Perelman School of Medicine at the University of Pennsylvania

Dani Lab

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Recent Publications


Ethanol produces multiple electrophysiological effects on ventral tegmental area neurons in freely moving rats.

Doyon WM, Ostroumov A, Ontiveros T, Gonzales RA, Dani JA. Addict Biol. 2020 Apr 7:e12899. doi: 10.1111/adb.12899

Acute Nicotine Exposure Alters Ventral Tegmental Area Inhibitory Transmission and Promotes Diazepam Consumption.

Ostroumov A, Wittenberg RE, Kimmey BA, Taormina MB, Holden WM, McHugh AT, Dani JA. eNeuro. 2020 Feb 24. pii: ENEURO.0348-19.2020. doi: 10.1523/ENEURO.0348-19.2020.


5-HT2A receptor activation normalizes stress-induced dysregulation of GABAergic signaling in the ventral tegmental area.

Kimmey BA, Ostroumov, Dani JA. PNAS. 2019 Dec 5.


Adolescent Nicotine Exposure Alters GABAA Receptor Signaling in the Ventral Tegmental Area and Increases Adult Ethanol Self-Administration.

Thomas AM, Ostroumov A, Kimmey BA, Taormina MB, Holden WM, Kim K, Brown-Mangum T, Dani JA.
Cell Rep. 2018 Apr 3;23(1):68-77. doi: 10.1016/j.celrep.2018.03.030.

Convergent Neuronal Plasticity and Metaplasticity Mechanisms of Stress, Nicotine, and Alcohol.

Ostroumov A, Dani JA.
Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:547-566. doi: 10.1146/annurev-pharmtox-010617-052735. Review.


The medial habenula and interpeduncular nucleus circuitry is critical in addiction, anxiety, and mood regulation.

McLaughlin I, Dani JA, De Biasi M.
J Neurochem. 2017 Aug;142 Suppl 2:130-143. doi: 10.1111/jnc.14008. Review.

Dopamine receptor activity participates in hippocampal synaptic plasticity associated with novel object recognition.

Yang K, Broussard JI, Levine AT, Jenson D, Arenkiel BR, Dani JA.
Eur J Neurosci. 2017 Jan;45(1):138-146. doi: 10.1111/ejn.13406. 


eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons.

Placzek AN, Prisco GV, Khatiwada S, Sgritta M, Huang W, Krnjević K, Kaufman RJ, Dani JA, Walter P, Costa-Mattioli M.
Elife. 2016 Dec 13;5. pii: e17517. doi: 10.7554/eLife.17517.

Stress Increases Ethanol Self-Administration via a Shift toward Excitatory GABA Signaling in the Ventral Tegmental Area.

Ostroumov A, Thomas AM, Kimmey BA, Karsch JS, Doyon WM, Dani JA.
Neuron. 2016 Oct 19;92(2):493-504. doi: 10.1016/j.neuron.2016.09.029.

Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine.

Huang W, Placzek AN, Viana Di Prisco G, Khatiwada S, Sidrauski C, Krnjević K, Walter P, Dani JA, Costa-Mattioli M.
Elife. 2016 Mar 1;5. pii: e12052. doi: 10.7554/eLife.12052.

Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2α.

Placzek AN, Molfese DL, Khatiwada S, Viana Di Prisco G, Huang W, Sidrauski C, Krnjević K, Amos CL, Ray R, Dani JA, Walter P, Salas R, Costa-Mattioli M.
Elife. 2016 Mar 1;5. pii: e12056. doi: 10.7554/eLife.12056.

Dopamine Regulates Aversive Contextual Learning and Associated In Vivo Synaptic Plasticity in the Hippocampus.

Broussard JI, Yang K, Levine AT, Tsetsenis T, Jenson D, Cao F, Garcia I, Arenkiel BR, Zhou FM, De Biasi M, Dani JA.
Cell Rep. 2016 Mar 1;14(8):1930-9. doi: 10.1016/j.celrep.2016.01.070.

Other selected publications

Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine.

Dani JA.
Int Rev Neurobiol. 2015;124:3-19. doi: 10.1016/bs.irn.2015.07.001.

Cigarettes and alcohol: The influence of nicotine on operant alcohol self-administration and the mesolimbic dopamine system.

Ostroumov A, Thomas AM, Dani JA, Doyon WM.
Biochem Pharmacol. 2015 Oct 15;97(4):550-7. doi: 10.1016/j.bcp.2015.07.038. Review.

Dopaminergic and cholinergic learning mechanisms in nicotine addiction.
Subramaniyan M, Dani JA.

Ann N Y Acad Sci. 2015 Sep;1349:46-63. doi: 10.1111/nyas.12871. Review.

Dopamine and norepinephrine receptors participate in methylphenidate enhancement of in vivo hippocampal synaptic plasticity.

Jenson D, Yang K, Acevedo-Rodriguez A, Levine A, Broussard JI, Tang J, Dani JA.
Neuropharmacology. 2015 Mar;90:23-32. doi: 10.1016/j.neuropharm.2014.10.029.

Cocaine inhibition of nicotinic acetylcholine receptors influences dopamine release.

Acevedo-Rodriguez A, Zhang L, Zhou F, Gong S, Gu H, De Biasi M, Zhou FM, Dani JA.
Front Synaptic Neurosci. 2014 Sep 4;6:19. doi: 10.3389/fnsyn.2014.00019.

Nicotine decreases ethanol-induced dopamine signaling and increases self-administration via stress hormones.

Doyon WM, Dong Y, Ostroumov A, Thomas AM, Zhang TA, Dani JA.
Neuron. 2013 Aug 7;79(3):530-40. doi: 10.1016/j.neuron.2013.06.006.

Quantitative unit classification of ventral tegmental area neurons in vivo.

Li W, Doyon WM, Dani JA.
J Neurophysiol. 2012 May;107(10):2808-20. doi: 10.1152/jn.00575.2011.

Withdrawal from chronic nicotine exposure alters dopamine signaling dynamics in the nucleus accumbens.

Zhang L, Dong Y, Doyon WM, Dani JA.
Biol Psychiatry. 2012 Feb 1;71(3):184-91. doi: 10.1016/j.biopsych.2011.07.024.

Reward, addiction, withdrawal to nicotine.

De Biasi M, Dani JA.
Annu Rev Neurosci. 2011;34:105-30. doi: 10.1146/annurev-neuro-061010-113734. Review.

Dopamine enables in vivo synaptic plasticity associated with the addictive drug nicotine.

Tang J, Dani JA.
Neuron. 2009 Sep 10;63(5):673-82. doi: 10.1016/j.neuron.2009.07.025.

Full list here