Publications

Neuroimaging changes in major depression with brief computer-assisted cognitive behavioral therapy compared to waitlist.
Molecular psychiatry. 2025 Mar 11; Authors: Sheline YI, Thase ME, Hembree EA, Balderston NL, Nitchie FJ, Batzdorf AS, Makhoul W, Lynch KG
The ENIGMA-Neuromodulation working group - A mission statement.
Brain stimulation. 2025 Mar-Apr;18(2):142-144 Epub 2025 Jan 10; Authors: Kuhn T, Indahlastari A, Vila-Rodriguez F, Fonzo G, Petersen N, Rotstein N, Davis T, Halavi S, Mehler D, Repple J, Hahn T, Bertazzoli G, Reggente N, Woods A, Dang BH, Mason X, Laidi C, Chou T, Bortoletto M, Kallioniemi E, Begue I, Balderston N, Porges E, Oberman L, Oathes D, Lisanby SH, van den Heuvel O, Kroemer N, Monti M, Venkatasubramanian G, Thomopoulos S, Jahanshad N, Thompson P, ENIGMA Neuromodulation Working Group
Intermittent theta-burst stimulation to the right dorsolateral prefrontal cortex may increase potentiated startle in healthy individuals.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024 Sep;49(10):1619-1629 Epub 2024 May 13; Authors: Teferi M, Gura H, Patel M, Casalvera A, Lynch KG, Makhoul W, Deng ZD, Oathes DJ, Sheline YI, Balderston NL
Neuromodulatory transcranial magnetic stimulation (TMS) changes functional connectivity proportional to the electric-field induced by the TMS pulse.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2024 Sep;165:16-25 Epub 2024 Jun 19; Authors: Balderston NL, Duprat RJ, Long H, Scully M, Deluisi JA, Figueroa-Gonzalez A, Teferi M, Sheline YI, Oathes DJ
Accelerated Intermittent Theta-Burst Stimulation and Treatment-Refractory Bipolar Depression: A Randomized Clinical Trial.
JAMA psychiatry. 2024 Sep 1;81(9):936-941; Authors: Sheline YI, Makhoul W, Batzdorf AS, Nitchie FJ, Lynch KG, Cash R, Balderston NL
The maintenance of complex visual scenes in working memory may require activation of working memory manipulation circuits in the dlPFC: a preliminary report.
Mental health science. 2024 Sep;2(3) Epub 2024 May 10; Authors: Nitchie F, Casalvera A, Teferi M, Patel M, Lynch KG, Makhoul W, Sheline YI, Balderston NL
Threat of shock increases distractor susceptibility during the short-term maintenance of visual information.
Social cognitive and affective neuroscience. 2024 Jun 13;19(1); Authors: Casalvera A, Goodwin M, Lynch KG, Teferi M, Patel M, Grillon C, Ernst M, Balderston NL
pNet: A toolbox for personalized functional networks modeling.
bioRxiv : the preprint server for biology. 2024 Apr 29; Authors: Ma Y, Li H, Zhou Z, Chen X, Ma L, Guray E, Balderston NL, Oathes DJ, Shinohara RT, Wolf DH, Nasrallah IM, Shou H, Satterthwaite TD, Davatzikos C, Fan Y
The interactive effects of different facets of threat uncertainty and cognitive load in shaping fear and anxiety responses.
