Publications | Capell Lab | Perelman School of Medicine at the University of Pennsylvania

KDM1A regulates nephron progenitor programs and is associated with human kidney disease risk.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2026 May 1;

Authors: Kolligundla LP, Mukhi D, Levinsohn J, Bergerson A, Hou Y, Liu H, Capell BC, Susztak K

Mechanism-tuned epigenetic precision in squamous cell carcinoma.

The Journal of investigative dermatology. 2026 Apr;146(4):881-884 Epub 2025 Dec 9;

Authors: Capell BC

Inhibiting LSD1 unlocks retinoid AP-1 programming to activate epithelial immunity and skin tumor suppression.

The Journal of clinical investigation. 2026 Apr 15;136(8) Epub 2026 Mar 12;

Authors: Kuprasertkul N, Moore AF, D'souza CA, Chini J, Ko EK, Huang S, Zhang S, Anderson AS, Egolf S, Pinheiro LV, Jaccard A, Magahis CT, Bao L, Aubert Y, Olingou C, Prouty SM, Brennan-Crispi D, Hill DA, Seykora JT, Wellen KE, Capell BC

Stress vesicles link epidermal mechanotransduction to stem cell differentiation.

Nature communications. 2026 Jan 23;17(1):1578;

Authors: Huang S, Kuri P, Zou J, Blanco A, Marshall M, Rice G, Prouty S, Dentchev T, Doepner M, Boerckel JD, Capell BC, Ridky TW, Rompolas P

UTX (KDM6A) promotes differentiation noncatalytically in somatic self-renewing epithelia.

Proceedings of the National Academy of Sciences of the United States of America. 2025 May 20;122(20):e2422971122 Epub 2025 May 15;

Authors: Pacella GN, Kuprasertkul N, Bao L, Huang S, D'souza C, Prouty SM, Anderson A, Maldonado López AM, Sinkfield M, Olingou C, Seykora JT, Capell BC

Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis.

Cell reports. 2025 Feb 25;44(2):115284 Epub 2025 Feb 10;

Authors: Nguyen PTT, Shiue M, Kuprasertkul N, Costa-Pinheiro P, Izzo LT, Pinheiro LV, Affronti HA, Gugiu G, Ghaisas S, Liu JY, Harris JC, Bradley CW, Seykora JT, Yang X, Kambayashi T, Mesaros C, Capell BC, Wellen KE

Disruption of H3K36 methylation provokes cellular plasticity to drive aberrant glandular formation and squamous carcinogenesis.

Developmental cell. 2024 Jan 22;59(2):187-198.e7 Epub 2024 Jan 9;

Authors: Ko EK, Anderson A, D'souza C, Zou J, Huang S, Cho S, Alawi F, Prouty S, Lee V, Yoon S, Krick K, Horiuchi Y, Ge K, Seykora JT, Capell BC

Targeting SERCA2 in organotypic epidermis reveals MEK inhibition as a therapeutic strategy for Darier disease.

JCI insight. 2023 Sep 22;8(18);

Authors: Zaver SA, Sarkar MK, Egolf S, Zou J, Tiwaa A, Capell BC, Gudjonsson JE, Simpson CL

Mettl3-catalyzed m(6)A regulates histone modifier and modification expression in self-renewing somatic tissue.

Science advances. 2023 Sep;9(35):eadg5234 Epub 2023 Sep 1;

Authors: Maldonado López AM, Ko EK, Huang S, Pacella G, Kuprasertkul N, D'souza CA, Reyes Hueros RA, Shen H, Stoute J, Elashal H, Sinkfield M, Anderson A, Prouty S, Li HB, Seykora JT, Liu KF, Capell BC

Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis.

Science advances. 2023 May 3;9(18):eadf0115;

Authors: Izzo LT, Trefely S, Demetriadou C, Drummond JM, Mizukami T, Kuprasertkul N, Farria AT, Nguyen PTT, Murali N, Reich L, Kantner DS, Shaffer J, Affronti H, Carrer A, Andrews A, Capell BC, Snyder NW, Wellen KE

Targeting SERCA2 in organotypic epidermis reveals MEK inhibition as a therapeutic strategy for Darier disease.

bioRxiv : the preprint server for biology. 2023 Mar 7;

Authors: Zaver SA, Sarkar MK, Egolf S, Zou J, Tiwaa A, Capell BC, Gudjonsson JE, Simpson CL

Endogenous DOPA inhibits melanoma through suppression of CHRM1 signaling.

