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Elizabeth A Grice
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Professor of Dermatology
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Department: Dermatology
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Graduate Group Affiliations
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Contact information
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421 Curie Blvd
32 1015 BRB II/III
Philadelphia, PA 19104
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32 1015 BRB II/III
Philadelphia, PA 19104
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Office: 215-898-3179
3e Lab: 215-573-1095
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3e Lab: 215-573-1095
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Publications
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Education:
21 9 B.A. 14 (Biology) c
27 Luther College, 2001.
21 a Ph.D. 1b (Human Genetics) c
31 Johns Hopkins University, 2006.
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Permanent link21 9 B.A. 14 (Biology) c
27 Luther College, 2001.
21 a Ph.D. 1b (Human Genetics) c
31 Johns Hopkins University, 2006.
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4b Skin microbiome; cutaneous host-microbe interactions; wound healing
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1d Research Description:
2c0 The skin is a formidable barrier and the first line of defense against the external environment. The skin is also colonized with microbial communities, which we hypothesize have critical functions in cutaneous health and disease. These functions may include but are not limited to colonization resistance to block invasion by opportunistic or pathogenic microbiota and regulation of immunity and inflammation. Various cutaneous disorders and infections are hypothesized to in part result from dysregulation of microbiota-host interactions. The Grice lab applies a variety of different approaches, model systems, and human tissues and isolates to elucidate mechanisms regulating such interactions.
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58 Currently, research in the laboratory is divided into the following focus areas:
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3c (1) Skin microbiome regulation of epithelial defense
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54 (2) Microbial regulation of tissue repair and inflammation in chronic wounds
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54 (3) Skin microbiota-driven mechanisms of colonization resistance to pathogens
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Description of Research Expertise
24 Research Interests:4b Skin microbiome; cutaneous host-microbe interactions; wound healing
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1d Research Description:
2c0 The skin is a formidable barrier and the first line of defense against the external environment. The skin is also colonized with microbial communities, which we hypothesize have critical functions in cutaneous health and disease. These functions may include but are not limited to colonization resistance to block invasion by opportunistic or pathogenic microbiota and regulation of immunity and inflammation. Various cutaneous disorders and infections are hypothesized to in part result from dysregulation of microbiota-host interactions. The Grice lab applies a variety of different approaches, model systems, and human tissues and isolates to elucidate mechanisms regulating such interactions.
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58 Currently, research in the laboratory is divided into the following focus areas:
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3c (1) Skin microbiome regulation of epithelial defense
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54 (2) Microbial regulation of tissue repair and inflammation in chronic wounds
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54 (3) Skin microbiota-driven mechanisms of colonization resistance to pathogens
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13c Chiesa Fuxench ZC, Rau A, Mitra N, Grice EA, Hoffstad O, Margolis DJ.: Is Seborrheic Dermatitis of Infancy and Childhood Related to In Utero Exposure to Antibiotics? A Population-Based Cohort Study From the United Kingdom. Int J Dermatol 2026.
16c Lovins V, Farias Amorim C, Robles N, Murga-Garrido S, Ting-Chun Pan J, Singh TP, DeNardo E, Carvalho LP, Carvalho EM, Scott P, Grice EA.: Staphylococcus aureus promotes strain-dependent immunopathology during cutaneous leishmaniasis through induction of IL-1β Cell Rep 44: 115624, May 2025.
12a Bae J, Campbell A, Hein M, Hillis SL, Grice E, Rakel BA, Gardner SE.: Relationship of opioid tolerance to patient and wound factors, and wound micro-environment in patients with open wounds. J Wound Care 34: S6-S16, Feb 2025.
193 Uberoi A, Murga-Garrido SM, Bhanap P, Campbell AE, Knight SAB, Wei M, Chan A, Senay T, Tegegne S, White EK, Sutter CH, Mesaros C, Sutter TR, Grice EA.: Commensal-derived tryptophan metabolites fortify the skin barrier: Insights from a 50-species gnotobiotic model of human skin microbiome. Cell Chem Biol 32(1): 111-125, Jan 2025.
14b Rau A, Leahr G, Del Pozo D, Hoffstad O, Chiesa Fuxench ZC, Grice E, Margolis DJ.: Atopic dermatitis: Association of maternal and child history of celiac disease and the child's development of atopic dermatitis. J Am Acad Dermatol S0190-9622(25)00178-1, 2025.
178 Eager JM, Cortes-Troncoso J, Kalan L, Campbell A, Rao A, Weingarten MS, Grice EA, Oropallo A, Margolis DJ, Sacan A, Spiller KL.: Differential Gene Expression in Healing and Non-Healing Diabetic Foot Ulcers and Discovery of Novel Ratiometric Biomarker to Predict Healing Outcome. Wound Repair Regen 2025.