Psychophysiology. 2023 Dec;60(12):e14404 Epub 2023 Aug 9; Authors: Seo D, Balderston NL, Berenbaum H, Hur J
Threat of shock increases distractor susceptibility during the short-term maintenance of visual information.
medRxiv : the preprint server for health sciences. 2023 Nov 23; Authors: Casalvera A, Goodwin M, Lynch K, Teferi M, Patel M, Grillon C, Ernst M, Balderston NL
The maintenance of complex visual scenes in working memory may require activation of working memory manipulation circuits in the dlPFC.
medRxiv : the preprint server for health sciences. 2023 Nov 12; Authors: Nitchie F, Casalvera A, Teferi M, Patel M, Lynch K, Makhoul W, Sheline Y, Balderston NL
Interleaved TMS/fMRI shows that threat decreases dlPFC-mediated top-down regulation of emotion processing.
medRxiv : the preprint server for health sciences. 2023 Nov 11; Authors: Patel M, Teferi M, Casalvera A, Lynch K, Nitchie F, Makhoul W, Oathes DJ, Sheline Y, Balderston NL
Role of the intraparietal sulcus (IPS) in anxiety and cognition: Opportunities for intervention for anxiety-related disorders.
International journal of clinical and health psychology : IJCHP. 2023 Oct-Dec;23(4):100385 Epub 2023 Mar 22; Authors: Brown L, White LK, Makhoul W, Teferi M, Sheline YI, Balderston NL
Functional connectomics in depression: insights into therapies.
Trends in cognitive sciences. 2023 Sep;27(9):814-832 Epub 2023 Jun 5; Authors: Chai Y, Sheline YI, Oathes DJ, Balderston NL, Rao H, Yu M
Toward personalized circuit-based closed-loop brain-interventions in psychiatry: using symptom provocation to extract EEG-markers of brain circuit activity.
Frontiers in neural circuits. 2023;17:1208930 Epub 2023 Aug 21; Authors: Zrenner B, Zrenner C, Balderston N, Blumberger DM, Kloiber S, Laposa JM, Tadayonnejad R, Trevizol AP, Zai G, Feusner JD
The role of dlPFC laterality in the expression and regulation of anxiety.
Neuropharmacology. 2023 Feb 15;224:109355 Epub 2022 Nov 26; Authors: White LK, Makhoul W, Teferi M, Sheline YI, Balderston NL
Cortical-subcortical structural connections support transcranial magnetic stimulation engagement of the amygdala.
Science advances. 2022 Jun 24;8(25):eabn5803 Epub 2022 Jun 22; Authors: Sydnor VJ, Cieslak M, Duprat R, Deluisi J, Flounders MW, Long H, Scully M, Balderston NL, Sheline YI, Bassett DS, Satterthwaite TD, Oathes DJ
Continuous Theta-Burst Stimulation to the Right Dorsolateral Prefrontal Cortex May Increase Potentiated Startle in Healthy Individuals.
Biological psychiatry global open science. 2023 Jul;3(3):470-479 Epub 2022 Apr 25; Authors: Teferi M, Makhoul W, Deng ZD, Oathes DJ, Sheline Y, Balderston NL
Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group.
Human brain mapping. 2022 Jan;43(1):255-277 Epub 2020 Jun 29; Authors: Zugman A, Harrewijn A, Cardinale EM, Zwiebel H, Freitag GF, Werwath KE, Bas-Hoogendam JM, Groenewold NA, Aghajani M, Hilbert K, Cardoner N, Porta-Casteràs D, Gosnell S, Salas R, Blair KS, Blair JR, Hammoud MZ, Milad M, Burkhouse K, Phan KL, Schroeder HK, Strawn JR, Beesdo-Baum K, Thomopoulos SI, Grabe HJ, Van der Auwera S, Wittfeld K, Nielsen JA, Buckner R, Smoller JW, Mwangi B, Soares JC, Wu MJ, Zunta-Soares GB, Jackowski AP, Pan PM, Salum GA, Assaf M, Diefenbach GJ, Brambilla P, Maggioni E, Hofmann D, Straube T, Andreescu C, Berta R, Tamburo E, Price R, Manfro GG, Critchley HD, Makovac E, Mancini M, Meeten F, Ottaviani C, Agosta F, Canu E, Cividini C, Filippi M, Kostić M, Munjiza A, Filippi CA, Leibenluft E, Alberton BAV, Balderston NL, Ernst M, Grillon C, Mujica-Parodi LR, van Nieuwenhuizen H, Fonzo GA, Paulus MP, Stein MB, Gur RE, Gur RC, Kaczkurkin AN, Larsen B, Satterthwaite TD, Harper J, Myers M, Perino MT, Yu Q, Sylvester CM, Veltman DJ, Lueken U, Van der Wee NJA, Stein DJ, Jahanshad N, Thompson PM, Pine DS, Winkler AM
Proof of concept study to develop a novel connectivity-based electric-field modelling approach for individualized targeting of transcranial magnetic stimulation treatment.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022 Jan;47(2):588-598 Epub 2021 Jul 28; Authors: Balderston NL, Beer JC, Seok D, Makhoul W, Deng ZD, Girelli T, Teferi M, Smyk N, Jaskir M, Oathes DJ, Sheline YI
Location-dependent threat and associated neural abnormalities in clinical anxiety.
