Olenick, M.A., Dominguez, R., and Holzbaur, E.L.F. (2019) Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons. J. Cell Biol. 218(1):220-233.
Guedes-Dias, P., Nirschl, J.F., Abreu, N.C., Tokito, M.K., Magiera, M.M., Janke, C., and Holzbaur, E.L.F. (2019) Kinesin-3 responds to local microtubule dynamics to target synaptic cargo delivery to the presynapse. Curr. Bio. 29:1-15.
Twelvetrees, A.E., Lesept, F., Holzbaur, E.L., and Kittler, J.T. (2019) The adaptor proteins HAP1a and GRIP1 collaborate to activate kinesin-1 isoform KIF5C. J Cell Sci, in press.
Hoshino, A., Wang, W.-J., Wada, S., McDermott-Roe, C., Evans, C.S., Gosis, B., Morley, M.P., Rathi, K.S., Li, J., Li, K., Yang, S., McManus, M.J., Bowman, C., Potluri, P., Levin, M., Damrauer, S., Wallace, D.C., Holzbaur, E.L., Arany, Z. (2019) The ADP/ATP translocase drives mitophagy independent of nucleotide exchange. Nature 575: 375-379.
Boecker, C.A., Olenick, M.A., Gallagher, E.R., Ward, M.E., and Holzbaur, E.L. (2019) Toolbox: live imaging of intracellular organelle transport in induced pluripotent stem cell-derived neurons. Traffic 21:138-155.
Stavoe, K.H., Gopal, P.P., Gubas, A., Tooze, S.A., Holzbaur, E.L. (2019) Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons. Elife 8:e44219.
Olenick, M.A. and Holzbaur, E.L. (2019) Dynein activators and adaptors at a glance. J. Cell Sci. 132, pii: jcs227132.
Boecker, C.A. and Holzbaur, E.L. (2019) Vesicular degradation pathways in neurons: at the crossroads of autophagy and endo-lysosome degradation. Curr Opin Neurobiol. 57: 94-101.
Moore, A.S. and Holzbaur, E.L. (2019) Imaging the dynamics of mitophagy in live cells. Methods Mol Bio. 1880:601-610.
Stavoe, A.K., and Holzbaur, E.L. (2019) Autophagy in neurons. Ann Rev Cell Dev Bio, in press.
Guedes-Dias, P., and Holzbaur, E.L. (2019) Axonal transport: driving synaptic function. Science 366:eaaw9997.
2018
McIntosh, B.B., Pyrpassopoulos, S., Holzbaur, E.L.F., and Ostap, E.M. (2018) Opposing kinesin and myosin-I motors drive membrane deformation and tubulation along engineered cytoskeletal networks. Curr. Bio. 28:236-248.
Lee, I.G., Olenick, M.A., Boczkowska, M., Franzini-Armstrong, C., Holzbaur, E.L.F., and Dominguez, R. (2018) A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity. Nat. Commun. 9:986.
Sweeney, H.L., and Holzbaur, E.L. (2018) Motor proteins. Cold Spring Harb Perspect Biol. 10, pii: a021931.
Stavoe, A.K.H., and Holzbaur, E.L. (2018) Axonal autophagy: mini-review for autophagy in the CNS. Neurosci. Lett. 18:30194.
Guedes-Dias, P., and Holzbaur, E. L.F. (2017) Huntingtin fibrils poke membranes. Cell 171:32-33.
Evans, C.S., and Holzbaur, E.L.F. (2018) Autophagy and mitophagy in ALS. Neurobiol. Dis. 122:35-40.
Moore, A.S., and Holzbaur, E.L. (2018) Mitochondrial-cytoskeletal interactions: dynamic associations that facilitate network function and remodeling. Curr. Opin. Physiol. 3:94-100.
Stavoe, A.K.H., and Holzbaur, E.L. (2018) What doesn’t kill you makes you stronger. Dev. Cell 47:402-403.
Klinman, E. and Holzbaur, E.L. (2018) Walking forward with kinesin. Trends Neurosci. 41:555-556.
2017
Gopal, P.P., Nirschl, J.J., Klinman, E., and Holzbaur, E.L. (2017) Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons. Proc. Natl. Acad. Sci. 114:E2466-E2475.
Lippert, L.G., Dadosh, T., Hadden, J.A., Karanwat, V., Diroll, B.T., Murray, C.B., Holzbaur, E.L., Schulten, K., Reck-Peterson, S.L., and Goldman, Y.E. (2017) Angular measurements of the dynein ring reveal a stepping mechanism dependent on a flexible stalk. Proc. Natl. Acad. Sci. 114:E4564-4573.
