Xiaowen Hu

Xiaowen Hu

faculty photo
Research Assistant Professor of Obstetrics and Gynecology
Department: Obstetrics and Gynecology

Contact information
421 Curie Blvd, Rm.1208
Biomedical Research Building II/III
Philadelphia, PA 19104
Office: 215-898-6381
B.S. (Biology)
Sichuan University, P.R. China, 2003.
Ph.D. (Biochemistry and Molecular Biology)
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 2009.
Post-Graduate Training
Postdoctoral Researcher, Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, PA, 2010-2015.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Jiang J, Yuan J, Hu Z, Xu M, Zhang Y, Long M, Fan Y, Montone KT, Tanyi JL, Tavana O, Chan HM, Zhang L, Hu X*: Systematic pan-cancer characterization of nuclear receptors identifies potential cancer biomarkers and therapeutic targets. Cancer Research 82: 46-59, Jan 2022.

Hu Z, Yuan J, Long M, Jiang J, Zhang Y, Zhang T, Xu M, Fan Y, Tanyi JL, Montone KT, Tavana O, Chan HM, Hu X*, Vonderheide RH*, Zhang L* : The Cancer Surfaceome Atlas integrates genomic, functional and drug response data to identify actionable targets. Nature Cancer 2: 1406–1422, Dec 2021.

Zhang L, Zhang Y, Hu X: Targeting the transcription cycle and RNA processing in cancer treatment. Current Opinion in Pharmacology 58: 69-75, Jun 2021.

Hu Z, Zhou J, Jiang J, Yuan J, Zhang Y, Wei X, Loo N, Wang Y, Pan Y, Zhang T, Zhong X, Long M, Montone KT, Tanyi JL, Fan Y, Wang TL, Shih IM, Hu X*, Zhang L*: Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment. Nature Communications 10(1): 733, 2019.

Hu X*, Sood AK, Dang CV, Zhang L: The role of long noncoding RNAs in cancer: the dark matter matters. Curr Opin Genet Dev 48: 8-15, 2018 Notes: *Corresponding author.

Hu X, Feng Y, Zhang D, Zhao SD, Greshock J, Hu Z, Zhang Y, Yang L, Zhong X, Wang L, Jean S, Li C, Huang Q, Katsaros D, Montone K, Tanyi JL, Lu Y, Boyd J, Nathanson KL, Li H, Mills GB, Zhang L: A Functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in human cancer. Cancer Cell 26(3): 344-57, 2014.

Hu X, Guo J, Zheng L, Li C, Zheng TM, Tanyi JL, Liang S, Benedetto C, Mitidieri M, Katsaros D, Zhao X, Zhang Y, Huang Q, Zhang L: The heterochronic microRNA let-7 inhibits cell motility by regulating the genes in the actin cytoskeleton pathway in breast cancer. Mol Cancer Res 11(3): 240-50, 2013.

Hu X, Meng D, Fang J: Apigenin inhibited migration and invasion of human ovarian cancer A2780 cells through focal adhesion kinase. Carcinogenesis 29(12): 2369-76, 2008.

Yuan J, Hu Z, Mahal BA, Zhao SD, Kensler KH, Pi J, Hu X, Zhang Y, Wang Y, Jiang J, Li C, Zhong X, Montone KT, Guan G, Tanyi JL, Fan Y, Xu X, Morgan MA, Long M, Zhang Y, Zhang R, Sood AK, Rebbeck TR, Dang CV, Zhang L: Integrated analysis of genetic ancestry and genomic alterations across cancers. Cancer Cell 34(4): 549-60, 2018.

Yan X, Hu Z, Feng Y, Hu X, Yuan J, Zhao SD, Zhang Y, Yang L, Shan W, He Q, Fan L, Kandalaft LE, Tanyi JL, Li C, Yuan CX, Zhang D, Yuan H, Hua K, Lu Y, Katsaros D, Huang Q, Montone K, Fan Y, Coukos G, Boyd J, Sood AK, Rebbeck T, Mills GB, Dang CV, Zhang L: Comprehensive genomic characterization of long non-coding RNAs across human cancers. Cancer Cell 28(4): 529-40, 2015.

Zhang Y, He Q, Hu Z, Feng Y, Fan L, Tang Z, Yuan J, Shan W, Li C, Hu X, Tanyi JL, Fan Y, Huang, Q, Montone K, Dang CV, Zhang L: Long noncoding RNA LINP1 regulates double strand DNA break repair in triple negative breast cancer. Nat Struct Mol Biol 23(6): 522-530, 2016.

Yang L, Zhang Y, Shan W, Hu Z, Yuan J, Pi J, Wang Y, Fan L, Tang Z, Li C, Hu X, Tanyi JL, Fan Y, Huang Q, Montone K, Dang CV, Zhang L: Repression of BET activity sensitizes homologous recombination-proficient cancers to PARP inhibition. Sci Transl Med 9:400, 2017.

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Last updated: 09/15/2023
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