Perelman School of Medicine at the University of Pennsylvania

Center for Research on Reproduction and Women's Health

Andrea Facciabene

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Research Assistant Professor of Radiation Oncology
Department: Radiation Oncology

Contact information
University of Pennsylvania Perelman School of Medicine
Department of Radiation Oncology
Smilow Center for Translational Research Rm. 8-133
3400 Civic Center Blvd., Bldg 421
Philadelphia, PA 19104
Office: 215-746-7071
Fax: 215-898-0090
BS (Pharmaceutical Biotechnology Science (summa cum laude))
University of Bologna, Bologna, Italy (Thesis: Centre of Drug Discovery, L'Aquila, Italy) Summa Cum Laude, 2000.
PhD (Molecular and Cellular Biology)
University of Perugia, Perugia, Italy. In collaboration with the Univ of California San Diego, San Diego, CA (coursework 11/01-5/06), 2006.
Post-Graduate Training
Research Fellowship, Gene Therapy, IRBM, Istituto di Ricerche di Biologia Molecolare-"P. Angeletti" (Merck & Co), Rome, Italy, 2000-2001.
Postdoctoral Research Fellowship, University of California San Diego, Department of Cancer Research San Diego, CA , 2005-2006.
Postdoctoral Research Fellowship, University of Pennsylvania, Ovarian Cancer Research Center , 2006-2007.
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Description of Research Expertise

Dr. Andrea Facciabene’s laboratory is focused on cancer immunotherapy and the investigation of the network of immune responses to tumors, combining basic research and clinical investigation. The Facciabene Lab goals are to advance understanding of tumor immunology and to use the new findings to develop efficacious new therapies. Our basic research includes the development of two new vaccination strategies: one uses mitochondria isolated from tumors, the other utilizes new tumor vasculature antigen. We also study regulation of anticancer immune response by the gut microbiota. Our clinic research includes the development of new preclinical immunotherapies.

Selected Publications

Pustylnikov S, Costabile F, Beghi S, Facciabene A.: Targeting mitochondria in cancer: current concepts and immunotherapy approaches. Transl Research July 2018 Notes: pii: S1931-5244(18)30114-2. doi: 10.1016/j.trsl.2018.07.013. [Epub ahead of print]

Lei J, Xie L, Zhao H, Gard C, Clemens JL, McLane MW, Feller MC, Ozen M, Novak C1, Alshehri W1, Alhejaily N, Shabi Y, Rosenzweig JM, Facciabene A, Burd I.: Maternal CD8+ T-cell depletion alleviates intrauterine inflammation-induced perinatal brain injury. Am J Reprod Immunol. 79(5):e12798, May 2018 Notes: online journal: doi: 10.1111/aji.12798.

Janos Tanyi, Mark Morgan, Andrea Facciabene: book chapter: Impact of gut microbiota on Ovarian Cancer Springer. Erle Robertson (eds.). Apr 2018.

Uribe-Herranz M, Bittinger K, Rafail S, Guedan S, Pierini S, Tanes C, Ganetsky A, Morgan MA, Gill S, Tanyi JL, Bushman FD, June CH, Facciabene A*.: Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12. JCI Insight 3(4), Feb 2018 Notes: *Corresponding Author; online journal: doi: 10.1172/jci.insight.94952. [Epub ahead of print]

De Sanctis F, Ugel S, Facciponte J, Facciabene A*: The dark side of tumor-associated endothelial cells. Semin Immunol. 35: 35-47, Feb 2018 Notes: *Corresponding Author.

Pierini S, Perales-Linares R, Uribe-Herranz M, Pol JG, Zitvogel L, Kroemer G, Facciabene A, Galluzzi L.: Trial watch: DNA-based vaccines for oncological indications. Oncoimmunology 6(12): e 1398878, Nov 2017 Notes: online journal: doi: 10.1080/2162402X.2017.1398878. eCollection 2017.

Lei J, Rosenzweig JM, Mishra MK, Alshehri W, Brancusi F, McLane M, Almalki A, Bahabry R, Arif H, Rozzah R, Alyousif G, Shabi Y, Alhehaily N, Zhong W1 Facciabene A, Kannan S, Kannan RM, Burd I.: Maternal dendrimer-based therapy for inflammation-induced preterm birth and perinatal brain injury. Scientific Report 7(1): 6106, Jul 2017 Notes: online journal: doi: 10.1038/s41598-017-06113-2.

Facciabene A, De Sanctis F, Pierini S, Reis ES, Balint K, Facciponte J, Rueter J, Kagabu M, Magotti P, Lanitis E, DeAngelis RA, Buckanovich RJ, Song WC, Lambris JD, Coukos G.: Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy. Oncoimmunology 6(9): e 1326442, Jun 2017 Notes: online journal: doi: 10.1080/2162402X.2017.1326442. eCollection 2017.

Monk BJ, Facciabene A,(Equal Contribution) Brady WE, Aghajanian C, Fracasso PM, Walker J, Lankes HA, Manjarrez KL, Danet-Desnoyers G, Bell-McGuinn KM, McCourt CK, Malykhin A, Hershberg RM, Coukos G. : Integrative Development of a TLR8 Agonist for Ovarian Cancer Chemo-immunotherapy. Clin Cancer Res. 23(8): 1955-66, Apr 2017.

Stavros R, Mireia Uribe-HErranz, Pierini S, Costas Koumenis, Facciabene A: The impact of Gut microbiome on the antitumor effects of Radiotherapy. AACR, Washington DC Apr 2017 Notes: Poster presentation.

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Last updated: 10/31/2018
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