Yu-chin Lien
Yu-Chin Lien
Research Assistant Professor of Pediatrics (Neonatology & Newborn Services)
Faculty, Center for Women's Health and Reproductive Medicine, Perelman School of Medicine, University of Pennsylvania
Investigator, Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania
Investigator, Philadelphia Regional Center for Children’s Environmental Health
Department: Pediatrics
Contact information
University of Pennsylvania
Perelman School of Medicine
421 Curie Boulevard
BRB II/III Room 1352
Philadelphia, PA 19104
Perelman School of Medicine
421 Curie Boulevard
BRB II/III Room 1352
Philadelphia, PA 19104
Office: 215-573-4916
Lab: 215-746-5138
Lab: 215-746-5138
Email:
ylien@pennmedicine.upenn.edu
ylien@pennmedicine.upenn.edu
Education:
B.S. (Pharmacy)
National Taiwan University, 1996.
M.S. (Pharmaceutical Sciences)
National Taiwan University, 1998.
Ph.D. (Toxicology)
University of Kentucky, 2006.
B.S. (Pharmacy)
National Taiwan University, 1996.
M.S. (Pharmaceutical Sciences)
National Taiwan University, 1998.
Ph.D. (Toxicology)
University of Kentucky, 2006.
Post-Graduate Training
Postdoctoral Research Scientist, Center for Radiological Research, Columbia University, 2006-2007.
Postdoctoral Researcher, Institute for Environmental Medicine, Perelman School of Medicine, University of Pennsylvania, 2007-2011.
Permanent linkPostdoctoral Research Scientist, Center for Radiological Research, Columbia University, 2006-2007.
Postdoctoral Researcher, Institute for Environmental Medicine, Perelman School of Medicine, University of Pennsylvania, 2007-2011.
Selected Publications
Meakin, A.S.; Gatford, K.L.; Lien, Y.C.; Wiese, M.D.; Simmons, R.A.; Morrison, J.L.: Characterisation of ciclesonide metabolism in human placentae across gestation. Placenta 154(2): 41-48, Sep 2024.Lien, Y.C.; Garifallou, J.P.; Leite, R.; Winn, V.D.; Parry, S.; Strauss III, J.F.; Simmons, R.A. : Single nuclei RNA-seq analysis reveals race and sex differences in the function of mid-gestation human placenta. 71th Annual Scientific Meeting, Society for Reproductive Investigation, Vancouver, Canada. Poster March 2024.
Lien, Y.C.; Kan, M.; Leite, R.; Himes, B.E.; Winn, V.D.; Parry, S.; Strauss III, J.F.; Simmons, R.A.: Race differences in energy metabolism and inflammatory status of mid-gestation human placenta. 71th Annual Scientific Meeting, Society for Reproductive Investigation, Vancouver, Canada. Podium March 2024.
Meakin, A.S.; Gatford, K.L.; Lien, Y.C.; Wiese, M.D.; Simmons, R.A.; Morrison, J.L. : Placental-specific ciclesonide to des-ciclesonide conversion is not impacted by gestational age or placental sex. Endocrine Society of Australia – Society for Reproductive Biology Annual Scientific Meeting, Brisbane, Australia. Poster November 2023.
Flaherty, S.E. III; Bezy, O.; LaCarubba, B.; Song, L.; Piper, M.; Pang, J.; Park, Y.; Asano, S.; Lien, Y.C.; Griffin, J.D.; Robertson, A.; Opsahl, A.; Shanthappa, D.H.; Ahn, Y.; Pashos, E.; Simmons, R.A.; Birnbaum, M.J.; Wu Z.: SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction. eLife 12(1): RP91114, Jul 2023.
Lien, Y.C.; Leite, R.; Winn, V.D.; Parry, S.; Simmons, R.A.: Racial differences in the metabolome and inflammatory status in second trimester human placenta. Aspen Perinatal Biology Symposium, Aspen, CO, poster August 2022.
Hanke, S.; Joshi, A.; Lien, Y.C.; Fu, W.; Wang, P.Z.; Tarapore, P.; Simmons, R.A.; Pinney, S.E.: PFOA exposure prior to hepatocyte differentiation leads to DNA methylation and expression changes linked to non-alcoholic fatty liver disease. Aspen Perinatal Biology Symposium, Aspen, CO, poster August 2022.
Lien, Y.C.; Leite, R.; Winn, V.D.; Parry, S.; Simmons, R.A: Racial differences in the metabolome in second trimester human placenta. 69th Annual Scientific Meeting, Society for Reproductive Investigation. Denver, CO, poster March 2022.
Lien, Y.C.; Pinney, S.E.; Lu, X.M.; Simmons, R.A.: Identification of novel regulatory regions induced by intrauterine growth restriction in rat islets. Endocrinology 163(2): bqab251, Feb 2022.
Lien, Y.C.; Zhang, Z.; Falk, M.J.; Parry, S.; Simmons, R.A.: Human placental transcriptome and metabolome reveal critical alterations in energy metabolism with fetal sex differences in spontaneous preterm birth. US DOHaD Conference, Chapel Hill, NC, poster November 2021.