Perelman School of Medicine at the University of Pennsylvania

Center for Research on Reproduction and Women's Health

Monica Ailawadi Mainigi

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Associate Professor of Obstetrics and Gynecology at the Hospital of the University of Pennsylvania
Attending, Infertility and Reproductive Endocrinology, Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending, Reproductive Surgical Facility, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending, Children’s Hospital of Philadelphia, Philadelphia, PA
Associate Program Director, Reproductive Endocrinology and Infertility Fellowship, University of Pennsylvania
Department: Obstetrics and Gynecology

Contact information
Clinical Practice:
PENN Fertility Care
Hospital of the University of Pennsylvania
3701 Market Street, 8th Floor

421 Curie Blvd BRB II/III Room 1352
Philadelphia, PA 19104
Office: 215-662-2972
BS (Biology)
Massachusetts Institute of Technology, 1996.
New York University School of Medicine, 2000.
Post-Graduate Training
Resident, Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA , 2000-2004.
National Research Service Award Postdoctoral Fellow, Center for Research on Reproduction and Women’s Health, University of Pennsylvania, Philadelphia, PA , 2004-2006.
Fellow, Reproductive Endocrinology and Infertility, Hospital of the University of Pennsylvania, Philadelphia, PA , 2006-2009.
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Description of Research Expertise

My laboratory focuses on examining the effects of the maternal environment on early implantation and placentation. For example, we are examining the role of ART technologies such as superovulation and frozen embryo transfer on implantation and placentation, as a model for how the maternal hormonal milieu affects early placentation. We arealos interested in epigenetic changes, specifically DNA methylation, occuring following ART and how this affects placentation, fetal growth and long-term health of the offspring. In addition, we have developed novel methods to study early human embryo implantation, including a "implantation-on-a-chip" device which is being used to study cells and factors regulating early trophoblast invasion at the earliest point of pregnancy establishment.

Description of Clinical Expertise

Clincally I see patients with infertilty as well as gynecologic issues including endometriosis and polycystic ovary disease. Additionally I have focused a portion of my clinical practice on adolescent gynecology, focusing on surgical treatment of structural disorders of the reproductive tract and endocrine disorders of puberty and menstruation. I see adolescent patients both at my office at 3701 Market Street as well as during office hours at the Children's Hospital of Philadelphia. Over the past 10 years I have established myself in the field of Pediatric and Adolescent Gynecology and am referred patients from throughout the mid-Atlantic.

Selected Publications

Huttler A, Koelper N, Mainigi M, Gracia C, Senapati S.: Impact of the COVID-19 pandemic on perception of planned oocyte cryopreservation in the United States. Fertility and Sterility Reports. epub ahead of print, May 2022

Sneha Mani , Jayashri Ghosh , Eric A. Rhon-Calderon, Yemin Lan, Teri Ord,Charikleia Kalliora, Joe Chan, Bryant Schultz, Elaine Vaughan-Williams, Christos Coutifaris, Carmen Sapienza, Suneeta Senapati, Marisa S. Bartolomei, Monica Mainigi: Embryo Cryopreservation leads to sex-specific DNA methylation perturbations in both human and mouse placentas. Human Molecular Genetics Accepted for Publication, June 2022.

Rubin ES, Huttler A, Mainigi M, Roe AH: Surgical uterine evacuation in patients with two cervices: a case series. Contraception 108:73-77, Apr 2022.

Morrison A, Bamba V, Mainigi M: Effects of estrogen replacement therapy on uterine size in girls with Turner Syndrome. North American Pediatric and Adolescent Gynecology Annual Meeting Chicago, IL, Apr 2022.

Park JY, Mani S, Clair G, Olson HM, Paurus VL, Anson C, Blundell C, Young R, Kanter J, Gordon S, Yi AY, Mainigi M*, Huh DD* (*co-senior authors): A microphysiological model of human trophoblast invasion during implantation. Nat Commun 13(1):1252, Mar 2022.

Mani S, Senapati S, Kalliora C, Mainigi M: Investigating the impact of 2-Methoxestradiol on uterine endothelial cells during early placentation. Society for Reproductive Investigation Denver, CO, Mar 2022.

Richardson H, Kalliora C, Mainigi M, Coutifaris C, Sammel MD, Senapati S: Impact of mode of conception on early pregnancy human chorionic gonadotropin rise and birthweight. Ferti Steril Reports 3(1):13-19., Dec 2021.

Kanter J, Mani S, Gordon S, Mainigi M: Uterine Natural Killer Cell Biology and Role in Early Pregnancy Establishment and Outcomes. Fertil Steril Revs 2:4, Oct 2021.

Simoni M, Mani S, Park JY, Huh D, Jurado K, Mainigi M: IFN-B disrupts invasive extravillous trophoblast function on an implantation-on-a-chip model. Oral presentation, American Society of Reproductive Medicine Annual Meeting Baltimore, MD, Oct 2021.

Bollig K, Huttler A, Bollig C, Mainigi M : Hysteroscopic uterine septum repair improves miscarriage and live birth rates in women seeking fertility treatment regardless of septum size. Oral presentation, American Society of Reproductive Medicine Annual Meeting Baltimore, MD, Oct 2021.

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Last updated: 06/10/2022
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