Publications
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Mitigation of Osteoclast-Mediated Arthritic Bone Remodeling By Short Chain Fatty Acids.
Arthritis & rheumatology (Hoboken, N.J.). 2024 Apr;76(4):647-659 Epub 2024 Feb 18; Authors: Yang KL, Mullins BJ, Lejeune A, Ivanova E, Shin J, Bajwa S, Possemato R, ... -
The hyphal-specific toxin candidalysin promotes fungal gut commensalism.
Nature. 2024 Mar;627(8004):620-627 Epub 2024 Mar 6; Authors: Liang SH, Sircaik S, Dainis J, Kakade P, Penumutchu S, McDonough LD, Chen YH, ... -
S1PR1 inhibition induces proapoptotic signaling in T cells and limits humoral responses within lymph nodes.
The Journal of clinical investigation. 2024 Jan 9;134(4); Authors: Dixit D, Hallisey VM, Zhu EY, Okuniewska M, Cadwell K, Chipuk JE, Axelrad JE, ... -
Cytokine signature in convalescent SARS-CoV-2 patients with inflammatory bowel disease receiving vedolizumab.
Scientific reports. 2024 Jan 2;14(1):186; Authors: Dallari S, Martinez Pazos V, Munoz Eusse J, Wellens J, Thompson C, Colombel JF, Satsangi J, ... -
Beyond antiviral: Interferon induced by bacteria maintains tolerance in the gut.
The Journal of experimental medicine. 2024 Jan 1;221(1) Epub 2023 Dec 13; Authors: Yang Y, Cadwell K -
Spatiotemporal-social association predicts immunological similarity in rewilded mice.
Science advances. 2023 Dec 22;9(51):eadh8310; Authors: Downie AE, Oyesola O, Barre RS, Caudron Q, Chen YH, Dennis EJ, Garnier R, ... -
Temporal Tracking of Plasma Cells in vivo Using J-chain CreERT2 Reporter System.
bioRxiv : the preprint server for biology. 2023 Dec 4; Authors: Borbet TC, Zaldaña K, Zavitsanou AM, Hines MJ, Bajwa S, Morrison T, Boehringer T, ... -
Activation of Nod2 signaling upon norovirus infection enhances antiviral immunity and susceptibility to colitis.
Gut microbes. 2023 Dec;15(2):2249960; Authors: Muharram G, Thépaut M, Lobert PE, Grandjean T, Boulard O, Delacre M, Wakeford E, ... -
Colonization with extended spectrum beta-lactamase and carbapenemases producing Enterobacteriaceae among hospitalized patients at the global level: A systematic review and meta-analysis.
PloS one. 2023;18(11):e0293528 Epub 2023 Nov 27; Authors: Abera D, Alemu A, Mihret A, Negash AA, Abegaz WE, Cadwell K -
Antibody, not Cellular, Immune Responses to SARS-CoV-2 Vaccination Outperform Infection in Inflammatory Bowel Disease Patients.
Inflammatory bowel diseases. 2023 Nov 3; Authors: González Cueto E, Edmans M, Wellens J, Cadwell K, Thompson C, Satsangi J, Wong SY -
Geography Influences Susceptibility to SARS-CoV-2 Serological Response in Patients With Inflammatory Bowel Disease: Multinational Analysis From the ICARUS-IBD Consortium.
Inflammatory bowel diseases. 2023 Nov 2;29(11):1693-1705; Authors: Wong SY, Wellens J, Helmus D, Marlow L, Brann S, Martinez Pazos V, Weinberg A, ... -
Immunomodulation by Enteric Viruses.
Annual review of virology. 2023 Sep 29;10(1):477-502 Epub 2023 Jun 28; Authors: Bernard-Raichon L, Cadwell K -
Bacterial contact induces polar plug disintegration to mediate whipworm egg hatching.
PLoS pathogens. 2023 Sep;19(9):e1011647 Epub 2023 Sep 22; Authors: Robertson A, Sall J, Venzon M, Olivas JJ, Zheng X, Cammer M, Antao N, ... -
Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization.
