Perelman School of Medicine at the University of Pennsylvania

Babushok Lab

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Welcome to the Website of the Babushok Lab!

The Babushok Lab conducts basic and translational research to understand the fundamental mechanisms of how bone marrow can fail, how the failure of bone marrow can lead to pre-malignant genetic changes and myelodysplastic syndrome and leukemia, and what is the relationship between our immune system and the development of clonal hematopoiesis.

We use state-of-the-art genome analysis, molecular biology and immunogenetic analyses, as well as in vitro and in vivo models to study the mechanisms of immune-mediated marrow failure and the factors that lead to the to the development of clonal hematopoiesis in bone marrow failure and aging.

Latest Publications from the Babushok Lab

Check our latest publications on Pubmed!

The predictive value of PNH clones, 6p CN-LOH, and clonal TCR gene rearrangement for aplastic anemia diagnosis. Shah YB, Priore SF, Li Y, Tang CN, Nicholas P, Kurre P, Olson TS, Babushok DV.Blood Adv. 2021 Aug 24;5(16):3216-3226.

Germline POT1 variants can predispose to myeloid and lymphoid neoplasms. Lim TL, Lieberman DB, Davis AR, Loren AW, Hausler R, Bigdeli A, Li Y, Powers J, Raper A, Regeneron Genetics Center, Carty SA, Nathanson KL, Bagg A, Hexner EO, Maxwell KN, Morrissette JJD, Babushok DV.Leukemia. 2021 Jun 30.

Human mutational constraint as a tool to understand biology of rare and emerging bone marrow failure syndromes. Oved JH, Babushok DV, Lambert MP, Wolfset N, Kowalska MA, Poncz M, Karczewski KJ, Olson TS.Blood Adv. 2020 Oct 27;4(20):5232-5245.