Monica Ailawadi Mainigi
Monica Ailawadi Mainigi
Associate Professor of Obstetrics and Gynecology at the Hospital of the University of Pennsylvania
Attending, Infertility and Reproductive Endocrinology, Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending, Reproductive Surgical Facility, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending, Children’s Hospital of Philadelphia, Philadelphia, PA
Program Director, Fellowship in Reproductive Endocrinology and Infertility
Department: Obstetrics and Gynecology
Contact information
Clinical Practice:
PENN Fertility Care
Hospital of the University of Pennsylvania
3701 Market Street, 8th Floor
Lab:
421 Curie Blvd BRB II/III Room 1352
Philadelphia, PA 19104
PENN Fertility Care
Hospital of the University of Pennsylvania
3701 Market Street, 8th Floor
Lab:
421 Curie Blvd BRB II/III Room 1352
Philadelphia, PA 19104
Office: 215-662-2972
Education:
BS (Biology)
Massachusetts Institute of Technology, 1996.
MD
New York University School of Medicine, 2000.
BS (Biology)
Massachusetts Institute of Technology, 1996.
MD
New York University School of Medicine, 2000.
Post-Graduate Training
Resident, Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA , 2000-2004.
National Research Service Award Postdoctoral Fellow, Center for Research on Reproduction and Women’s Health, University of Pennsylvania, Philadelphia, PA , 2004-2006.
Fellow, Reproductive Endocrinology and Infertility, Hospital of the University of Pennsylvania, Philadelphia, PA , 2006-2009.
Permanent linkResident, Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA , 2000-2004.
National Research Service Award Postdoctoral Fellow, Center for Research on Reproduction and Women’s Health, University of Pennsylvania, Philadelphia, PA , 2004-2006.
Fellow, Reproductive Endocrinology and Infertility, Hospital of the University of Pennsylvania, Philadelphia, PA , 2006-2009.
Description of Research Expertise
My laboratory focuses on examining the effects of the maternal environment on early implantation and placentation. For example, we are examining the role of ART technologies such as superovulation and frozen embryo transfer on implantation and placentation, as a model for how the maternal hormonal milieu affects early placentation. We arealos interested in epigenetic changes, specifically DNA methylation, occuring following ART and how this affects placentation, fetal growth and long-term health of the offspring. In addition, we have developed novel methods to study early human embryo implantation, including a "implantation-on-a-chip" device which is being used to study cells and factors regulating early trophoblast invasion at the earliest point of pregnancy establishment.Description of Clinical Expertise
Clincally I see patients with infertilty as well as gynecologic issues including endometriosis and polycystic ovary disease. Additionally I have focused a portion of my clinical practice on adolescent gynecology, focusing on surgical treatment of structural disorders of the reproductive tract and endocrine disorders of puberty and menstruation. I see adolescent patients both at my office at 3701 Market Street as well as during office hours at the Children's Hospital of Philadelphia. Over the past 10 years I have established myself in the field of Pediatric and Adolescent Gynecology and am referred patients from throughout the mid-Atlantic.Selected Publications
Kanter J, Gordon SM, Mani S, Sokalska A, Park JY, Senapati S, Huh DD, Mainigi M.: Hormonal stimulation reduces numbers and impairs function of human uterine natural killer cells during implantation. Hum Reproduction 38(6): 1047-1059, June 2023.Michael Simoni, Sneha Mani, Se-jeong Kim, Dan Huh, Scott Gordon, Monica Mainigi : Pregnancy changes the abundance, gene expression and function of uterine immune cell populations. Society of Reproductive Investigation March 2023.
Bollig KJ, Mainigi M, Senapati S, Lin AE, Levitsky LL, Bamba V.: Turner syndrome: fertility counselling in childhood and through the reproductive lifespan. Curr Opin Endocrinol Diabetes Obes. 30(1):16-26 , February 2023.
Huttler A, Koelper N, Mainigi M, Gracia C, Senapati S.: Impact of the COVID-19 pandemic on perception of planned oocyte cryopreservation in the United States. Fertility and Sterility Reports. 3(2):145-152., May 2022
Sneha Mani , Jayashri Ghosh , Eric A. Rhon-Calderon, Yemin Lan, Teri Ord,Charikleia Kalliora, Joe Chan, Bryant Schultz, Elaine Vaughan-Williams, Christos Coutifaris, Carmen Sapienza, Suneeta Senapati, Marisa S. Bartolomei, Monica Mainigi: Embryo Cryopreservation leads to sex-specific DNA methylation perturbations in both human and mouse placentas. Human Molecular Genetics 31(22):3855-3872, November 2022.
Bollig KJ, Mainigi M, Senapati S, Lin AE, Levitsky LL, Bamba V.: Turner syndrome: fertility counseling in childhood and through the reproductive lifespan. Curr Opin Endocrinol Diabetes Obes Epub ahead of print, Nov 2022.
Iris T. Lee, Dara S. Berger, Monica Ailawadi Mainigi: Effect of race on ovarian response to gonadotropin stimulation in in vitro fertilization. ASRM Annual Meeting: Oral Presentation (Prize Paper Candidate) Oct 2022.
Kassie Jean Bollig, Suneeta Senapati, Nathan C. Koelper, Aimee Morrison, Monica Ailawadi Mainigi: Follicle stimulating hormone level as a predictor of spontaneous menarche: a retrospective cohort study of 133 patients with Turner Syndrome. ASRM Annual Meeting: Oral Presentation Oct 2022.
Kassie Jean Bollig, Monica Ailawadi Mainigi, Nathan C. Koelper, Aimee Morrison, Suneeta Senapati: Follicle Stimulating Hormone Trends in patients with Turner Syndrome are associated with more than karyotype and spontaneous menarche status: race matters. ASRM Annual Meeting: Oral Presentation Oct 2022.
Kassie Jean Bollig, Suneeta Senapati, Nathan C. Koelper, Aimee Morrison, Monica Ailawadi Mainigi: Time to postmenopausal follicle stimulating hormone levels and karyotype: a longitudinal study of patients with Turner Syndrome. ASRM Annual Meeting: Oral Presentation Oct 2022.