Science advances. 2022 Sep 2;8(35):eabn4007;

Authors: Doepner M, Lee I, Natale CA, Brathwaite R, Venkat S, Kim SH, Wei Y, Vakoc CR, Capell BC, Katzenellenbogen JA, Katzenellenbogen BS, Feigin ME, Ridky TW

Loss of TET2 Tips the Scales Toward Tumorigenesis.

The Journal of investigative dermatology. 2022 May;142(5):1253-1255 Epub 2022 Jan 31;

Authors: Capell BC

Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma.

International journal of molecular sciences. 2022 Mar 23;23(7);

Authors: Hedberg ML, Berry CT, Moshiri AS, Xiang Y, Yeh CJ, Attilasoy C, Capell BC, Seykora JT

MLL4 mediates differentiation and tumor suppression through ferroptosis.

Science advances. 2021 Dec 10;7(50):eabj9141;

Authors: Egolf S, Zou J, Anderson A, Simpson CL, Aubert Y, Prouty S, Ge K, Seykora JT, Capell BC

Perforating and granulomatous exogenous ochronosis.

Journal of cutaneous pathology. 2021 Oct;48(10):1219-1222 Epub 2021 Jan 20;

Authors: Pei S, Fischer AS, Milbar H, Capell BC, Elenitsas R, Rubin AI

Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization.

Cell stem cell. 2021 Sep 2;28(9):1582-1596.e6 Epub 2021 Jun 7;

Authors: Huang S, Kuri P, Aubert Y, Brewster M, Li N, Farrelly O, Rice G, Bae H, Prouty S, Dentchev T, Luo W, Capell BC, Rompolas P

Epigenetic and metabolic interplay in cutaneous squamous cell carcinoma.

Experimental dermatology. 2021 Aug;30(8):1115-1125 Epub 2021 Apr 22;

Authors: Pacella G, Capell BC

Methyltransferases in the Pathogenesis of Keratinocyte Cancers.

Cancers. 2021 Jul 7;13(14);

Authors: Ko EK, Capell BC

The METTL3-m(6)A Epitranscriptome: Dynamic Regulator of Epithelial Development, Differentiation, and Cancer.

Genes. 2021 Jun 30;12(7);

Authors: Maldonado López A, Capell BC

From Enhancers to Keratinocyte Cancers.

The Journal of investigative dermatology. 2021 May;141(5):1134-1136;

Authors: Capell BC

The endangered physician-scientist and COVID-19.

Cell reports. Medicine. 2021 Feb 16;2(2):100190 Epub 2021 Jan 14;

Authors: Rao RC, Dlouhy BJ, Capell BC, Akeju O

Whole-Exome and Transcriptome Analysis of UV-Exposed Epidermis and Carcinoma In Situ Reveals Early Drivers of Carcinogenesis.

The Journal of investigative dermatology. 2021 Feb;141(2):295-307.e13 Epub 2020 Jul 8;

Authors: Zheng Q, Capell BC, Parekh V, O'Day C, Atillasoy C, Bashir HM, Yeh C, Shim EH, Prouty SM, Dentchev T, Lee V, Wushanley L, Kweon Y, Suzuki-Horiuchi Y, Pear W, Grice EA, Seykora JT

LSD1: a viable therapeutic target in cutaneous squamous cell carcinoma?

Expert opinion on therapeutic targets. 2020 Jul;24(7):671-678 Epub 2020 May 7;

Authors: Egolf S, Capell BC

FBXW7 Triggers Degradation of KMT2D to Favor Growth of Diffuse Large B-cell Lymphoma Cells.

Cancer research. 2020 Jun 15;80(12):2498-2511 Epub 2020 Apr 29;

Authors: Saffie R, Zhou N, Rolland D, Önder Ö, Basrur V, Campbell S, Wellen KE, Elenitoba-Johnson KSJ, Capell BC, Busino L

Loss of Methylation Modification Marks the Presence of Psoriasis.