Communications biology. 2021 Nov 4;4(1):1263; Authors: Suarez-Jimenez B, Balderston NL, Bisby JA, Leshin J, Hsiung A, King JA, Pine DS, Burgess N, Grillon C, Ernst M
Neurophysiological and clinical effects of the NMDA receptor antagonist lanicemine (BHV-5500) in PTSD: A randomized, double-blind, placebo-controlled trial.
Depression and anxiety. 2021 Nov;38(11):1108-1119 Epub 2021 Jul 12; Authors: Ramakrishnan N, Lijffijt M, Green CE, Balderston NL, Murphy N, Grillon C, Iqbal T, Vo-Le B, O'Brien B, Murrough JW, Swann AC, Mathew SJ
Methylphenidate modulates interactions of anxiety with cognition.
Translational psychiatry. 2021 Oct 21;11(1):544; Authors: Gaillard C, Lago TR, Gorka AX, Balderston NL, Fuchs BA, Reynolds RC, Grillon C, Ernst M
Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group.
Translational psychiatry. 2021 Oct 1;11(1):502; Authors: Harrewijn A, Cardinale EM, Groenewold NA, Bas-Hoogendam JM, Aghajani M, Hilbert K, Cardoner N, Porta-Casteràs D, Gosnell S, Salas R, Jackowski AP, Pan PM, Salum GA, Blair KS, Blair JR, Hammoud MZ, Milad MR, Burkhouse KL, Phan KL, Schroeder HK, Strawn JR, Beesdo-Baum K, Jahanshad N, Thomopoulos SI, Buckner R, Nielsen JA, Smoller JW, Soares JC, Mwangi B, Wu MJ, Zunta-Soares GB, Assaf M, Diefenbach GJ, Brambilla P, Maggioni E, Hofmann D, Straube T, Andreescu C, Berta R, Tamburo E, Price RB, Manfro GG, Agosta F, Canu E, Cividini C, Filippi M, Kostić M, Munjiza Jovanovic A, Alberton BAV, Benson B, Freitag GF, Filippi CA, Gold AL, Leibenluft E, Ringlein GV, Werwath KE, Zwiebel H, Zugman A, Grabe HJ, Van der Auwera S, Wittfeld K, Völzke H, Bülow R, Balderston NL, Ernst M, Grillon C, Mujica-Parodi LR, van Nieuwenhuizen H, Critchley HD, Makovac E, Mancini M, Meeten F, Ottaviani C, Ball TM, Fonzo GA, Paulus MP, Stein MB, Gur RE, Gur RC, Kaczkurkin AN, Larsen B, Satterthwaite TD, Harper J, Myers M, Perino MT, Sylvester CM, Yu Q, Lueken U, Veltman DJ, Thompson PM, Stein DJ, Van der Wee NJA, Winkler AM, Pine DS
The novel vasopressin receptor (V1aR) antagonist SRX246 reduces anxiety in an experimental model in humans: a randomized proof-of-concept study.
