faculty photo

Renyu Liu, M.D., M.S., Ph.D.

Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania
Attending Anesthesiologist, Hospital of the University of Pennsylvania, Philadelphia, PA
Faculty, The Institute for Translational Medicine and Therapeutics, University of Pennsylvania
Center of Penn Global Heath Scholar, University of Pennsylvania
Director for the Center of Product Innovation , Department of Anesthesiology and Critical Care at the Perelman School of Medicine
Department: Anesthesiology and Critical Care

Contact information
Department of Anesthesiology and Critical Care
336 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104
Office: 2157461485
Fax: 2153495078
Lab: 2158983891
Graduate Group Affiliations
M.D. (Medicine)
Xuzhou Medical College, China, 1990.
Jiaotong University School of Medicine, China, 1993.
Tottori University School of Medicine, Japan, 2000.
Post-Graduate Training
Resident in Anesthesiology, Renji Hospital, Shanghai Second Medical University, Shanghai, China, 1993-1995.
Postdoctoral Research Fellow, University of Pennsylvania, Philadelphia, PA, 2001-2004.
Intern in Medicine, Mercy Fitzgerald Hospital/Mercy Hospital of Philadelphia, PA, 2004-2005.
Resident in Anesthesiology and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA, 2005-2008.
Entrepreneurship Fellowship, Yale University, 2022-2022.
Mack Technology Fellowship, Wharton School, University of Pennsylvania, 2023-2023.
American Board of Anesthesiology, 2009.
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Description of Research Expertise

My major research interests are as follows:
1) To investigate the molecular recognition mechanism of opioids and their receptors using biophysical, biochemical, thermodynamic, protein engineering, and high-resolution structural approaches.
2) Pharmacological effects of opioid receptor agonists.
3) Anesthetic interaction with proteins
4) Preoperative evaluation and outcome

Description of Clinical Expertise

Anesthesia for general surgery patients
Perioperative Medicine
outside OR anesthesia services
optimal opioid usage in perioperative period

Description of Other Expertise

Editor in Chief, Translational Perioperative and Pain Medicine

Selected Publications

Ji F, Wang Z, Ma N, Riley J, Armstead WA, Liu R: Herkinorin dilates cerebral vessels via kappa opioid receptor and cyclic adenosine monophosphate (cAMP) signalling in a piglet model. Brain Res 1490: 95-100, 2013.

Perez-Aguilar JM, Saven JG, Liu R: Human µ opioid receptor models with evaluation of the accuracy using the crystal structure of the murine µ opioid receptor. J Anesth Clin Res 3(218): doi:10.4172/2155-6148.1000218, 2012.

Bu W, Liu R, Cheung-Lau JC, Dmochowski IJ, Loll PJ, Eckenhoff RG: Ferritin couples iron and fatty acid metabolism. FASEB J 26(6): 2394-23400, 2012.

Liu R, Bu W, Xi J, Mortazavi SR, Cheung-Lau J, Dmochowski IJ, Loll PJ: Beyond the detergent effect: A binding site for sodium dodecyl sulfate (SDS) in mammalian apoferritin Acta Crystallogr D Biol Crystallogr 68(5): 497-504, 2012.

Liu R, Perez-Aguilar JM, Liang D, Saven JG: Binding site and affinity prediction of general anesthetics to protein targets using docking. Anesth Analg 114(5): 947-955, 2012.

Liu R, Garcia PS, Fleisher LA: Interest in anesthesia as reflected by keyword searches using common search engines. J Anesth Clin Res 3(1): 192. DOI: 10.4172/2155- 6148.1000192, 2012.

Oakley S, Vedula S, Bu W, Xi J, Liu R, Eckenhoff RG, Loll PJ: Recognition of anesthetic barbiturates by a protein binding site: A high resolution structural analysis. PLoS One 7(2): e32070, 2012 Notes:

Su D, Riley J, Kiessling WJ, Armstead WM, Liu R : Salvinorin A produces cerebrovasodilation through activation of nitric oxide synthase, κ receptor, and adenosine triphosphate-sensitive potassium channel. Anesthesiology 114(2): 374-379, 2011.

Zhou R, Perez-Aguilar JM, Meng Q, Saven JG, Liu R: Opioid binding sites in human serum albumin. Anesth Analg 114(1): 122-128, 2012.

Su D, Riley J, Kiessling WJ, Armstead WM, Liu R: Salvinorin A pretreatment preserves cerebrovascular autoregulation after brain hypoxic/ischemic injury via ERK/MAPK in piglets. Anesth Anal 114(1): 200-204, 2011.

Su D, Reiley J, Armstead W, Liu R: Salvinorin A dilates pial artery by activating NOS, opioid receptor and the KATP channel. Anesthesiology Page: A713, 2010.

Yan Z, Tanner JW, Lin D, Chalian AA, Savino JS, Fleisher LA, Liu R: Airway trauma in an academic cardiac electrophysiology laboratory center with high patient volume. Anesth Analg 116(1): 112-117, 2013.

Wang Z, Ma N, Rily J, Armstead WA, Liu R: Salvinorin A administration after global cerebral hypoxia/ischemia preserves cerebrovascular autoregulation via kappa opioid receptor in piglets. PLoS One 7(7): e41724, 2012.

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Last updated: 06/01/2024
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