2025 International Workshop on Pulmonary Imaging Program

Continental Breakfast

7:00 AM - 7:40 AM

Introductory Remarks

Rahim R. Rizi, Ph.D.
University of Pennsylvania

7:40 AM - 7:50 AM

Welcome Remarks

S. William Stavropoulous, M.D.
Interim Chair, Department of Radiology
University of Pennsylvania

7:50 AM - 8:00 AM

Novel Pathways in the Pathogenesis of COPD  

James Crapo, M.D.
National Jewish Health

Structural Predictors of Lung Function Decline in Young Smokers with Normal Spirometry

Wisia Wedzicha, M.D., Ph.D.
Imperial College London

CT Assessed Sildenafil Effects on Regional Pulmonary V/Q in a Smoking and Non-smoking Population 

Eric A. Hoffman, Ph.D.
University of Iowa

Leveraging CT Scan Findings to Understand Emphysema Pathobiology in COPD

Francesca Polverino, M.D., Ph.D.
Baylor College of Medicine

The Lungs and Heart are Connected Precisely: Cardiopulmonary Interactions of Machine-learned CT Emphysema Subtypes

R. Graham Barr, M.D., DrPH
Columbia University

Discussion

Break

10:00 am - 10:15 am

Adaptable Human Endothelium for Organ Regeneration and Radiation Mitigation

Shahin Rafii, M.D.
Cornell University

Mucus Plugging - A New Phenotype in Practice

Mario Castro, M.D., MPH
University of Kansas Medical Center

Defining Ideal and Impaired Respiratory Health: A Step Toward Health Promotion and Disease Interception

Gabrielle Liu, M.D., M.S.
University of California, Davis

Circulating Glycosaminoglycans as Critical Illness Biomarkers

Eric P. Schmidt, M.D.
Harvard Medical School, Massachusetts General Hospital

Insights into Pulmonary Vascular Disease from Hyperpolarized Xenon MRI

Sudar Rajagopal, M.D., Ph.D.
Duke University

Biovariability of Quantitative Lung Measures During the Menstrual Cycle

Jessica Sieren, Ph.D.
University of Iowa

Discussion

Lunch

12:25 pm - 1:10 pm

¹²⁹Xe in the Clinic: First Impressions, Use Cases, and Future Directions

Robby Thomen, Ph.D.
University of Missouri

Same-day Repeatability of Hyperpolarized ¹²⁹Xe MRI Features in Patients with Pulmonary Arterial Hypertension and Systemic Sclerosis

Peter Niedbalski, Ph.D.
University of Kansas Medical Center

Alveolar Structural Dynamics During Mechanical Ventilation: Insights from Multiscale Dynamic Imaging

Jacob Herrmann, Ph.D.
University of Iowa

Unsupervised Machine Learning Technique for Analyzing Lung Ultrasound

Hersh Sagreiya, M.D.
University of Pennsylvania

Assessing Physiological Outcomes of Endobronchial Valve Intervention Using Hyperpolarized Xenon Cine MRI During Spontaneous Breathing

Hooman Hamedani, Ph.D.
University of Pennsylvania

Exploring COPD Phenotypic Landscape Using Elastic Principal Graphs

Sundaresh Ram, Ph.D.
Emory University & Georgia Institute of Technology

Discussion

Break

2:25 pm - 2:40 pm

Interstitial Lung Abnormalities (ILA): A Radiologist's Perspective

Hiroto Hatabu, M.D., Ph.D.
Brigham and Women's Hospital

4DCT Artifact Detection and Correction for Functional Lung Avoidance Radiation Therapy

Joseph Reinhardt, Ph.D.
University of Iowa

Medical Countermeasures for Radiation-induced Lung Injury

Heather Himburg, Ph.D.
Medical College of Wisconsin

Artificial Intelligence-assisted Lung Modeling with Application to Early Detection of Radiation-induced Lung Injury

