Faculty

Jonni S. Moore, Ph.D.

Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania

Department: Pathology and Laboratory Medicine

Graduate Group Affiliations

Immunology

Contact information

211 and 297 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104

Office: (215) 898-6853
Fax: (215) 898-4227

Email:
moorej@pennmedicine.upenn.edu

Publications

Search PubMed for articles

Education
B.A. (Biology)
University of Virginia, Charlottesville, 1972.
Ph.D. (Microbiology)
Thomas Jefferson University, Philadelphia, 1984.

Links
Search PubMed for articles
Primary Work Website
Immunology graduate group faculty webpage.

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

Research Summary

Research in our laboratory centers on technology development with a focus on complex technologies, in particular cytomics. We pioneered new technology in flow cytometry liquid biopsies including the detection of extracellular vesicles as a rich source of prognostic and diagnostic information and developing this technology for diagnostics/prognostics in cardiovascular disease, traumatic brian injury and relapsing breast cancer. Most recently we have focused on the development of high dimensional deep phenotyping approaches for the identification of biomarkers of cancer responses using advance cytomic technology.
Current collaborators:
Lewis Chodosh, MD, PhD, Cancer Biology
Erica Carpenter, MBA, PhD, Department of Medicine
John Wherry, PhD, Department of Microbiology, Parker Institute for Cancer Immunotherapy

Selected Publications

Derek D. Jones1, Jennifer Jakubowski1, William Murphy1, and Jonni S. Moore1: Evaluation of the Imaging Capabilities of the Discover A8. International Society for the Advancement of Cytometry 2026, Abstract, Wiley, June 2026.

O'Reilly EM, Cabanski CR, Lyman JP, Wainberg ZA, Fisher GA, Wolff RA, Ko AH, O'Hara MH, Spencer CN, Yu JX, Da Silva DM, Padrón LJ, Arnott J, Fairchild J, Moore JS, Peng B, Hoos WA, O'Donnell-Tormey J, Boffo S, Dugan U, Kimmelman AC, Amaravadi RK, Vonderheide RH.: Clinical and translational results from a phase 1 trial of gemcitabine/nab-paclitaxel with nivolumab/ipilimumab or hydroxychloroquine/ipilimumab in untreated metastatic pancreatic adenocarcinoma. J Immunother Cancer. BMJ Publishing Group/ Society for Immunotherapy of Cancer, Jan 30;14(1):e012864, Jan 2026.

Chislock EM, Pan TC, Pant D, Chen Y, Woodfield G, Graves J, Lawrence-Paul MR, Belka GK, Wang J, Bayne L, Blanchard T, Smith M, Ji X, Shih NNC, Soucier-Ernst D, Goodman N, Nivar I, Goodspeed B, DeLuca S, Ndicu J, Clark C, Langer M, William Stavropoulos S, DeMuth W, Morschauser A, Murphy W, Nayak A, Feldman M, Clark A, Yu L, Judge K, Bornheimer S, Pletcher CH Jr, Moore JS, DeMichele A, Chodosh : DTC-Flow: a flow cytometry-based detection platform for characterizing bone marrow disseminated tumor cells in breast cancer. NPJ Breast Cancer. Springer Nature (Nature Portfolio), 2025 Nov 24;11(1):139, November 2025 Notes: in partnership with the Breast Cancer Research Foundation.

Shifu Tian, Charles H. Pletcher Jr., Hongen Wang, William Murphy, Jonni S. Moore : Evaluating Micro-5 as a Biosafety Alternative to Cyclex-D in Novel Aerosol Containment Testing ISAC Annual Meeting, Cyto 2025 Denver June 2025 Notes: Peer Reviewed Poster presentation at CYTO 2025.

Jennifer Jakubowski, William Murphy, Derek D. Jones, Jacquelyn Thomas, Jonni S. Moore ,Department of Pathology and Laboratory Medicine, Abramson Cancer Center, Penn Cytomics and Cell Sorting Resource Laboratory, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA : How to Build Effective Training Modalities in a Shared Resource Laboratory. CYTO 2025 annual meeting of ISAC-Denver June 2025 Notes: Peer reviewed poster presentation at CYTO 2025.

William Murphy1, Richard Schretzenmair1, Samantha Pearson1, Jennifer Jakubowski1, Derek Jones1, Robert Balderas2, Jonni Moore1 1University of Pennsylvania, Penn Cytomics and Cell Sorting Shared Resource Laboratory, Philadelphia, PA 2BD Biosciences, Sane Jose, CA : Impact of Instrument Configuration and Compensation Methods on the Performance of a Large Library of Fluorochromes: Critical Concerns for Panel and Assay Design Annual meeting of ISAC, CYTO 2025 June 2025 Notes: Peer-reviewed poster presentation at CYTO 2025.

Pearson, S., Schretzenmair, R., Moore, J., Jones, D. : When the Powerhouse Powers Down: Development of a Functional Flow Cytometric Panel to Identify Changes in Mitochondrial Phenotypes During Induced Cell Death Pathways Annual meeting of ISAC, CYTO 2025 Denver June 2025 Notes: Peer-reviewed poster presented at CYTO 2025.

Apostolia M. Tsimberidou, Farah A. Alayli, Kwame Okrah, Alexandra Drakaki, Danny N. Khalil, Shivaani Kummar, Saad A. Khan, F. Stephen Hodi, David Y. Oh, Christopher R. Cabanski, Shikha Gautam, Stefanie L. Meier, Meelad Amouzgar, Shannon M. Pfeiffer, Robin Kageyama, EnJun Yang, Marko Spasic, Michael T. Tetzlaff, Wai Chin Foo, Travis J. Hollmann, Yanyun Li, Matthew Adamow, Phillip Wong, Jonni S. Moore, Sharlene Velichko, Richard O. Chen, Dinesh Kumar, Samantha Bucktrout, Ramy Ibrahim, Ute Dugan, Lisa Salvador, Vanessa M. Hubbard-Lucey, Jill O’Donnell-Tormey, Sandra Santulli-Marotto, Lisa H. Butterfield, Diane M. Da Silva, Justin Fairchild, Theresa M. LaVallee, Lacey J. Padrón, Padmanee Sharma: Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer. . J Exp Med 221: 221 (10), August 2024 Notes: ): e20240152. doi: https://doi.org/10.1084/jem.20240152

Bellomo TR, Tsao NL, Johnston-Cox H, Borkowski K, Shakt G, Judy R, Moore J, Ractcliffe SJ, Fiehn O, Floyd TF, Wehrli FW, Mohler E, Newman JW, Damrauer SM. : Metabolite patterns associated with individual response to supervised exercise therapy in patients with intermittent claudication. JVS Vasc Sci. 3: 379-388, October 2022 Notes: doi: 10.1016/j.jvssci.2022.10.002.

Moen Sen, 1 Ryan M. Hausler, 1 Keely Dulmage, 2 Taylor A. Black, 1 William Murphy, 3 Charles H. Pletcher Jr, 3Ling Wang, 2 Chang Chen, 2 Stephanie S. Yee, 1 Scott J. Bornheimer, 4 Kara N. Maxwell, 1 Ben Z. Stanger, 5Jonni S. Moore, 3 Jeffrey C. Thompson, 6 and Erica L. Carpenter 1: Transcriptional profiling of single tumor cells from pleural effusions reveals heterogeneity of epithelial to mesenchymal transition and extra-cellular matrix marker expression. Clin Trans Med 12(7), July (online) 2022.