Faculty

Michael Silverman, MD, PhD

Assistant Professor of Pediatrics (Infectious Diseases)

Department: Pediatrics

Graduate Group Affiliations

Contact information

Children's Hospital of Philadelphia
Division of Infectious Diseases
3615 Civic Center Blvd
Philadelphia, PA 19104

Email:
silvermam1@email.chop.edu

Education:
BS (Biology)
Cornell University, 1998.
MD, PhD (Medicine and Immunology)
University of Pennsylvania School of Medicine, 2007.

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

Immunocompromised patients

Description of Research Expertise

Microbiome, Immunology, HLA, MHC, antibiotics, intestinal immune system, autoimmune (type I) diabetes, IgA deficiency, Early life immune system development

Selected Publications

Jean-Bernard Lubin 1, Michael A Silverman 1 2 3 4, Paul J Planet 1 2 3: Comparison of gnotobiotic communities reveals milk-adapted metabolic functions and unexpected amino acid metabolism by the pre-weaning microbiome. Gut Microbes Page: DOI: 10.1080/19490976.2024.2387875, August 2024.

Jamal Green, John Deschaine, Jean-Bernard Lubin, Julia Flores, Sarah Maddux, Tereza Duranova, Logan Grimes, Paul J. Planet, Laurence C. Eisenlohr, Michael A. Silverman.: Early-life exposures to specific commensal microbes prevent type 1 diabetes. bioRxiv Page: doi.org/10.1101/2024.02.15.580579. February 2024.

Julia N. Flores,1,2 Jean-Bernard Lubin,1 and *Michael A. Silverman1-4: The case for microbial intervention at weaning. Gut Microbes 2024.

Conrey PE, Denu L, O'Boyle KC, Rozich I, Green J, Maslanka J, Lubin JB, Duranova T,Haltzman BL, Gianchett L, Oldridge DA, De Luna N, Vella LA, Allman D, Spergel J, Tanes C, Bittinger K, Henrickson SE, Silverman MA: IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation. Science Immunology May 2023

Liat Shenhav, Kelsey Fehr, Myrtha E. Reyna, Charisse Petersen, Darlene L. Y. Dai, Ruixue Dai, Vanessa Breton, Laura Rossi, Marek Smieja, Elinor Simons, Michael A. Silverman, Maayan Levy, Lars Bode, Catherine J. Field, Jean S Marshall, Theo J. Moraes, Piush J. Mandhane, Stuart E. Turvey, Padmaja Subbarao, Michael G. Surette, Meghan B. Azad: Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development. Cell September 2023.

Jean-Bernard Lubin, Jamal Green, Sarah Maddux, Lidiya Denu, Tereza Duranova, Matthew Lanza, Meghan Wynosky-Dolfi, Igor E. Brodsky, Paul J. Planet, Michael A. Silverman: Arresting microbiome development limits immune system maturation and resistance to infection. Cell Host and Microbe March 2023 Notes: https://doi.org/10.1016/j.chom.2023.03.006.

Alexander B. Smith, Matthew L. Jenior, Orlaith Keenan, Jessica L. Hart, Jonathan Specker, Arwa Abbas, Paula C. Rangel, Chao Di, Jamal Green, Jennifer A. Gaddy, Maribeth R. Nicholson, Clare Laut, Jason A. Papin, Frederic D. Bushman, Jessi Erlichman, Robert Baldassano, Michael A. Silverman, Gary M. Dunny1, Boone M. Prentice, Eric P. Skaar, Joseph P. Zackular: Microbial Cooperation Enhances Clostridioides difficile Pathogenesis. Nature Sep 2022.

Sarah Maddux, Jamal Green, Jean-Bernard Lubin, Julia Flores, Isaiah Rozich, Tereza Duranova, Paul J. PlanetMichael A. Silverman: Akkermansia muciniphila modulates adaptive immunity to commensal microbes in young NOD mice bioRxiv Page: https://doi.org/10.1101/2022.08.16.504185, August 2022.

Silverman MA and Green JL. : Insight into host-microbe interactions using microbial flow cytometry coupled to next generation sequencing. Journal of the Pediatric Infectious Diseases Society 10: S106-S111, December 2021.

Robert B Lindell, Michael S Wolf, Alicia M Alcamo, Michael A Silverman, Daniel E Dulek, William R Otto, Timothy S Olson, Carrie L Kitko, Paisit Paueksakon and Kathleen Chiotos: Immune dysregulation due to Toxoplasma gondii reactivation after allogeneic hematopoietic cell transplant: a case series and review of the literature. Frontiers in Pediatrics 10(9): 719679, August 2021.