Cell host & microbe. 2023 Sep 13;31(9):1450-1468.e8 Epub 2023 Aug 30; Authors: Jang KK, Heaney T, London M, Ding Y, Putzel G, Yeung F, Ercelen D, ... -
Sphingosine 1-phosphate receptor 1 inhibition induces a pro-apoptotic signaling cascade in T cells.
bioRxiv : the preprint server for biology. 2023 Aug 22; Authors: Dixit D, Hallisey VM, Zhu EYS, Okuniewska M, Cadwell K, Chipuk JE, Axelrad JE, ... -
Rewilding of laboratory mice enhances granulopoiesis and immunity through intestinal fungal colonization.
Science immunology. 2023 Jun 23;8(84):eadd6910; Authors: Chen YH, Yeung F, Lacey KA, Zaldana K, Lin JD, Bee GCW, McCauley C, ... -
Functional characterization of helminth-associated Clostridiales reveals covariates of Treg differentiation.
bioRxiv : the preprint server for biology. 2023 Jun 7; Authors: Sargsian S, Lejeune A, Ercelen D, Jin WB, Varghese A, Loke P, Lim YAL, ... -
Defensosomes: a new role for autophagy proteins in innate immune defense.
Autophagy. 2023 Jun;19(6):1887-1889 Epub 2022 Nov 21; Authors: Ching KL, Torres VJ, Cadwell K -
A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8.
Nature communications. 2023 May 25;14(1):3026; Authors: Rodriguez-Rodriguez BA, Ciabattoni GO, Duerr R, Valero-Jimenez AM, Yeung ST, Crosse KM, Schinlever AR, ... -
Genetic and Environmental interactions contribute to immune variation in rewilded mice.
bioRxiv : the preprint server for biology. 2023 May 2; Authors: Oyesola O, Downie AE, Howard N, Barre RS, Kiwanuka K, Zaldana K, Chen YH, ... -
Bacterial contact induces polar plug disintegration to mediate whipworm egg hatching.
bioRxiv : the preprint server for biology. 2023 Mar 13; Authors: Robertson A, Sall J, Venzon M, Olivas JJ, Zheng X, Cammer M, Antao N, ... -
Pathogen-Specific Alterations in the Gut Microbiota Predict Outcomes in Flare of Inflammatory Bowel Disease Complicated by Gastrointestinal Infection.
Clinical and translational gastroenterology. 2023 Feb 1;14(2):e00550; Authors: Axelrad JE, Chen Z, Devlin J, Ruggles KV, Cadwell K -
Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization.
bioRxiv : the preprint server for biology. 2023 Feb 1; Authors: Jang KK, Heaney T, London M, Ding Y, Yeung F, Ercelen D, Chen YH, ... -
Gut microbiome of helminth-infected indigenous Malaysians is context dependent.
Microbiome. 2022 Dec 7;10(1):214; Authors: Tee MZ, Er YX, Easton AV, Yap NJ, Lee IL, Devlin J, Chen Z, ... -
Clostridia isolated from helminth-colonized humans promote the life cycle of Trichuris species.
Cell reports. 2022 Nov 29;41(9):111725; Authors: Sargsian S, Chen Z, Lee SC, Robertson A, Thur RS, Sproch J, Devlin JC, ... -
Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia.
Nature communications. 2022 Nov 1;13(1):5926; Authors: Bernard-Raichon L, Venzon M, Klein J, Axelrad JE, Zhang C, Sullivan AP, Hussey GA, ... -
Into the wild: How exposure to wild or domesticated fungi shapes immune responses in mice.
PLoS pathogens. 2022 Oct;18(10):e1010841 Epub 2022 Oct 13; Authors: Chen YH, Cadwell K -
The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death.
Nature. 2022 Oct;610(7932):547-554 Epub 2022 Oct 5; Authors: Matsuzawa-Ishimoto Y, Yao X, Koide A, Ueberheide BM, Axelrad JE, Reis BS, Parsa R, ... -
APOL1 variant-expressing endothelial cells exhibit autophagic dysfunction and mitochondrial stress.
