Babushok Lab

Welcome to the Website of the Babushok Lab!

The Babushok Lab conducts basic and translational research to understand the fundamental mechanisms of how bone marrow can fail, how the failure of bone marrow can lead to pre-malignant genetic changes and myelodysplastic syndrome and leukemia, and what is the relationship between our immune system and the development of clonal hematopoiesis.

We use state-of-the-art genome analysis, molecular biology and immunogenetic analyses, as well as in vitro and in vivo models to study the mechanisms of immune-mediated marrow failure and the factors that lead to the to the development of clonal hematopoiesis in bone marrow failure and aging.

Latest Publications from the Babushok Lab

Human mutational constraint as a tool to understand biology of rare and emerging bone marrow failure syndromes. Oved JH, Babushok DV, Lambert MP, Wolfset N, Kowalska MA, Poncz M, Karczewski KJ, Olson TS.Blood Adv. 2020 Oct 27;4(20):5232-5245.

Aplastic anemia in a patient with CVID due to NFKB1 haploinsufficiency. Sklarz T, Hurwitz SN, Stanley NL, Juusola J, Bagg A, Babushok DV. Cold Spring Harb Mol Case Stud. 2020 Sep 24:mcs.a005769.

Secondary myelodysplastic syndrome and leukemia in acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria. Sun L, Babushok DV.Blood. 2020 Jul 2;136(1):36-49.

Postvaccination graft dysfunction/aplastic anemia relapse with massive clonal expansion of autologous CD8+ lymphocytes. Ritz C, Meng W, Stanley NL, Baroja ML, Xu C, Yan P, Huang AC, Hausler R, Nicholas P, Fan JM, Lieberman D, Carreno BM, Luning Prak ET, Olson TS, Babushok DV. Blood Adv. 2020 Apr 14;4(7):1378-1382.

Check our latest publications on Pubmed!

News

Babushok Lab medical student wins 2021 American Society of Hematology Minority Medical Student Award!

4/25/2021

Natasha Stanley received the prestigious 2021 American Society of Hematology Minority Medical Student Award to study the safety and efficacy of COVID19 vaccines in patients with immune-mediated bone marrow failure.

Apply for a PostDoc Position!

4/25/2021

We are looking for an enthusiastic and dedicated Ph.D. or M.D./Ph.D. scientist to join our laboratory as a Post-Doctoral Fellow at the Perelman School of Medicine University of Pennsylvania. Our lab is committed to excellence and improving the care of patients with bone marrow failure, and to promoting diversity and inclusion in hematology research.

Events

62nd ASH Annual Meeting & Exposition

December 5-8, 2020

Attend the world’s most comprehensive hematology event of the year for an invaluable educational experience and the opportunity to review thousands of scientific abstracts highlighting updates on the most critical topics in hematology.