Perelman School of Medicine at the University of Pennsylvania

Babushok Lab

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Selected Publications

Search Pubmed for Articles by Babushok Lab

2022

  • Colden M, Kumar S, Munkhbileg B, Babushok DV. Insights into the emergence of paroxysmal nocturnal hemoglobinuria. Frontiers in Immunology. 2022. In Press.
  • Babushok DV. Eltrombopag: a springboard to early responses in SAA. Blood. 2022 Jan 6;139(1):1-2.

 

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2021

  • Babushok DV. When does a PNH clone have clinical significance? Hematology Am Soc Hematol Educ Program. 2021 Dec 10;2021(1):143-152. doi: 10.1182/hematology.2021000245. PMID: 34889408
  • Kumar S, Babushok DV. Analysis of evolutionary conservation of GPI-anchored proteins between humans and mice. Blood Cells Mol Dis. 2021 Dec;92:102622. doi: 10.1016/j.bcmd.2021.102622. Epub 2021 Oct 30. PMID: 34749066
  • Zha J, Kunselman LK, Xie HM, Ennis B, Shah YB, Qin X, Fan JM, Babushok DV, Olson TS. Inducible Sbds Deletion Impairs Bone Marrow Niche Capacity to Engraft Donor Bone Marrow After Transplantation. Blood Adv. 2021 Oct 8:bloodadvances.2021004640. doi: 10.1182/bloodadvances.2021004640. PMID: 34625796
  • Shah YB, Priore SF, Li Y, Tang CN, Nicholas P, Kurre P, Olson TS, Babushok DV. The predictive value of PNH clones, 6p CN-LOH, and clonal TCR gene rearrangement for aplastic anemia diagnosis. Blood Adv. 2021 Aug 24;5(16):3216-3226. doi: 10.1182/bloodadvances.2021004201. PMID: 34427585
  • Lim TL, Lieberman DB, Davis AR, Loren AW, Hausler R, Bigdeli A, Li Y, Powers J, Raper A, Regeneron Genetics Center, Carty SA, Nathanson KL, Bagg A, Hexner EO, Maxwell KN, Morrissette JJD, Babushok DV. Germline POT1 variants can predispose to myeloid and lymphoid neoplasms. Leukemia. 2021 Jun 30. doi: 10.1038/s41375-021-01335-w. PMID: 34193977
  • Freyer CW, Gier S, Moyer ME, Berryman N, Carulli A, Ganetsky A, Timlin C, Babushok DV, Frey NV, Gill SI, Hexner EO, Loren AW, Mangan JK, Martin ME, McCurdy S, Perl AE, Smith J, Luger SM, Stadtmauer EA, Porter DL. Leucovorin Rescue After Methotrexate Graft-Versus-Host Disease Prophylaxis Shortens the Duration of Mucositis, Time to Neutrophil Engraftment, and Hospital Length of Stay. Transplant Cell Ther. 2021 May;27(5):431.e1-431.e8. doi: 10.1016/j.jtct.2021.01.028. Epub 2021 Feb 5. PMID: 33965188