Frontiers in genetics. 2022;13:769936 Epub 2022 Sep 27; Authors: Blazer A, Qian Y, Schlegel MP, Algasas H, Buyon JP, Cadwell K, Cammer M, ... -
ACE2-containing defensosomes serve as decoys to inhibit SARS-CoV-2 infection.
PLoS biology. 2022 Sep;20(9):e3001754 Epub 2022 Sep 13; Authors: Ching KL, de Vries M, Gago J, Dancel-Manning K, Sall J, Rice WJ, Barnett C, ... -
Efficacy of triple dose albendazole treatment for soil-transmitted helminth infections.
PloS one. 2022;17(8):e0272821 Epub 2022 Aug 12; Authors: Tee MZ, Lee SC, Er YX, Yap NJ, Ngui R, Easton AV, Siow VWY, ... -
Microbiome-Independent Effects of Antibiotics in a Murine Model of Nosocomial Infections.
mBio. 2022 Jun 28;13(3):e0124022 Epub 2022 May 25; Authors: Lacey KA, Gonzalez S, Yeung F, Putzel G, Podkowik M, Pironti A, Shopsin B, ... -
Microbial byproducts determine reproductive fitness of free-living and parasitic nematodes.
Cell host & microbe. 2022 Jun 8;30(6):786-797.e8 Epub 2022 Apr 11; Authors: Venzon M, Das R, Luciano DJ, Burnett J, Park HS, Devlin JC, Kool ET, ... -
Pathogen Species Is Associated With Mortality in Nosocomial Bloodstream Infection in Patients With COVID-19.
Open forum infectious diseases. 2022 Jun;9(6):ofac083 Epub 2022 Apr 5; Authors: Gago J, Filardo TD, Conderino S, Magaziner SJ, Dubrovskaya Y, Inglima K, Iturrate E, ... -
Variable susceptibility of intestinal organoid-derived monolayers to SARS-CoV-2 infection.
PLoS biology. 2022 Mar;20(3):e3001592 Epub 2022 Mar 31; Authors: Jang KK, Kaczmarek ME, Dallari S, Chen YH, Tada T, Axelrad J, Landau NR, ... -
Gut microbiome dysbiosis during COVID-19 is associated with increased risk for bacteremia and microbial translocation.
bioRxiv : the preprint server for biology. 2022 Mar 2; Authors: Venzon M, Bernard-Raichon L, Klein J, Axelrad JE, Zhang C, Hussey GA, Sullivan AP, ... -
IL-17RA-signaling in Lgr5(+) intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment.
Immunity. 2022 Feb 8;55(2):237-253.e8 Epub 2022 Jan 25; Authors: Lin X, Gaudino SJ, Jang KK, Bahadur T, Singh A, Banerjee A, Beaupre M, ... -
Playing dirty with virus transmission.
The Journal of experimental medicine. 2022 Feb 7;219(2) Epub 2021 Dec 28; Authors: Herrmann C, Cadwell K -
COVID-19 and the Forgotten Organ: Prolonged Changes to the Metabolic Output of the Gut Microbiome.
Gastroenterology. 2022 Feb;162(2):394-396 Epub 2021 Nov 17; Authors: Venzon M, Cadwell K -
Interactions of Autophagy and the Immune System in Health and Diseases.
Autophagy reports. 2022;1(1):438-515 Epub 2022 Oct 5; Authors: Pant A, Yao X, Lavedrine A, Viret C, Dockterman J, Chauhan S, Chong-Shan Shi, ... -
ACE2-containing defensosomes serve as decoys to inhibit SARS-CoV-2 infection.
bioRxiv : the preprint server for biology. 2021 Dec 23; Authors: Ching KL, de Vries M, Gago J, Dancel-Manning K, Sall J, Rice WJ, Barnett C, ... -
Atovaquone and Berberine Chloride Reduce SARS-CoV-2 Replication In Vitro.
