Perelman School of Medicine at the University of Pennsylvania

The 2019 International Workshop on Pulmonary Imaging

Scientific Program

Download a PDF copy of the program brochure
Download a PDF copy of the scientific abstracts
 

Thursday, February 28th, 2019

7:00 – 7:50 am
Continental Breakfast and Registration
7:50 – 8:00 am
Introductory Remarks
Rahim R. Rizi, Ph.D.
University of Pennsylvania
8:00 – 8:10 am
Welcome Remarks
Mitchell D. Schnall, M.D., Ph.D.
University of Pennsylvania
Session I: Keynote Lectures – Part I
Moderator: Rahim R. Rizi, Ph.D.
8:10 – 8:25 am
Advances in Pulmonary Imaging: An NHLBI Perspective
Lisa Postow, Ph.D.
National Institutes of Health
8:25 – 8:45 am
COPD – Functional Imaging for the Surgeon
Joel D. Cooper, M.D.
University of Pennsylvania
8:45 – 9:05 am
To Enable Artificial Intelligence, Don’t Forget the Human
Geoffrey D. Rubin, M.D.
Duke University
9:05 – 9:25 am
Advances in CT Serving to Provide Lung Structure-Function Relationships with High Resolution and Ultra-low Dose
Eric Hoffman, Ph.D.
University of Iowa
9:25 – 9:40 am
Discussion
9:40 – 9:55 am
Break
Session II: Keynote Lectures – Part II
Moderators: John Mugler, Ph.D. and Sean B. Fain, Ph.D.
9:55 – 10:15 am
PET/CT Approaches to Guide Lung Cancer Treatment – FDG and Beyond
David Mankoff, M.D., Ph.D.
University of Pennsylvania
10:15 – 10:35 am
3D Confocal Microscopic Imaging in Mouse Models of Emphysema
Wayne Mitzner, Ph.D.
Johns Hopkins University
10:35 – 10:55 am
AI in CT Analysis of New Emphysema Sub-types
R. Graham Barr, M.D., Ph.D.
Columbia University
10:55 – 11:15 am
Emerging Role of Machine Learning in Evaluation of Pulmonary Nodules: Opportunities and Challenges
Warren B. Gefter, M.D.
University of Pennsylvania
11:15 – 11:35 am
Native Airway Tree Structure and Chronic Obstructive Pulmonary Disease
Benjamin M. Smith, M.D.
McGill University, Canada
11:35 – 11:55 am
CT and MRI of Mucous Plugs in Asthma: Consequences for the Small Airways
Mark L. Schiebler, M.D.
University of Wisconsin
11:55 am – 12:10 pm
Discussion
12:10 – 1:00 pm
Lunch
Session III: Graduate Student and Postdoctoral Presentations – Part I
Moderator: Kai Ruppert, Ph.D.
1:00 – 1:10 pm
Imaging Ventilation Inhomogeneity Using Hyperpolarized Gas MRI
Hooman Hamedani
University of Pennsylvania
1:10 – 1:20 pm
Accelerated MRI Approaches for Gas Exchange Mapping
Brandon Zanette, Ph.D.
The Hospital for Sick Children (SickKids), Canada
1:20 – 1:30 pm
Hyperpolarized 3He MRI for Lung Ventilation Imaging in Asthmatic Subjects: Calculating the Temporal Effect of Inhaled Beta-agonists and Inter-user Variability
Ummul A. Shammi
University of Missouri
1:30 – 1:40 pm
Quantification of Neonatal Dynamic Tracheal Collapse Via UTE MRI, with Correlation to Later Tracheostomy in Bronchopulmonary Dysplasia
Nara S. Higano, Ph.D.
Cincinnati Children’s Hospital
1:40 – 1:50 pm
Imaging Bronchoconstriction Using Oxygen Enhanced Proton MRI – A Quantitative Biomarker for Asthma
Rui Carlos Sa, Ph.D.
University of California, San Diego
1:50 – 2:00 pm
Iterative Static Motion Compensated (IS-MoCo) Reconstruction: Application to High Resolution Lung Imaging
Xucheng Zhu
University of California, San Francisco
2:00 – 2:10 pm
Discussion
2:10 – 2:20 pm
Break
Session IV: Quantitative Lung Imaging and Its Therapeutic Application
Moderator: Jim Wild, Ph.D.
2:20 – 2:40 pm
Quantitative Imaging Parameters from Hyperpolarized-gas MRI: Where Do We Stand with Validation?
John Mugler, Ph.D.
University of Virginia
2:40 – 3:00 pm
 