148 Chiesa Fuxench ZC, Mitra N, Grice E, Hoffstad O, Margolis DJ.: Is seborrhoeic dermatitis of infancy and childhood related to maternal history of seborrhoeic dermatitis? A large population-based cohort study from the UK. Br J Dermatol 192: 72-77, Dec 2024.
148 Barbieri JS, Ellenberg S, Grice E, Tierney A, VanderBeek SB, Papadopoulos M, Mason J, Mason A, Dattilo J, Margolis DJ.: Challenges in designing a randomized, double-blind noninferiority trial for treatment of acne: The SD-ACNE trial. Clin Trials Jul 2024.
167 White EK, Uberoi A, Pan JT, Ort JT, Campbell AE, Murga-Garrido SM, Harris JC, Bhanap P, Wei M, Robles NY, Gardner SE, Grice EA.: Alcaligenes faecalis corrects aberrant matrix metalloproteinase expression to promote reepithelialization of diabetic wounds. Sci Adv 10: eadj2020, Jun 2024.
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Selected Publications
1df Solanki S, Tasnim SM, Thompson LL, Alle M, Ward B, Slominski AT, Janjetovic Z, Jozwicka T, Erdmańska P, Minzaghi D, Sutter CH, Grice EA, Sutter TR.: Comparative 28-day mouse study of topically applied aryl hydrocarbon receptor ligands: microbiota-derived indoles, therapeutic tapinarof, pollutants 2,3,7,8-tetrachlorodibenzo-p-dioxin and diesel exhaust particles. Chem Biol Interact 433: 112066, Mar 2026.13c Chiesa Fuxench ZC, Rau A, Mitra N, Grice EA, Hoffstad O, Margolis DJ.: Is Seborrheic Dermatitis of Infancy and Childhood Related to In Utero Exposure to Antibiotics? A Population-Based Cohort Study From the United Kingdom. Int J Dermatol 2026.
16c Lovins V, Farias Amorim C, Robles N, Murga-Garrido S, Ting-Chun Pan J, Singh TP, DeNardo E, Carvalho LP, Carvalho EM, Scott P, Grice EA.: Staphylococcus aureus promotes strain-dependent immunopathology during cutaneous leishmaniasis through induction of IL-1β Cell Rep 44: 115624, May 2025.
12a Bae J, Campbell A, Hein M, Hillis SL, Grice E, Rakel BA, Gardner SE.: Relationship of opioid tolerance to patient and wound factors, and wound micro-environment in patients with open wounds. J Wound Care 34: S6-S16, Feb 2025.
193 Uberoi A, Murga-Garrido SM, Bhanap P, Campbell AE, Knight SAB, Wei M, Chan A, Senay T, Tegegne S, White EK, Sutter CH, Mesaros C, Sutter TR, Grice EA.: Commensal-derived tryptophan metabolites fortify the skin barrier: Insights from a 50-species gnotobiotic model of human skin microbiome. Cell Chem Biol 32(1): 111-125, Jan 2025.
14b Rau A, Leahr G, Del Pozo D, Hoffstad O, Chiesa Fuxench ZC, Grice E, Margolis DJ.: Atopic dermatitis: Association of maternal and child history of celiac disease and the child's development of atopic dermatitis. J Am Acad Dermatol S0190-9622(25)00178-1, 2025.
178 Eager JM, Cortes-Troncoso J, Kalan L, Campbell A, Rao A, Weingarten MS, Grice EA, Oropallo A, Margolis DJ, Sacan A, Spiller KL.: Differential Gene Expression in Healing and Non-Healing Diabetic Foot Ulcers and Discovery of Novel Ratiometric Biomarker to Predict Healing Outcome. Wound Repair Regen 2025.
148 Chiesa Fuxench ZC, Mitra N, Grice E, Hoffstad O, Margolis DJ.: Is seborrhoeic dermatitis of infancy and childhood related to maternal history of seborrhoeic dermatitis? A large population-based cohort study from the UK. Br J Dermatol 192: 72-77, Dec 2024.
148 Barbieri JS, Ellenberg S, Grice E, Tierney A, VanderBeek SB, Papadopoulos M, Mason J, Mason A, Dattilo J, Margolis DJ.: Challenges in designing a randomized, double-blind noninferiority trial for treatment of acne: The SD-ACNE trial. Clin Trials Jul 2024.
167 White EK, Uberoi A, Pan JT, Ort JT, Campbell AE, Murga-Garrido SM, Harris JC, Bhanap P, Wei M, Robles NY, Gardner SE, Grice EA.: Alcaligenes faecalis corrects aberrant matrix metalloproteinase expression to promote reepithelialization of diabetic wounds. Sci Adv 10: eadj2020, Jun 2024.
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