Viruses. 2021 Dec 4;13(12); Authors: Rodriguez-Rodriguez BA, Noval MG, Kaczmarek ME, Jang KK, Thannickal SA, Cifuentes Kottkamp A, Brown RS, ... -
Autophagy in major human diseases.
The EMBO journal. 2021 Oct 1;40(19):e108863 Epub 2021 Aug 30; Authors: Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, ... -
Serologic Response to Messenger RNA Coronavirus Disease 2019 Vaccines in Inflammatory Bowel Disease Patients Receiving Biologic Therapies.
Gastroenterology. 2021 Aug;161(2):715-718.e4 Epub 2021 Apr 20; Authors: Wong SY, Dixon R, Martinez Pazos V, Gnjatic S, Colombel JF, Cadwell K, ICARUS-IBD Working Group -
Editorial overview: The virome in health and disease.
Current opinion in virology. 2021 Aug;49:139-141 Epub 2021 Jun 12; Authors: Cadwell K, Wang D -
Gut microbiome dysbiosis during COVID-19 is associated with increased risk for bacteremia and microbial translocation.
Research square. 2021 Jul 27; Authors: Venzon M, Bernard-Raichon L, Klein J, Axelrad JE, Hussey GA, Sullivan AP, Casanovas-Massana A, ... -
Enteric viruses evoke broad host immune responses resembling those elicited by the bacterial microbiome.
Cell host & microbe. 2021 Jun 9;29(6):1014-1029.e8 Epub 2021 Apr 23; Authors: Dallari S, Heaney T, Rosas-Villegas A, Neil JA, Wong SY, Brown JJ, Urbanek K, ... -
Single-Cell Transcriptional Survey of Ileal-Anal Pouch Immune Cells From Ulcerative Colitis Patients.
Gastroenterology. 2021 Apr;160(5):1679-1693 Epub 2021 Feb 5; Authors: Devlin JC, Axelrad J, Hine AM, Chang S, Sarkar S, Lin JD, Ruggles KV, ... -
The role of gastrointestinal pathogens in inflammatory bowel disease: a systematic review.
Therapeutic advances in gastroenterology. 2021;14:17562848211004493 Epub 2021 Mar 31; Authors: Axelrad JE, Cadwell KH, Colombel JF, Shah SC -
Effects of Intestinal Fungi and Viruses on Immune Responses and Inflammatory Bowel Diseases.
Gastroenterology. 2021 Mar;160(4):1050-1066 Epub 2020 Dec 19; Authors: Iliev ID, Cadwell K -
Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells.
Cell reports. 2021 Jan 26;34(4):108677; Authors: Maisonneuve C, Tsang DKL, Foerster EG, Robert LM, Mukherjee T, Prescott D, Tattoli I, ... -
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1).
Autophagy. 2021 Jan;17(1):1-382 Epub 2021 Feb 8; Authors: Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, ... -
Mapping the evolutionary landscape of Zika virus infection in immunocompromised mice.
Virus evolution. 2020 Jul;6(2):veaa092 Epub 2020 Dec 11; Authors: Johnson KEE, Noval MG, Rangel MV, De Jesus E, Geber A, Schuster S, Cadwell K, ... -
Paneth Cell-Derived Lysozyme Defines the Composition of Mucolytic Microbiota and the Inflammatory Tone of the Intestine.
Immunity. 2020 Aug 18;53(2):398-416.e8; Authors: Yu S, Balasubramanian I, Laubitz D, Tong K, Bandyopadhyay S, Lin X, Flores J, ... -
A single early-in-life antibiotic course increases susceptibility to DSS-induced colitis.
Genome medicine. 2020 Jul 25;12(1):65; Authors: Ozkul C, Ruiz VE, Battaglia T, Xu J, Roubaud-Baudron C, Cadwell K, Perez-Perez GI, ... -
An intestinal organoid-based platform that recreates susceptibility to T-cell-mediated tissue injury.