Quantitative Imaging of Lung Function with Proton MRI in Normal Subjects and Patients with Lung Disease
Susan Hopkins, M.D., Ph.D.
University of California, San Diego
3:00 – 3:20 pm
 
Delivering on the Promise of Regional Functional Lung Imaging
Andreas Fouras, Ph.D.
Monash University, Australia
3:20 – 3:40 pm
Molecular Imaging-guide Intratumoral Radiofrequency Hyperthermia-enhanced Direct Gene Therapy for NSCLC
Xiaoming Yang, M.D., Ph.D.
University of Washington
3:40 – 3:50 pm
Discussion
3:50 – 4:05 pm
Break
Session V: Pulmonary Fibrosis: Biology and Imaging
Moderators: Warren B. Gefter, M.D. and Michael F. Beers, M.D.
4:05 – 4:25 pm
 
Idiopathic Pulmonary Fibrosis: Diffuse Lung Injury Modified by Lung Mechanics
Jeffrey Galvin, M.D.
University of Maryland
4:25 – 4:40 pm
New Insights and Emerging Paradigms for Better Understanding Idiopathic Pulmonary Fibrosis: Lessons from Rare Human Mutations and Novel Preclinical Models
Michael F. Beers, M.D.
University of Pennsylvania
4:40 – 4:55 pm
 
Type I Collagen Targeted Imaging of Pulmonary Fibrosis: Initial Human Experience
Peter Caravan, Ph.D.
Massachusetts General Hospital
4:55 – 5:10 pm
Functional and Structural Hyperpolarized Gas and 1H MRI in the Assessment of Disease Progression and Change in IPF
Jim Wild, Ph.D.
Sheffield University, United Kingdom
5:10 – 5:25 pm
Imaging Dissolved Phase Hyperpolarized 129Xe MRI: Applications in Pulmonary Fibrosis
Sean B. Fain, Ph.D.
University of Wisconsin, Madison
5:25 – 5:40 pm
Tracking CCR2 Monocytes in Lung Fibrosis with PET/CT
Delphine L. Chen, M.D.
St. Louis Children’s Hospital
5:40 – 5:55 pm
Micro CT of Ex-vivo Whole Lungs in IPF
John McDonough, Ph.D.
Leuven University, Belgium
5:55 – 6:10 pm
Discussion
6:10 – 8:00 pm
Poster Session and Reception
 