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2020

  • Oved JH, Babushok DV, Lambert MP, Wolfset N, Kowalska MA, Poncz M, Karczewski KJ, Olson TS. Human mutational constraint as a tool to understand biology of rare and emerging bone marrow failure syndromes. Blood Adv. 2020 Oct 27;4(20):5232-5245. doi: 10.1182/bloodadvances.2020002687. PMID: 33104793
  • Abella BS, Jolkovsky EL, Biney BT, Uspal JE, Hyman MC, Frank I, Hensley SE, Gill S, Vogl DT, Maillard I, Babushok DV, Huang AC, Nasta SD, Walsh JC, Wiletyo EP, Gimotty PA, Milone MC, Amaravadi RK; Prevention and Treatment of COVID-19 With Hydroxychloroquine (PATCH) Investigators. Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers: A Randomized Clinical Trial. JAMA Intern Med. 2021 Feb 1;181(2):195-202. doi: 10.1001/jamainternmed.2020.6319.
  • Sklarz T, Hurwitz SN, Stanley NL, Juusola J, Bagg A, Babushok D. Aplastic anemia in a patient with CVID due to NFKB1 haploinsufficiency. Cold Spring Harb Mol Case Stud. 2020 Dec 17;6(6):a005769.
  • Sung PJ, Babushok DV. Born to RUNX1. Blood. 2020 May 21;135(21):1824-1825. doi: 10.1182/blood.2020006152. PMID: 32437563
  • Sun L, Babushok DV. Secondary myelodysplastic syndrome and leukemia in acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria. Blood. 2020 Jul 2;136(1):36-49. doi: 10.1182/blood.2019000940. PMID: 32430502
  • Ritz C, Meng W, Stanley NL, Baroja ML, Xu C, Yan P, Huang AC, Hausler R, Nicholas P, Fan JM, Lieberman D, Carreno BM, Luning Prak ET, Olson TS, Babushok DV. Postvaccination graft dysfunction/aplastic anemia relapse with massive clonal expansion of autologous CD8+ lymphocytes. Blood Adv. 2020 Apr 14;4(7):1378-1382. doi: 10.1182/bloodadvances.2019000853. PMID: 32267929

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2019

  • Abella BS, Jolkovsky EL, Biney BT, Uspal JE, Hyman MC, Frank I, Hensley SE, Gill S, Vogl DT, Maillard I, Babushok DV, Huang AC, Nasta SD, Walsh JC, Wiletyo EP, Gimotty PA, Milone MC, Amaravadi RK; Prevention and Treatment of COVID-19 With Hydroxychloroquine (PATCH) Investigators. Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers: A Randomized Clinical Trial. JAMA Intern Med. 2021 Feb 1;181(2):195-202. doi: 10.1001/jamainternmed.2020.6319.PMID: 33001138
  • Babushok DV. Eltrombopag: wielding a double-edged sword? Blood. 2019 Jun 13;133(24):2555-2556. doi: 10.1182/blood.2019001327.PMID: 31196876
  • Linaburg T, Davis AR, Frey NV, Khawaja MR, Landsburg DJ, Schuster SJ, Svoboda J, Li Y, Borovskiy Y, Olson TS, Bagg A, Hexner EO, Babushok DV. Hodgkin lymphoma patients have an increased incidence of idiopathic acquired aplastic anemia.PLoS One. 2019 Apr 5;14(4):e0215021. doi: 10.1371/journal.pone.0215021. eCollection 2019.PMID: 30951562 
  • Oved JH, Stanley N, Babushok DV, Huang Y, Duke JL, Monos DS, Teachey DT, Olson TS. Development of hemolytic paroxysmal nocturnal hemoglobinuria without graft loss following hematopoietic stem cell transplantation for acquired aplastic anemia. Pediatr Transplant. 2019 Jun;23(4):e13393. doi: 10.1111/petr.13393. Epub 2019 Mar 22.PMID: 30900367
  • Ganetsky A, Han JH, Hughes ME, Babushok DV, Frey NV, Gill SI, Hexner EO, Loren AW, Luger SM, Mangan JK, Martin ME, Smith J, Freyer CW, Gilmar C, Schuster M, Stadtmauer EA, Porter DL. Oral Vancomycin Prophylaxis Is Highly Effective in Preventing Clostridium difficile Infection in Allogeneic Hematopoietic Cell Transplant Recipients. Clin Infect Dis. 2019 May 30;68(12):2003-2009. doi: 10.1093/cid/ciy822.PMID: 30256954
  • Babushok DV, Nelson EJ, Morrissette JJD, Joshi S, Palmer MB, Frank D, Cambor CL, Hexner EO. Myelofibrosis patients can develop extramedullary complications including renal amyloidosis and sclerosing hematopoietic tumor while otherwise meeting traditional measures of ruxolitinib response. Leuk Lymphoma. 2019 Mar;60(3):852-855. doi: 10.1080/10428194.2018.1509319. Epub 2018 Sep 19.PMID: 30227762 .
  • Ganetsky A, Frey NV, Hexner EO, Loren AW, Gill SI, Luger SM, Mangan JK, Martin ME, Babushok DV, Drobyski WR, Smith J, Timlin C, Freyer CW, Stadtmauer EA, Porter DL. Tocilizumab for the treatment of severe steroid-refractory acute graft-versus-host disease of the lower gastrointestinal tract. Bone Marrow Transplant. 2019 Feb;54(2):212-217. doi: 10.1038/s41409-018-0236-z. Epub 2018 May 24.PMID: 29795429

