• Publications

Publications on PubMed 

Selected Publications, 2025

Autophagic stress activates distinct compensatory secretory pathways in neurons.

Palumbos SD, Popolow J, Goldsmith J, Holzbaur ELF. Proc Natl Acad Sci U S A. 2025 Jul 15;122(28):e2421886122. doi: 10.1073/pnas.2421886122. Epub 2025 Jul 7. PMID: 40623183 

 

Structural-functional characterization of the MIRO1-TRAK1 complex.

Ravitch EE, Baltrusaitis EE, Perez TA, Barrie KR, Fenton AR, Holzbaur ELF, Dominguez R.Nat Commun. 2025 Jul 4;16(1):6173. doi: 10.1038/s41467-025-61174-6. PMID: 40615373 

 

Mitophagy in Neurons: Mechanisms Regulating Mitochondrial Turnover and Neuronal Homeostasis.

Basak B, Holzbaur ELF.J Mol Biol. 2025 Apr 21:169161. doi: 10.1016/j.jmb.2025.169161. Online ahead of print. PMID: 40268233

 

Protocol for live imaging of axonal transport in iPSC-derived iNeurons.

Dou D, Holzbaur ELF, Boecker CA. STAR Protoc. 2025 Mar 21;6(1):103556. doi: 10.1016/j.xpro.2024.103556. Epub 2025 Jan 12. PMID: 39804773

 

Selected Publications, 2024

FMRP regulates MFF translation to locally direct mitochondrial fission in neurons.

Fenton AR, Peng R, Bond C, Hugelier S, Lakadamyali M, Chang YW, Holzbaur ELF, Jongens TA. Nat Cell Biol. 2024 Dec;26(12):2061-2074. doi: 10.1038/s41556-024-01544-2. PMID: 39548330 

 

Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27.

Gallagher ER, Oloko PT, Fitch TC, Brown EM, Spruce LA, Holzbaur ELF. Curr Biol. 2024 Dec 16;34(24):5739-5757.e8. doi: 10.1016/j.cub.2024.10.061. PMID: 39541976

 

Cell-to-cell tunnels rescue neurons from degeneration.

Riley JF, Holzbaur ELF. Nature. 2024 Oct;634(8032):38-40. doi: 10.1038/d41586-024-02862-z. PMID: 39261692

 

Visualization and Quantification of Organelle Axonal Transport in Cultured Neurons.

Aiken J, Holzbaur ELF. Methods Mol Biol. 2024;2831:219-234. doi: 10.1007/978-1-0716-3969-6_15. PMID: 39134853

 

ASCB statement of commitment to diversity, equity, and inclusion.

Murray SA, Holzbaur ELF, Munson M, Cimini D, Lane TF, Alvania R, Applewhite DA, Chang F, Chen EH, Earnshaw WC, Evans CS, Li R, Mierzwa BE, Oliver T, Segarra VA, Skop AR, Weaver LN, Asai DJ, Boyce M, Zavala ME, Hammonds-Odie L, Vigoreaux J. Mol Biol Cell. 2024 Aug 1;35(8):ed3. doi: 10.1091/mbc.E24-06-0244. PMID: 39037589 

 

A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy.

Tudorica DA, Basak B, Puerta Cordova AS, Khuu G, Rose K, Lazarou M, Holzbaur ELF, Hurley JH. J Cell Biol. 2024 Jul 1;223(7):e202309015. doi: 10.1083/jcb.202309015. Epub 2024 May 10.PMID: 38728007 

 

An interphase actin wave promotes mitochondrial content mixing and organelle homeostasis.

Coscia SM, Moore AS, Thompson CP, Tirrito CF, Ostap EM, Holzbaur ELF. Nat Commun. 2024 May 7;15(1):3793. doi: 10.1038/s41467-024-48189-1.PMID: 38714822 

 

Mitochondrially-associated actin waves maintain organelle homeostasis and equitable inheritance.

Coscia SM, Moore AS, Wong YC, Holzbaur ELF. Curr Opin Cell Biol. 2024 Jun;88:102364. doi: 10.1016/j.ceb.2024.102364. Epub 2024 Apr 30.PMID: 38692079 

 

Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery.

Aiken J, Holzbaur ELF. Curr Biol. 2024 Apr 22;34(8):1687-1704.e8. doi: 10.1016/j.cub.2024.03.010. Epub 2024 Mar 29.PMID: 38554708 

 

RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors.

Dou D, Aiken J, Holzbaur ELF. J Cell Biol. 2024 Jun 3;223(6):e202307092. doi: 10.1083/jcb.202307092. Epub 2024 Mar 21.PMID: 38512027 

 

Selected Publications, 2023

Interaction between the mitochondrial adaptor MIRO and the motor adaptor TRAK.

