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Thursday, October 18th, 2018
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7:00 – 8:00 am
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Continental Breakfast
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8:00 – 8:10 am
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Introductory Remarks
Rahim R. Rizi, Ph.D.
University of Pennsylvania
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8:10 – 8:15 am
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Welcome Remarks
Mitchell D. Schnall, M.D., Ph.D.
University of Pennsylvania
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Session I: Keynote Lectures
Moderator: Rahim R. Rizi, Ph.D.
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8:15 – 8:40 am
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Cancer Imaging and Metabolic Therapy
Chi Dang, M.D., Ph.D.
Ludwig Institute for Cancer Research
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8:40 – 9:05 am
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Metabolic Oncologic Imaging: Why It Matters
Peter Choyke, M.D.
National Institutes of Health
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9:05 – 9:25 am
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Probing Metabolic Networks in Human Subjects
Craig Malloy, M.D.
University of Texas, Southwestern
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9:25 – 9:45 am
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Development and Translation of Hyperpolarized Carbon-13 MRI for Human Cancer and Brain Research
Daniel Vigneron, Ph.D.
University of California, San Francisco
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9:45 – 10:00 am
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Discussion
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10:00 – 10:15 am
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Break
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Session II: Moving Hyperpolarized Carbon-13 into the Clinic – Opportunities & Challenges
Moderator: John Kurhanewicz, Ph.D.
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10:15 – 10:35 am
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What Hyperpolarized 13C MR Has to Achieve to be Used Routinely in Neurological and Psychiatric Research and Clinical Practice
Douglas Rothman, Ph.D.
Yale University
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10:35 – 10:55 am
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Phospholipid Metabolism in Mutant IDH1 Glioma – MRS Studies
Sabrina Ronen, Ph.D.
University of California, San Francisco
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10:55 – 11:15 am
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Feeding the Failing Heart
Daniel Kelly, M.D.
University of Pennsylvania
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11:15 – 11:35 am
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Toward Using In-cell HP MRS to Study Metabolism
Kayvan Keshari, Ph.D.
Memorial Sloan Kettering Cancer Center
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11:35 – 11:55 am
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Physiologic and Metabolic Imaging of Pancreatic Tumor Xenografts in Mice – Imaging Biomarkers to Guide Treatment
Murali K. Cherukuri, Ph.D.
National Institutes of Health
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11:55 am – 12:10 pm
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Discussion
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12:10 – 1:00 pm
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Lunch
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Session III: Graduate Student and Postdoctoral Presentations – Part I
Moderators: Jeremy Gordon, Ph.D.
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1:00 – 1:10 pm
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The Use of Hyperpolarized Imaging for Assessing Lung Transplantation Outcomes in Rats
Sarmad Siddiqui
University of Pennsylvania
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1:10 – 1:20 pm
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Hyperpolarized Micro-NMR for Sensitive and High-Throughput Analysis of Metabolic Flux in Rare Cells
Sangmoo Jeong, Ph.D.
Memorial Sloan Kettering Cancer Center
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1:20 – 1:30 pm
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Mitochondrial Uncoupling Alters Pancreatic Cancer Metabolism
Lotte B. Berterlsen, Ph.D.
Aarhus University, Denmark
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1:30 – 1:40 pm
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CRISPR-Cas9 Genome Editing to Guide Selection of DNP-13C-MRI Probes Sensitive to Metabolic Heterogeneities in Cancer
Nicholas R. Perkons
University of Pennsylvania
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1:40 – 1:50 pm
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Dynamic Metabolic Imaging of Co-Polarized [2-13C]Pyruvate and [1,4-13C2]Fumarate Using 3D-Spiral CSI with Alternate Spectral Band Excitation
Maninder Singh, Ph.D.
University of Maryland
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1:50 – 2:00 pm
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Hyperpolarized 129Xe Imaging in Lung Cancer
Luis A. Loza
University of Pennsylvania
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2:00 – 2:10 pm
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Break
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Session IV: IND and Regulatory Guidelines
Moderators: Jan Henrik Ardenkjaer-Larsen, Ph.D.
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2:10 – 2:30 pm
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The NCI IND of C-13 Pyruvate: A Resource for the Community
Paula M. Jacobs, Ph.D.
National Institutes of Health
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2:30 – 2:50 pm
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Unmet Needs, Strategies and Opportunities in Cancer Imaging
Huiming Zhang, Ph.D.
National Institutes of Health
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2:50 – 3:10 pm
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Production of Filled Pharmacy Kits and Terminal Sterilization for Human Studies
James Slater, Ph.D.
University of California, San Francisco
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3:10 – 3:25 pm
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Review of the Status and Challenges of Hyperpolarized Imaging
Jonathan Murray
GE Healthcare
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3:25 – 3:40 pm
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Review of Current Status of Hyperpolarized Agents for Research and Clinical Trials
C.T. Tan, Ph.D.
