Preliminary
(subject to change)
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Thursday, February 23rd, 2023
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6:50 – 7:40 am
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Continental Breakfast
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7:40 – 7:50 am
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Introductory Remarks
Rahim R. Rizi, Ph.D.
University of Pennsylvania
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7:50 – 8:00 am
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Welcome Remarks
Mitchell D. Schnall, M.D., Ph.D.
University of Pennsylvania
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Session I: Keynote Lectures – Part I
Moderator: Warren Gefter, M.D.
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8:00 – 8:25 am
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A Birds-eye View of Pulmonary Challenges and How Imaging Might Help
Fernando Martinez, M.D.
Weill Cornell Medicine
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8:25 – 8:45 am
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Imaging Needs to Guide Interventional Treatments for COPD Patients
Gerard J. Criner, M.D.
Temple University
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8:45 – 9:05 am
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Origins of Quantitative Functional X-ray Computed Tomography of the Lung and What’s Next
Eric A. Hoffman, Ph.D.
University of Iowa
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9:05 – 9:25 am
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MRI in Cystic Fibrosis: Successful Translation of Functional MRI into Clinical
Medicine
Hans-Ulrich Kauczor, M.D.
University Hospital Heidelberg, Germany
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9:25 – 9:45 am
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The Small Airways: A Key Target for Quantitative, Functional Lung Imaging
Warren Gefter, M.D.
University of Pennsylvania
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9:45 – 10:00 am
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Discussion
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10:00 – 10:15 am
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Break
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Session II: Keynote Lectures – Part II
Moderator: Hans-Ulrich Kauczor, M.D.
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10:15 – 10:35 am
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Artificial Intelligence in Chest Imaging: Is the Future Really Here?
Edwin van Beek, M.D., Ph.D.
University of Edinburgh, U.K.
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10:35 – 10:55 am
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Latest Advances in Imaging in Asthma – Targeted Therapy
Mario Castro, M.D.
University of Kansas Medical Center
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10:55 – 11:15 am
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Role of Imaging in COPD, in 2023 and Beyond
MeiLan Han, M.D.
University of Michigan
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11:15 – 11:35 am
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Sarcopenia: The Multiple Pathways of Muscle Loss
George R. Washko, M.D.
Brigham and Women's Hospital
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11:35 – 11:55 am
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Towards Routine Quantitative Lung Imaging
Joon Beom Seo, M.D., Ph.D.
University of Ulsan, South Korea
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11:55 – 12:10 pm
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Defining Human Specific Mechanisms of Lung Development, Injury & Regeneration
Maria Basil, M.D., Ph.D.
University of Pennsylvania
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12:10 – 12:20 pm
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Discussion
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12:20 – 1:10 pm
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Lunch
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Session III: Early Investigators
Moderator: Stephen Kadlecek, Ph.D.
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1:10 – 1:20 pm
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Tracking Intratidal Blood Volume Redistribution with Dynamic Dual-energy CT
Jacob Herrmann, Ph.D.
University of Iowa
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1:20 – 1:30 pm
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Translating 129Xe MRI to Clinical Practice: Preliminary Experience
Robert Thomen, Ph.D.
University of Missouri
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1:30 – 1:40 pm
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Optimizing Dynamic Contrast Analysis for Imaging Pulmonary Perfusion in Injured Lungs
Yi Xin, Ph.D.
Massachusetts General Hospital
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1:40 – 1:50 pm
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Emerging MRI Techniques and Insights for the Neonatal Lung
Nara Higano, Ph.D.
Cincinnati Children's Hospital Medical Center
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1:50 – 2:00 pm
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Polymorphic Deep Learning for Robust Segmentation Across Species and Diseases
Sarah E. Gerard, Ph.D.
University of Iowa
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2:00 – 2:15 pm
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Discussion
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2:15 – 2:30 pm
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Break
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Session IV: Lung Cancer
Moderator: David Mankoff, M.D., Ph.D.
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2:30 – 2:45 pm
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Lung Cancer Screening Efficacy Enhanced Through Radiomic Biomarkers
Jessica C. Sieren, Ph.D.
University of Iowa
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2:45 – 3:00 pm
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Molecular Imaging of Lung Cancer: Metabolism and Proliferation
David Mankoff, M.D., Ph.D.
