Welcome to the Website of the Babushok Lab!
The Babushok Lab conducts basic and translational research to understand the fundamental mechanisms of how bone marrow can fail, how the failure of bone marrow can lead to pre-malignant genetic changes and myelodysplastic syndrome and leukemia, and what is the relationship between our immune system and the development of clonal hematopoiesis.
We use state-of-the-art genome analysis, molecular biology and immunogenetic analyses, as well as in vitro and in vivo models to study the mechanisms of immune-mediated marrow failure and the factors that lead to the to the development of clonal hematopoiesis in bone marrow failure and aging.
Latest Publications from the Babushok Lab
JCI Insight - Pathogenicity and impact of HLA class I alleles in aplastic anemia patients of different ethnicities, JCI Insight, 2022, In Press
Inherited bone marrow failure with macrothrombocytopenia due to germline tubulin beta class I (TUBB) variant - Shah - British Journal of Haematology - Wiley Online Library, British Journal of Haematology, 2022, In Press
Insights into the emergence of paroxysmal nocturnal hemoglobinuria, Frontiers in Immunology, 2022 In Press.
Eltrombopag: a springboard to early responses in SAA. Babushok DV. Blood. 2022 Jan 6;139(1):1-2.
When does a PNH clone have clinical significance? Babushok DV. Hematology Am Soc Hematol Educ Program. 2021 Dec 10;2021(1):143-152
Analysis of evolutionary conservation of GPI-anchored proteins between humans and mice. Kumar S, Babushok DV.Blood Cells Mol Dis. 2021 Dec;92:102622.
The predictive value of PNH clones, 6p CN-LOH, and clonal TCR gene rearrangement for aplastic anemia diagnosis. Shah YB, Priore SF, Li Y, Tang CN, Nicholas P, Kurre P, Olson TS, Babushok DV.Blood Adv. 2021 Aug 24;5(16):3216-3226.
Germline POT1 variants can predispose to myeloid and lymphoid neoplasms. Lim TL, Lieberman DB, Davis AR, Loren AW, Hausler R, Bigdeli A, Li Y, Powers J, Raper A, Regeneron Genetics Center, Carty SA, Nathanson KL, Bagg A, Hexner EO, Maxwell KN, Morrissette JJD, Babushok DV.Leukemia. 2021 Jun 30.
Human mutational constraint as a tool to understand biology of rare and emerging bone marrow failure syndromes. Oved JH, Babushok DV, Lambert MP, Wolfset N, Kowalska MA, Poncz M, Karczewski KJ, Olson TS.Blood Adv. 2020 Oct 27;4(20):5232-5245.
Babushok Lab undergraduate student Shannon Zheng awarded 2022 Pincus-Magaziner Family Undergraduate Research and Travel Fund!
April 19, 2022
Undergraduate student Shannon Zheng awarded 2022 Pincus-Magaziner Family Undergraduate Research and Travel Fund for her research project on HLA alleles in aplastic anemia.
Postdoctoral Fellow Sushant Kumar Awarded the Uplifting Athletes Young Investigator Draft Research Award
Saturday, February 5, 2022 from 6:00 - 9:00 PM
Connect virtually to view Dr. Sushant Kumar receive research grant award by Uplifting Athletes at the 2022 Young Investigator Draft!
63rd American Society of Hematology Meeting and Exposition in Atlanta, Georgia
Dec 10 - 14, 2021
62nd ASH Annual Meeting & Exposition
December 5-8, 2020
Attend the world’s most comprehensive hematology event of the year for an invaluable educational experience and the opportunity to review thousands of scientific abstracts highlighting updates on the most critical topics in hematology.