Friday, March 1st, 2019

7:00 – 7:45 am
Continental Breakfast
Session VI: Genetics and Omics of COPD & Risk of Rapid Progression in COPD 
Moderator: James D. Crapo, M.D.
7:45 – 8:00 am
Introduction to COPDGene
James D. Crapo, M.D.
National Jewish Health
8:00 – 8:15 am
Genetic Findings in COPDGene
Edwin K. Silverman, M.D., Ph.D.
Brigham and Women’s Hospital
8:15 – 8:30 am
RNA-Seq Findings in COPD
Peter J. Castaldi, M.D.
Brigham and Women’s Hospital
8:30 – 8:45 am
CT-Based Patterns: Relationship to Progression and Mortality
David Lynch, M.D.
National Jewish Health
8:45 – 9:00 am
Quantitative Imaging of Interstitial Abnormalities
Samuel Ash, M.D.
Harvard University
9:00 – 9:15 am
Quantitative CT in COPD: Findings from the CanCOLD Study
Miranda Kirby, Ph.D.
Ryerson University, Canada
9:15 – 9:30 am
Detecting Progression of Airway Disease in COPD
Jean-Paul Charbonnier, Ph.D.
Radboud University, Netherlands
9:30 – 9:45 am
Discussion
9:45 – 10:00 am
Break
Session VII: Machine Learning and Deep Learning – Imaging in COPD
Moderator: David Lynch, M.D.
10:00 – 10:15 am
Deep Learning in Characterizing Emphysema
Stephen M. Humphries, Ph.D.
National Jewish Health
10:15 – 10:30 am
Clinical Relevance of Multidimensional Diseases Axes: Application of Unsupervised Factor Analysis in COPD
John Hokanson, Ph.D.
University of Colorado 
10:30 – 10:45 am
Imaging Analysis in Smoking-Related Lung Cancer
Jessica C. Sieren, Ph.D.
University of Iowa
10:45 – 11:00 am
Pulmonary Vascular Destruction in COPD
Farbod N. Rahaghi, M.D., Ph.D.
Brigham and Women’s Hospital
11:00 – 11:15 am
Characterizing Air Trapping on Expiratory CT Scans
Craig J. Galbán, Ph.D.
University of Michigan
11:15 – 11:30 am
Deep Learning to Support Lung Segmentation
Joseph Reinhardt, Ph.D.
University of Iowa
11:30 – 11:45 am
Central Airway Abnormalities in COPD
Surya P. Bhatt, M.D.
University of Alabama, Birmingham
11:45 am – 12:00 pm
Parametric Response Mapping of Small Airway Disease in COPD
MeiLan Han, M.D.
University of Michigan
12:00 – 12:15 pm
Discussion
12:15 – 1:05 pm
Lunch
Session VIII: Comorbidities of COPD
Moderator: John Hokanson, Ph.D.
1:05 – 1:20 pm
Correlating Cardiovascular Disease in COPD
Greg Kinney, Ph.D.
University of Colorado
1:20 – 1:35 pm
 
Evaluation of Extrapulmonary Disease in COPD
Alejandro A. Diaz, M.D.
Harvard University
1:35 – 1:50 pm
Bone Disease in COPDGene
Elizabeth Regan, M.D., Ph.D.
National Jewish Health
1:50 – 1:55 pm
Discussion
Session IX: Graduate Student and Postdoctoral Presentations – Part II
Moderators: Hooman Hamedani and Faraz Amzajerdian
1:55 – 2:05 pm
CT Ventilation Imaging Evaluation 2019 (CTVIE19): An AAPM Grand Challenge
Bilal Tahir, Ph.D. 
Sheffield University, United Kingdom
2:05 – 2:15 pm
Voxel-wise Measurement of Lung Inflation Changes in Prone vs. Supine Positions in Pigs with Lung Injury
Yi Xin
University of Pennsylvania
2:15 – 2:25 pm
Jacobian Based Ventilation Derived from Lung Proton MRI: Correlation with Ventilation Defects on Hyperpolarized Gas MRI
Katherine J. Carey
University of Wisconsin, Madison
2:25 – 2:35 pm
Toward 4D MRI of Lung Biomechanics: Highly Accelerated Dynamic Acquisition of 3D Grid-tagged He-3 Lung Images Using Compressed Sensing
William J. Garrison
University of Virginia
2:35 – 2:45 pm
Distinguishing Cystic Fibrosis Severity Using Dynamic 19F Lung MR Imaging
Sang Hun Chung
University of North Carolina, Chapel Hill
2:45 – 2:50 pm
Discussion
2:50 – 3:05 pm
Break
Session X: Imaging Pulmonary Structure and Function
Moderator: Susan Hopkins, M.D., Ph.D.
3:05 – 3:20 pm
Can Imaging Better Elucidate Airway Structure In Vivo?
Robert Brown, M.D.
Johns Hopkins University
3:20 – 3:35 pm
 
