Perelman School of Medicine at the University of Pennsylvania

Center for Research on Reproduction and Women's Health

Monica Ailawadi Mainigi

faculty photo
William Shippen, Jr. Assistant Professor of Human Reproduction
Attending, Infertility and Reproductive Endocrinology, Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending, Reproductive Surgical Facility, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending, Children’s Hospital of Philadelphia, Philadelphia, PA
Associate Program Director, Reproductive Endocrinology and Infertility Fellowship, University of Pennsylvania
Department: Obstetrics and Gynecology

Contact information
Clinical Practice:
PENN Fertility Care
Hospital of the University of Pennsylvania
3701 Market Street, 8th Floor

Lab:
421 Curie Blvd BRB II/III Room 1352
Philadelphia, PA 19104
Office: 215-662-2972
Education:
BS (Biology)
Massachusetts Institute of Technology, 1996.
MD
New York University School of Medicine, 2000.
Post-Graduate Training
Resident, Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA , 2000-2004.
National Research Service Award Postdoctoral Fellow, Center for Research on Reproduction and Women’s Health, University of Pennsylvania, Philadelphia, PA , 2004-2006.
Fellow, Reproductive Endocrinology and Infertility, Hospital of the University of Pennsylvania, Philadelphia, PA , 2006-2009.
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Description of Research Expertise

My laboratory focuses on examining the effects of the maternal environment on early implantation and placentation. For example, we are examining the role of ART technologies such as superovulation and frozen embryo transfer on implantation and placentation, as a model for how the maternal hormonal milieu affects early placentation. We arealos interested in epigenetic changes, specifically DNA methylation, occuring following ART and how this affects placentation, fetal growth and long-term health of the offspring. In addition, we have developed novel methods to study early human embryo implantation, including a "implantation-on-a-chip" device which is being used to study cells and factors regulating early trophoblast invasion at the earliest point of pregnancy establishment.

Description of Clinical Expertise

Clincally I see patients with infertilty as well as gynecologic issues including endometriosis and polycystic ovary disease. Additionally I have focused a portion of my clinical practice on adolescent gynecology, focusing on surgical treatment of structural disorders of the reproductive tract and endocrine disorders of puberty and menstruation. I see adolescent patients both at my office at 3701 Market Street as well as during office hours at the Children's Hospital of Philadelphia. Over the past 10 years I have established myself in the field of Pediatric and Adolescent Gynecology and am referred patients from throughout the mid-Atlantic.

Selected Publications

Kanter J, Mani S, Gordon S, Mainigi M: Uterine Natural Killer Cell Biology and Role in Early Pregnancy Establishment and Outcomes. Fertil Steril Revs May 2021 In-press.

Pereira M, Mainigi M, Strauss, J: Secretory products of the corpus luteum and preeclampsia. Human Reproduction Update March 2021 Notes: Online: Ahead of Print.

Arnav Lal, William Roudebush, Monica Mainigi, Renee Chsed: Fluorescent-dependent comparative Ct method for qPCR gene expression analysis in IVF clinical pre-implantation embryo testing. Biology Methods & Protocol. Accepted for Publication (eds.). 6(1):bpab001, January 2021.

Sullivan-Pyke C, Mani S, Rhon-Calderon EA, Ord T, Coutifaris C, Bartolomei MS, Mainigi M: Timing of exposure to gonadotropins has differential effects on the conceptus: evidence from a mouse model. Biol Reprod Page: 854-865, Oct 2020.

Gordon SM, Nishiguchi MA, Chase JM, Mani S, Mainigi MA, Behrens EM.: Interferons drive development of novel interleukin-15-responsive macrophages. J Immunol 205(4):1113-1124, Aug 2020.

Segal TR, Amini P, Wang J, Peters G, Skomorovska-Prokvolit Y, Mainigi MA, Goldfarb JM, Mesiano S, Weinerman R: Superovulation with human chorionic gonadotropin (hCG) trigger and gonadotropin releasing hormone agonist (GnRHa) trigger differentially alter levels of essential angiogenic factors in the endometrium in a mouse ART model. Biol Reprod 102(5): 1122-113, April 2020.

Mani S, Ghosh J, Coutifaris C, Sapienza C, Mainigi M: Epigenetic changes and Assisted Reproductive Technologies. Epigenetics 15(1-2: 12-25, January 2020.

Senapati S, Ghosh J, Mani S, Kalliora C, Ruiz E, Coutifaris C, Sapienza C, Mainigi M: Female embryos are more susceptible to perturbations in DNA Methylation in frozen-thaw embryo transfer cycles. American Society of Reproductive Medicine Annual Meeting, Virtual Presentation 2020.

Senapati S, Berger D, Kalliora C, Ruiz E, Sapienza C, Coutifaris C, Mainigi M: Sex-specific embryo cleavage kinetics and perinatal outcomes after blastocyst transfer. American Society for Reproductive Medicine Annual Meeting, Virtual Presentation 2020.

Mani S, Ghosh J, Lan Y, Senapati S, Ord T, Sapienza C, Coutifaris C, Mainigi M: Epigenetic changes in preterm birth placenta suggest a role for ADAMTS genes in spontaneous preterm birth. Hum Mol Genet 28(1):84-95, Jan 2019.

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Last updated: 09/22/2021
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