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2018

  • Babushok DV, Nelson EJ, Morrissette JJD, Joshi S, Palmer MB, Frank D, Cambor CL, Hexner EO. Myelofibrosis patients can develop extramedullary complications including renal amyloidosis and sclerosing hematopoietic tumor while otherwise meeting traditional measures of ruxolitinib response. Leuk Lymphoma. 2018 Sep 19:1-4. doi: 10.1080/10428194.2018.1509319. [Epub ahead of print] PubMed PMID: 30227762.
  • Babushok DV, Stanley NL, Morrissette JJD, Lieberman DB, Olson TS, Chou ST, Hexner EO. Germline duplication of ATG2B and GSKIP genes is not required for the familial myeloid malignancy syndrome associated with the duplication of chromosome 14q32. Leukemia. 2018 Aug 7. doi: 10.1038/s41375-018-0231-9. [Epub ahead of print] PubMed PMID: 30087419.
  • Aynardi J, Manur R, Hess PR, Chekol S, Morrissette JJD, Babushok D, Hexner E, Rogers HJ, Hsi ED, Margolskee E, Orazi A, Hasserjian R, Bagg A. JAK2V617F-positive acute myeloid leukaemia (AML): a comparison between de novo AML and secondary AML transformed from an underlying myeloproliferative neoplasm. A study from the Bone Marrow Pathology Group. Br J Haematol. 2018 Jul;182(1):78-85. doi: 10.1111/bjh.15276. Epub 2018 May 16. PubMed PMID: 29767839. 
  • Ganetsky A, Frey NV, Hexner EO, Loren AW, Gill SI, Luger SM, Mangan JK, Martin ME, Babushok DV, Drobyski WR, Smith J, Timlin C, Freyer CW, Stadtmauer EA, Porter DL. Tocilizumab for the treatment of severe steroid-refractory acute graft-versus-host disease of the lower gastrointestinal tract. Bone Marrow Transplant. 2018 May 24. doi: 10.1038/s41409-018-0236-z. [Epub ahead of print] PubMed PMID: 29795429.
  • Soderquist CR, Ewalt MD, Czuchlewski DR, Geyer JT, Rogers HJ, Hsi ED, Wang SA, Bueso-Ramos CE, Orazi A, Arber DA, Hexner EO, Babushok DV, Bagg A. Myeloproliferative neoplasms with concurrent BCR-ABL1 translocation and JAK2 V617F mutation: a multi-institutional study from the bone marrow pathology group. Mod Pathol. 2018 May;31(5):690-704. doi: 10.1038/modpathol.2017.182. Epub 2018 Jan 12. PubMed PMID: 29327708; PubMed Central PMCID: PMC6008160.
  • Sarthy J, Zha J, Babushok D, Shenoy A, Fan JM, Wertheim G, Himebauch A, Munchel A, Taraseviciute A, Yang S, Shima H, Narumi S, Meshinchi S, Olson TS. Poor outcome with hematopoietic stem cell transplantation for bone marrow failure and MDS with severe MIRAGE syndrome phenotype. Blood Adv. 2018 Jan 23;2(2):120-125. doi: 10.1182/bloodadvances.2017012682. PubMed PMID: 29365320; PubMed Central PMCID: PMC5787871.

