Kyle Bittinger
Kyle Bittinger, Ph.D.
Associate Professor of Pediatrics (Gastroenterology, Hepatology and Nutrition) at the Children's Hospital of Philadelphia
Bioinformatics Laboratory Director, Microbiome Center, Children's Hospital of Philadelphia
Director of Analytics, Center for Microbial Medicine, Children's Hospital of Philadelphia
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Microbiome Center
Roberts Center for Pediatric Research
2716 South Street, 14th Floor
Philadelphia, PA 19146-2305
Microbiome Center
Roberts Center for Pediatric Research
2716 South Street, 14th Floor
Philadelphia, PA 19146-2305
Office: 267-425-1641
Email:
bittingerk@chop.edu
bittingerk@chop.edu
Graduate Group Affiliations
Education
B.S. (Chemistry)
University of Pittsburgh, 2001.
Ph.D. (Physical Chemistry)
Massachusetts Institute of Technology, 2008.
Permanent linkB.S. (Chemistry)
University of Pittsburgh, 2001.
Ph.D. (Physical Chemistry)
Massachusetts Institute of Technology, 2008.
Selected Publications
Semon A, Manzer HS, Keenan O, Zhou TH, Tiffany C, She Q, Knight M, Weiss AS, Donohoe K, Morrow BT, Glover RC, Kovalik ME, Tanes C, Bittinger K, Zemel BS, Wu GD, Silverman MA, Gerber JS, Cano RodrÃguez R, Lacy DB, Karakasheva TA, Alameh MG, Weissman D, Schultz-Cherry SL, Rosch JW, Planet PJ, Moustafa AM, Furth EE, Abt MC, Kelsen JR, Conrad MA, Hamilton KE, Zackular JP: Early-life colonization with Clostridioides difficile remodels the developing gut. Science 393(6815): 1045, Sep 2026.Payette F, Long AE, Hu W, Bittinger K, Moustafa AM, Stefanovski D, Abraham M, Aitken MR: Diagnosis of bacteraemia in neonatal foals using 16S rRNA high-throughput sequencing. Equine Vet J Jul 2026 Notes: doi: 10.1002/evj.70222. Epub ahead of print.
Duan J, Marques AD, Hogenauer M, Hwang Y, Zhang Y, Timperman A, Higgins S, Wilson NG, Fitts EA, Lim HK, Bittinger K, Moustafa AM, Collman RG, Bushman FD: Optimizing methods for virome analysis based on studies of a synthetic viral community. mSystems Page: e0018826, Jun 2026 Notes: doi: 10.1128/msystems.00188-26. Epub ahead of print.
Strysko J, Hu W, Mochankana K, John-Thubuka J, Zankere T, Gopolang B, Theiller E, Jones SM, Tembo CV, Ntereke TD, Gatonye T, Lechiile K, Keatholetswe T, Bianco C, Coffin SE, McGann C, Bittinger K, Lautenbach E, Mannathoko N, Mokomane M, Mosepele M, Richard-Greenblatt M, Nakstad B, Goldfarb DM, Planet PJ, Moustafa AM: Integrated epidemiologic investigation and genomic confirmation of a Klebsiella pneumoniae neonatal sepsis outbreak in Botswana. PLOS Glob Public Health 6(6): e0006468, Jun 2026.
Daniel SG, Matute JD, Dhudasia MB, Rosewood H, Wilson NG, Patterson A, Hao F, Underwood M, Bittinger K, Mukhopadhyay S: Gut microbiome in preterm infants with different weight gain outcomes. Gut Microbiol 2: 100010, May 2026.
Sun H, Noya-Alarcon O, Wang J, Daniel SG, Bittinger K, Mohamed W, Scanlan PD, Shah C, Kundu T, Blaser MJ, Mueller NT, Lander O, Bevilaqua M, Robles DV, Contreras M, Dominguez-Bello MG: Rapid microbiome restructuring associated with medical exposure in remote Amazonian Indigenous communities. Cell Rep 45(5): 117343, May 2026.
Boyle NR, Sekela JJ, Wang M, Mannochio-Russo H, Pyo JJ, Kim MS, Tian S, Koo I, Friedman ES, Tanes C, Anitha M, Tian Y, Morgan EW, Murray IA, Zackular JP, Bittinger K, Lewis JD, Perdew GH, Wu GD, Zemel BS, Dorrestein PC, Bisanz JE, Redinbo MR, Patterson AD: Glucuronidation metabolomic fingerprinting to map host-microbe metabolism. Nat Commun May 2026 Notes: doi: 10.1038/s41467-026-73398-1. Epub ahead of print.
Odih EE, Abdulahi JA, Amulele AV, Bates M, Heinz E, Hu W, Jain K, Magobo R, Olwagen CP, Tembo JM, Sonda T, Strysko J, Tigoi CC, Bittinger K, Cornick J, Foster-Nyarko E, Gumbi W, Jones SM, Musyani CL, McGann CM, Moustafa AM, Musicha P, Mwansa JCL, Ndumba ML, Stanton TD, Omuoyo DO, Pearse O, Phillips LT, Planet PJ, Rodrigues CMC, Secka F, Sands K, Theiller E, Zuza AM, Basu S, Chan GJ, Iregbu KC, Mazarati JB, Alemayehu SS, Walsh TR, Zahra R, Dramowski A, Fwoloshi S, Labi AK, Madrid L, Obeng-Nkrumah N, Ojok D, Wadugu BD, Whitelaw AC, Bhargava A, Jindal A, Agarwal RK, Aiken AM, Berkley JA, Coffin SE, Feasey NA, Govender NP, Hamer DH, Madhi SA, Sankar MJ, Wyres KL, Holt KE: Contribution of nosocomial transmission to Klebsiella pneumoniae neonatal sepsis in Africa and South Asia: An observational study of infection clusters inferred from pathogen genomics and temporal data. PLoS Med 23(5): e1005077, May 2026 Notes: Epub ahead of print.
Ferro LE, Bittinger K, Trudo SP, Kim JK, Hunt CM, Brewer B, Polson SW, Trabulsi JC: Influence of Singular First Foods on the Infant Gut Microbiome: A Randomized Controlled Trial. J Nutr 156(5): 101470, May 2026.
Tanes C, Wilson NG, Smith M, Patel TT, Merenstein C, Bushman FD, Bittinger K, Buffenstein R: The naked mole-rat microbiome is associated with healthy aging and social structure. Cell Rep 45(4): 117265, Apr 2026 Notes: Epub ahead of print.