Blood. 2020 Jun 25;135(26):2388-2401; Authors: Matsuzawa-Ishimoto Y, Hine A, Shono Y, Rudensky E, Lazrak A, Yeung F, Neil JA, ... -
Systematic review: gastrointestinal infection and incident inflammatory bowel disease.
Alimentary pharmacology & therapeutics. 2020 Jun;51(12):1222-1232 Epub 2020 May 5; Authors: Axelrad JE, Cadwell KH, Colombel JF, Shah SC -
Rewilding Nod2 and Atg16l1 Mutant Mice Uncovers Genetic and Environmental Contributions to Microbial Responses and Immune Cell Composition.
Cell host & microbe. 2020 May 13;27(5):830-840.e4 Epub 2020 Mar 24; Authors: Lin JD, Devlin JC, Yeung F, McCauley C, Leung JM, Chen YH, Cronkite A, ... -
Altered Immunity of Laboratory Mice in the Natural Environment Is Associated with Fungal Colonization.
Cell host & microbe. 2020 May 13;27(5):809-822.e6 Epub 2020 Mar 24; Authors: Yeung F, Chen YH, Lin JD, Leung JM, McCauley C, Devlin JC, Hansen C, ... -
Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer.
The Journal of clinical investigation. 2020 Apr 1;130(4):2111-2128; Authors: Xie Y, Zhao Y, Shi L, Li W, Chen K, Li M, Chen X, ... -
Autophagy and microbial pathogenesis.
Cell death and differentiation. 2020 Mar;27(3):872-886 Epub 2020 Jan 2; Authors: Keller MD, Torres VJ, Cadwell K -
Decoy exosomes provide protection against bacterial toxins.
Nature. 2020 Mar;579(7798):260-264 Epub 2020 Mar 4; Authors: Keller MD, Ching KL, Liang FX, Dhabaria A, Tam K, Ueberheide BM, Unutmaz D, ... -
Reinvigorating NIH Grant Peer Review.
Immunity. 2020 Jan 14;52(1):1-3; Authors: Crotty S, Blish C, Cadwell K, Chi H, Goldrath A, Green D, Kaech SM, ... -
Regulation of interferon signaling in response to gut microbes by autophagy.
Gut microbes. 2020;11(1):126-134 Epub 2019 May 23; Authors: Martin PK, Cadwell K -
Tumor Necrosis Factor-α-Induced Apoptosis in the Intestinal Epithelium due to Chronic Nuclear Factor Kappa B Signaling Is Mediated by Receptor Interacting Serine/Threonine Kinase 1.
Cellular and molecular gastroenterology and hepatology. 2020;9(2):337-338 Epub 2019 Nov 16; Authors: Yao X, Cadwell K -
Universal Principled Review: A Community-Driven Method to Improve Peer Review.
Cell. 2019 Dec 12;179(7):1441-1445; Authors: Krummel M, Blish C, Kuhns M, Cadwell K, Oberst A, Goldrath A, Ansel KM, ... -
IFN-I and IL-22 mediate protective effects of intestinal viral infection.
Nature microbiology. 2019 Oct;4(10):1737-1749 Epub 2019 Jun 10; Authors: Neil JA, Matsuzawa-Ishimoto Y, Kernbauer-Hölzl E, Schuster SL, Sota S, Venzon M, Dallari S, ... -
Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges.
The Journal of experimental medicine. 2019 Apr 1;216(4):786-806 Epub 2019 Mar 12; Authors: Silva HM, Báfica A, Rodrigues-Luiz GF, Chi J, Santos PDA, Reis BS, Hoytema van Konijnenburg DP, ... -
Staphylococcus aureus Leukocidins Target Endothelial DARC to Cause Lethality in Mice.
Cell host & microbe. 2019 Mar 13;25(3):463-470.e9 Epub 2019 Feb 21; Authors: Lubkin A, Lee WL, Alonzo F 3rd, Wang C, Aligo J, Keller M, Girgis NM, ... -
Enteric Infections Are Common in Patients with Flares of Inflammatory Bowel Disease.