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2017

  • Peslak SA, Olson T, Babushok DV. Diagnosis and Treatment of Aplastic Anemia. Curr Treat Options Oncol. 2017 Nov 16;18(12):70. doi: 10.1007/s11864-017-0511-z. Review. PubMed PMID: 29143887; PubMed Central PMCID: PMC5804354.
  • Babushok DV, Duke JL, Xie HM, Stanley N, Atienza J, Perdigones N, Nicholas P, Ferriola D, Li Y, Huang H, Ye W, Morrissette JJD, Kearns J, Porter DL, Podsakoff GM, Eisenlohr LC, Biegel JA, Chou ST, Monos DS, Bessler M, Olson TS. Somatic HLA Mutations Expose the Role of Class I-Mediated Autoimmunity in Aplastic Anemia and its Clonal Complications. Blood Adv. 2017 Oct 10;1(22):1900-1910. PubMed PMID: 28971166; PubMed Central PMCID: PMC5621748.
  • Reilly CR, Babushok DV, Martin K, Spivak JL, Streiff M, Bahirwani R, Mondschein J, Stein B, Moliterno A, Hexner EO. Multicenter analysis of the use of transjugular intrahepatic portosystemic shunt for management of MPN-associated portal hypertension. Am J Hematol. 2017 Sep;92(9):909-914. doi: 10.1002/ajh.24798. Epub 2017 Jul 26. PubMed PMID: 28543980; PubMed Central PMCID: PMC5547000.
  • Stanley N, Olson TS, Babushok DV. Recent advances in understanding clonal haematopoiesis in aplastic anaemia. Br J Haematol. 2017 May;177(4):509-525. doi: 10.1111/bjh.14510. Epub 2017 Jan 20. Review. PubMed PMID: 28107566; PubMed Central PMCID: PMC5435524.

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2016

  • Babushok DV, Stanley N, Xie HM, Huang H, Bagg A, Olson TS, Bessler M. Clonal Replacement Underlies Spontaneous Remission in Paroxysmal Nocturnal Haemoglobinuria. Br J Haematol. 2017 Feb;176(3):487-490. doi: 10.1111/bjh.13963. Epub 2016 Feb 23. PubMed PMID: 26913981; PubMed Central PMCID: PMC5446267.
  • Perdigones N, Perin JC, Schiano I, Nicholas P, Biegel JA, Mason PJ, Babushok DV, Bessler M. Clonal hematopoiesis in patients with dyskeratosis congenita. Am J Hematol. 2016 Dec;91(12):1227-1233. doi: 10.1002/ajh.24552. Epub 2016 Oct 21. PubMed PMID: 27622320; PubMed Central PMCID: PMC5118079.
  • Babushok DV, Grignon AL, Li Y, Atienza J, Xie HM, Lam HS, Hartung H, Bessler M, Olson TS. Disrupted lymphocyte homeostasis in hepatitis-associated acquired aplastic anemia is associated with short telomeres. Am J Hematol. 2016 Feb;91(2):243-7. doi: 10.1002/ajh.24256. PubMed PMID: 26615915; PubMed Central PMCID: PMC4724330.
  • Betensky M, Babushok D, Roth JJ, Mason PJ, Biegel JA, Busse TM, Li Y, Lind C, Papazoglou A, Monos D, Podsakoff G, Bessler M, Olson TS. Clonal evolution and clinical significance of copy number neutral loss of heterozygosity of chromosome arm 6p in acquired aplastic anemia. Cancer Genet. 2016 Jan-Feb;209(1-2):1-10. doi: 10.1016/j.cancergen.2015.10.002. Epub 2015 Oct 30. PubMed PMID: 26702937; PubMed Central PMCID: PMC4738084.
  • Babushok DV, Bessler M, Olson TS. Genetic predisposition to myelodysplastic syndrome and acute myeloid leukemia in children and young adults. Leuk Lymphoma. 2016;57(3):520-36. doi: 10.3109/10428194.2015.1115041. Epub 2015 Dec 23. PubMed PMID: 26693794; PubMed Central PMCID: PMC4798888.