University of Pennsylvania
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3:00 – 3:15 pm
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The Role of Surgery in the Treatment of Mesothelioma
Joseph Friedberg, M.D.
Temple University
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3:15 – 3:30 pm
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Quantitative Imaging for Lung Cancer in the Era of Immuno-oncology
Ho Yun Lee, M.D., Ph.D.
Sungkyunkwan University, South Korea
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3:30 – 3:45 pm
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Intraoperative Molecular Imaging of Lung Cancer
Sunil Singhal, M.D.
University of Pennsylvania
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3:45 – 3:55 pm
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Discussion
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3:55 – 4:05 pm
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Break
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Session V: COVID and Post-COVID Lung Imaging
Moderator: Maurizio Cereda, M.D.
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4:05 – 4:20 pm
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Are 129Xe MRI Ventilation Abnormalities Clinically Relevant in Post-acute COVID-19 Syndrome, 3 and 15 Months Post-infection?
Grace Parraga, Ph.D. (presented by Alexander Matheson, B.S.)
Western University, Canada
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4:20 – 4:35 pm
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Leveraging CXR and CT Advanced Quantitative Imaging and Machine Learning Beyond COVID-19 Diagnosis to Quantification and Prognostication
Eduardo J. Mortani Barbosa Jr., M.D.
University of Pennsylvania
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4:35 – 4:50 pm
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Longitudinal Monitoring of Lung Function and Structure Post-COVID-19 Hospitalisation with Multinuclear Lung MRI
Jim Wild, Ph.D.
University of Sheffield, U.K.
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4:50 – 5:05 pm
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Visualizing Gas Exchange Defects Using Hyperpolarized 129Xe MRI in Patients with Post-acute COVID-19 Respiratory Symptoms
Peter Niedbalski, Ph.D.
University of Kansas Medical Center
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5:05 – 5:15 pm
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Discussion
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5:15 – 5:30 pm
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Break
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Session VI: Assessment of Structural and Functional Changes in ARDS
Moderator: Marcos Vidal Melo, M.D., Ph.D.
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5:30 – 5:45 pm
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Regional Blood Flow and Inflammation During Low Tidal Volume Mechanical Ventilation
Marcos Vidal Melo, M.D., Ph.D.
Columbia University
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5:45 – 6:00 pm
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Imaging Lung Perfusion to Guide ARDS Care
Maurizio Cereda, M.D.
Massachusetts General Hospital
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6:00 – 6:15 pm
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Ventilating the Injured Lung: Insights from Quantitative CT Imaging
David Kaczka, M.D., Ph.D.
University of Iowa
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6:15 – 6:30 pm
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New Approaches to Lung Repair
Nicolino V. Dorrello, M.D.
Columbia University
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6:30 – 6:45 pm
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Leveraging Imaging to Inform Molecular Subphenotypes of ARDS
Nadir Yehya, M.D.
Children's Hospital of Philadelphia
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6:45 – 7:00 pm
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Discussion
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Friday, February 24th, 2023
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7:00 – 8:00 am
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Continental Breakfast
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Session VII: Interstitial Lung Disease
Moderator: Michael Beers, M.D.
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8:00 – 8:15 am
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Leveraging Novel Preclinical Models, Big Data Omics, and New Paradigms to Drive Discovery in Idiopathic Pulmonary Fibrosis
Michael F. Beers, M.D.
University of Pennsylvania
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8:15 – 8:30 am
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Regional Patterns of Fibrosis, Gas Exchange and Perfusion in IPF Using Chest CT and MRI
Sean B. Fain, Ph.D.
University of Iowa
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8:30 – 8:45 am
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Molecular Imaging of Fibrosis and Fibrogenesis in ILD
Peter Caravan, Ph.D.
Massachusetts General Hospital
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8:45 – 9:00 am
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Discussion
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9:00 – 9:15 am
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Break
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Session VIII: Machine Learning and Deep Learning – Imaging in COPD
Moderator: Saurabh Jha, MD
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9:15 – 9:35 am
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Unsupervised Machine Learning of Quantitative CT Emphysema Subtypes
R. Graham Barr, M.D., DrPH
Columbia University
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9:35 – 9:50 am
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AI in Chest Imaging: From Detection to Prediction
Joon Beom Seo, M.D., Ph.D.