Baltrusaitis EE, Ravitch EE, Fenton AR, Perez TA, Holzbaur ELF, Dominguez R. J Biol Chem. 2023 Dec;299(12):105441. doi: 10.1016/j.jbc.2023.105441. Epub 2023 Nov 8.PMID: 37949220 

 

Axonal transport of autophagosomes is regulated by dynein activators JIP3/JIP4 and ARF/RAB GTPases.

Cason SE, Holzbaur ELF. J Cell Biol. 2023 Dec 4;222(12):e202301084. doi: 10.1083/jcb.202301084. Epub 2023 Nov 1.PMID: 37909920 

 

A kinesin-1 adaptor complex controls bimodal slow axonal transport of spectrin in Caenorhabditis elegans.

Glomb O, Swaim G, Munoz LLancao P, Lovejoy C, Sutradhar S, Park J, Wu Y, Cason SE, Holzbaur ELF, Hammarlund M, Howard J, Ferguson SM, Gramlich MW, Yogev S. Dev Cell. 2023 Oct 9;58(19):1847-1863.e12. doi: 10.1016/j.devcel.2023.08.031. PMID: 37751746 

 

Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling.

Harding O, Holzer E, Riley JF, Martens S, Holzbaur ELF. Mol Cell. 2023 Sep 7;83(17):3188-3204.e7. doi: 10.1016/j.molcel.2023.08.005.PMID: 37683611 

 

Aging Differentially Affects Axonal Autophagosome Formation and Maturation.

Tsong H, Holzbaur EL, Stavoe AK.Autophagy. 2023 Dec;19(12):3079-3095. doi: 10.1080/15548627.2023.2236485. PMID: 37464898 

 

SQSTM1/P62 promotes lysophagy via formation of liquid-like condensates maintained by HSP27.

Gallagher ER, Holzbaur ELF. Autophagy. 2023 Nov;19(11):3029-3030. doi: 10.1080/15548627.2023.2210943. PMID: 37194327 

 

Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes.

Dou D, Smith EM, Evans CS, Boecker CA, Holzbaur ELF. Cell Rep. 2023 May 30;42(5):112448. doi: 10.1016/j.celrep.2023.112448. Epub 2023 May 1.PMID: 37133994 

 

Myo19 tethers mitochondria to endoplasmic reticulum-associated actin to promote mitochondrial fission.

Coscia SM, Thompson CP, Tang Q, Baltrusaitis EE, Rhodenhiser JA, Quintero-Carmona OA, Ostap EM, Lakadamyali M, Holzbaur ELF. J Cell Sci. 2023 Mar 1;136(5):jcs260612. doi: 10.1242/jcs.260612. PMID: 36744380 

 

The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy.

Gallagher ER, Holzbaur ELF. Cell Rep. 2023 Feb 28;42(2):112037. doi: 10.1016/j.celrep.2023.112037. Epub 2023 Jan 25.PMID: 36701233 

 

Ensembles of human myosin-19 bound to calmodulin and regulatory light chain RLC12B drive multimicron transport.

Pollard LW, Coscia SM, Rebowski G, Palmer NJ, Holzbaur ELF, Dominguez R, Ostap EM. J Biol Chem. 2023 Feb;299(2):102906. doi: 10.1016/j.jbc.2023.102906. PMID: 36642185 

 

Neuronal Autophagy by the Numbers.

Cason SE, Mogre SS, Koslover EF, Holzbaur ELF. Autophagy Rep. 2023 Jan 11;2(1):2163091. doi: 10.1080/27694127.2022.2163091. eCollection 2023.PMID: 40395291 

 

Single-Molecule Studies of Motor Adaptors Using Cell Lysates.

Fenton AR, Cason SE, Holzbaur ELF. Methods Mol Biol. 2023;2623:97-111. doi: 10.1007/978-1-0716-2958-1_7.PMID: 36602682

 

Employing Live-Cell Imaging to Study Motor-Mediated Transport.

Cason SE, Fenton AR, Holzbaur ELF. Methods Mol Biol. 2023;2623:45-59. doi: 10.1007/978-1-0716-2958-1_3.PMID: 36602678

 

Selected Publications, 2022

Spatiotemporal analysis of axonal autophagosome-lysosome dynamics reveals limited fusion events and slow maturation.

Cason SE, Mogre SS, Holzbaur ELF, Koslover EF.Mol Biol Cell. 2022 Nov 1;33(13):ar123. doi: 10.1091/mbc.E22-03-0111. PMID: 36044338 

 

VAB-8 stops dynein in its tracks to regulate synaptic delivery.

Palumbos SD, Holzbaur ELF. Dev Cell. 2022 Aug 8;57(15):1789-1791. doi: 10.1016/j.devcel.2022.07.009.PMID: 35944475 

 

Selective motor activation in organelle transport along axons.