The American journal of gastroenterology. 2018 Oct;113(10):1530-1539 Epub 2018 Aug 3; Authors: Axelrad JE, Joelson A, Green PHR, Lawlor G, Lichtiger S, Cadwell K, Lebwohl B -
Autophagy proteins suppress protective type I interferon signalling in response to the murine gut microbiota.
Nature microbiology. 2018 Oct;3(10):1131-1141 Epub 2018 Sep 10; Authors: Martin PK, Marchiando A, Xu R, Rudensky E, Yeung F, Schuster SL, Kernbauer E, ... -
There was collusion: Microbes in inflammatory bowel disease.
PLoS pathogens. 2018 Sep;14(9):e1007215 Epub 2018 Sep 20; Authors: Wong SY, Cadwell K -
Sugar Turns Bacteria Sweet: A Peace Offering in the Gut.
Cell. 2018 Sep 20;175(1):36-37; Authors: Cadwell K -
The Intestinal Virome and Immunity.
Journal of immunology (Baltimore, Md. : 1950). 2018 Sep 15;201(6):1615-1624; Authors: Neil JA, Cadwell K -
B Cell Defects Observed in Nod2 Knockout Mice Are a Consequence of a Dock2 Mutation Frequently Found in Inbred Strains.
Journal of immunology (Baltimore, Md. : 1950). 2018 Sep 1;201(5):1442-1451 Epub 2018 Jul 16; Authors: Wong SY, Coffre M, Ramanan D, Hines MJ, Gomez LE, Peters LA, Schadt EE, ... -
Getting a Taste for Parasites in the Gut.
Immunity. 2018 Jul 17;49(1):16-18; Authors: Loke P, Cadwell K -
Gut colonization with vancomycin-resistant Enterococcus and risk for subsequent enteric infection.
Gut pathogens. 2018;10:28 Epub 2018 Jul 9; Authors: Axelrad JE, Lebwohl B, Cuaresma E, Cadwell K, Green PHR, Freedberg DE -
A20 and ABIN-1 team up against intestinal epithelial cell death.
The Journal of experimental medicine. 2018 Jul 2;215(7):1771-1773 Epub 2018 Jun 22; Authors: Cadwell K -
Autophagy and Inflammation.
Annual review of immunology. 2018 Apr 26;36:73-101 Epub 2017 Nov 16; Authors: Matsuzawa-Ishimoto Y, Hwang S, Cadwell K -
Tropism for tuft cells determines immune promotion of norovirus pathogenesis.
Science (New York, N.Y.). 2018 Apr 13;360(6385):204-208; Authors: Wilen CB, Lee S, Hsieh LL, Orchard RC, Desai C, Hykes BL Jr, McAllaster MR, ... -
Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins.
The Journal of cell biology. 2018 Mar 5;217(3):813-822 Epub 2017 Dec 13; Authors: Cadwell K, Debnath J -
Myeloid ATG16L1 does not affect adipose tissue inflammation or body mass in mice fed high fat diet.
Obesity research & clinical practice. 2018 Mar-Apr;12(2):174-186 Epub 2017 Nov 2; Authors: Litwinoff EMS, Gold MY, Singh K, Hu J, Li H, Cadwell K, Schmidt AM -
Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium.
The Journal of experimental medicine. 2017 Dec 4;214(12):3687-3705 Epub 2017 Oct 31; Authors: Matsuzawa-Ishimoto Y, Shono Y, Gomez LE, Hubbard-Lucey VM, Cammer M, Neil J, Dewan MZ, ... -
A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity.
Nature communications. 2017 Sep 11;8(1):518; Authors: Ruiz VE, Battaglia T, Kurtz ZD, Bijnens L, Ou A, Engstrand I, Zheng X, ... -
Tregs restrain dendritic cell autophagy to ameliorate autoimmunity.
