Joseph Cichon, MD, PhD
Assistant Professor of Anesthesiology and Critical Care
Director of In vivo imaging center for anesthetics and psychedelics, Penn
Department: Anesthesiology and Critical Care
Graduate Group Affiliations
Contact information
Hospital of the University of Pennsylvania
Department of Anesthesiology and Critical Care
3400 Spruce Street, Suite 680 Dulles
Philadelphia, PA 19104
Department of Anesthesiology and Critical Care
3400 Spruce Street, Suite 680 Dulles
Philadelphia, PA 19104
Education:
BS
Pennsylvania State University, 2008.
MS
Pennsylvania State University, 2009.
PhD (Neuroscience & Physiology)
NYU School of Medicine, 2015.
MD
NYU School of Medicine, 2017.
Permanent linkBS
Pennsylvania State University, 2008.
MS
Pennsylvania State University, 2009.
PhD (Neuroscience & Physiology)
NYU School of Medicine, 2015.
MD
NYU School of Medicine, 2017.
Description of Clinical Expertise
NeuroanesthesiaDescription of Research Expertise
The cellular and circuit mechanisms of rapid-acting antidepressants.Selected Publications
Joseph Cichon, Thomas T. Joseph, Xinguo Lu, Andrzej Z. Wasilczuk, Max B. Kelz, Steven J. Mennerick, Charles F. Zorumski & Peter Nagele : Nitrous Oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect. Nature Communication. Nature (16), 2999, April 2025.The Last Show with David Cooper: Laughing gas appears to reduce depression, but researchers don't totally understand why. Corus Radio network 2025.
Daniel Markman, Andrzej Z. Wasilczuk, and Joseph Michael Cichon: General Anesthesia Occludes Ketamine's Antidepressant Response in a Rodent Model of Chronic Stress. Psychedelic Medicine Mary Ann Liebert, May 2024 Notes: Published online ahead of print. https://doi.org/10.1089/psymed.2024.000.
Joseph Cichon, Andrzej Z. Wasilczuk, Loren L. Looger, Diego Contreras, Max B. Kelz & Alex Proekt: Ketamine triggers a switch in excitatory neuronal activity across neocortex. Nature Neuroscience Nature Neuroscience 26: 39-52, Nov 2022 Notes: https://doi.org/10.1038/s41593-022-01203-5.
Joseph Cichon, Renyu Liu, and Hoang V. Le: Therapeutic Potential of Salvinorin A and Its Analogues in Various Neurological Disorders. Transl Perioper Pain Med 9(2): 452–457, June 2022.
Sun L, Zhou H, Cichon J, Yang G.: Experience and sleep-dependent synaptic plasticity: from structure to activity. Philos Trans R Soc Lond B Biol Sci 375: 20190234, May 2020.
Cichon J, Magrané J, Shtridler E, Chen C, Sun L, Yang G, Gan WB.: Imaging neuronal activity in the central and peripheral nervous systems using new Thy1.2-GCaMP6 transgenic mouse lines. J Neurosci Methods 334: 108535, Jan 2020.
Alder A, Zhao R, Shin M, Yasuda R, Gan W: Somatostatin-expressing interneurons enable and maintain learning-dependent sequential activation of pyramidal neurons. Neuron 102(1): 202-217, Feb 2019 Notes: Developed the motor learning paradigm used in this paper. Made the original discovery that the activity of somatostatin neurons is differentially modified by different tasks.
Cichon J, Sun L, Yang G.: Spared Nerve Injury Model of Neuropathic Pain in Mice. Bio Protoc 8: e2777, Mar 2018.
Cichon J, Blanck TJJ, Gan WB, Yang G.: Activation of cortical somatostatin interneurons prevents the development of neuropathic pain. Nat Neurosci 20: 1122-1132, Aug 2017.