University of Ulsan, South Korea
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9:50 – 10:05 am
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Synthesizing Lung Functional Images Using Deep Learning
Joseph M. Reinhardt, Ph.D.
University of Iowa
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10:05 – 10:20 am
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Assessments of Emphysema and Pulmonary Fibrosis on CT Using Deep Learning
Stephen Humphries, Ph.D.
National Jewish Health
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10:20 – 10:35 am
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Recent Advances in Assessing Vascular Morphology and Perfusion in Pulmonary Vascular Disease
Raul San Jose Estepar, Ph.D.
Brigham and Women's Hospital
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10:35 – 10:50 am
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Discussion
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10:50 – 11:05 am
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Break
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Session IX: Post-Doctoral Fellow and Graduate Student Presentations
Moderator: Kai Ruppert, Ph.D.
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11:05 – 11:13 am
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Denoising Diffusion-weighted Hyperpolarized 129Xe Images with Patch-based Higher-order Singular Value Decomposition
Stephanie A. Soderlund
Cincinnati Children’s Hospital Medical Center
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11:13 – 11:21 am
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Time-resolved Dynamic Lung Water Magnetic Resonance Imaging During Exercise Stress
Felicia Seemann
National Institutes of Health
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11:21 – 11:29 am
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3D Quantification of Clustered Lung Volume Defects in Different Lung Diseases Utilizing Hyperpolarized Gas MR Images
Gabriela Delgado
University of Missouri
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11:29 – 11:37 am
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Effect of CFTR Modulator Therapy with Elexacaftor/Tezacaftor/Ivacaftor on Pulmonary Ventilation Derived by 3D Phase-resolved Functional Lung MRI in Cystic Fibrosis Patients
Filip Klimeš
Hannover Medical School, Germany
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11:37 – 11:45 am
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Quantitative Mapping of Cardiopulmonary Oscillations Using Hyperpolarized 129Xe Gas Exchange MRI
Junlan Lu
Duke University
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11:45 – 11:53 am
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Pulmonary Vascular Redistribution Following 2.5-year Anti-IL-5Rα Treatment in Eosinophilic Asthma
Marrissa J. McIntosh
Robarts Research Institute and Western University, Canada
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11:53 – 12:01 am
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Lung Volume Dependence and Repeatability of Hyperpolarized 129Xe MRI Gas Uptake Metrics in Healthy Volunteers and Patients with COPD
William J. Garrison
University of Virginia
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12:01 – 12:10 pm
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Discussion
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12:10 – 1:00 pm
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Lunch
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Session X: Pre-COPD and Small Airways
Moderator: Eric Hoffman, Ph.D.
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1:00 – 1:15 pm
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Investigating COPD Progression Through Quantitative CT
Craig J. Galbán, Ph.D. (presented by Sundaresh Ram, Ph.D.)
University of Michigan
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1:15 – 1:30 pm
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Dysanapsis: Origins and Clinical Significance Thanks to Pulmonary Imaging
Benjamin M. Smith, M.D.
McGill University and Columbia University
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1:30 – 1:45 pm
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Physiologic Characterization of Respiratory Function Using Fluoroscopy-based X-ray Velocimetry
Naresh M. Punjabi, M.D., Ph.D.
University of Miami
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1:45 – 2:00 pm
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New Metrics for Quantification of Airway Disease in COPD
Surya P. Bhatt, M.D.
University of Alabama at Birmingham
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2:00 – 2:15 pm
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Reliable Lung Quantification via CT Using Virtual Imaging Trials
Ehsan Abadi, Ph.D.
Duke University
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2:15 – 2:30 pm
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Mucus Plugs Occluding COPD Airways: A Review of Their Clinical Impact
Alejandro A. Diaz, M.D., MPH
Brigham and Women’s Hospital
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2:30 – 2:45 pm
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Discussion
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2:45 – 3:10 pm
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Break
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Session XI: Assessment of Pulmonary Disorders in the Pediatric Population and Imaging Asthmatic Patients
Moderator: Zackary Cleveland, Ph.D.
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3:10 – 3:25 pm
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Structural and Functional Proton MRI in Pediatric Lung Disease
Giles Santyr, Ph.D.