Cason SE, Holzbaur ELF. Nat Rev Mol Cell Biol. 2022 Nov;23(11):699-714. doi: 10.1038/s41580-022-00491-w. PMID: 35637414

 

ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function.

Baron DM, Fenton AR, Saez-Atienzar S, Giampetruzzi A, Sreeram A, Shankaracharya, Keagle PJ, Doocy VR, Smith NJ, Danielson EW, Andresano M, McCormack MC, Garcia J, Bercier V, Van Den Bosch L, Brent JR, Fallini C, Traynor BJ, Holzbaur ELF, Landers JE.Cell Rep. 2022 Apr 5;39(1):110598. doi: 10.1016/j.celrep.2022.110598.PMID: 35385738 Free PMC article.

 

Proteomic profiling shows mitochondrial nucleoids are autophagy cargo in neurons: implications for neuron maintenance and neurodegenerative disease.

Goldsmith J, Holzbaur ELF.Autophagy. 2022 Aug;18(8):2003-2005. doi: 10.1080/15548627.2022.2056865. PMID: 35343362 

 

Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons.

Goldsmith J, Ordureau A, Harper JW, Holzbaur ELF. Neuron. 2022 Mar 16;110(6):967-976.e8. doi: 10.1016/j.neuron.2021.12.029. PMID: 35051374 

 

Microtubule dynamics influence the retrograde biased motility of kinesin-4 motor teams in neuronal dendrites.

Masucci EM, Relich PK, Lakadamyali M, Ostap EM, Holzbaur ELF. Mol Biol Cell. 2022 May 15;33(6):ar52. doi: 10.1091/mbc.E21-10-0480. PMID: 34705476 

 

Selected Publications, 2021

Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy.

Strong LM, Chang C, Riley JF, Boecker CA, Flower TG, Buffalo CZ, Ren X, Stavoe AK, Holzbaur EL, Hurley JH. Elife. 2021 Sep 10;10:e70372. doi: 10.7554/eLife.70372.PMID: 34505572 

 

Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors.

Fenton AR, Jongens TA, Holzbaur ELF. Nat Commun. 2021 Jul 28;12(1):4578. doi: 10.1038/s41467-021-24862-7.PMID: 34321481 

 

Hyperactive LRRK2 kinase impairs the trafficking of axonal autophagosomes.

Boecker CA, Holzbaur ELF.Autophagy. 2021 Aug;17(8):2043-2045. doi: 10.1080/15548627.2021.1936933. PMID: 34110246 

 

ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy.

Harding O, Evans CS, Ye J, Cheung J, Maniatis T, Holzbaur ELF. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2025053118. doi: 10.1073/pnas.2025053118.PMID: 34099552

 

Cytoskeletal regulation guides neuronal trafficking to effectively supply the synapse.

Aiken J, Holzbaur ELF. Curr Biol. 2021 May 24;31(10):R633-R650. doi: 10.1016/j.cub.2021.02.024.PMID: 34033795 

 

Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway.

Cason SE, Carman PJ, Van Duyne C, Goldsmith J, Dominguez R, Holzbaur ELF. J Cell Biol. 2021 Jul 5;220(7):e202010179. doi: 10.1083/jcb.202010179. Epub 2021 May 20.PMID: 34014261 

 

Actin mixes up mitochondria for inheritance.

Moore AS, Holzbaur ELF. Nature. 2021 May 14. doi: 10.1038/d41586-021-01115-7.

 

Cega: a single particle segmentation algorithm to identify moving particles in a noisy system.

Masucci EM, Relich PK, Ostap EM, Holzbaur ELF, Lakadamyali M. Mol Biol Cell. 2021 Apr 19;32(9):931-941. doi: 10.1091/mbc.E20-11-0744. PMID: 33788586 

 

Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes.

Boecker CA, Goldsmith J, Dou D, Cajka GG, Holzbaur ELF. Curr Biol. 2021 May 24;31(10):2140-2154.e6. doi: 10.1016/j.cub.2021.02.061. Epub 2021 Mar 24.PMID: 33765413 

 

Actin cables and comet tails organize mitochondrial networks in mitosis.

Moore AS, Coscia SM, Simpson CL, Ortega FE, Wait EC, Heddleston JM, Nirschl JJ, Obara CJ, Guedes-Dias P, Boecker CA, Chew TL, Theriot JA, Lippincott-Schwartz J, Holzbaur ELF. Nature. 2021 Mar;591(7851):659-664. doi: 10.1038/s41586-021-03309-5.

 

NIX initiates mitochondrial fragmentation via DRP1 to drive epidermal differentiation.

Simpson CL, Tokito MK, Uppala R, Sarkar MK, Gudjonsson JE, Holzbaur ELF. Cell Rep. 2021 Feb 2;34(5):108689. doi: 10.1016/j.celrep.2021.108689.PMID: 33535046