Psychopharmacology. 2021 Sep;238(9):2393-2403 Epub 2021 May 10; Authors: Lago TR, Brownstein MJ, Page E, Beydler E, Manbeck A, Beale A, Roberts C, Balderston N, Damiano E, Pineles SL, Simon N, Ernst M, Grillon C
Combining transcranial magnetic stimulation with functional magnetic resonance imaging for probing and modulating neural circuits relevant to affective disorders.
Wiley interdisciplinary reviews. Cognitive science. 2021 Jul;12(4):e1553 Epub 2021 Jan 19; Authors: Oathes DJ, Balderston NL, Kording KP, DeLuisi JA, Perez GM, Medaglia JD, Fan Y, Duprat RJ, Satterthwaite TD, Sheline YI, Linn KA
Fear conditioning and extinction in alcohol dependence: Evidence for abnormal amygdala reactivity.
Addiction biology. 2021 Jan;26(1):e12835 Epub 2019 Nov 8; Authors: Muench C, Charlet K, Balderston NL, Grillon C, Heilig M, Cortes CR, Momenan R, Lohoff FW
Responding to uncertain threat: A potential mediator for the effect of mindfulness on anxiety.
Journal of anxiety disorders. 2021 Jan;77:102332 Epub 2020 Oct 25; Authors: Papenfuss I, Lommen MJJ, Grillon C, Balderston NL, Ostafin BD
Patients with anxiety disorders rely on bilateral dlPFC activation during verbal working memory.
Social cognitive and affective neuroscience. 2020 Dec 24;15(12):1288-1298; Authors: Balderston NL, Flook E, Hsiung A, Liu J, Thongarong A, Stahl S, Makhoul W, Sheline Y, Ernst M, Grillon C
A generalized workflow for conducting electric field-optimized, fMRI-guided, transcranial magnetic stimulation.
Nature protocols. 2020 Nov;15(11):3595-3614 Epub 2020 Sep 30; Authors: Balderston NL, Roberts C, Beydler EM, Deng ZD, Radman T, Luber B, Lisanby SH, Ernst M, Grillon C
Better cognitive efficiency is associated with increased experimental anxiety.
Psychophysiology. 2020 Aug;57(8):e13559 Epub 2020 Mar 17; Authors: Grillon C, Lago T, Stahl S, Beale A, Balderston N, Ernst M
Intrinsic connections between thalamic sub-regions and the lateral prefrontal cortex are differentially impacted by acute methylphenidate.
Psychopharmacology. 2020 Jun;237(6):1873-1883 Epub 2020 Apr 19; Authors: Gorka AX, Lago TR, Balderston N, Torrisi S, Fuchs B, Grillon C, Ernst M
Mechanistic link between right prefrontal cortical activity and anxious arousal revealed using transcranial magnetic stimulation in healthy subjects.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2020 Mar;45(4):694-702 Epub 2019 Dec 2; Authors: Balderston NL, Beydler EM, Roberts C, Deng ZD, Radman T, Lago T, Luber B, Lisanby SH, Ernst M, Grillon C
Low-frequency parietal repetitive transcranial magnetic stimulation reduces fear and anxiety.
Translational psychiatry. 2020 Feb 17;10(1):68; Authors: Balderston NL, Beydler EM, Goodwin M, Deng ZD, Radman T, Luber B, Lisanby SH, Ernst M, Grillon C
Device-Based Modulation of Neurocircuits as a Therapeutic for Psychiatric Disorders.
Annual review of pharmacology and toxicology. 2020 Jan 6;60:591-614; Authors: Deng ZD, Luber B, Balderston NL, Velez Afanador M, Noh MM, Thomas J, Altekruse WC, Exley SL, Awasthi S, Lisanby SH
Dimensional connectomics of anxious misery, a human connectome study related to human disease: Overview of protocol and data quality.