Reza Avaz, Ph.D.
Texas A&M University

Experience the Profound Clinical Impact of NAEOTOM Alpha (Photon-counting CT) in Thoracic Imaging

Matthew Fuld, Ph.D.
Siemens Healthineers

Discussion

Break

4:10 pm - 4:25 pm

Distribution of Lung Expansion and Strains at the PEEP of Maximal Compliance

Marcos Vidal Melo, Ph.D.
Columbia University

Efficacy of Multi-Frequency Ventilation in Acute Lung Injury: A Quantitative CT Imaging Assessment

David Kaczka, M.D., Ph.D.
University of Iowa

ARDS: A Syndrome in Distress

Pratik Sinha, Ph.D.
Washington University in St. Louis

Imaging to Understand Heterogeneous and Individualized Treatment Effects

Nadir Yehya, M.D.
Children's Hospital of Philadelphia

Phenotyping and Characterization of Lung Injury by CT Scan Using AI in Spontaneously Breathing Patients with Respiratory Failure

Emanuele Rezoagli, M.D., Ph.D.
University of Milan-Bicocca

Quantitative and Functional Cardiothoracic Imaging in the Era of Artificial Intelligence: The Road to Transforming Clinical Practice

Eduardo Barbosa, M.D.
University of Pennsylvania

Distribution of Lung Ventilation Strain and Subsequent Inflammation: A Translational PET-CT Study

Gaetano Perchiazzi, M.D., Ph.D.
Uppsala University

Effects of Abdominal and Thoracic Mass Loading on Respiratory Mechanics and Lung Volumes in a Swine Model of Acute Hypoxemic Respiratory Failure

Maurizio Cereda, M.D.
Harvard Medical School, Massachusetts General Hospital

Discussion

Continental Breakfast

7:00 AM - 8:00 AM

Radiation Therapy Treatment Planning Approaches for Mitigation of RILI

John Bayouth, Ph.D.
Oregon Health & Science University

Multiparametric PET-MR Imaging of Pulmonary Fibrosis

Peter Caravan, Ph.D.
Harvard Medical School, Massachusetts General Hospital

Hyperpolarized ¹²⁹Xe MRI Membrane Uptake Associates with Changes in Lung Function and Prognosis in Patients with Idiopathic Pulmonary Fibrosis Initiating Therapy

Robert Tighe, M.D.
Duke University

Association of CT-Assessed Dysanapsis with Subclinical Interstitial Lung Disease in Older Adults

Anna Podolanczuk, M.D.
Cornell University

Discussion

Break

9:10 am - 9:20 am

Communicating Variability in Deep Learning CT Reconstructions with Posterior Sampling 

Grace Gang, Ph.D.
University of Pennsylvania

Identifying Subtypes of Human Disease Using Ontology-based Machine Learning

Justin Reese, Ph.D.
Lawrence Berkeley National Laboratory

Large-scale Harmonization of Emphysema Measures

Andrew Laine, Ph.D.
Columbia University

Deep Learning-based Classification of Usual Interstitial Pneumonia on CT is Associated with Progression of Interstitial Lung Abnormalities in the COPDGene Study

Stephen Humphries, Ph.D.
National Jewish Health

ITK-Lung: A Software Framework for Lung Image Processing and Analysis

James Gee, Ph.D.
University of Pennsylvania

Pulmonary Image Synthesis: Intensity Transforms and Beyond

Sarah Gerard, Ph.D.
University of Iowa

Imaging and Computational Biomarkers in Long COVID Patients: A Three-year Follow-up

Ching-Long Lin, Ph.D.
University of Iowa

Discussion

Break

11:15 am - 11:25 am

Association of Contrast Enhanced Dual Energy CT-derived Pulmonary Arterial Tree-to-Lung Ratio (ArtLR) with COPD 

Soheil Hosseini, M.Sc. 
University of Iowa 

3D Phase-resolved Functional Lung MRI as a Predictor of Treatment Outcomes in Severe Eosinophilic Asthma Patients Undergoing Mepolizumab Therapy