Millipore Sigma
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3:40 – 3:55 pm
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Shunt, Don’t Block: A New Approach to Dual Nuclear Coil Design
Matthew G. Erickson, M.D., Ph.D.
University of Florida
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3:55 – 4:00 pm
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Discussion
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4:00 – 4:15 pm
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Break
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Session V: Technical Advances – Polarization and Probes I
Moderator: Simon Duckett, Ph.D.
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4:15 – 4:35 pm
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Recent Advances in Dissolution-DNP Polarization
Jan Henrik Ardenkjaer-Larsen, Ph.D.
Technical University of Denmark
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4:35 – 4:55 pm
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Parahydrogen Derived Polarization for Metabolic Imaging
Eduard Chekmenev, Ph.D.
Vanderbilt University
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4:55 – 5:15 pm
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Development of a Preclinical PHIP Polarizer
Shawn Wagner, Ph.D.
Cedars-Sinai Medical Center
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5:15 – 5:35 pm
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Hyperpolarized 13C MR Using Photo-induced Nonpersistent Radicals
Arnaud Comment, Ph.D.
GE Healthcare
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5:35 – 5:55 pm
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New Approaches in SABRE: Cleavable Metabolic / pH-Sensing "Double Agents", and Preparation of Purified Agents via Heterogeneous Catalysis and Catalyst Immobilization
Boyd Goodson, Ph.D.
Southern Illinois University
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5:55 – 6:15 pm
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Para-hydrogen Induced Hyperpolarization for Quantitative NMR Analysis at Sub-Micromolar Concentrations
Marco Tessari, Ph.D.
Radboud University, Netherland
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6:15 – 6:35 pm
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New Developments on Obtaining Molecular Structure and Dynamics from Transient Hyperpolarization
Christian Hilty, Ph.D.
Texas A&M University
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6:35 – 6:55 pm
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Hyperpolarization Chemistry and Spin Physics for Next Generation Biosensing
Thomas Theis, Ph.D.
Duke University
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6:55 – 7:10 pm
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Discussion
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Friday, October 19th, 2018
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7:00 – 8:00 am
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Continental Breakfast
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Session VI: Keynote Lectures II
Moderator: Chi Dang, M.D., Ph.D.
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7:50 – 8:15 am
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Clinical Development Strategy for Hyperpolarized MR Imaging Techniques
Mitchell D. Schnall, M.D., Ph.D.
University of Pennsylvania
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8:15 – 8:40 am
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Role of Metabolism in Supporting Cancer Proliferation
Matthew G. Vander Heiden, Ph.D.
Massachusetts Institute of Technology
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8:40 – 9:05 am
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Current Status of Hyperpolarized 13C MR of Prostate Cancer Patients
John Kurhanewicz, Ph.D.
University of California, San Francisco
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9:05 – 9:15 am
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Discussion
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9:15 – 9:30 am
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Break
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Session VII: Technical Advances – Polarization and Probes II
Moderators: Rahim R. Rizi, Ph.D. and Warren S. Warren, Ph.D.
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9:30 – 9:50 am
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Scaling Up SABRE Variants to Clinically Useful Levels with Biologically Interesting, Long-Lived Agents
Warren S. Warren, Ph.D.
Duke University
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9:50 – 10:10 am
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Using SABRE to Hyperpolarize Pyruvate, Urea and Nicotinamide: Progress Towards In vivo Assessment
Simon Duckett, Ph.D.
University of York, United Kingdom
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10:10 – 10:30 am
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In Vivo and in Cells Metabolic Studies Using PHIP-SAH Hyperpolaried [1-13C] Pyruvate
Silvio Aime, Ph.D.
University of Torino, Italy
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10:30 – 10:40 am
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Discussion
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10:40 – 10:50 am
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Break
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Session VIII: Maximizing the Information Harvest
Moderator: Matthew Merritt, Ph.D.
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10:50 – 11:10 am
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A Dual Metabolomics/Hyperpolarization Approach Identifies Profound TCA Cycle Disruption as a Consequence of B-Lapachone Treatment of Pancreatic Cancer Cells
Matthew Merritt, Ph.D.
University of Florida
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11:10 – 11:25 am
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Development of Hyperpolarized 13C Metabolic Biomarkers of Prostate Cancer Aggressiveness – from Cells to Patient Derived Tissues
Renuka Sriram, Ph.D.
University of California, San Francisco
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11:25 – 11:40 am
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Methods for Examining Perfused Cancer Cells with Hyperpolarized Substrates Under Hypoxic Conditions
Anthony Mancuso, Ph.D.
University of Pennsylvania
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11:40 – 11:55 am
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Excitation and Encoding in Hyperpolarized 13C MRI
Charles Cunningham, Ph.D.
