Perelman School of Medicine at the University of Pennsylvania

Center for Research on Reproduction and Women's Health

Andrea Facciabene

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Research Associate Professor of Radiation Oncology
Department: Radiation Oncology

Contact information
University of Pennsylvania Perelman School of Medicine
Department of Radiation Oncology
Smilow Center for Translational Research Rm. 8-133
3400 Civic Center Blvd., Bldg 421
Philadelphia, PA 19104
Office: 215-746-7071
Fax: 215-898-0090
Education:
BS (Pharmaceutical Biotechnology Science (summa cum laude))
University of Bologna, Bologna, Italy (Thesis: Centre of Drug Discovery, L'Aquila, Italy) Summa Cum Laude, 2000.
PhD (Molecular and Cellular Biology)
University of Perugia, Perugia, Italy. In collaboration with the Univ of California San Diego, San Diego, CA (coursework 11/01-5/06), 2006.
Post-Graduate Training
Research Fellowship, Gene Therapy, IRBM, Istituto di Ricerche di Biologia Molecolare-"P. Angeletti" (Merck & Co), Rome, Italy, 2000-2001.
Postdoctoral Research Fellowship, University of California San Diego, Department of Cancer Research San Diego, CA , 2005-2006.
Postdoctoral Research Fellowship, University of Pennsylvania, Ovarian Cancer Research Center , 2006-2007.
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Description of Research Expertise

Dr. Andrea Facciabene’s laboratory is focused on cancer immunotherapy and the investigation of the network of immune responses to tumors, combining basic research and clinical investigation. The Facciabene Lab goals are to advance understanding of tumor immunology and to use the new findings to develop efficacious new therapies. Our basic research includes the development of two new vaccination strategies: one uses mitochondria isolated from tumors, the other utilizes new tumor vasculature antigen. We also study regulation of anticancer immune response by the gut microbiota. Our clinic research includes the development of new preclinical immunotherapies.

Selected Publications

Uribe-Herranz M, Rafail S, Beghi S, Gil-de-Gómez L, Verginadis I, Bittinger K, Pustylnikov S, Pierini S, Perales-Linares R, Blair IA, Mesaros CA, Snyder NW, Bushman F, Koumenis C, Facciabene A. : Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response. J Clin Invest. 130(1): 466-479, Jan 2 2020

Pierini S, Tanyi JL, Simpkins F, George E, Uribe-Herranz M, Drapkin R, Burger R, Morgan MA, Facciabene A.: Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target. JCI Insight 5(16), Aug 2020.

Adams SF, Grimm AJ, Chiang CL, Mookerjee A, Flies D, Jean S, McCann GA, Michaux J, Pak H, Huber F, Neal C, Dangaj D, Bassani-Sternberg M, Rusakiewicz S, Facciabene A, Coukos G, Gimotty PA, Kandalaft LE.: Rapid tumor vaccine using Toll-like receptor-activated ovarian cancer ascites monocytes. J Immunother Cancer 8(2), Aug 2020.

Zhao H, Xie L, Clemens JL, Zong L, McLane MW, Arif H, Feller MC, Jia B, Zhu Y, Facciabene A, Ozen M, Lei J, Burd I.: Mouse Bone Marrow-Derived Mesenchymal Stem Cells Alleviate Perinatal Brain Injury Via a CD8+ T Cell Mechanism in a Model of Intrauterine Inflammation. Reprod Sci 27(7): 1465-1476, July 2020.

Chao HH, Karagounis IV, Thomas C, François NB, Facciabene A, Koumenis C, Maity A.: Combination of CHEK1/2 inhibition and ionizing radiation results in abscopal tumor response through increased micronuclei formation. Oncogene 39(22): 4344-4357, May 2020.

Mohiuddin JJ, Chu B, Facciabene A, Poirier K, Wang X, Doucette A, Zheng C, Xu W, Anstadt EJ, Amaravadi RK, Karakousis GC, Mitchell TC, Huang AC, Shabason JE, Lin A, Swisher-McClure S, Maity A, Schuchter LM, Lukens JN.: Association of antibiotic exposure with survival and toxicity in patients with melanoma receiving immunotherapy. J Natl Cancer Inst April 2020.

Dangaj D, Bruand M, Grimm AJ, Ronet C, Barras D, Duttagupta PA, Lanitis E, Duraiswamy J, Tanyi JL, Benencia F, Conejo-Garcia J, Ramay HR, Montone KT, Powell DJ Jr, Gimotty PA, Facciabene A, Jackson DG, Weber JS, Rodig SJ, Hodi SF, Kandalaft LE, Irving M, Zhang L, Foukas P, Rusakiewicz S, Delorenzi M, Coukos G.: Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors. Cancer Cell. Jun 10;35(6):.e10. doi: 10.1016/j.ccell.2019.05.004. PMID: 31185212 35: 885-900, Jun 2019

Russell KL, Gorgulho CM, Allen A, Vakaki M, Wang Y, Facciabene A, Lee D, Roy P, Buchser WJ, Appleman LJ, Maranchie J, Storkus WJ, Lotze MT.: Inhibiting Autophagy in Renal Cell Cancer and the Associated Tumor Endothelium. Cancer Journal 25: 165-177, May/June 2019.

Pustylnikov S1, Costabile F1, Beghi S1, Facciabene A.: Targeting mitochondria in cancer: current concepts and immunotherapy approaches. Transl Research 202: 35-51, Dec 2018

Lei J, Xie L, Zhao H, Gard C, Clemens JL, McLane MW, Feller MC, Ozen M, Novak C1, Alshehri W1, Alhejaily N, Shabi Y, Rosenzweig JM, Facciabene A, Burd I.: Maternal CD8+ T-cell depletion alleviates intrauterine inflammation-induced perinatal brain injury. Am J Reprod Immunol. 79(5):e12798, May 2018 Notes: online journal: doi: 10.1111/aji.12798.

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Last updated: 10/01/2020
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