NeuroImage. Clinical. 2020;28:102489 Epub 2020 Nov 3; Authors: Seok D, Smyk N, Jaskir M, Cook P, Elliott M, Girelli T, Scott JC, Balderston N, Beer J, Stock J, Makhoul W, Gur RC, Davatzikos C, Shinohara R, Sheline Y
A Proof-of-Mechanism Study to Test Effects of the NMDA Receptor Antagonist Lanicemine on Behavioral Sensitization in Individuals With Symptoms of PTSD.
Frontiers in psychiatry. 2019;10:846 Epub 2019 Dec 13; Authors: Lijffijt M, Green CE, Balderston N, Iqbal T, Atkinson M, Vo-Le B, Vo-Le B, O'Brien B, Grillon C, Swann AC, Mathew SJ
Exercise modulates the interaction between cognition and anxiety in humans.
Cognition & emotion. 2019 Jun;33(4):863-870 Epub 2018 Jul 23; Authors: Lago TR, Hsiung A, Leitner BP, Duckworth CJ, Balderston NL, Chen KY, Grillon C, Ernst M
Statistical power comparisons at 3T and 7T with a GO / NOGO task.
NeuroImage. 2018 Jul 15;175:100-110 Epub 2018 Apr 3; Authors: Torrisi S, Chen G, Glen D, Bandettini PA, Baker CI, Reynolds R, Yen-Ting Liu J, Leshin J, Balderston N, Grillon C, Ernst M
Extended amygdala connectivity changes during sustained shock anticipation.
Translational psychiatry. 2018 Jan 31;8(1):33; Authors: Torrisi S, Gorka AX, Gonzalez-Castillo J, O'Connell K, Balderston N, Grillon C, Ernst M
The relationship between dlPFC activity during unpredictable threat and CO(2)-induced panic symptoms.
Translational psychiatry. 2017 Nov 30;7(12):1266; Authors: Balderston NL, Liu J, Roberson-Nay R, Ernst M, Grillon C
Effect of Threat on Right dlPFC Activity during Behavioral Pattern Separation.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 2017 Sep 20;37(38):9160-9171 Epub 2017 Aug 21; Authors: Balderston NL, Hsiung A, Ernst M, Grillon C
Corrigendum: Psychopaths Show Enhanced Amygdala Activation during Fear Conditioning.
Frontiers in psychology. 2017;8:1457 Epub 2017 Aug 22; Authors: Schultz DH, Balderston NL, Baskin-Sommers AR, Larson CL, Helmstetter FJ
Reducing State Anxiety Using Working Memory Maintenance.
Journal of visualized experiments : JoVE. 2017 Jul 19;(125); Authors: Balderston NL, Hsiung A, Liu J, Ernst M, Grillon C
Threat of shock increases excitability and connectivity of the intraparietal sulcus.
eLife. 2017 May 30;6; Authors: Balderston NL, Hale E, Hsiung A, Torrisi S, Holroyd T, Carver FW, Coppola R, Ernst M, Grillon C
The effects of stimulus novelty and negativity on BOLD activity in the amygdala, hippocampus, and bed nucleus of the stria terminalis.
Social cognitive and affective neuroscience. 2017 May 1;12(5):748-757; Authors: Pedersen WS, Balderston NL, Miskovich TA, Belleau EL, Helmstetter FJ, Larson CL
Resting state connectivity of the human habenula at ultra-high field.
NeuroImage. 2017 Feb 15;147:872-879 Epub 2016 Oct 22; Authors: Torrisi S, Nord CL, Balderston NL, Roiser JP, Grillon C, Ernst M
Effect of anxiety on behavioural pattern separation in humans.
Cognition & emotion. 2017 Feb;31(2):238-248 Epub 2015 Oct 19; Authors: Balderston NL, Mathur A, Adu-Brimpong J, Hale EA, Ernst M, Grillon C
Anxiety Patients Show Reduced Working Memory Related dlPFC Activation During Safety and Threat.