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2015

  • Babushok DV, Olson TS, Bessler M. Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia. N Engl J Med. 2015 Oct 22;373(17):1673. doi: 10.1056/NEJMc1509703. PubMed PMID: 26488703; PubMed Central PMCID: PMC4752195.
  • Babushok DV, Perdigones N, Perin JC, Olson TS, Ye W, Roth JJ, Lind C, Cattier C, Li Y, Hartung H, Paessler ME, Frank DM, Xie HM, Cross S, Cockroft JD, Podsakoff GM, Monos D, Biegel JA, Mason PJ, Bessler M. Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia. Cancer Genet. 2015 Apr;208(4):115-28. doi: 10.1016/j.cancergen.2015.01.007. Epub 2015 Feb 2. PubMed PMID: 25800665; PubMed Central PMCID: PMC4433860.
  • Babushok DV, Bessler M. Genetic predisposition syndromes: when should they be considered in the work-up of MDS? Best Pract Res Clin Haematol. 2015 Mar;28(1):55-68. doi: 10.1016/j.beha.2014.11.004. Epub 2014 Nov 12. Review. PubMed PMID: 25659730; PubMed Central PMCID: PMC4323616.

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2014

  • Babushok DV, Cardamone D, Rulander N, Master SR, Hexner EO. A common, under-recognized cause of elevated serum erythropoietin. Am J Med. 2014 Dec;127(12):e7-8. doi: 10.1016/j.amjmed.2014.08.006. Epub 2014 Aug 19. PubMed PMID: 25149545; PubMed Central PMCID: PMC5621041.
  • Babushok D, Hexner E. Allogeneic transplantation for myelofibrosis: for whom, when, and what are the true benefits? Curr Opin Hematol. 2014 Mar;21(2):114-22. doi: 10.1097/MOH.0000000000000015. Review. PubMed PMID: 24378706; PubMed Central PMCID: PMC4104209.
  • Babushok DV, Xie HM, Roth JJ, Perdigones N, Olson TS, Cockroft JD, Gai X, Perin JC, Li Y, Paessler ME, Hakonarson H, Podsakoff GM, Mason PJ, Biegel JA, Bessler M. Single nucleotide polymorphism array analysis of bone marrow failure patients reveals characteristic patterns of genetic changes. Br J Haematol. 2014 Jan;164(1):73-82. doi: 10.1111/bjh.12603. Epub 2013 Oct 14. PubMed PMID: 24116929; PubMed Central PMCID: PMC3986350.

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2013

Babushok DV, Li Y, Roth JJ, Perdigones N, Cockroft JD, Biegel JA, Mason PJ, Bessler M. Common polymorphic deletion of glutathione S-transferase theta predisposes to acquired aplastic anemia: Independent cohort and meta-analysis of 609 patients. Am J Hematol. 2013 Oct;88(10):862-7. doi: 10.1002/ajh.23521. Epub 2013 Jul 23. PubMed PMID: 23798465; PubMed Central PMCID: PMC3983712.

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2012

Babushok D, Cuker A. VWF sequence variants: innocent until proven guilty. Blood. 2012 Mar 1;119(9):1959-60. doi: 10.1182/blood-2012-01-403634. PubMed PMID: 22383789.

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2007

Babushok DV, Ohshima K, Ostertag EM, Chen X, Wang Y, Mandal PK, Okada N, Abrams CS, Kazazian HH Jr. A novel testis ubiquitin-binding protein gene arose by exon shuffling in hominoids. Genome Res. 2007 Aug;17(8):1129-38. Epub 2007 Jul 10. PubMed PMID: 17623810; PubMed Central PMCID: PMC1933510.
Babushok DV, Kazazian HH Jr. Progress in understanding the biology of the human mutagen LINE-1. Hum Mutat. 2007 Jun;28(6):527-39. Review. PubMed PMID: 17309057.
Babushok DV, Ostertag EM, Kazazian HH Jr. Current topics in genome evolution: molecular mechanisms of new gene formation. Cell Mol Life Sci. 2007 Mar;64(5):542-54. Review. PubMed PMID: 17192808.

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2006

Babushok DV, Ostertag EM, Courtney CE, Choi JM, Kazazian HH Jr. L1 integration in a transgenic mouse model. Genome Res. 2006 Feb;16(2):240-50. Epub 2005 Dec 19. PubMed PMID: 16365384; PubMed Central PMCID: PMC1361720.

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Search Pubmed for Articles by Babushok Lab