Foteini Mourkioti - Faculty Biosketch

Foteini Mourkioti, PhD

Associate Professor of Orthopaedic Surgery

Co-Director, Penn Institute of Regenerative Medicine, Musculoskeletal Regeneration Program

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Department: Orthopaedic Surgery

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46 Contact information
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McKay Orthopaedic Research Laboratory
1a 377A Stemmler Hall
3a 3450 Hamilton Walk
Philadelphia, PA 19104-6081

2e Office: 215-898-8214
32 Fax: 215-573-2133
32 Lab: 215-573-3645
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Email:
fmour@pennmedicine.upenn.edu

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1f Graduate Group Affiliations 8

Bioengineering
Cell and Molecular Biology

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18 Publications
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26 Search PubMed for articles c

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Links
a4 Search PubMed for articles
73 Penn Center for Musculoskeletal Disorders
66 Penn Institute of Regenerative Medicine
75 The Pennsylvania Muscle Institute
6d McKay Orthopaedic Research Laboratory
83 Penn Cardiovascular Institute
63 Mourkioti Lab
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13 Education:
21 7 BA 14 (Biology) c
49 University of Patras, Faculty of Biology, Greece, 1998.
21 8 PhD 2f (Genetics and Developmental Biology) c
88 Max-Planck Institute for Biophysical Chemistry, Department Molecular Developmental Biology, Goettingen, Germany, 2002.
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1f Post-Graduate Training
24 97 Muscle Biology, Mouse Genetics and Heart Failure, European Molecular Biology Laboratory (EMBL), Mouse Biology Unit, Italy, 2003-2008.
24 a3 Stem Cell Biology, Stanford University School of Medicine, Baxter Laboratory for Stem Cell Biology, Clinical Sciences Research Center, 2009-2009.
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b6 > Perelman School of Medicine > Faculty > Details a

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Description of Research Expertise

126 Keywords: muscle stem cells, stem cell activation, muscle disorders, mechanobiology, aging, telomeres, NF-kB signaling, muscle regeneration, stem cell regulation, muscular dystrophy, cardiomyopathy, mitochondria, oxidative stress, M2 macrophages, muscle atrophy, muscle wasting.
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Selected Publications

14b He Q, Lu J, Liang Q, Yao L, Sun T, Wang H, Duffy M, Jiang X, Lin Y, Lee JH, Ahn J, Dyment NA, Mourkioti F, Boerckel JD, Qin L. : Prg4+ fibroadipogenic progenitors in muscle are crucial for bone fracture repair. Proc Natl Acad Sci U S A 5(122): 31, Aug 2025.

145 Chakkalakai SA, Grossman NZ, Mejias Rivera L, Roberts DW, Pacifici M, Mourkioti F, Shore EM.: An Inducible Knock-In Mouse Model of Fibrodysplasia Ossificans Progressiva (FOP) Shows Spontaneous Formation of Heterotopic Ossification. JBMR Plus July 2025.

124 Hilman MC, Mourkioti F, Das S, Cullen DK.: Tensile Forces and Nanofiber Alignment Influence Both Innervated and Non-Innervated Skeletal Myofiber Formation in Custom Mechanobioreactors. Biotechnology J. 20(6), Jun 2025.

173 Park G, Grey JA, Mourkioti F, Han WM.: 3D Mechanical Confinement Directs Muscle Stem Cell Fate and Function. Advanced Biology 9(4), April 2025 Notes: This paper was chosen for the Cover Page of the journal for the month of April: https://advanced.onlinelibrary.wiley.com/doi/10.1002/adbi.202570098.

e0 Ma N., Mourkioti F: Ex vivo two-photon imaging of whole-mount skeletal muscles to visualize stem cell behavior. STAR Protocols 5(1): 1-14, March 2024.

11e Das S, Hilman MC, Yang F, Mourkioti F, Yang W, Cullen DK.: Motor neurons and endothelial cells additively promote development and fusion of human iPSC-derived skeletal myocytes. Skeletal Muscle 7(14), March 2024.

148 Tichy ED, Lee JH, Li G, Estep KN, Johnson FB, Mourkioti F.: Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length. NPJ Microgravity 15(9): 76, September 2023 Notes: DOI : 10.1038/s41526-023-00303-1.

164 Bautista C.A., Srikumar A., Tichy E.D., Qian G., Jiang X., Qin L., Mourkioti F., Dyment N. CD206: CD206+ tendon resident macrophages and potential crosstalk with fibroblasts and the ECM during tendon growth and maturation. Front. Physiol., Sec. Skeletal Physiology 14, February 2023.

161 Ma N., Chen D., Lee, J.H., Kuri P., Hernandez E.B., Kocan B., Mahmood H., Tichy E.D., Rompolas P., Mourkioti F.: Piezo1 regulates the regenerative capacity of skeletal muscles via orchestration of stem cell morphological states. Science Advances. Science, 8(11): 1-14, March 2022.

e2 Stanley A, Tichy ED, Kocan J, Roberts DW, Shore EM and Mourkioti F.: Dynamics of skeletal muscle-resident stem cells during myogenesis in fibrodysplasia ossificans progressiva 74 NPJ Regenerative Medicine-Nature 7(1), January 2022 Notes: doi: 10.1038/s41536-021-00201-8.

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26 Last updated: 11/07/2025
34 The Trustees of the University of Pennsylvania c