Monica Ailawadi Mainigi

Monica Ailawadi Mainigi

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Associate Professor of Obstetrics and Gynecology at the Hospital of the University of Pennsylvania
Attending, Infertility and Reproductive Endocrinology, Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending, Reproductive Surgical Facility, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending, Children’s Hospital of Philadelphia, Philadelphia, PA
Program Director, Fellowship in Reproductive Endocrinology and Infertility
Department: Obstetrics and Gynecology

Contact information
Clinical Practice:
PENN Fertility Care
Hospital of the University of Pennsylvania
3701 Market Street, 8th Floor

421 Curie Blvd BRB II/III Room 1352
Philadelphia, PA 19104
Office: 215-662-2972
BS (Biology)
Massachusetts Institute of Technology, 1996.
New York University School of Medicine, 2000.
Post-Graduate Training
Resident, Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA , 2000-2004.
National Research Service Award Postdoctoral Fellow, Center for Research on Reproduction and Women’s Health, University of Pennsylvania, Philadelphia, PA , 2004-2006.
Fellow, Reproductive Endocrinology and Infertility, Hospital of the University of Pennsylvania, Philadelphia, PA , 2006-2009.
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Description of Research Expertise

My laboratory focuses on examining the effects of the maternal environment on early implantation and placentation. For example, we are examining the role of ART technologies such as superovulation and frozen embryo transfer on implantation and placentation, as a model for how the maternal hormonal milieu affects early placentation. We are also interested in epigenetic changes, specifically DNA methylation, occurring following ART and how this affects placentation, fetal growth and long-term health of the offspring. In addition, we have developed novel methods to study early human embryo implantation, including a "implantation-on-a-chip" device which is being used to study cells and factors regulating early trophoblast invasion at the earliest point of pregnancy establishment. Specifically we are examining how maternal immune cell subtypes play a role in placentation and may play a role in adverse pregnancy outcomes.

Description of Clinical Expertise

Clincally I see patients with infertilty as well as gynecologic issues including endometriosis and polycystic ovary disease. Additionally I have focused a portion of my clinical practice on adolescent gynecology, focusing on surgical treatment of structural disorders of the reproductive tract and endocrine disorders of puberty and menstruation. I see adolescent patients both at my office at 3701 Market Street as well as during office hours at the Children's Hospital of Philadelphia. Over the past 12 years I have established myself as an expert in the field of Pediatric and Adolescent Gynecology and am referred patients from throughout the mid-Atlantic.

Selected Publications

Thea N Golden, Sneha Mani, Rebecca L Linn, Rita Leite, Natalie A Trigg, Annette Wilson, Lauren Anton, Monica Mainigi, Colin C Conine, Brett A Kaufman, Jerome F Strauss, Samuel Parry, Rebecca A Simmons: Extracellular vesicles alter trophoblast function in pregnancies complicated by COVID-19. bioRxiv May 2024.

Sneha Mani, James Garifallou, Se-jeong Kim, Michael K. Simoni, Dan Dongeun Huh, Scott M. Gordon and Monica Mainigi: Uterine macrophages and NK cells exhibit population and gene-level changes after implantation but maintain pro-invasive properties. Frontiers in Immunology 15:1364036, March 2024.

Simoni MK, Negatu SG, Park JY, Mani S, Arreguin MC, Amses K, Huh DD, Mainigi M, Jurado KA.: Type I interferon alters invasive extravillous trophoblast function. bioRxiv March 2024.

Hunter D. Reavis*, Stefan M. Gysler*, Grace B. McKenney, Matthew Knarr, Hannah J. Lusk, Priyanka Rawat, Hannah S. Rendulich, Marilyn Mitchell, Dara S. Berger, Jamie S. Moon, Suyeon Ryu, Monica Mainigi, Marcin P. Iwanicki, Dave S. Hoon, Laura M. Sanchez, Ronny Drapkin: Norepinephrine induces anoikis resistance in high-grade serous ovarian cancer precursor cells. JCI Insight 9(5):e170961, March 2024.

Soledad Henríquez, Maria Jose Valdivia, Monica Mainigi, Claudio Villarroel, Luis Velasquez, Jerome F. Strauss III, Luigi Devoto : The role of estrogen metabolites in human ovarian function. Steroids 203:109368, March 2024.

Rhon-Calderon EA, Hemphill CN, Vrooman LA, Rosier CL, Lan Y, Ord T, Coutifaris C, Mainigi M, Schultz RM, Bartolomei MS.: Trophectoderm biopsy of blastocysts following IVF and embryo culture increases epigenetic dysregulation in a mouse model. Human Reproduction 39(1): 154-176, January 2024.

Lee IT, Berger DS, Koelper N, Senapati S, Mainigi M. : Race, ovarian responsiveness, and live birth after in vitro fertilization Fertility and Sterility 120(5): 1023-1032, November 2023.

Suneeta Senapati, M.D., Jayashri Ghosh, PhD, Charikleia Kalliora, MD, MSc, Olivia Hatton, BS, Christos Coutifaris, M.D., PH.D., Marisa Bartolomei, PhD and Monica A Mainigi, M.D: Trophectoderm Biopsy is Associated with Perturbations in Placental DNA Methylation in Pregnancies After Frozen-Thawed Embryo Transfer. American Society for Reproductive Medicine October 2023.

Kanter J, Gordon SM, Mani S, Sokalska A, Park JY, Senapati S, Huh DD, Mainigi M.: Hormonal stimulation reduces numbers and impairs function of human uterine natural killer cells during implantation. Hum Reproduction 38(6): 1047-1059, June 2023.

Michael Simoni, Sneha Mani, Se-jeong Kim, Dan Huh, Scott Gordon, Monica Mainigi : Pregnancy changes the abundance, gene expression and function of uterine immune cell populations. Society of Reproductive Investigation March 2023.

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Last updated: 05/31/2024
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