Potential of Hyperpolarized Gas MRI: What Has this Field Achieved so Far?
Talissa A. Altes, M.D.
University of Missouri
3:35 – 3:50 pm
Observing Pulmonary Function in Real Time Using Hyperpolarized 129Xe MRI
Kai Ruppert, Ph.D.
University of Pennsylvania
3:50 – 4:05 pm
Deterioration of Regional Lung Strain and Inflammation during Mechanical Ventilation Studied with PET/CT
Marcos Vidal Melo, Ph.D.
Massachusetts General Hospital
4:05 – 4:20 pm
Unstable Inflation and Personalized Care in ARDS
Maurizio Cereda, M.D.
University of Pennsylvania
4:20 – 4:35 pm
Inhaled Gas MR Imaging of Severe Asthma
Sarah Svenningsen, Ph.D.
McMaster University, Canada
4:35 – 4:45 pm
Discussion
4:45 – 5:00 pm
Break
Session XI: Assessment of Pediatric Pulmonary Disorders
Moderators: Giles Santyr, Ph.D., and Joseph Piccione, M.D.
5:00 – 5:15 pm
Pediatric Pulmonary Imaging with 1H MRI: Initial Experience
Peder Larson, Ph.D.
University of California, San Francisco
5:15 – 5:30 pm
The Role of Lung Imaging in Cystic Fibrosis
Jennifer Goralski, M.D.
University of North Carolina
5:30 – 5:45 pm
Pulmonary MRI in the Neonate: Phenotyping and Outcomes Prediction
Jason Woods, Ph.D.
Cincinnati Children’s Hospital
5:45 – 6:00 pm
Hyperpolarized 129Xe MRI of Pediatric CF Lung Disease
Marcus Couch, Ph.D.
The Hospital for Sick Children (SickKids), Canada
6:00 – 6:15 pm
Spatial Identification and Longitudinal Monitoring of Lung Abnormalities with Proton MRI in Adults with Cystic Fibrosis
Rebecca Theilman, Ph.D.
University of California, San Diego
6:15 – 6:30 pm
Fourier Decomposition MRI in CF
Sylvia Nyilas, Ph.D.
University of Bern, Switzerland
6:30 – 6:45 pm
Discussion
 