Ayloo, S., Guedes-Dias, P., Ghiretti, A.E., and Holzbaur, E.L. (2017) Dynein efficiently navigates the dendritic cytoskeleton to drive the retrograde trafficking of BDNF/TrkB signaling endosomes. Mol. Biol. Cell 28:2543-2554.
Klinman, E., Tokito, M., and Holzbaur, E.L.F. (2017) CDK5-dependent activation of dynein in the axon initial segment regulates polarized cargo transport in neurons. Traffic 18:808-824.
Nirschl, J.J., Ghiretti, A.E., and Holzbaur, E.L. (2017) The impact of cytoskeletal organization on the local regulation of neuronal transport. Nature Reviews Neurosci. 18:585-597.
2016
Ghiretti, A.E., Thies, E., Tokito, M.K., Lin, T., Ostap, E.M., Kneussel, M., and Holzbaur, E.L. (2016) Activity dependent regulation of distinct transport and cytoskeletal remodeling functions of the dendritic kinesin KIF21B.Neuron 92, 857-72.
Moore, A.S., Wong, Y.C., Simpson, C.L., and Holzbaur, E.L. (2016) Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission-fusion balance within mitochondrial networks.Nat. Commun. 7, 12886.
Moore, A.S., and Holzbaur, E.L. (2016) Spatiotemporal dynamics of autophagy receptors in selective mitophagy. Autophagy 12, 1956-7.
Olenick, M.A., Tokito, M., Boczkowska, M., Dominguez, R., and Holzbaur, E.L. (2016) Hook adaptors induce unidirectional processive motility by enhancing the dynein-dynactin interaction. J. Biol. Chem. 291, 18239-51.
Maday, S., and Holzbaur, E.L. (2016). Compartment-specific regulation of autophagy in primary neurons. J Neurosci 36, 5933-5945.
Moore, A.S., and Holzbaur, E.L. (2016). Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy. Proc Natl Acad Sci U S A 113, E3349-3358.
Twelvetrees, A.E., Pernigo, S., Sanger, A., Guedes-Dias, P., Schiavo, G., Steiner, R.A., Dodding, M.P., and Holzbaur, E.L. (2016). The Dynamic Localization of Cytoplasmic Dynein in Neurons Is Driven by Kinesin-1. Neuron 90, 1000-1015.
Wilson, M.H., Bray, M.G., and Holzbaur, E.L. (2016). Methods for Assessing Nuclear Rotation and Nuclear Positioning in Developing Skeletal Muscle Cells. Methods Mol Biol 1411, 269-290.
Muhia, M., Thies, E., Labonte, D., Ghiretti, A.E., Gromova, K.V., Xompero, F., Lappe-Siefke, C., Hermans-Borgmeyer, I., Kuhl, D., Schweizer, M., et al. (2016). The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory. Cell Rep 15, 968-977.
Nirschl, J.J., Ghiretti, A.E., and Holzbaur, E.L. (2016). Lipid Rafts Assemble Dynein Ensembles. Trends Biochem Sci 41, 393-394.
Nirschl, J.J., Magiera, M.M., Lazarus, J.E., Janke, C., and Holzbaur, E.L. (2016). alpha-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons. Cell Rep 14, 2637-2652.
Klinman, E., and Holzbaur, E.L. (2016). Comparative analysis of axonal transport markers in primary mammalian neurons. Methods Cell Biol 131, 409-424.
Nirschl, J.J., and Holzbaur, E.L. (2016). Live-cell imaging of retrograde transport initiation in primary neurons. Methods Cell Biol 131, 269-276.
2015
Klinman, E., and Holzbaur, E.L. (2015). Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein. Cell Rep 12, 462-473.
Kast, D.J., Zajac, A.L., Holzbaur, E.L., Ostap, E.M., and Dominguez, R. (2015). WHAMM Directs the Arp2/3 Complex to the ER for Autophagosome Biogenesis through an Actin Comet Tail Mechanism. Curr Biol 25, 1791-1797.
Ayloo, S., and Holzbaur, E.L. (2015). Reconstitution of microtubule-based motility using cell extracts. Methods Cell Biol 128, 57-68.
Ballister, E.R., Ayloo, S., Chenoweth, D.M., Lampson, M.A., and Holzbaur, E.L. (2015). Optogenetic control of organelle transport using a photocaged chemical inducer of dimerization. Curr Biol 25, R407-408.
Wong, Y.C., and Holzbaur, E.L. (2015). Autophagosome dynamics in neurodegeneration at a glance. J Cell Sci 128, 1259-1267.
