Perelman School of Medicine at the University of Pennsylvania

Center for Research on Reproduction and Women's Health

Monica Ailawadi Mainigi

faculty photo
William Shippen, Jr. Assistant Professor of Human Reproduction
Attending, Infertility and Reproductive Endocrinology, Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending, Reproductive Surgical Facility, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending, Children’s Hospital of Philadelphia, Philadelphia, PA
Associate Program Director, Reproductive Endocrinology and Infertility Fellowship, University of Pennsylvania
Department: Obstetrics and Gynecology

Contact information
Clinical Practice:
PENN Fertility Care
Hospital of the University of Pennsylvania
3701 Market Street, 8th Floor

Lab:
421 Curie Blvd BRB II/III Room 1352
Philadelphia, PA 19104
Office: 215-662-2972
Education:
BS (Biology)
Massachusetts Institute of Technology, 1996.
MD
New York University School of Medicine, 2000.
Post-Graduate Training
Resident, Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA , 2000-2004.
National Research Service Award Postdoctoral Fellow, Center for Research on Reproduction and Women’s Health, University of Pennsylvania, Philadelphia, PA , 2004-2006.
Fellow, Reproductive Endocrinology and Infertility, Hospital of the University of Pennsylvania, Philadelphia, PA , 2006-2009.
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Description of Research Expertise

My laboratory focuses on examining the effects of the maternal environment on early implantation and placentation. For example, we are examining the role of ART technologies such as superovulation and frozen embryo transfer on implantation and placentation, as a model for how the maternal hormonal milieu affects early placentation. We arealos interested in epigenetic changes, specifically DNA methylation, occuring following ART and how this affects placentation, fetal growth and long-term health of the offspring. In addition, we have developed novel methods to study early human embryo implantation, including a "implantation-on-a-chip" device which is being used to study cells and factors regulating early trophoblast invasion at the earliest point of pregnancy establishment.

Description of Clinical Expertise

Clincally I see patients with infertilty as well as gynecologic issues including endometriosis and polycystic ovary disease. Additionally I have focused a portion of my clinical practice on adolescent gynecology, focusing on surgical treatment of structural disorders of the reproductive tract and endocrine disorders of puberty and menstruation. I see adolescent patients both at my office at 3701 Market Street as well as during office hours at the Children's Hospital of Philadelphia. Over the past 10 years I have established myself in the field of Pediatric and Adolescent Gynecology and am referred patients from throughout the mid-Atlantic.

Selected Publications

Morrison A, Bamba V. Mainigi M. : Effects of estrogen replacement therapy on uterine size in girls with Turner Syndrome. North American Pediatric and Adolescent Gynecology Annual Meeting April 2022.

Mani S, Senapati S, Kalliora C, Mainigi M: Investigating the impact of 2-Methoxestradiol on uterine endothelial cells during early placentation. Society for Reproductive Investigation March 2022.

Rubin E, Mainigi M, Roe A: Surgical uterine evacuation in patients with two cervices: a case series. Contraception Accepted for Publication, Jan 2022.

Park JY, Mani S, Clair G, Olson H, Paurus V, Anson C, Blundell C, Young R, Kanter J, Gordon S, Yi A, Mainigi M*, Huh D* (*co-senior authors): A microphysiological model of human trophoblast invasion during implantation. Nat Commun Accepted for publication, Jan 2022.

Senapati S, Mani S, Ghosh J, Coutifaris C, Sapienza C, Mainigi M: Epigenetics and Assisted Reproductive Technologies. Epigenetic Epidemiology December 2021.

Richardson, Kalliora C, Mainigi M, Coutifaris C, Samme M, Senapati S: Impact of mode of conception on early pregnancy human chorionic gonadotropin rise and birthweight. Ferti Steril Reports Accepted for Publication, Dec 2021.

Kanter J, Mani S, Gordon S, Mainigi M: Uterine Natural Killer Cell Biology and Role in Early Pregnancy Establishment and Outcomes. Fertil Steril Revs Volume 2 (Issue 4), Oct 2021.

Kanter J, Mani S, Gordon S, Park JY, Huh D, Mainigi M: Gonadotropin stimulation alters human maternal uterine immune cell number and function during the window of implantation. American Society of Reproductive Medicine Annual Meeting October 2021.

Simoni M, Mani S, Park JY, Huh D, Jurado K, Mainigi M: IFN-B disrupts invasive extravillous trophoblast function on an implantation-on-a-chip model American Society of Reproductive Medicine Annual Meeting October 2021.

Bollig K, Huttler A, Bollig C, Mainigi M. : Hysteroscopic uterine septum repair improves miscarriage and live birth rates in women seeking fertility treatment regardless of septum size American Society of Reproductive Medicine Annual Meeting October 2021.

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Last updated: 01/14/2022
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