Depression and anxiety. 2017 Jan;34(1):25-36 Epub 2016 Apr 25; Authors: Balderston NL, Vytal KE, O'Connell K, Torrisi S, Letkiewicz A, Ernst M, Grillon C
The neural basis of improved cognitive performance by threat of shock.
Social cognitive and affective neuroscience. 2016 Nov;11(11):1677-1686 Epub 2016 Jun 30; Authors: Torrisi S, Robinson O, O'Connell K, Davis A, Balderston N, Ernst M, Grillon C
Working memory maintenance is sufficient to reduce state anxiety.
Psychophysiology. 2016 Nov;53(11):1660-1668 Epub 2016 Jul 19; Authors: Balderston NL, Quispe-Escudero D, Hale E, Davis A, O'Connell K, Ernst M, Grillon C
Psychopaths Show Enhanced Amygdala Activation during Fear Conditioning.
Frontiers in psychology. 2016;7:348 Epub 2016 Mar 10; Authors: Schultz DH, Balderston NL, Baskin-Sommers AR, Larson CL, Helmstetter FJ
Functionally distinct amygdala subregions identified using DTI and high-resolution fMRI.
Social cognitive and affective neuroscience. 2015 Dec;10(12):1615-22 Epub 2015 May 11; Authors: Balderston NL, Schultz DH, Hopkins L, Helmstetter FJ
Resting state connectivity of the bed nucleus of the stria terminalis at ultra-high field.
Human brain mapping. 2015 Oct;36(10):4076-88 Epub 2015 Jul 14; Authors: Torrisi S, O'Connell K, Davis A, Reynolds R, Balderston N, Fudge JL, Grillon C, Ernst M
fMRI functional connectivity applied to adolescent neurodevelopment.
Annual review of clinical psychology. 2015;11:361-77 Epub 2015 Jan 2; Authors: Ernst M, Torrisi S, Balderston N, Grillon C, Hale EA
Prefrontal cortical regulation of fear learning.
Trends in neurosciences. 2014 Aug;37(8):455-64 Epub 2014 Jun 11; Authors: Gilmartin MR, Balderston NL, Helmstetter FJ
Rapid amygdala responses during trace fear conditioning without awareness.
PloS one. 2014;9(5):e96803 Epub 2014 May 13; Authors: Balderston NL, Schultz DH, Baillet S, Helmstetter FJ
The interplay of attention and emotion: top-down attention modulates amygdala activation in psychopathy.
Cognitive, affective & behavioral neuroscience. 2013 Dec;13(4):757-70; Authors: Larson CL, Baskin-Sommers AR, Stout DM, Balderston NL, Curtin JJ, Schultz DH, Kiehl KA, Newman JP
How to detect amygdala activity with magnetoencephalography using source imaging.
Journal of visualized experiments : JoVE. 2013 Jun 3;(76); Authors: Balderston NL, Schultz DH, Baillet S, Helmstetter FJ
Dissociation between implicit and explicit responses in postconditioning UCS revaluation after fear conditioning in humans.
Behavioral neuroscience. 2013 Jun;127(3):357-68; Authors: Schultz DH, Balderston NL, Geiger JA, Helmstetter FJ
The effect of threat on novelty evoked amygdala responses.
PloS one. 2013;8(5):e63220 Epub 2013 May 3; Authors: Balderston NL, Schultz DH, Helmstetter FJ
Resting-state connectivity of the amygdala is altered following Pavlovian fear conditioning.
Frontiers in human neuroscience. 2012;6:242 Epub 2012 Aug 23; Authors: Schultz DH, Balderston NL, Helmstetter FJ
The human amygdala plays a stimulus specific role in the detection of novelty.
NeuroImage. 2011 Apr 15;55(4):1889-98 Epub 2011 Jan 20; Authors: Balderston NL, Schultz DH, Helmstetter FJ
Conditioning with masked stimuli affects the timecourse of skin conductance responses.
Behavioral neuroscience. 2010 Aug;124(4):478-89; Authors: Balderston NL, Helmstetter FJ