The Hospital for Sick Children, Canada
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3:25 – 3:40 pm
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Translational Xe MRI in Pediatrics
Jason Woods, Ph.D.
Cincinnati Children's Hospital Medical Center
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3:40 – 3:55 pm
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Body Composition CT Metrics and Lung Function in Asthma Participants: Analyses from the Severe Asthma Research Program
Mark L. Schiebler, M.D.
University of Wisconsin, Madison
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3:55 – 4:10 pm
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Phenotyping Asthma/COPD Overlap in Patients with Mild Lung Disease with Xenon MRI and Lung Function - Results from the Novelty Cohort
Laurie Smith, Ph.D.
University of Sheffield, U.K.
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4:10 – 4:25 pm
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Discussion
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4:25 – 4:40 pm
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Break
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Session XII: Proton MRI of the Lung
Moderator: John Mugler, Ph.D.
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4:40 – 4:55 pm
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Phase Resolved Functional Lung (PREFUL) MRI: Latest Developments and Clinical Translation
Jens Vogel-Claussen, M.D.
Hannover Medical School, Germany
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4:55 – 5:10 pm
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4D Proton MRI of the Lung at High Spatiotemporal Resolution
Wilson Miller, Ph.D.
University of Virginia
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5:10 – 5:25 pm
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Proton MR Imaging at 0.55T
Adrienne Campbell, Ph.D.
National Institutes of Health
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5:25 – 5:40 pm
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Quantitative Measures of Ventilation, Perfusion, and Ventilation-perfusion in the Human Lung Using Proton MRI
Rui Carlos Sa, Ph.D.
National Institutes of Health
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5:40 – 5:55 pm
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Discussion
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6:00 – 8:30 pm
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Poster Session
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Saturday, February 25th, 2023
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7:00 – 7:45 am
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Continental Breakfast
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Session XIII: Imaging of Lung Transplant and Cell Therapy
Moderator: Joel Cooper, M.D.
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7:45 – 8:00 am
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Predicting the Outcome of Lung Transplantation Using Machine Learning
Pratik Chaudhari, Ph.D.
University of Pennsylvania
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8:00 – 8:15 am
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The Role of CT Imaging in Lung Transplant
Micheal McInnis, M.D.
University of Toronto, Canada
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8:15 – 8:30 am
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Hyperpolarized 129Xe Ventilation and Gas Exchange as Markers for Lung Transplantation
Faraz Amzajerdian
University of Pennsylvania
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8:30 – 8:45 am
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Lung Metabolism and Graft Preservation on Ex Vivo Lung Perfusion
Kentaro Noda, Ph.D.
University of Pittsburgh
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8:45 – 9:00 am
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Metabolic Changes in the Donor Lung During Ischemia as a Function of Time and Temperature
Zachary Schug, Ph.D.
Wistar Institute
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9:00 – 9:15 am
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Contemporary Challenges and Opportunities to Improve Equity and Use of Organs for Lung Transplant
Edward Cantu, M.D.
University of Pennsylvania
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9:15 – 9:30 am
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Neutrophil Trafficking After Lung Transplantation
Daniel Kreisel, M.D., Ph.D.
Washington University in St. Louis
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9:30 – 9:45 am
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Discussion
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9:45 – 10:00 am
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Break
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Session XIV: Advances in CT Imaging and Photon Counting
Moderator: Peter B. Noël, Ph.D.
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10:00 – 10:15 am
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Photon-Counting CT – Opportunities for Interdisciplinary Preclinical and Clinical Research
Peter B. Noël, Ph.D.
University of Pennsylvania
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10:15 – 10:30 am
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Fundamentals of Photon Counting CT and Experiences with the First Clinically Available System
Juan Carlos Ramirez-Giraldo, Ph.D.
Siemens Healthineers
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10:30 – 10:45 am
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End-to-end Radiomics Standardization Framework
Grace Gang, Ph.D.
University of Pennsylvania
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10:45 – 11:00 am
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Hierarchical Phase Contrast Tomography: A Method for Imaging Multiscale Three-dimensional Structures in Whole Human Lung
Claire Walsh, Ph.D.
University College London, U.K.
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11:00 – 11:15 am
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Discussion
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11:15 – 11:30 am
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Break
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Session XV: Lung Imaging with Hyperpolarized 129Xe
Moderator: Rosa Tamara Branca, Ph.D.