Sunnybrook Research Institute, Canada
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11:55 am – 12:05 pm
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Discussion
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12:05 – 1:00 pm
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Lunch
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Session IX: Graduate Student and Postdoctoral Presentations – Part II
Moderator: Cornelius von Morze, Ph.D.
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1:00 – 1:10 pm
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Metal-Free Hyperpolarized Metabolites Produced via Rapid Catalyst Capture
Danila Barskiy, Ph.D.
University of California, Berkeley
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1:10 – 1:20 pm
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Quantum Monte Carlo Simulations to Explore the Limits of SABRE
Jacob R. Lindale, Ph.D.
Duke University
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1:20 – 1:30 pm
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Hyperpolarized 13C Imaging of Treatment Responses on Prostate Cancer Patients Using 3D Dynamic CS-EPSI Techniques
Hsin-Yu Chen, Ph.D.
University of California, San Francisco
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1:30 – 1:40 pm
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Hyperpolarized MRI Visualizes Warburg Effects and Predicts mTOR Inhibitor Treatment Response in Patient-Derived ccRCC Xenograft Models
Roozbeh Eskandari, Ph.D.
Memorial Sloan Kettering Cancer Center
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1:40 – 1:50 pm
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Parametric Measurement of Acute Myocardial Infarction in a Large Preclinical Model – Metabolism and Perfusion Quantified
Esben S. Hansen, Ph.D.
Aarhus University, Denmark
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1:50 – 2:00 pm
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Monitoring Lung Cancer in Rodents Using Hyperpolarized Carbon-13
Tahmina Achekzai
University of Pennsylvania
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2:00 – 2:10 pm
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Break
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Session X: Cancer Detection and Monitoring with PET
Moderator: David Mankoff, M.D., Ph.D.
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2:10 – 2:30 pm
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NCI’s Vision/Initiatives Funding Opportunities in Cancer Biology
Nancy Boudreau, Ph.D.
National Institutes of Health
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2:30 – 2:50 pm
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Translating PET Cancer Metabolism Imaging to Patients: Beyond FDG
David Mankoff, M.D., Ph.D.
University of Pennsylvania
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2:50 – 3:10 pm
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PET Tracers to Guide Metabolically-targeted Therapy
Charles Manning, Ph.D.
Vanderbilt University
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3:10 – 3:30 pm
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Fluoroglutamine PET/CT: First in-Human Trial
Mark Dunphy, M.D.
Memorial Sloan Kettering Cancer Center
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3:30 – 3:50 pm
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Imaging Cancer Glutamine Metabolism by PET and MRI
Rong Zhou, Ph.D.
University of Pennsylvania
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3:50 – 4:00 pm
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Discussion
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4:00 – 4:15 pm
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Break
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Session XI: Metabolism and Pathways – Part I
Moderator: Douglas Rothman, Ph.D.
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4:15 – 4:35 pm
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Multi-scale Platform for Combined Magnetic Resonance Spectroscopy and Optical Imaging of Metabolism in 3D Cell Cultures
Sean B. Fain, Ph.D.
University of Wisconsin, Madison
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4:35 – 4:55 pm
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Hyperpolarized 13C MRI and Biomarkers of Androgen Signaling in Castrate-resistant Prostate Cancer
Mark Titus, Ph.D.
University of Texas, MD Anderson Cancer Center
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4:55 – 5:15 pm
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Deuterium Metabolic Imaging (DMI) – A Novel MR-based Method to Map Metabolism in 3D
Robin de Graaf, Ph.D.
Yale University
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5:15 – 5:35 pm
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Effects of B1 and Slice Profile Inhomogeneities on Dynamic HP 13C MRI
James Bankson, Ph.D.
University of Texas, MD Anderson Cancer Center
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5:35 – 5:55 pm
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Cardiac Carbon: Coils, Code and Challenges
Jack Miller, Ph.D.
University of Oxford, United Kingdom
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5:55 – 6:15 pm
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Quantitative Imaging of Brain Energy Metabolisms and Neuroenergetics at Ultrahigh Field
Wei Chen, Ph.D.
University of Minnesota
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6:15 – 6:35 pm
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Metabolic Modeling of 13C Hyperpolarized Data for Studying Brain Metabolism and Neurotransmission
Graeme Mason, Ph.D.
Yale University
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6:35 – 6:50 pm
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Discussion
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Saturday, October 20th, 2018
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7:00 – 8:00 am
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Continental Breakfast
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Session XII: Advances in Acquisition Strategies
Moderator: Kayvan Keshari, Ph.D.
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8:00 – 8:20 am
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Hyperpolarized Functional and Metabolic Kidney Imaging
Christoffer Laustsen, Ph.D.
