Publications

Prostanoids
  • Mazaleuskaya, L.L., Lawson, J.A., Li, X., Grant G., Ricciotti E. and FitzGerald G.A. A broad-spectrum lipidomics screen of anti-inflammatory drug combinations in human blood. JCI Insight 1(12): e87031, 2016.
  • Tang S.Y., Pawelzik S.-C., Chen, L., Lawson, J., and FitzGerald, G.A. Cardiovascular Consequences of Prostanoid I Receptor Deletion in Microsomal Prostaglandin E Synthase-1 -Deficient Hyperlipidemic Mice. Circulation 134(4):328-38, 2016.
  • Liang X., Bettinger K., Abernathy D., Bushman R., and FitzGerald G.A. Bidirectional interactions between indomethacin and the murine intestinal microbiota. Elife 2015; 10.7554/eLife.08973.
  • Hui Y, Ricciotti E, Crichton I, Yu Z, Wang D, Stubbe J, Wang M, Puré E, FitzGerald GA. (2010)
    Targeted deletions of cyclooxygenase-2 and atherogenesis in mice. Circulation 121(24): 2654-2660.
  • Wang D, Patel V, Gao E, Rong Z, Levin M, Yu Z, Ferrari V, Lu MM, Xu J, Zhang H, Hui Y, Lawson J,Yi Y, FitzGerald GA. (2009)
    Cardiomyocyte cyclooxygenase –2 influences cardiac rhythm and function. Proc Natl Acad Sci 106: 7548-7552.
  • Song, W., Paschos, G., Fries, S., Reilly, M., Rokach, J., Chang, C.-T., Patel, P.,Lawson, J. and FitzGerald, G.A. (2009).
    Novel EPA derived F3 isoprostanes as biomarkers of lipid peroxidation. J. Biol. Chem. 284: 23636-23643.
  • Yu Y, Lucitt M, Stubbe J, Cheng Y, Jensen BL, Hansen B, Smyth E, FitzGerald GA. (2009)
    Prostaglandin F²α elevates blood pressure and promotes atherogenesis. Proc Natl Acad Sci 106: 7985-7990.
  • Wang M, Zukas AM, Hui Y, Ricciotti E, Pure E, FitzGerald GA. (2006)
    Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis. Proc Natl Acad Sci 103: 14507-14512.
  • Cheng Y, Wang M, Yu Y, Lawson J, Funk C, FitzGerald GA. (2006)
    Cyclooxygenases, mPGES-1 and cardiovascular function. J Clin Invest 116: 1391-1399.
  • Egan K, Smyth E, Fries S, Rader D, FitzGerald GA. (2004)
    Prostacyclin confers atheroprotection on female mice. Science 306: 1954-1957.
  • Grosser T, Yusuff S, Cheskis E, Pack MA, FitzGerald GA. (2002)
    Developmental expression of functional cyclooxygenases in zebrafish. Proc Natl Acad Sci USA 99: 8418-8423.
  • Cheng Y, Austin SC, Rocca B, Koller BH, Coffman TM, Lawson JA, FitzGerald GA. (2002)
    Role of prostacyclin in the cardiovascular response to thromboxane A2. Science 296: 539-541.
  • Catella-Lawson F, Reilly MP, Kapoor SC, Cucchiara AJ, DeMarco S, Tournier B, Vyas SN, FitzGerald GA. (2001)
    Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med 345: 1809-1817.
Molecular Clocks
  • Kress GJ, Liao F, Dimitry J, Cedeno MR, FitzGerald GA, Holtzman DM, Musiek ES Regulation of amyloid-β dynamics and pathology by the circadian clock. J Exp Med. 2018 Jan 30. pii: jem.20172347.
  • Skarke C., Lahens N., Rhoades S., Bittinger K., Bailey A., Hoffmann C., Olson R.S., Chen L., Yang G., Price T., Moore J., Grant G.R., Bushman F.D., Weljie A.M., & FitzGerald G.A. Characterization of the Human Chronobiome. Nature Scientific Reports 7(1):17141, 2017.
  • Yang G., Chen L, Grant G.R.,Paschos G.,Musiek E.S.,Song W-L.,Lee V.,McLoughlin S.C., Grosser T., Cotsarelis G., and FitzGerald G.A. Timed expression of Bmal1 influences postnatal aging and survival. Sci. Trans. Med. 8(324):324ra16 2016.
  • Liang X., Bushman R and FitzGerald G.A. Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock. PNAS 112(33):10479-84, 2015.
  • Baggs JE, Price TS, DiTacchio L, Panda S, FitzGerald GA, Hogenesch JB (2009)
    Network features of the mammalian circadian clock. PLoS Biol 7(3): e52.
  • Curtis A, Cheng Y, Kapoor S, Reilly D, Price TS, FitzGerald GA. (2007)
    Circadian variation in blood pressure and the vascular response to asynchronous stress. Proc Natl Acad Sci 104: 3450-3455.
  • Rudic RD, McNamara P, Curtis AM, Boston RC, Panda S, Hogenesch JB, FitzGerald GA. (2004)
    BMAL1 and CLOCK, two essential components of the circadian clock are involved in glucose homeostasis. PLOS Biol 2: 1893-1899.
  • McNamara P, Seo S-B, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA. (2001)
    Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: A humoral mechanism to reset a peripheral clock. Cell 105: 877-889.
Review
  • FitzGerald G.A. ImPRECISION: Limitations to Interpretation of a Large Randomized Clinical Trial. Circulation.135 (2):113-115, 2017.
  • Grosser T, Ricciotti E, FitzGerald GA. The Cardiovascular Pharmacology of Nonsteroidal Anti-Inflammatory Drugs. Trends Pharmacol Sci. Jun 23. pii: S0165-6147(17)30116-5, 2017.
  • Paschos G.K. and FitzGerald G.A. Circadian clocks and Metabolism: implications for microbiome and aging. Trends in Genetics pii: S0168-9525(17)30127-0, 2017.
  • Cline AM and FitzGerald GA. (2012)
    What Great Creation. Sci Transl Med 4(154): 154cm10.
  • Paschos G. and FitzGerald G.A. (2010).
    Circadian clocks and vascular function. Circ. Res. 106(5):833-41.
  • Skarke C and FitzGerald GA. (2010)
    Training translators for smart drug discovery. Sci Transl Med 2(26): 26cm12.

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