The Journal of investigative dermatology. 2020 Jun;140(6):1127-1128;

Authors: Capell BC, Seykora JT

Pharmacologic Activation of the G Protein-Coupled Estrogen Receptor Inhibits Pancreatic Ductal Adenocarcinoma.

Cellular and molecular gastroenterology and hepatology. 2020;10(4):868-880.e1 Epub 2020 May 4;

Authors: Natale CA, Li J, Pitarresi JR, Norgard RJ, Dentchev T, Capell BC, Seykora JT, Stanger BZ, Ridky TW

The Unexpected Noncatalytic Roles of Histone Modifiers in Development and Disease.

Trends in genetics : TIG. 2019 Sep;35(9):645-657 Epub 2019 Jul 10;

Authors: Aubert Y, Egolf S, Capell BC

LSD1 Inhibition Promotes Epithelial Differentiation through Derepression of Fate-Determining Transcription Factors.

Cell reports. 2019 Aug 20;28(8):1981-1992.e7;

Authors: Egolf S, Aubert Y, Doepner M, Anderson A, Maldonado-Lopez A, Pacella G, Lee J, Ko EK, Zou J, Lan Y, Simpson CL, Ridky T, Capell BC

Paget's Diseases: United by Epidermis and Epigenetics.

The Journal of investigative dermatology. 2019 Apr;139(4):753-754;

Authors: Capell BC

Histone modifiers: Dynamic regulators of the cutaneous transcriptome.

Journal of dermatological science. 2018 Mar;89(3):226-232 Epub 2017 Dec 18;

Authors: Ghosh K, O'Neil K, Capell BC

KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis.

Genes & development. 2018 Jan 15;32(2):181-193 Epub 2018 Feb 12;

Authors: Lin-Shiao E, Lan Y, Coradin M, Anderson A, Donahue G, Simpson CL, Sen P, Saffie R, Busino L, Garcia BA, Berger SL, Capell BC

BAP1: case report and insight into a novel tumor suppressor.

BMC dermatology. 2017 Nov 22;17(1):13;

Authors: Ghosh K, Modi B, James WD, Capell BC

Cytoplasmic chromatin triggers inflammation in senescence and cancer.

Nature. 2017 Oct 19;550(7676):402-406 Epub 2017 Oct 4;

Authors: Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M, Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL

Presumed serum sickness following thymoglobulin treatment of acute cellular rejection of a cardiac allograft.

Cutis. 2017 Sep;100(3):186-188;

Authors: Ratushny V, Capell BC, Rosenbach M

Risk factors for positive or equivocal margins after wide local excision of 1345 cutaneous melanomas.

Journal of the American Academy of Dermatology. 2017 Aug;77(2):333-340.e1;

Authors: Miller CJ, Shin TM, Sobanko JF, Sharkey JM, Grunyk JW, Elenitsas R, Chu EY, Capell BC, Ming ME, Etzkorn JR

The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging.

The Journal of investigative dermatology. 2016 Nov;136(11):2133-2139 Epub 2016 Aug 17;

Authors: Ghosh K, Capell BC

MLL1 is essential for the senescence-associated secretory phenotype.

Genes & development. 2016 Feb 1;30(3):321-36;

Authors: Capell BC, Drake AM, Zhu J, Shah PP, Dou Z, Dorsey J, Simola DF, Donahue G, Sammons M, Rai TS, Natale C, Ridky TW, Adams PD, Berger SL

Autophagy mediates degradation of nuclear lamina.

Nature. 2015 Nov 5;527(7576):105-9 Epub 2015 Oct 28;

Authors: Dou Z, Xu C, Donahue G, Shimi T, Pan JA, Zhu J, Ivanov A, Capell BC, Drake AM, Shah PP, Catanzaro JM, Ricketts MD, Lamark T, Adam SA, Marmorstein R, Zong WX, Johansen T, Goldman RD, Adams PD, Berger SL

CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma.

Cancer discovery. 2015 Oct;5(10):1072-85 Epub 2015 Jul 16;

Authors: McNeal AS, Liu K, Nakhate V, Natale CA, Duperret EK, Capell BC, Dentchev T, Berger SL, Herlyn M, Seykora JT, Ridky TW

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape.

