Publications | FARWELL LAB | Perelman School of Medicine at the University of Pennsylvania

CD8 PET imaging with [89Zr]Zr-berdoxam-crefmirlimab in patients with solid tumors: the Phase II iCorrelate study.

J Immunother Cancer. 2026 Mar; 14(3):e012208 doi: 10.1136/jitc-2025-012208.

Authors: Postow MA, Zang PD, Pal SK, Mauguen A, Farwell M, Gordon M, Hays D, Wong JYC, Chen D, Ulaner GA, Esposito G, McConathy J, Graham MM, Shields AF, Van den Abbeele AD, Butler MO, Thomas JS, Twardowski P, Narang J, Singh AP, Dey A, Maresca KP, Keliher E, Liu F, Potdevin G, Schmidt G, Le W, Wilson I, Mascioni A, Jia F, Korn R, Ferris MR, Schmiedehausen K, Pandit-Taskar N, Margolin KA

Beyond Routine Surveillance Imaging for Melanoma: Emerging Technologies for Detecting Early Recurrence and Guiding Clinical Management.

Am Soc Clin Oncol Educ Book. 2026 Jun; 46(3):e520544 doi: 10.1200/EDBK-26-520544.

Authors: de Souza Carvalho G, Cunha de Sousa Martins CL, Wang K, Farwell MD, Salama AKS

[18F]Fluorthanatrace PET in Ovarian Cancer: Comparison with [18F]FDG PET, Lesion Location, Tumor Grade, and Breast Cancer Gene Mutation Status.

J Nucl Med. 2025 Jan; 66(1):34-39 doi: 10.2967/jnumed.124.267627.

Authors: Weeks JK, Pantel AR, Gitto SB, Liu F, Schubert EK, Pryma DA, Farwell MD, Mankoff DA, Mach RH, Simpkins F, Lin LL

MRS and Optical Imaging Studies of Therapeutic Response to Combination Therapy Targeting BRAF/MEK in Murine Melanomas.

Acad Radiol. 2025 Feb; S1076-6332(25)00090-X:Epub ahead of print doi: 10.1016/j.acra.2025.01.035..

Authors: Gupta PK, Li LZ, Singh DK, Nova S, Arias-Mendoza F, Orlovskiy S, Chawla S, Nelson DS, Farwell MD, Nath K

A biorthogonal chemistry approach for high-contrast antibody imaging of lymphoma at early time points.

EJNMMI Res. 2025 Mar; 15(1):26 doi: 10.1186/s13550-025-01213-x.

Authors: Sarkar S, Pham JM, Edwards KJ, Sharma N, Xu K, King AP, Del Castillo AF, Farwell MD, Pryma DA, Schuster SJ, Sellmyer MA

PARP1-targeted alpha therapy enhances target expression.

EJNMMI Res. 2025 Jun; 15(1):63 doi: 10.1186/s13550-025-01256-0.

Authors: Babazada H, Martorano P, Lee H, Geng S, Batra V, Maris JM, Pryma DA, Gitto SB, Farwell MD

FDG PET/CT Imaging 1 Week after a Single Dose of Pembrolizumab Predicts Treatment Response in Patients with Advanced Melanoma.

Clin Cancer Res. 2024 May; 30(9):1758-1767 doi: 10.1158/1078-0432.CCR-23-2390.

Authors: Anderson TM, Chang BH, Huang AC, Xu X, Yoon D, Shang CG, Mick R, Schubert E, McGettigan S, Kreider K, Xu W, Wherry EJ, Schuchter LM, Amaravadi RK, Mitchell TC, Farwell MD

Artificial intelligence in immunotherapy PET/SPECT imaging.

Eur Radiol. 2024 Sep; 34(9):5829-5841 doi: 10.1007/s00330-024-10637-3.

Authors: McGale JP, Chen DL, Trebeschi S, Farwell MD, Wu AM, Cutler CS, Schwartz LH, Dercle L

68Ga-DOTATATE PET to Characterize Lesions in the Neuroaxis.

Clin Nucl Med. 2024 Jan; 49(1):9-15 doi: 10.1097/RLU.0000000000004966.

Authors: Hartmann K, Gillman JA, Lazor JW, Ware JB, Weeks JK, Nasrallah IM, Farwell MD, Pantel AR

Relationship of Ketosis With Myocardial Glucose Uptake Among Patients Undergoing FDG PET/CT for Evaluation of Cardiac Sarcoidosis.