Saturday, March 2nd, 2019

7:00 – 8:00 am
Continental Breakfast
Session XII: Imaging of Lung Transplant and Cell Therapy
Moderator: Joel D. Cooper, M.D.
8:00 – 8:15 am
Clinical and Experimental Approaches to Improving Outcomes in Lung Transplantation
Wayne Hancock, Ph.D.
University of Pennsylvania
8:15 – 8:30 am
Lung Transplantation: Donor Risk Assessment and Therapies
Edward Cantu, M.D.
University of Pennsylvania
8:30 – 8:45 am
Improved Early Detection and Classification of CLAD with Integrated Imaging Approach
Rahim R. Rizi, Ph.D.
University of Pennsylvania
8:45 – 9:00 am
Limitations and Opportunities for Improvement in Diagnosing Chronic Rejection After Lung Transplantation 
Joshua Diamond, M.D.
University of Pennsylvania
9:00 – 9:15 am
Imaging of Stem Cell Therapies for Lung Injury Using Novel Hyperpolarized MRI Approaches
Giles Santyr, Ph.D.
The Hospital for Sick Children (SickKids), Canada
9:15 – 9:30 am
Early Lung Ventilation Abnormalities in Pediatric Hematopoietic Stem-cell Transplantation
Laura Walkup, Ph.D.
Cincinnati Children’s Hospital
9:30 – 9:45 am
Discussion
9:45 – 10:00 am
Break
Session XIII: MRI-Based Approaches: Which Nuclei is Best?
Moderator: Rahim R. Rizi, Ph.D.
10:00 – 10:15 am
Correlating Lung Function from Hyperpolarized 129Xe MRI with Underlying Biomolecular Perturbations
Y. Michael Shim, M.D.
University of Virginia
10:15 – 10:30 am
Using Hyperpolarized 129Xe MRI to Diagnose and Monitor Pulmonary Vascular Disease
Bastiaan Driehuys, Ph.D.
Duke University
10:30 – 10:45 am
Phase Resolved Functional Lung (PREFUL) MRI: Technique and Clinical Application
Jens Vogel-Claussen, M.D.
Hannover Medical School, Germany
10:45 – 11:00 am
Assessing Lung Structural and Functional Properties with 19F-MRI of Inhaled Fluorocarbon Gas
Pete Thelwall, Ph.D.
Newcastle University, United Kingdom
11:00 – 11:15 am
Pulmonary MRI Using Hyperpolarized and Inert Gases and Xenon Biosensor MRI
Mitchell Albert, Ph.D.
Thunder Bay Regional Research Institute, Canada
11:15 – 11:30 am
Quantifying Hyperpolarized 129Xe Dynamics in the Lungs with 3D Radial Keyhole Imaging
Zackary I. Cleveland, Ph.D.
Cincinnati Children’s Hospital
11:30 – 11:45 am
Validation of Accelerated Lung Morphometry Using Single and Multi-breath 129Xe MRI
Alexei Ouriadov, Ph.D.
Western University, Canada
11:45 am – 12:00 pm
Quantitative Imaging of Gas Uptake and Delivery to Tissues in the Free-Breathing Animal
Stephen Kadlecek, Ph.D.
University of Pennsylvania
12:00 – 12:15 pm
Discussion
12:15 – 1:05 pm
Lunch
Session XIV: Graduate Student and Postdoctoral Presentations – Part III
Moderators: Sarmad Siddiqui and Mehrdad Pourfathi
1:05 – 1:15 pm
Association Between CT-derived Emphysema/Small Airway Disease and MRI-derived Assessments of Lung Functionality in Advanced COPD Subjects
Ryan Baron
University of Pennsylvania
1:15 – 1:25 pm
Dynamic Contrast-enhanced (DCE) MRI of Patients with Idiopathic Pulmonary Fibrosis
Iris Y. Zhou, Ph.D.
Massachusetts General Hospital
1:25 – 1:35 pm
Finite Element Simulations of Hyperpolarised Gas Diffusion MRI in Micro CT Models of the Lung – Linking Imaging and Models at Different Length Scales
Fung Chan
University of Sheffield, United Kingdom
1:35 – 1:45 pm
A Diagnostic Algorithm for Detecting Pulmonary Arterial Hypertension Using Hyperpolarized 129Xe MRI
Ziyi Wang
Duke University
1:45 – 1:55 pm
Theoretical Model of the Effect of Superparamagnetic Iron-oxide Nanoparticles on the Apparent Relaxation of 129Xe in the Lungs
Vlora Riberdy
The Hospital for Sick Children (SickKids), Canada
1:55 – 2:05 pm
Discussion
2:05 – 2:15 pm
Break
Session XV: Producing Hyperpolarized Gas
Moderator: Stephen Kadlecek, Ph.D.
2:15 – 2:30 pm
 
New Developments in 129Xe and 131Xe Hyperpolarization via Clinical-Scale Stopped-Flow Spin-Exchange Optical Pumping
Boyd Goodson, Ph.D.
Southern Illinois University
2:30 – 2:45 pm
Hyperpolarized Propane: Clinical-scale Production of Long Lived Spin States, Condensation, and Imaging
Eduard Chekmenev, Ph.D.
Wayne State University
2:45 – 3:00 pm
Current Status of Commercial HP Xenon Technology, Dissemination and Regulatory Approval
Kiarash Emami, Ph.D.
Polarean Imaging PLC
3:00 – 3:15 pm
Recent Innovations in Hyperpolarized Xenon Production
F. William Hersman, Ph.D.
Xemed LLC
3:15 – 3:30 pm
High Throughput 129Xe SEOP Polarizer
Graham Norquay, Ph.D.
University of Sheffield, United Kingdom
3:30 – 3:40 pm
Discussion
3:40 – 3:45 pm
Final Remarks
Stephen Kadlecek, Ph.D.
University of Pennsylvania