Publications

1. Shujing Liu, Alain H Rook, Alexander C Huang, Amit Maity, Zhiyuan Qin, Yeqing Chen, Delu Song, Yanxiang Deng, Zhi Huang, Giorgos C. Karakousis, Tara C. Mitchell, Ravi K. Amaravadi, Lynn M. Schuchter, Zev A. Binder, Donald M. O'Rourke, Meenhard Herlyn, Wei Guo, Xiaowei Xu: Topical resiquimod elicits systemic protection and improves anti-PD1 therapy in melanoma via priming of CD8+ T cells. Cancer Immunology Research June 2026.
2. Nelson F. Freeburg, Daniel Chafamo1, Gayathri Konanur Gopikrishna, Regan M. Murphy, Jacqueline J. Peng, Shridhar Parthasarathy, Sydney Dumont, Edward G. Estrada, Meghan T. Logun, Yusha Sun, Xin Wang, Payal Grover, Jesse L. Rodriguez, Daniel L. Zhang, Kristen Park, Yao Fu, Nadine Ben Hamouda, Isaias Hernandez-Verdin, Lamia Lamrani, Kelly A. Hicks, Natalie A. Cooper, Christina Ekwegbara, Emma Grace Bawden, Joshua J. Waterfall, Jaime Fuentealba, Marion Alcantara, John T. Seykora, Stephen M. Prouty, David Barrett, Esha Banerjee, Arin Cox, Charles-Antoine Assenmacher, Camilla Macia, Melinda Yin, Erica L. Carpenter, Guo-li Ming, Catherine Sautès-Fridman, Wolf H. Fridman, Eric Tartour, E. John Wherry, Sebastian Amigorena, Joseph A. Fraietta, MacLean P. Nasrallah, Hongjun Song, Tyler E. Miller, Stephen J. Bagley, Donald M. O'Rourke, Zev A. Binder*, Cécile Alanio*, Dana Silverbush*: The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM. Cell June 2026.
3. Erica L Carpenter, Jacob E Till, Dominique Ballinger, Camilla Macia, Carlos Leche, Melinda Yin, Arati S Desai, Timothy Prior, Maikel Mansour, Emily McCoy, Thara Patel, Shivani Shah, H Isaac Chen, Eric Zager, Christina Jackson, Steven Brem, Zev A Binder, Donald M O'Rourke, Nduka Amankulor, Nike Beaubier, Stephen J Bagley: Next-Generation Sequencing of Intraoperatively Acquired Cerebrospinal Fluid and Matched Tumor Tissue in Patients Undergoing Surgical Resection for Glioblastoma. JCO Precision Oncology September 2025.
4. Stephen J. Bagley, Arati S. Desai, Joseph A. Fraietta, Dana Silverbush, Daniel Chafamo, Nelson F. Freeburg, Gayathri Konanur Gopikrishna, Andrew J. Rech, Ali Nabavizadeh, Linda J. Bagley, Jungmin Park, Danuta Jarocha, Rene Martins, Nicolas Sarmiento, Eileen Maloney, Lester Lledo, Carly Stein, Amy Marshall, Rachel M. Leskowitz, Julie K. Jadlowsky, Shane Mackey, Shannon Christensen, Bike Su Oner, Gabriela Plesa, Andrea Brennan, Vanessa Gonzalez, Fang Chen, David Barrett, Robert Colbourn, MacLean P. Nasrallah, Zissimos Mourelatos, Wei-Ting Hwang, Cecile Alanio, Donald L. Siegel, Carl H. June, Elizabeth O. Hexner, Zev A. Binder & Donald M. O'Rourke: Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a phase 1 trial. Nature Medicine June 2025.
5. Benjamin Lin, Abigail K. Shelton, Erin Smithberger, Julia Ziebro, Kasey R. Skinner, Ryan E. Bash, Richard Kirkman, Allie Stamper, Madison Butler, Alex Flores, Steven P. Angus, Michael P. East, Timothy F. Cloughesy, David A. Nathanson, Michael E. Berens, Jann N. Sarkaria, Zev A. Binder, Donald M. O'Rourke, Timothy C. Howton, Brittany N. Lasseigne, Christopher D. Willey, Gary L. Johnson, Anita B. Hjelmeland, Frank B. Furnari & C. Ryan Miller: Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma. Acta Neuropathologica Communications June 2025 Notes: DOI https://doi.org/10.1186/s40478-025-02068-y.
6. Sun Y, Wang X, Zhang DY, Zhang Z, Bhattarai JP, Wang Y, Park KH, Dong W, Hung YF, Yang Q, Zhang F, Rajamani K, Mu S, Kennedy BC, Hong Y, Galanaugh J, Sambangi A, Kim SH, Wheeler G, Gonçalves T, Wang Q, Geschwind DH, Kawaguchi R, Viaene AN, Helbig I, Kessler SK, Hoke A, Wang H, Xu F, Binder ZA, Isaac Chen H, Pai EL, Stone S, Nasrallah MP, Christian KM, Fuccillo M, Toni N, Wu Z, Cheng HJ, O'Rourke DM, Ma M, Ming GL, Song H. : Brain-wide neuronal circuit connectome of human glioblastoma. Nature Jan 2025.