Genes & development. 2013 Aug 15;27(16):1787-99 Epub 2013 Aug 9;

Authors: Shah PP, Donahue G, Otte GL, Capell BC, Nelson DM, Cao K, Aggarwala V, Cruickshanks HA, Rai TS, McBryan T, Gregory BD, Adams PD, Berger SL

Genome-wide epigenetics.

The Journal of investigative dermatology. 2013 Jun;133(6):e9;

Authors: Capell BC, Berger SL

Human longevity and common variations in the LMNA gene: a meta-analysis.

Aging cell. 2012 Jun;11(3):475-81 Epub 2012 Mar 27;

Authors: Conneely KN, Capell BC, Erdos MR, Sebastiani P, Solovieff N, Swift AJ, Baldwin CT, Budagov T, Barzilai N, Atzmon G, Puca AA, Perls TT, Geesaman BJ, Boehnke M, Collins FS

Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect.

Proceedings of the National Academy of Sciences of the United States of America. 2011 Mar 22;108(12):4997-5002 Epub 2011 Mar 7;

Authors: Verstraeten VL, Peckham LA, Olive M, Capell BC, Collins FS, Nabel EG, Young SG, Fong LG, Lammerding J

Rapidly fatal pulmonary fibrosis in a patient with psoriatic arthritis treated with adalimumab.

The Journal of rheumatology. 2011 Feb;38(2):398-9;

Authors: Cohen JV, Capell BC, Kinniry PA, Epstein AL

From the rarest to the most common: insights from progeroid syndromes into skin cancer and aging.

The Journal of investigative dermatology. 2009 Oct;129(10):2340-50 Epub 2009 Apr 23;

Authors: Capell BC, Tlougan BE, Orlow SJ

A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model.

Proceedings of the National Academy of Sciences of the United States of America. 2008 Oct 14;105(41):15902-7 Epub 2008 Oct 6;

Authors: Capell BC, Olive M, Erdos MR, Cao K, Faddah DA, Tavarez UL, Conneely KN, Qu X, San H, Ganesh SK, Chen X, Avallone H, Kolodgie FD, Virmani R, Nabel EG, Collins FS

Diabetes increases p53-mediated apoptosis following ischemia.

Plastic and reconstructive surgery. 2008 Apr;121(4):1135-1143;

Authors: Jazayeri L, Callaghan MJ, Grogan RH, Hamou CD, Thanik V, Ingraham CR, Capell BC, Pelo CR, Gurtner GC

Mechanisms of cardiovascular disease in accelerated aging syndromes.

Circulation research. 2007 Jul 6;101(1):13-26;

Authors: Capell BC, Collins FS, Nabel EG

A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells.

Proceedings of the National Academy of Sciences of the United States of America. 2007 Mar 20;104(12):4949-54 Epub 2007 Mar 14;

Authors: Cao K, Capell BC, Erdos MR, Djabali K, Collins FS

Human laminopathies: nuclei gone genetically awry.

Nature reviews. Genetics. 2006 Dec;7(12):940-52;

Authors: Capell BC, Collins FS

Successful management of orbital cellulitis and temporary visual loss after blepharoplasty.

Plastic and reconstructive surgery. 2006 Sep;118(3):67e-72e;

Authors: Chiu ES, Capell BC, Press R, Aston SJ, Jelks EB, Jelks GW

Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome.

Proceedings of the National Academy of Sciences of the United States of America. 2006 Feb 28;103(9):3250-5 Epub 2006 Feb 21;

Authors: Varga R, Eriksson M, Erdos MR, Olive M, Harten I, Kolodgie F, Capell BC, Cheng J, Faddah D, Perkins S, Avallone H, San H, Qu X, Ganesh S, Gordon LB, Virmani R, Wight TN, Nabel EG, Collins FS

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome.

Proceedings of the National Academy of Sciences of the United States of America. 2005 Sep 6;102(36):12879-84 Epub 2005 Aug 29;

Authors: Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN, Gordon LB, Der CJ, Cox AD, Collins FS