Faculty

Michael Silverman, MD, PhD

Assistant Professor of Pediatrics (Infectious Diseases)

Department: Pediatrics

Graduate Group Affiliations

Contact information

Children's Hospital of Philadelphia
Division of Infectious Diseases
3615 Civic Center Blvd
Philadelphia, PA 19104

Email:
silvermam1@email.chop.edu

Education:
BS (Biology)
Cornell University, 1998.
MD, PhD (Medicine and Immunology)
University of Pennsylvania School of Medicine, 2007.

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

Immunocompromised patients

Description of Research Expertise

Microbiome, Immunology, HLA, MHC, antibiotics, intestinal immune system, autoimmune (type I) diabetes, IgA deficiency, Early life immune system development

Selected Publications

Christine M. Tin1, Bianca Cordazzo Vargas, Darryl A. Abbott, Aditi Lohar, Tiffany C. Taylor, Ivan Valishev, Sarah Weinshel, Vung Lian, Matthew Butoryak, Michael A. Silverman, Liat Shenhav, William H. DePas, Timothy W. Hand: Single-cell quantitation of the microbiota by flow cytometry: MicFLY. Cell Host and Microbe June 2026.

Omry Koren, Maria Carmen Collado, Benoit Chassaing, Michael A Silverman, Liza Konnikova: Microbial metabolites at the front line: Orchestrating gastrointestinal and systemic barrier immunity across the lifespan. Cell Reports June 2026.

Alexa Semon1,2,3†, Haider S. Manzer1,2,10†, Orlaith Keenan1,2,4, Tiffany H. Zhou1,2,4, Connor Tiffany1,2,10, Qianxuan She1,2,4,5,9,10, Montana Knight6, Ashley S. Weiss1,2,4, Kassy Donohoe1,2, Brendan T. Morrow7,8, Rochelle C. Glover1,2,10, Maria E. Kovalik3, Ceylan Tanes5,10, Kyle Bittinger5,9,10, Babette S. Zemel5,9, Gary D. Wu11, Michael A. Silverman9,10,12, Jeffrey S. Gerber8,12, Rubén Cano Rodríguez13, D. Borden Lacy13,14,15, Tatiana A. Karakasheva5,16, Mohamad- Gabriel Alameh1, Drew Weissman17, Stacey L. Schultz-Cherry7, Jason W. Rosch7, Paul J. Planet9,10,12,18, Ahmed M. Moustafa5,9,10, Emma E. Furth19, Michael C. Abt3,4, Judith R. Kelsen5,9, Maire A. Conrad5,9,10, Kathryn E. Hamilton5,16, Joseph P. Zackular1,2,3,10*: Early-life colonization with Clostridioides difficile remodels the neonatal gut. Science 2026 Notes: accepted for publication.

Maryam abedi, Priyandarshini Rai, Yeqiao Zhou, Chengyang Liu, Isabelle Johnson, Aditi Chandra, Maria Fasolino, Susan Rostami, Wei Wang, Zaw Min, Yinjing LI, Ming Yu, Atishay Jay, Vung Lian, Michael Silverman, Klaus Kaestner, Ali Naji, Robert B. Faryabi, Golnaz Vahedi: Joint profiling of gene expression and chromatin accessibility in the pancreatic lymph nodes and spleens in human type 1 diabetes. Science Immunology November 2025 Notes: accepted for publication.

Jean-Bernard Lubin, Paul J. Planet, Michael A. Silverman: Microbial succession at weaning is guided by microbial metabolism of host glycans. Microbiome October 2025.

Michael Silverman and Kathryn Knoop: Setting the table for immune tolerance. Science 389(6761): 684-685, August 2025.

Shenhav L, Azad M, and Silverman MA.: Human Milk as a Microbial Pacemaker. Cell Host and Microbe 33(6): 762-765, June 2025.

Natalie A Trigg, Simon K Zhou, Jordan C Harris, Madeline N Lamonica, Molly A Nelson, Michael A Silverman, Taku Kambayashi, Colin C Conine: A lack of commensal microbiota influences the male reproductive tract intergenerationally in mice. Reproduction 169(4): e240204, March 2025.

Jean-Bernard Lubin, Paul J. Planet, Michael A. Silverman: Microbial succession at weaning is guided by microbial metabolism of host glycans. bioRxiv Page: doi: 10.1101/2025.02.20.639370, February 2025.

Siqi Linsey Zhang, Carolyn M McGann, Tereza Duranova, Jonathan Strysko, Andrew P Steenhoff, Alemayehu Gezmu, Britt Nakstad, Tonya Arscott-Mills, One Bayani, Banno Moorad, Nametso Tlhako, Melissa Richard-Greenblatt, Paul J Planet, Susan E Coffin, Michael A Silverman: Maternal and neonatal IgG against Klebsiella pneumoniae are associated with lower risk of neonatal sepsis: a case-control study of hospitalized neonates in Botswana. PLOS Global Public Health 4(12): e0003350, December 2024.