Jason M Brenchley, Ph.D.

faculty photo
Adjunct Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
4 Center Dr. Rm 201
Barrier Immunity Section
Lab of Viral Diseases
Bethesda, MD 20892
Office: 301-496-1498
BS (Microbiology)
Idaho State University, 1998.
BS (Chemistry)
Idaho State University, 1998.
MS (Chemistry)
Idaho State University, 1999.
PhD (Immunology)
University of Texas Southwestern Medical Center at Dallas, 2003.
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Selected Publications

Starke, C.E., C.L. Vinton, K. Ladell, J.E. McLaren, A.M. Ortiz, J.C. Mudd, J.K. Flynn, S.H. Lai, F. Wu, V.M. Hirsch, S. Darko, D.C. Douek, D.A. Price and J.M. Brenchley: SIV-specific CD8+ T cells are clonotypically distinct acrdoss lymphoid and mucosal tissues. Journal of Clinical Investigation 2020.

Lai, S.H., C.E. Starke, J.K. Flynn, C.L. Vinton, A.M. Ortiz, J.C. Mudd, and J.M. Brenchley*: Simian Immunodeficiency Virus Infects Functionally Polarized Memory CD4 T Cells Equivalently In Vivo. Journal of Virology 2019.

Ortiz, A.M., J.K. Flynn, S.R. DiNapoli, O. Sortino, I. Vujkovic-Cvijin, Y. Belkaid, I. Sereti, and J.M. Brenchley: Antiretroviral therapy administration in healthy rhesus macaques is associated with transient shifts in intestinal bacterial diversity and modest immunological perturbations. Journal of Virology 2019.

Vinton, C.V., S.J. Magaziner, K.A. Dowd, S.J. Robertson, E. Amaro-Carambot, E.P. Karmele, A.M. Ortiz, C.E. Starke, J.C. Mudd, S.S. Whitehead, S.J. Best, T.C. Pierson, H.D. Hickman, and J.M. Brenchley: Simian immunodeficiency virus infection of rhesus macaques results in delayed Zika virus clearance. mBio 2019.

Ortiz, A.M., J.K. Flynn, S.R. DiNapoli, I. Vujkovic-Cvijin, C.E. Starke, S.H. Lai, M.E. Long, O. Sortino, C.L. Vinton, J.C. Mudd, L. Johnston, K. Busman-Sahay, Y. Belkaid, J.D. Estes, and J.M. Brenchley*: Experimental microbial dysbiosis does not promote disease progression in SIV-infected macaques. Nature Medicine 2018.

Mudd, J.C., K. Busman-Sahay, S.R. DiNapoli, S. Lai, V. Sheik, A. Lisco, C. Deleage, B. Richardson, D.J. Palesch, M. Paiardini, M. Cameron, I. Sereti, R.K. Reeves, J.D. Estes, and J.M. Brenchley*: Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells. Nature communications 2018.

DiNapoli, S.R., A.M. Ortiz, F. Wu, K. Matsuda, H.L. Twigg, 3rd, V.M. Hirsch, K. Knox, and J.M. Brenchley*.: Tissue-resident macrophages can contain replication-competent virus in antiretroviral-naive, SIV-infected Asian macaques. Journal of Virology 2017.

Vinton, C.L., A.M. Ortiz, N. Calantone, J.C. Mudd, C. Deleage, D.R. Morcock, S. Whitted, J.D. Estes, V.M. Hirsch, and J.M. Brenchley*: Cytotoxic T Cell Functions Accumulate When CD4 Is Downregulated by CD4(+) T Cells in African Green Monkey. Journal of Immunology 2017.

Ortiz, A.M., Z.A. Klase, S.R. DiNapoli, I. Vujkovic-Cvijin, K. Carmack, M.R. Perkins, N. Calantone, C.L. Vinton, N.E. Riddick, J. Gallagher, N.R. Klatt, J.M. McCune, J.D. Estes, M. Paiardini, and J.M. Brenchley*.: IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques. Mucosal immunology 2016.

Vinton, C., F. Wu, J. Rossjohn, K. Matsuda, J. McCluskey, V.M. Hirsch, D.A. Price, and J.M. Brenchley*. : MAIT cells are systemically depleted in SIV-infected rhesus macaques. Journal of Virology 2016.

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Last updated: 03/05/2020
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