The Journal of clinical investigation. 2017 Jun 30;127(7):2789-2804 Epub 2017 Jun 5; Authors: Alissafi T, Banos A, Boon L, Sparwasser T, Ghigo A, Wing K, Vassilopoulos D, ... -
Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis.
Nature reviews. Immunology. 2016 Nov;16(11):661-675 Epub 2016 Oct 3; Authors: Cadwell K -
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice.
Nature microbiology. 2016 Aug 22;1(11):16140; Authors: Livanos AE, Greiner TU, Vangay P, Pathmasiri W, Stewart D, McRitchie S, Li H, ... -
Helminth infection promotes colonization resistance via type 2 immunity.
Science (New York, N.Y.). 2016 Apr 29;352(6285):608-12 Epub 2016 Apr 14; Authors: Ramanan D, Bowcutt R, Lee SC, Tang MS, Kurtz ZD, Ding Y, Honda K, ... -
Intrinsic Defense Mechanisms of the Intestinal Epithelium.
Cell host & microbe. 2016 Apr 13;19(4):434-41 Epub 2016 Mar 31; Authors: Ramanan D, Cadwell K -
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy. 2016;12(1):1-222; Authors: Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, ... -
Ubiquilin 1 Promotes IFN-γ-Induced Xenophagy of Mycobacterium tuberculosis.
PLoS pathogens. 2015 Jul;11(7):e1005076 Epub 2015 Jul 30; Authors: Sakowski ET, Koster S, Portal Celhay C, Park HS, Shrestha E, Hetzenecker SE, Maurer K, ... -
The virome in host health and disease.
Immunity. 2015 May 19;42(5):805-13; Authors: Cadwell K -
Autophagy mediates tolerance to Staphylococcus aureus alpha-toxin.
Cell host & microbe. 2015 Apr 8;17(4):429-40 Epub 2015 Mar 26; Authors: Maurer K, Reyes-Robles T, Alonzo F 3rd, Durbin J, Torres VJ, Cadwell K -
Expanding the role of the virome: commensalism in the gut.
Journal of virology. 2015 Feb;89(4):1951-3 Epub 2014 Dec 10; Authors: Cadwell K -
Gastrointestinal dissemination and transmission of Staphylococcus aureus following bacteremia.
Infection and immunity. 2015 Jan;83(1):372-8 Epub 2014 Nov 10; Authors: Kernbauer E, Maurer K, Torres VJ, Shopsin B, Cadwell K -
Autophagy is a key tolerance mechanism during Staphylococcus aureus infection.
Autophagy. 2015;11(7):1184-6; Authors: Maurer K, Torres VJ, Cadwell K -
An enteric virus can replace the beneficial function of commensal bacteria.
Nature. 2014 Dec 4;516(7529):94-8 Epub 2014 Nov 19; Authors: Kernbauer E, Ding Y, Cadwell K -
Autophagy, viruses, and intestinal immunity.
Current opinion in gastroenterology. 2014 Nov;30(6):539-46; Authors: Kernbauer E, Cadwell K -
Autophagy gene Atg16L1 prevents lethal T cell alloreactivity mediated by dendritic cells.
Immunity. 2014 Oct 16;41(4):579-91 Epub 2014 Oct 9; Authors: Hubbard-Lucey VM, Shono Y, Maurer K, West ML, Singer NV, Ziegler CG, Lezcano C, ... -
Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus.
Immunity. 2014 Aug 21;41(2):311-24 Epub 2014 Jul 31; Authors: Ramanan D, Tang MS, Bowcutt R, Loke P, Cadwell K -
Autophagy facilitates Salmonella replication in HeLa cells.
mBio. 2014 Mar 11;5(2):e00865-14; Authors: Yu HB, Croxen MA, Marchiando AM, Ferreira RB, Cadwell K, Foster LJ, Finlay BB -
Autophagy proteins control goblet cell function by potentiating reactive oxygen species production.
