Babushok Lab

Welcome to the Website of the Babushok Lab!

The Babushok Lab conducts basic and translational research to understand the fundamental mechanisms of how bone marrow can fail, how the failure of bone marrow can lead to pre-malignant genetic changes and myelodysplastic syndrome and leukemia, and what is the relationship between our immune system and the development of clonal hematopoiesis.

We use state-of-the-art genome analysis, molecular biology and immunogenetic analyses, as well as in vitro and in vivo models to study the mechanisms of immune-mediated marrow failure and the factors that lead to the to the development of clonal hematopoiesis in bone marrow failure and aging.

Latest Publications from the Babushok Lab

Check our latest publications on Pubmed!

JCI - ATM-dependent DNA damage response constrains cell growth and drives clonal hematopoiesis in telomere biology disorders

Origins of T-cell-mediated autoimmunity in acquired aplastic anaemia

Modified Delphi Panel Consensus Recommendations for Management of Severe Aplastic Anemia | Blood Advances | American Society of Hematology (ashpublications.org)

Hypomethylating agents are associated with high rates of hematologic toxicity in patients with secondary myeloid neoplasms developing after acquired aplastic anemia. Haematologica 2024 Early View | Haematologica

Non-steroidal anti-inflammatory drugs as a targeted therapy for bone marrow failure in Ghosal Hematodiaphyseal Dysplasia - PubMed (nih.gov), Blood, 2022.

JCI Insight - Pathogenicity and impact of HLA class I alleles in aplastic anemia patients of different ethnicities, JCI Insight, 2022.

News

Babushok Lab Medical Student Researcher Aura Enache is Awarded 2024 Alpha Omega Alpha Carolyn L Kuckein Student Research Fellowship!

May 10, 2024

Babushok Lab Undergraduate Student Receives Phi Beta Kappa Award!

April 8, 2024

Joanna Papaioannou an undergraduate researcher at the Babushok Lab was elected to Phi Beta Kappa! Congratulations Joanna!

Events

Team Telomere Scientific Summit 2024

July 8th-July 11th, 2024

Babushok Lab Researchers Presenting at Team Telomere Scientific Summit 2024

AAMDSIF 40th Anniversary Summit

10/26/2023-10/27/2023

In honor of the AAMDSIF 40th Anniversary, this hybrid Summit will convene leading international experts in bone marrow failure to review significant advances in diagnosis and treatment and to determine future priorities for translational research.