Aarhus University, Denmark
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8:20 – 8:40 am
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Optimum Acquisitions for Hyperpolarised Metabolic Imaging
Rolf Schulte, Ph.D.
GE Healthcare
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8:40 – 9:00 am
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Imaging of Treatment Refractory, Latent Cellular Domains in Hepatocellular Carcinoma
Terence Gade, M.D., Ph.D.
University of Pennsylvania
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9:00 – 9:20 am
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In Vivo Hyperpolarization Transfer in a Clinical MRI Scanner
Cornelius von Morze, Ph.D.
University of California, San Francisco
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9:20 – 9:40 am
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Probing Lung Inflammatory Injury Using Hyperpolarized 13C MRI
Mehrdad Pourfathi, M.S.
University of Pennsylvania
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9:40 – 9:55 am
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Discussion
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9:55 – 10:10 am
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Break
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Session XIII: Metabolism and Pathways – Part II
Moderator: Christoffer Laustsen, Ph.D.
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10:10 – 10:30 am
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Imaging Superoxide Levels in Tissues with PET
Robert Mach, Ph.D.
University of Pennsylvania
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10:30 – 10:50 am
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Applications of Deuterium Magnetic Resonance Imaging to Gliomas
Henk de Feyter, Ph.D.
Yale University
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10:50 – 11:10 am
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Applications of Hyperpolarized 13C MRI in Traumatic Brain Injury
Dirk Mayer, Ph.D.
University of Maryland
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11:10 – 11:30 am
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Extending Volumetric Coverage Using 3D Hyperpolarized C-13 EPI with Calibrationless Parallel Imaging
Jeremy Gordon, Ph.D.
University of California, San Francisco
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11:30 – 11:50 am
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13C Hyperpolarization in Nanodiamonds: Applications to Spectroscopy and Imaging
Ashok Ajoy, Ph.D.
University of California, Berkeley
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11:50 am – 12:10 pm
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Noninvasive Evaluation of Metabolic Flexibility in Heart and Contracting Skeletal Muscle
Timothy R. DeGrado, Ph.D.
Mayo Clinic
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12:10 – 12:20 pm
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Discussion
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12:20 – 1:10 pm
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Lunch
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Session XIV: Graduate Student and Postdoctoral Presentations – Part III
Moderators: Mehrdad Pourfathi and Sarmad Siddiqui
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1:10 – 1:20 pm
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Multimodal Molecular In Vivo Imaging Reveals Tumor Microenvironments from Integrating Hyperpolarized 13C MRI, 18F-FDG PET, and EPR Imaging in Pancreatic Ductal Adenocarcinoma
Kazu Yamamoto, Ph.D.
National Institutes of Health
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1:20 – 1:30 pm
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Quantifying Glutamine Metabolism in Pancreatic Cancer
Ilana Kotliar
Memorial Sloan Kettering Cancer Center
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1:30 – 1:40 pm
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Iterative Joint Spatial-Spectral Reconstruction for Hyperpolarized 13C Imaging with Prior Knowledge
Minjie Zhu
University of Maryland
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1:40 – 1:50 pm
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Increasing 13C Relaxation Times with D2O Solvation
Andrew Cho
Memorial Sloan Kettering Cancer Center
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1:50 – 2:00 pm
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Terminal Diazirines Enable Reverse Polarization Transfer from 15N Singlets
Guannan Zhang, Ph.D.
Duke University
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2:00 – 2:10 pm
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Design of Molecular Probes with Long T1 for Hyperpolarized MRI
Yohei Kondo
University of Tokyo, Japan
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2:10 – 2:20 pm
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Break
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Session XV: Metabolism and Pathways – Part III
Moderator: Jerry Glickson, Ph.D.
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2:20 – 2:40 pm
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Taking Advantage of Orthogonal Metabolic Pathways for Targeted Infection Imaging
Mark Sellmyer, M.D., Ph.D.
University of Pennsylvania
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2:40 – 3:00 pm
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Metabolic Imaging of Targeted Therapy in Preclinical Cancer Models
Sui Seng Tee, Ph.D.
Memorial Sloan Kettering Cancer Center
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3:00 – 3:20 pm
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Stable Isotope Tracing and Quantification of Compartmentalized Metabolism
Nathaniel Snyder, Ph.D.
Drexel University
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3:20 – 3:40 pm
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13C Tracer Studies Using MIMOSA – A New Window on Quantitative Fluxomic
Richard Kibbey, M.D., Ph.D.
Yale University
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3:40 – 4:00 pm
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Metabolic Network Analysis in Cancer: Quantification of Flux
Alexander Shestov, Ph.D.
University of Pennsylvania
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4:00 – 4:10 pm
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Final Remarks
Stephen Kadlecek, Ph.D.
University of Pennsylvania
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