Wong, Y.C., and Holzbaur, E.L. (2015). Temporal dynamics of PARK2/parkin and OPTN/optineurin recruitment during the mitophagy of damaged mitochondria. Autophagy 11, 422-424.
McIntosh, B.B., Holzbaur, E.L., and Ostap, E.M. (2015). Control of the initiation and termination of kinesin-1-driven transport by myosin-Ic and nonmuscle tropomyosin. Curr Biol 25, 523-529.
Ballister, E. R., Ayloo, S., Chenoweth, D. M., Lampson, M. A., and Holzbaur, E. L. (2015) Optogenetic control of organelle transport using a photocaged chemical inducer of dimerization.Curr. Biol 25, R407-8.
Wong, Y. C., and Holzbaur, E. L. (2015) Autophagosome dynamics in neurodegeneration at a glance.J. Cell Sci. 128:1259-67.
Wong, Y. C. and Holzbaur, E. L. (2015) Temporal dynamics of PARK2/parkin and OPTN/optineurin recruitment during the mitophagy of damaged mitochondria.Autophagy 11:422-4.
McIntosh, B. B., Holzbaur, E. L., and Ostap, E. M. (2015) Control of the initiation and termination of kinesin-1-driven transport by myosin-Ic and nonmuscle tropomyosin.Curr. Biol. 25:523-9.
Wilson, M. H., and Holzbaur, E. L. (2015) Nesprins achor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.Development 142:218-28.
2014
Wong, Y.C. and Holzbaur, E.L. (2014) Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation.Proc. Natl. Acad. Sci. USA 111: E4439-48.
Ayloo, S., Lazaru, J.E., Dodda, A., Tokito, M., Ostap, E.M., and Holzbaur, E.L. (2014) Dynactin functions as both a dynamic tether and brake during dynein-driven motility. Nat. Commun. 5, 4807.
Maday, S. and Holzbaur, E. L. (2014) Autophagosome biogenesis in primary neurons follows an ordered and spatially regulated pathway.Dev. Cell 30, 71-85.
Fu, M.-M. and Holzbaur, E. L. (2014) Integrated regulation of motor-driven organelle transport by scaffolding proteins. Trends in Cell Biology 24, 564-74.
Fu, M.-M., Nirschl, J. J., and Holzbaur, E. L. (2014) LC3 binding to the scaffolding protein JIP1 regulates processive dynein-driven transport of autophagosomes.Dev. Cell 29:577-90.
Wong, Y. C., and Holzbaur, E. L. (2014) The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.J. Neurosci. 34:1293-305.
Castle, M. J., Perlson, E., Holzbaur, E. L., and Wolfe, J. H. (2014) Long-distance axonal transport of AAV9 is driven by dynein and kinesin-2 and is trafficked in a highly motile Rab7-positive compartment.Mol. Ther. 22:554-66.
Castle, M. J., Gershenson, Z. T., Giles, A. R., Holzbaur, E. L., and Wolfe, J. H. (2014) Adeno-associated virus serotypes 1, 8, and 9 share conserved mechanisms for anterograde and retrograde transport.Hum. Gene Therapy 25, 705-20.
Fu, M.M., and Holzbaur, E.L. (2014) MAPK8IP1/JIP1 regulates the trafficking of autophagosomes in neurons. Autophagy 10, 2079-81.
Maday, S., Twelvetrees, A.E., Moughamian, AJ., and Holzbaur, E.L. (2014) Axonal transport: cargo-specific mechanisms of motility and regulation. Neuron 84, 292-309.
Mategazza, A.R., Zajac, A.L., Twelvetrees, A., Holzbaur, E.L., Amigorena, S., and Marks, M.S. (2014) TLR-dependent phagosome tubulation in dendritic cells promotes phagosome cross-talk to optimize MHC-II antigen presentation. Proc. Natl. Acad. Sci. USA 111, 15508-13.
Thom, C.S., Traxler, E.A., Khandros, E., Nickas, J.M., Zhou, O.Y., Lazarus, J.E., Silva, A.P., Prabhu, D., Yao, Y., Aribeana, C., Fuchs, S.Y., Mackay, J.P., Holzbaur, E.L., and Weiss, M.J. (2014) Trim58 degrades dynein and regulates terminal erythropoiesis. Dev. Cell 30, 688-700.
De La Cruz, E.M., and Holzbaur, E.L. (2014) Navigating the cell: how motors function in vivo. J Cell Sci 127:2997-8.
Hendricks, A.G., Goldman, Y.E., and Holzbaur, E.L. (2014) Reconstituting the motility of isolated intracellular cargoes. Methods Enzymol. 540, 249-62.