Perelman School of Medicine at the University of Pennsylvania

Babushok Lab

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Welcome to the Website of the Babushok Lab!

The Babushok Lab conducts basic and translational research to understand the fundamental mechanisms of how bone marrow can fail, how the failure of bone marrow can lead to pre-malignant genetic changes and myelodysplastic syndrome and leukemia, and what is the relationship between our immune system and the development of clonal hematopoiesis.

We use state-of-the-art genome analysis, molecular biology and immunogenetic analyses, as well as in vitro and in vivo models to study the mechanisms of immune-mediated marrow failure and the factors that lead to the to the development of clonal hematopoiesis in bone marrow failure and aging.

Latest Publications from the Babushok Lab

Linaburg T, Davis AR, Frey NV, Khawaja MR, Landsburg DJ, Schuster SJ, Svoboda J, Li Y, Borovskiy Y, Olson TS, Bagg A, Hexner EO, Babushok DV. Hodgkin lymphoma patients have an increased incidence of idiopathic acquired aplastic anemia.PLoS One. 2019 Apr 5;14(4):e0215021.

Babushok DV. A brief, but comprehensive, guide to clonal evolution in aplastic anemia. Hematology Am Soc Hematol Educ Program. 2018 Nov 30;2018(1):457-466.

Babushok DV, Stanley NL, Morrissette JJD, Lieberman DB, Olson TS, Chou ST, Hexner EO. Germline duplication of ATG2B and GSKIP genes is not required for the familial myeloid malignancy syndrome associated with the duplication of chromosome 14q32. Leukemia. 2018 Aug 7.

Check our latest publications on Pubmed!