Circ Cardiovasc Imaging. 2024 Aug; 17(8):e016774 doi: 10.1161/CIRCIMAGING.124.016774.

Authors: Vidula MK, Selvaraj S, Rojulpote C, Bhattaru A, Kc W, Hansbury M, Schubert E, Clancy CB, Rossman M, Goldberg LR, Farwell M, Pryma D, Bravo PE

Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8+ T cells.

Cancer Cell. 2024 Sep; 42(9):1582-1597.e10 doi: 10.1016/j.ccell.2024.08.007.

Authors: Wang K, Coutifaris P, Brocks D, Wang G, Azar T, Solis S, Nandi A, Anderson S, Han N, Manne S, Kiner E, Sachar C, Lucas M, George S, Yan PK, Kier MW, Laughlin AI, Kothari S, Giles J, Mathew D, Ghinnagow R, Alanio C, Flowers A, Xu W, Tenney DJ, Xu X, Amaravadi RK, Karakousis GC, Schuchter LM, Buggert M, Oldridge D, Minn AJ, Blank C, Weber JS, Mitchell TC, Farwell MD, Herati RS, Huang AC

Kinetic Analysis and Metabolism of Poly(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted 18F-Fluorthanatrace PET in Breast Cancer.

J Nucl Med. 2024 Dec; 65(12):1862-1868 doi: 10.2967/jnumed.124.268254.

Authors: Young AJ, Pantel AR, Kiani M, Doot RK, Bagheri S, Pryma DA, Farwell MD, Li S, Lee H, Schubert EK, Secreto A, Zuckerman SP, Nayak A, Choi H, Carlin S, DeMichele A, Mankoff DA, Zhou R, Mach RH, McDonald ES

Harnessing imaging tools to guide immunotherapy trials: summary from the National Cancer Institute Cancer Imaging Steering Committee workshop.

Lancet Oncol. 2023 Mar; 24(3):e133-e143 doi: 10.1016/S1470-2045(22)00742-2.

Authors: Shankar LK, Schöder H, Sharon E, Wolchok J, Knopp MV, Wahl RL, Ellingson BM, Hall NC, Yaffe MJ, Towbin AJ, Farwell MD, Pryma D, Poussaint TY, Wright CL, Schwartz L, Harisinghani M, Mahmood U, Wu AM, Leung D, de Vries EGE, Tang Y, Beach G, Reeves SA

Imaging With PET/CT of Diffuse CD8 T-Cell Infiltration of Skeletal Muscle in Patients With Inclusion Body Myositis.

Neurology. 2023 Sep; 101(11):e1158-e1166 doi: 10.1212/WNL.0000000000207596.

Authors: Quinn C, Moulton K, Farwell M, Le W, Wilson I, Goel N, McConathy J, Greenberg SA

Kinetic and Static Analysis of Poly-(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted 18F-Fluorthanatrace PET Images of Ovarian Cancer.

J Nucl Med. 2022 Jan; 63(1):44-50 doi: 10.2967/jnumed.121.261894.

Authors: Young AJ, Pantel AR, Viswanath V, Dominguez TL, Makvandi M, Lee H, Li S, Schubert EK, Pryma DA, Farwell MD, Mach RH, Simpkins F, Lin LL, Mankoff DA, Doot RK

CD8-targeted PET Imaging of Tumor Infiltrating T cells in Patients with Cancer: A Phase I First-in-Human Study of 89Zr-Df-IAB22M2C, a Radiolabeled anti-CD8 Minibody.

J Nucl Med. 2022 May; 63(5):720-726 doi: 10.2967/jnumed.121.262485.

Authors: Farwell MD, Gamache RF, Babazada H, Hellmann MD, Harding JJ, Korn R, Mascioni A, Le W, Wilson I, Gordon MS, Wu AM, Ulaner GA, Wolchok JD, Postow MA, Pandit-Taskar N

Analysis of Routine Computed Tomographic Scans With Radiomics and Machine Learning: One Step Closer to Clinical Practice.

JAMA Oncol. 2022 Jan; 8(3):393–394 doi:10.1001/jamaoncol.2021.6768.

Authors: Farwell MD, Mankoff DA

PSMA-targeting TGFβ-insensitive Armored CAR T-cells in Metastatic Castration Resistant Prostate Cancer: a Phase 1 Trial.

Nat Med. 2022 Apr; 28(4):724-734 doi: 10.1038/s41591-022-01726-1.