Filip Klimes, Ph.D.
Hannover Medical School

3D UTE Phase-Resolved Functional Lung (PREFUL) MRI in Neonates with Bronchopulmonary Dysplasia

Samal Munidasa, Ph.D. 
Cincinnati Children’s Hospital Medical Center 

Distinguishing Dose-dependent Radiation Lung Injury Using Hyperpolarized ¹²⁹Xe MR Spectroscopy 

Luis Loza, B.Sc. 
University of Pennsylvania 

Oxygen-enhanced MRI (OE-MRI) Biomarkers of Ventilation and Gas Uptake Correlate with Pulmonary Function Tests in Cystic Fibrosis

Sarah Needleman, Ph.D. 
University College London 

DCE-MRI Quantifies Microvascular Changes in Lung Transplant Recipients with Chronic Lung Allograft Rejection 

Antonia Susnjar, Ph.D. 
Harvard Medical School 

3D Ultrashort Echo Time (UTE) and 2D Dynamic MRI for Evaluating Ventilation and Chest Wall Motion in Pediatric Pectus Malformation Patients 

Bochun Mei, B.S.
University of California, San Francisco

T1 Mapping in the Lungs Using a Variable Flip Angle Approach with UTE-MR 

Saman Khodaei, M.Sc. 
University of Iowa 

Discussion

Lunch

12:23 pm - 1:10 pm

The Specific Physiological Properties Assessed by Different Imaging Methods of Ventilation and Perfusion

Tilo Winkler, Ph.D.
Harvard Medical School, Massachusetts General Hospital

Indoor Air Pollution and COPD Morbidity: The Role of CT in Identifying High-risk Populations

Sarath Raju, M.D.
Johns Hopkins University

Silent Zone Revealed: A Computational Imaging Approach for Small Airways Disease Staging in COPD

Craig Galban, Ph.D.
University of Michigan

Thoracic Respiratory Biomarkers in COPD

Punam Saha, Ph.D.
University of Iowa

Discussion

Break

2:20 pm - 2:35 pm

MRI in the Neonate as a Contributor to Outcomes Improvement

Jason Woods, Ph.D.
Cincinnati Children's Hospital Medical Center 

Dynamic Airway Computed Tomography and Flexible Bronchoscopy for Diagnosis of Tracheomalacia in Children - A Comparison Study 

Jordan Rapp, M.D. & Aoife Corcoran, M.D.
Children's Hospital of Philadelphia

Using Fluid Dynamics and Work of Breathing to Guide Treatment in Neonates

Alister Bates, Ph.D.
Cincinnati Children's Hospital Medical Center 

Surgical Approaches for Tracheomalacia

Tom Hamilton, M.D.
Children's Hospital of Philadelphia

Discussion

Break

3:50 pm - 4:05 pm

1H Functional Lung MRI: State of the Art and Future Perspectives

Jens Vogel-Claussen, M.D.
Hannover Medical School

1H Pulmonary MRI Methods: Structure/function Mapping and Multi-parametric Imaging 

Peder Larson, Ph.D.
University of California, San Francisco

Pulmonary Imaging using 0.55T MRI

Adrienne Campbell-Washburn, Ph.D.
National Institutes of Health

Discussion

Break

5:20 pm - 5:30 pm

Poster presentations and reception (Smilow Commons)

5:30 pm - 8:00 pm

Continental Breakfast

7:00 am - 7:45 am

Advances in Lung Transplantation: A Tale of Successes and Unsolved Conundrums

Christian Bermudez, M.D.
University of Pennsylvania

Enhancing Normothermic Ex Situ Preservation: Valuable Insights and Lessons from Heart Perfusion 

Alvaro Rojas-Pena, M.D.
University of Michigan

Repair of Lung Injury by Human Lung Progenitors in Xenotransplant Model

Nicolino Dorrello, M.D.
Columbia University

Assessment of Lung Function in Transplant Patients Using Hyperpolarized ¹²⁹Xe MRS