The EMBO journal. 2013 Dec 11;32(24):3130-44 Epub 2013 Nov 1; Authors: Patel KK, Miyoshi H, Beatty WL, Head RD, Malvin NP, Cadwell K, Guan JL, ... -
Autophagy meets phagocytosis.
Immunity. 2013 Sep 19;39(3):425-7; Authors: Cadwell K, Philips JA -
A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection.
Cell host & microbe. 2013 Aug 14;14(2):216-24; Authors: Marchiando AM, Ramanan D, Ding Y, Gomez LE, Hubbard-Lucey VM, Maurer K, Wang C, ... -
Bacteria, it's what's for dinner.
Cell host & microbe. 2013 Jun 12;13(6):627-8; Authors: Cadwell K -
FIP200 regulates targeting of Atg16L1 to the isolation membrane.
EMBO reports. 2013 Mar 1;14(3):284-91 Epub 2013 Feb 8; Authors: Nishimura T, Kaizuka T, Cadwell K, Sahani MH, Saitoh T, Akira S, Virgin HW, ... -
Atg16L1 deficiency confers protection from uropathogenic Escherichia coli infection in vivo.
Proceedings of the National Academy of Sciences of the United States of America. 2012 Jul 3;109(27):11008-13 Epub 2012 Jun 19; Authors: Wang C, Mendonsa GR, Symington JW, Zhang Q, Cadwell K, Virgin HW, Mysorekar IU -
Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy. 2012 Apr;8(4):445-544; Authors: Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, ... -
Viruses, autophagy genes, and Crohn's disease.
Viruses. 2011 Jul;3(7):1281-311 Epub 2011 Jul 21; Authors: Hubbard VM, Cadwell K -
Crohn's disease susceptibility gene interactions, a NOD to the newcomer ATG16L1.
Gastroenterology. 2010 Nov;139(5):1448-50 Epub 2010 Sep 25; Authors: Cadwell K -
Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine.
Cell. 2010 Jun 25;141(7):1135-45; Authors: Cadwell K, Patel KK, Maloney NS, Liu TC, Ng AC, Storer CE, Head RD, ... -
Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes.
Autophagy. 2009 Jul;5(5):625-35 Epub 2009 Jul 10; Authors: Stephenson LM, Miller BC, Ng A, Eisenberg J, Zhao Z, Cadwell K, Graham DB, ... -
Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters.
Autophagy. 2009 May;5(4):511-9 Epub 2009 May 6; Authors: Ju JS, Miller SE, Jackson E, Cadwell K, Piwnica-Worms D, Weihl CC -
A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease.
Autophagy. 2009 Feb;5(2):250-2 Epub 2009 Feb 8; Authors: Cadwell K, Patel KK, Komatsu M, Virgin HW 4th, Stappenbeck TS -
Role of autophagy and autophagy genes in inflammatory bowel disease.
Current topics in microbiology and immunology. 2009;335:141-67; Authors: Cadwell K, Stappenbeck TS, Virgin HW -
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.
Nature. 2008 Nov 13;456(7219):259-63 Epub 2008 Oct 5; Authors: Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, ... -
Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens.
Cell host & microbe. 2008 Nov 13;4(5):458-69; Authors: Zhao Z, Fux B, Goodwin M, Dunay IR, Strong D, Miller BC, Cadwell K, ... -
The autophagy gene ATG5 plays an essential role in B lymphocyte development.
Autophagy. 2008 Apr;4(3):309-14 Epub 2007 Dec 24; Authors: Miller BC, Zhao Z, Stephenson LM, Cadwell K, Pua HH, Lee HK, Mizushima NN, ... -
The specificities of Kaposi's sarcoma-associated herpesvirus-encoded E3 ubiquitin ligases are determined by the positions of lysine or cysteine residues within the intracytoplasmic domains of their targets.
Journal of virology. 2008 Apr;82(8):4184-9 Epub 2008 Feb 13; Authors: Cadwell K, Coscoy L -
Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase.
Science (New York, N.Y.). 2005 Jul 1;309(5731):127-30; Authors: Cadwell K, Coscoy L