Authors: Narayan V, Barber-Rotenberg JS, Jung IY, Lacey SF, Rech AJ, Davis MM, Hwang WT, Lal P, Carpenter EL, Maude SL, Plesa G, Vapiwala N, Chew A, Moniak M, Sebro RA, Farwell MD, Marshall A, Gilmore J, Lledo L, Dengel K, Church SE, Hether TD, Xu J, Gohil M, Buckingham TH, Yee SS, Gonzalez VE, Kulikovskaya I, Chen F, Tian L, Tien K, Gladney W, Nobles CL, Raymond HE; Prostate Cancer Cellular Therapy Program Investigators, Hexner EO, Siegel DL, Bushman FD, June CH, Fraietta JA, Haas NB

Monitoring Therapeutic Response to Anti-FAP CAR T Cells Using [18F]AlF-FAPI-74.

Clin Cancer Res. 2022 Dec; 28(24):5330-5342 doi: 10.1158/1078-0432.CCR-22-1379..

Authors: Lee IK, Noguera-Ortega E, Xiao Z, Todd L, Scholler J, Song D, Liousia M, Lohith K, Xu K, Edwards KJ, Farwell MD, June CH, Albelda SM, Puré E, Sellmyer MA

Using CD69 PET Imaging to Monitor Immunotherapy-Induced Immune Activation.

Cancer Immunol Res. 2022 Sep; 10(9):1084-1094 doi: 10.1158/2326-6066.CIR-21-0874.

Authors: Edwards KJ, Chang B, Babazada H, Lohith K, Park DH, Farwell MD, Sellmyer MA

In vivo visualization of PARP inhibitor pharmacodynamics.

JCI Insight. 2021 Apr; 6(866):e146592 doi: 10.1172/jci.insight.146592.

Authors: McDonald ES, Pantel AR, Shah PD, Farwell MD, Clark AS, Doot RK, Pryma DA, Carlin SD

18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Following Chimeric Antigen Receptor T-cell Therapy in Large B-cell Lymphoma.

Mol Imaging Biol. 2021 Dec; 23(6):818-826 doi: 10.1007/s11307-021-01627-8.

Authors: Ruff A, Ballard HJ, Pantel AR, Namoglu EC, Hughes ME, Nasta SD, Chong EA, Bagg A, Ruella M, Farwell MD, Svoboda J, Sellmyer MA

Immune PET Imaging

Radiol Clin North Am. 2021 Sep; 59(5):875-886 doi: 10.1016/j.rcl.2021.05.010.

Authors: Iyalomhe O, Farwell MD

A Single Dose of Neoadjuvant PD-1 Blockade Predicts Clinical Outcomes in Resectable Melanoma.

Nat Med. 2019 Feb; 25(3):454-461

Authors: Huang AC, Orlowski RJ, Xu X, Mick R, George SM, Yan PK, Manne S, Kraya A, Wubbenhorst B, Dorfman L, D’Andrea K, Liu S, Chilukuri L, Kozlov A, Carberry M, Giles L, Kier M, Quagliarello F, McGettigan S, Kreider K, Annamalai L, Zhao A, Mogg R, Xu W, Blumenschein W, Yearley JH, Linette G, Amaravadi RK, Schuchter LM, Nathanson KL, Farwell MD, Karakousis GC, Wherry EJ, Mitchell TC

Prevalence and quantitative analysis of indium-111 pentetreotide (Octreoscan) uptake in the pancreatic head on SPECT/CT imaging: establishing a region of interest-based pathological uptake threshold.

Nucl Med Commun. 2019 Jul; 40(7):727-733 doi: 10.1097/MNM.0000000000001022. .

Authors: Derakhshan JJ, Farwell MD

Imaging CAR T Cell Trafficking with eDFHR as a PET Reporter Gene.

Mol Ther. 2020 Jan; 28(1):42-51 doi: 10.1016/j.ymthe.2019.10.007 .

Authors: Sellmyer MA, Richman SA, Lohith K, Hou C, Weng CC, Mach RH, O’Connor RS, Milone MC, Farwell MD

First-in-Humans Imaging with 89Zr-Df-IAB22M2C Anti-CD8 Minibody in Patients with Solid Malignancies: Preliminary Pharmacokinetics, Biodistribution, and Lesion Targeting.

J Nucl Med. 2020 Apr; 61(4):512-519 doi: 10.2967/jnumed.119.229781 .