Kai Ruppert, Ph.D.
University of Pennsylvania

The Role of Eosinophils in Early and Late Stages of Lung Allograft Immunoregulation 

Alexander Sasha Krupnick, M.D.
University of Maryland

Cellular Senescence in Donor's Lung as a Risk Factor for Developing Chronic Rejection 

Mauricio Rojas, M.D.
Ohio State University

X-ray Velocimetry to Predict Outcome in Endobronchial Valve Placement 

Trishul Siddharthan, M.D.
University of Miami

Discussion

Break

9:45 am - 10:00 am

Photon-counting CT: Unlocking New Opportunities in Diagnostic Imaging

Peter Noel, Ph.D.
University of Pennsylvania

Ensuring Precise Lung CT Quantification Amid Technological Variabilities

Ehsan Abadi, Ph.D.
Duke University

Taking a Closer Look: HiP-CT for Detailed Lung Vasculature Analysis

Adam Szmul, Ph.D.
University College London

PixelPrint4D: A 3D Printing Method for Fabricating Patient-specific Deformable Pulmonary CT Phantoms

Jessica Im, Ph.D.
University of Pennsylvania

Discussion

Break

11:15 am - 11:30 am

Untangling Dyspnea Using ¹²⁹Xe MRI and Spectroscopy

Bastiaan Driehuys, Ph.D.
Duke University

Technical Developments in ¹²⁹Xenon MRI for Clinical Implementation

Jim Wild, Ph.D.
University of Sheffield

Xe MRI in Pediatric Rare-lung Diseases and Bone-marrow Transplantation

Laura Walkup, Ph.D.
Cincinnati Children's Hospital Medical Center

The Membrane in the Middle: Interstitial Lung Diseases on Xenon MRI

David Mummy, Ph.D.
Duke University

Discussion

Lunch

12:45 pm - 1:30 pm

Hyperpolarization Decay During Acquisition: What it Breaks and How to Fix it Analytically

Juan Parra-Robles, Ph.D.
Cincinnati Children's Hospital Medical Center

Exploratory Study of Vascular Consequences from Electronic Cigarette Use by ¹²⁹Xe MRI in Healthy Young Adults: A Pilot Study to Design a Multi-center Clinical Trial 

Y. Michael Shim, M.D.
University of Virginia School of Medicine

Ventilation Defect Burden Predicts Lung Cancer Resection Outcomes

Sarah Svenningsen, Ph.D.
McMaster University

Clinical Applications of Xenon MRI

Alex Duskek
Polarean Inc. 

Discussion

Break

2:45 pm - 3:00 pm

Beyond the Basics: Leveraging Advanced Ventilation Metrics to Differentiate Lung Health and Disease in Xenon MRI 

Chase Hall, M.D.
University of Kansas Medical Center

Uncovering Silent Zones of Disease in COPD 

Sandeep Boddhuluri, Ph.D. 
University of Alabama at Birmingham

Mucus Pathology from Imaging Observations to Interventions

Alejandro Diaz, M.D., MPH
Massachusetts General Hospital, Bringham and Women's Hospital

Lung Function and Airway Epithelial Barrier Integrity in Primary Cooks Using LPG or Biomass: An Imaging-based Assessment 

Alejandro Comellas, M.D.
University of Iowa

Discussion

Break

4:15 pm - 4:30 pm

TBA

TBA

Ventilation Lung Imaging Using Proton-hyperpolarized Gas Contrast Agents and RASER Sensing Using Proton-only Clinical MRI Scanners

Eduard Chekmenev, Ph.D.
Wayne State University

Hyperpolarized Propane Gas Imaging with a Point-of-care MRI Scanner and Exploring “Continuous-flow” HPXe Production with a "Stopped-flow" Hyperpolarizer

Boyd Goodson, Ph.D.
Southern Illinois University

Closing Remarks

Adjourn