anim Microbiome 7(1): 71, Jul 2025.
242 Feigenberg SJ, Costabile F, Tanes C, Bittinger K, O'Connor R, Agarwal D, Skoufos G, Salaris S, Hatzigeorgiou A, Kostopoulos N, Lloyd S, Friedes C, Chen L, Yegya-Raman N, Cengel K, Levin W, Valentić B, Quarton T, Shestov AA, Berman A, Bradley J, Maity A, Koumenis C, Ben-Josef E, Facciabene A: Enhancing outcomes in medically inoperable early-stage NSCLC with gut-targeted antibiotics and stereotactic body radiotherapy: results from a randomized pilot study. J Immunother Cancer 13(6): e011356, Jul 2025.
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