7. Meghan Logun, Xin Wang, Yusha Sun, Stephen J Bagley, Nannan Li, Arati Desai, Daniel Y Zhang, MacLean P Nasrallah, Emily Ling-Lin Pai, Bike Su Oner, Gabriela Plesa, Donald Siegel, Zev A Binder*, Guo-Li Ming*, Hongjun Song*, Donald M O'Rourke*: Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy. Cell Stem Cell S1934-5909(24): 00409-0, Dec 2024.
8. Nannan Li, Jesse L. Rodriguez, Yibo Yin, Meghan T Logun, Logan Zhang, Shengkun Yu, Kelly A. Hicks, Vicky Zhang, Laura Zhang, Chuncheng Xie, Jiabin Wang, Joseph A Fraietta, Zev A. Binder*, Zhiguo Lin*, and Donald M. O'Rourke*: Armored Bicistronic CAR T Cells with Dominant-negative TGF-β Receptor II to Overcome Resistance in Glioblastoma. Mol Ther 32(10): 3522-3538, Oct 2024.
9. Jingxian Liu, Song Cao, Kathleen J. Imbach, Marina A. Gritsenko, Tung-Shing M. Lih, Jennifer E. Kyle*, Tomer M. Yaron*, Zev A. Binder*, Yize Li*, Ilya Strunilin*, Yi-Ting Wang*, Chia-Feng Tsai*, Weiping Ma*, Lijun Chen*, Natalie M. Clark, Andrew Shinkle, Nataly Naser Al Deen, Wagma Caravan, Andrew Houston, Faria A. Simin, Matthew A. Wyczalkowski, Liang-Bo Wang, ErikStorrs, Siqi Chen, Ritvik Illindala, Yuping D. Li, Reyka G. Jayasinghe, Dmitry Rykunov, Sandra L. Cottingham, Rosalie K. Chu, Karl K. Weitz, Ronald J. Moore, Tyler Sagendorf, Vladislav A. Petyuk, Michael Nestor, Lisa M. Bramer, Kelly G. Stratton, Athena A. Schepmoes, Sneha P. Couvillion, Josie Eder, Young-Mo Kim, Yuqian Gao, Thomas L. Fillmore, Rui Zhao, Matthew E. Monroe, Austin N. Southard-Smith, Yang E. Li, Rita Jui-Hsien Lu, Jared L. Johnson, Maciej Wiznerowicz, Galen Hostetter, Chelsea J. Newton, Karen A. Ketchum, Ratna R. Thangudu, Jill S. Barnholtz-Sloan, Pei Wang, David Fenyö, Eunkyung An, Mathangi Thiagarajan, Ana I. Robles, D. R. Mani, Richard D. Smith, Eduard Porta-Pardo, Lewis C. Cantley, Antonio Iavarone, Feng Chen, Mehdi Mesri, MacLean P. Nasrallah, Hui Zhang, Adam C. Resnick, Milan G. Chheda, Karin D. Rodland, Tao Liu, Li Ding, Philadelphia Coalition for a Cure, Clinical Proteomic Tumor Analysis Consortium: Multi-scale signaling and tumor evolution in high-grade gliomas. Cancer Cell 42(7): 1217-1238.e19, Jul 2024.
10. Elinor Willis, Jillian Verrelle, Esha Banerjee, Charles-Antoine Assenmacher, James C. Tarrant, Nicholas Skuli, Moriah L. Jacobson, Donald M. O'Rouke,Zev A. Binder*, and Enrico Radaelli1*: Humanization with CD34-positive hematopoietic stem cells in NOG-EXL mice results in improved long-term survival and less severe myeloid cell hyperactivation phenotype relative to NSG-SGM3 mice. Veterinary Pathology 61(4): 664-674, Jul 2024.
11. Stephen J. Bagley, Meghan Logun, Joseph A. Fraietta, Xin Wang, Arati S. Desai, Linda J. Bagley, Danuta Jarocha, Rene Martins, Eileen Maloney, Lester Lledo, Carly Stein, Amy Marshall, Rachel Leskowitz, Julie K. Jadlowsky, Shannon Christensen, Bike Su Oner, Gabriela Plesa, Andrea Brennan, Vanessa Gonzalez, Fang Chen, Yusha Sun, Whitney Gladney, David Barrett, Ali Nabavizadeh, MacLean P. Nasrallah, Wei-Ting Hwang, Guo-Li Ming, Hongjun Song, Donald L. Siegel, Carl H. June, Elizabeth O. Hexner,Zev A. Binder*, Donald M. O'Rourke*: Intrathecal Bivalent CAR T Cells Targeting EGFR and IL13Rα2 in Recurrent Glioblastoma: Phase 1 Trial Interim Results. Nat Med 30(5): 1320-1329, May 2024.