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11:30 – 11:45 am
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Dissecting Pulmonary Gas Exchange and Hemodynamics with 129Xe MRI
Bastiaan Driehuys, Ph.D.
Duke University
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11:45 – 12:00 am
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Combining HP 129Xe and UTE MRI with Proteomics to Phenotype Cystic Fibrosis Lung Disease
Zackary I. Cleveland, Ph.D.
Cincinnati Children's Hospital Medical Center
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12:00 – 12:15 pm
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Sensing the Heat with Spin Polarized 129Xe
Rosa Tamara Branca, Ph.D.
University of North Carolina at Chapel Hill
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12:15 – 12:30 pm
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How to Capture an Atom: Developing Molecular Sensors with Useful Xenon-binding Properties
Ivan Dmochowski, Ph.D.
University of Pennsylvania
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12:30 – 12: 45 pm
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Role of 129Xe MRI in Determining the Significance of Pulmonary Pathology in Challenging Cases (Examples of COPD, E-cigarette, and Aging)
Y. Michael Shim, M.D.
University of Virginia
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12:45 – 1:00 pm
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129Xe MRI Phenotypes of Post-HSCT Pulmonary Complications
Laura L. Walkup, Ph.D.
Cincinnati Children's Hospital Medical Center
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1:00 – 1:15 pm
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Assessing Lung Structure via Hyperpolarized 129Xe MR Spectroscopy: Peeking into Peaks
Kai Ruppert, Ph.D.
University of Pennsylvania
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1:15 – 1:30 pm
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Discussion
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1:30 – 2:15 pm
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Lunch
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Session XVI: COPD and AI
Moderator: Sean B. Fain, Ph.D.
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2:15 – 2:30 pm
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Data Harmonization on Large Cohorts of Lung CT Scans
Andrew F. Laine, Ph.D.
Columbia University
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2:30 – 2:45 pm
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Image-based Multiscale Modeling of the Lung to Quantify Regional Mechanical Stress In Vivo
Reza Avaz, Ph.D.
Texas A&M University
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2:45 – 2:55 pm
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Dynamic Imaging of the Lung with Hyperpolarized 129Xe
Hooman Hamedani, Ph.D.
University of Pennsylvania
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2:55 – 3:05 pm
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Airway Aerodynamics: MRI-based Modeling and Validation
Alister Bates, Ph.D.
Cincinnati Children's Hospital Medical Center
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3:05 – 3:15 pm
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AI-based Detection of COPD on Computed Tomography
Sandeep Bodduluri, Ph.D.
University of Alabama at Birmingham
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3:15 – 3:30pm
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Discussion
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3:30 – 3:45 pm
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Break
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Session XVII: Lung Imaging with 19F
Moderator: Brandon Zanette, Ph.D.
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3:45 – 4:00 pm
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19F Lung Imaging with Octafluorocyclobutane
Mitchell Albert, Ph.D.
Thunder Bay Regional Health Research Institute, Canada
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4:00 – 4:15 pm
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Imaging Change in Ventilation Properties with 19F-MRI: Quantitative, Repeatable and Accessible Imaging of Lung Function
Peter Thelwall, Ph.D.
Newcastle University, U.K.
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4:15 – 4:30 pm
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Beyond FEV1: Dynamic Perfluorinated Gas MRI in Cystic Fibrosis
Jennifer Goralski, M.D.
University of North Carolina at Chapel Hill
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4:30 – 4:45 pm
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Discussion
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Session XVIII: Clinical Translation and Latest Technical Developments
Moderator: G. Wilson Miller, Ph.D.
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4:45 – 5:00 pm
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Late Breaking News: FDA Approval and Launch of Hyperpolarized Xenon MRI
Alex Dusek, Chief Commercial Officer
Polarean
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5:00 – 5:15 pm
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Next-generation Gas Hyperpolarization and HP Imaging on Point-of-care MRI Scanners
Boyd Goodson, Ph.D.
Southern Illinois University
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5:15 – 5:30 pm
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Next-generation Enabling Hyperpolarized Clinical Technologies Using Parahydrogen
Eduard Chekmenev, Ph.D.
Wayne State University
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5:30 – 5:45 pm
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Closing Remarks
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5:45 pm
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Adjourn
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