Authors: Pandit-Taskar N, Postow MA, Hellmann MD, Harding JJ, Barker CA, O'Donoghue JA, Ziolkowska M, Ruan S, Lyashchenko SK, Tsai F, Farwell M, Mitchell TC, Korn R, Le W, Lewis JS, Weber WA, Behera D, Wilson I, Gordon M, Wu AM, Wolchok JD

Breast Cancer 18F-ISO-1 Uptake as a Marker of Proliferation Status.

J Nucl Med. 2020 May; 61(5):665-670 doi: 10.2967/jnumed.119.232363..

Authors: McDonald ES, Doot RK, Young AJ, Schubert EK, Tchou J, Pryma DA, Farwell MD, Nayak A, Ziober A, Feldman MD, DeMichele A, Clark AS, Shah PD, Lee H, Carlin SD, Mach RH, Mankoff DA

Positron Emission Tomography Imaging of Poly-(Adenosine Diphosphate-Ribose) Polymerase 1 Expression in Breast Cancer: A Nonrandomized Clinical Trial.

JAMA Oncol. 2020 Jun; 6(6):921-923 doi: 10.1001/jamaoncol.2020.0334..

Authors: McDonald ES, Doot RK, Pantel AR, Farwell MD, Mach RH, Maxwell KN, Mankoff DA

A PET imaging agent for evaluating PARP-1 expression in ovarian cancer.

J Clin Invest. 2018 May; 128(5):2116-2126 doi: 10.1172/JCI97992..

Authors: Makvandi M, Pantel A, Schwartz L, Schubert E, Xu K, Hsieh CJ, Hou C, Kim H, Weng CC, Winters H, Doot R, Farwell MD, Pryma DA, Greenberg RA, Mankoff DA, Simpkins F, Mach RH, Lin LL

FDG-Avid Focal Liver Reaction From Proton Therapy in a Patient With Primary Esophageal Adenocarcinoma.

Clin Nucl Med. 2018 May; 43(5):e139-e141 doi: 10.1097/RLU.0000000000002035.

Authors: Ahmed HS, Pantel AR, Metz JM, Plastaras JP, Farwell MD

Radiosynthesis and in vitro evaluation of [11C]Shield-1, a PET probe for imaging CAR T cells that express the iCasp9 suicide gene.

J Nucl Med. 2018 May; 59(Supplement 1):61 Oral Presentation.

Authors: Lohith K, Kwon S, Padakanti P, Thanna S, Hou C, Weng CC, Sellmyer M, Mach R, Farwell M

A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours.

Br J Cancer. 2018 Nov; 119(10):1200-1207

Authors: Maity A, Mick R, Huang AC, George SM, Farwell MD, Lukens JN, Berman AT, Mitchell TC, Bauml J, Schuchter LM, O'Hara M, Lin LL, Demichele A, Christodouleas JP, Haas NB, Patsch DM, Hahn SM, Minn AJ, Wherry EJ, Vonderheide RH

Early positron emission tomography/computed tomography as a predictor of response after CTL019 chimeric antigen receptor–T-cell therapy in B-cell non-Hodgkin lymphomas.

Cytotherapy. 2018 Dec; 20(12):1415-1418 doi: 10.1016/j.jcyt.2018.10.003.

Authors: Shah NN, Nagle SJ, Torigian DA, Farwell MD, Hwang WT, Frey N, Nasta SD, Landsburg D, Mato A, June CH, Schuster SJ, Porter DL, Svoboda J

Early detection of pemetrexed-induced inhibition of thymidylate synthase in non-small cell lung cancer with FLT-PET imaging.

Oncotarget. 2017 Apr; 8(15):24213-24223 doi: 10.18632/oncotarget.12085..

Authors: Chen X, Yang Y, Berger I, Khalid U, Patel A, Cai J, Farwell MD, Langer C, Aggarwal C, Albelda SM, Katz SI

Making Molecular Imaging a Clinical Tool for Precision Oncology: A Review.

JAMA Oncology. 2017 May; 3(5):695-701 doi: 10.1001/jamaoncol.2016.5084..

Authors: Mankoff DA, Farwell MD, Clark AS, Pryma DA

Synthesis and initial characterization of [125I]-5-iodotubercidin, a radioligand for imaging adenosine kinase.

J Nucl Med. 2017 May; 58(Supplement 1):866 Poster Presentation.

Authors: Lohith K, Kwon S, Padakanti P, Lieberman B, Sandau U, Boison D, Mach R, Farwell M