Publications on PubMed 


Olenick, M.A., Dominguez, R., and Holzbaur, E.L.F. (2019) Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons.  J. Cell Biol. 218(1):220-233.

Guedes-Dias, P., Nirschl, J.F., Abreu, N.C., Tokito, M.K., Magiera, M.M., Janke, C., and Holzbaur, E.L.F. (2019) Kinesin-3 responds to local microtubule dynamics to target synaptic cargo delivery to the presynapse.  Curr. Bio. 29:1-15.

Twelvetrees, A.E., Lesept, F., Holzbaur, E.L., and Kittler, J.T. (2019) The adaptor proteins HAP1a and GRIP1 collaborate to activate kinesin-1 isoform KIF5C.  J Cell Sci, in press.

Hoshino, A., Wang, W.-J., Wada, S., McDermott-Roe, C., Evans, C.S., Gosis, B., Morley, M.P., Rathi, K.S., Li, J., Li, K., Yang, S., McManus, M.J., Bowman, C., Potluri, P., Levin, M., Damrauer, S., Wallace, D.C., Holzbaur, E.L., Arany, Z. (2019) The ADP/ATP translocase drives mitophagy independent of nucleotide exchange. Nature 575: 375-379.

Boecker, C.A., Olenick, M.A., Gallagher, E.R., Ward, M.E., and Holzbaur, E.L. (2019) Toolbox: live imaging of intracellular organelle transport in induced pluripotent stem cell-derived neurons. Traffic 21:138-155.

Stavoe, K.H., Gopal, P.P., Gubas, A., Tooze, S.A., Holzbaur, E.L. (2019) Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons. Elife 8:e44219.

Olenick, M.A. and Holzbaur, E.L. (2019) Dynein activators and adaptors at a glance. J. Cell Sci. 132, pii: jcs227132.

Boecker, C.A. and Holzbaur, E.L. (2019) Vesicular degradation pathways in neurons: at the crossroads of autophagy and endo-lysosome degradation.  Curr Opin Neurobiol. 57: 94-101.

Moore, A.S. and Holzbaur, E.L. (2019) Imaging the dynamics of mitophagy in live cells.  Methods Mol Bio. 1880:601-610.  

Stavoe, A.K., and Holzbaur, E.L. (2019) Autophagy in neurons. Ann Rev Cell Dev Bio, in press.

Guedes-Dias, P., and Holzbaur, E.L. (2019) Axonal transport: driving synaptic function. Science 366:eaaw9997.



McIntosh, B.B., Pyrpassopoulos, S., Holzbaur, E.L.F., and Ostap, E.M. (2018) Opposing kinesin and myosin-I motors drive membrane deformation and tubulation along engineered cytoskeletal networks.  Curr. Bio. 28:236-248.

Lee, I.G., Olenick, M.A., Boczkowska, M., Franzini-Armstrong, C., Holzbaur, E.L.F., and Dominguez, R. (2018) A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity.  Nat. Commun. 9:986.

Sweeney, H.L., and Holzbaur, E.L. (2018) Motor proteins. Cold Spring Harb Perspect Biol. 10, pii: a021931.

Stavoe, A.K.H., and Holzbaur, E.L. (2018) Axonal autophagy: mini-review for autophagy in the CNS.  Neurosci. Lett. 18:30194.

Guedes-Dias, P., and Holzbaur, E. L.F. (2017) Huntingtin fibrils poke membranes. Cell 171:32-33.

Evans, C.S., and Holzbaur, E.L.F. (2018) Autophagy and mitophagy in ALS.  Neurobiol. Dis. 122:35-40.

Moore, A.S., and Holzbaur, E.L. (2018) Mitochondrial-cytoskeletal interactions: dynamic associations that facilitate network function and remodeling. Curr. Opin. Physiol. 3:94-100.

Stavoe, A.K.H., and Holzbaur, E.L. (2018) What doesn’t kill you makes you stronger. Dev. Cell 47:402-403.

Klinman, E. and Holzbaur, E.L. (2018) Walking forward with kinesin. Trends Neurosci. 41:555-556.



Gopal, P.P., Nirschl, J.J., Klinman, E., and Holzbaur, E.L. (2017) Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons. Proc. Natl. Acad. Sci. 114:E2466-E2475.

Lippert, L.G., Dadosh, T., Hadden, J.A., Karanwat, V., Diroll, B.T., Murray, C.B., Holzbaur, E.L., Schulten, K., Reck-Peterson, S.L., and Goldman, Y.E. (2017) Angular measurements of the dynein ring reveal a stepping mechanism dependent on a flexible stalk.  Proc. Natl. Acad. Sci. 114:E4564-4573.

Ayloo, S., Guedes-Dias, P., Ghiretti, A.E., and Holzbaur, E.L. (2017) Dynein efficiently navigates the dendritic cytoskeleton to drive the retrograde trafficking of BDNF/TrkB signaling endosomes.  Mol. Biol. Cell 28:2543-2554.

Klinman, E., Tokito, M., and Holzbaur, E.L.F. (2017) CDK5-dependent activation of dynein in the axon initial segment regulates polarized cargo transport in neurons.  Traffic 18:808-824.

Nirschl, J.J., Ghiretti, A.E., and Holzbaur, E.L. (2017) The impact of cytoskeletal organization on the local regulation of neuronal transport.  Nature Reviews Neurosci. 18:585-597.



Ghiretti, A.E., Thies, E., Tokito, M.K., Lin, T., Ostap, E.M., Kneussel, M., and Holzbaur, E.L. (2016) Activity dependent regulation of distinct transport and cytoskeletal remodeling functions of the dendritic kinesin KIF21B.Neuron 92, 857-72.

Moore, A.S., Wong, Y.C., Simpson, C.L., and Holzbaur, E.L. (2016) Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission-fusion balance within mitochondrial networks.Nat. Commun. 7, 12886.

Moore, A.S., and Holzbaur, E.L. (2016) Spatiotemporal dynamics of autophagy receptors in selective mitophagy.  Autophagy 12, 1956-7.

Olenick, M.A., Tokito, M., Boczkowska, M., Dominguez, R., and Holzbaur, E.L. (2016) Hook adaptors induce unidirectional processive motility by enhancing the dynein-dynactin interaction.  J. Biol. Chem. 291, 18239-51.

Maday, S., and Holzbaur, E.L. (2016). Compartment-specific regulation of autophagy in primary neurons. J Neurosci 36, 5933-5945.

Moore, A.S., and Holzbaur, E.L. (2016). Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy. Proc Natl Acad Sci U S A 113, E3349-3358.

Twelvetrees, A.E., Pernigo, S., Sanger, A., Guedes-Dias, P., Schiavo, G., Steiner, R.A., Dodding, M.P., and Holzbaur, E.L. (2016). The Dynamic Localization of Cytoplasmic Dynein in Neurons Is Driven by Kinesin-1. Neuron 90, 1000-1015.

Wilson, M.H., Bray, M.G., and Holzbaur, E.L. (2016). Methods for Assessing Nuclear Rotation and Nuclear Positioning in Developing Skeletal Muscle Cells. Methods Mol Biol 1411, 269-290.

Muhia, M., Thies, E., Labonte, D., Ghiretti, A.E., Gromova, K.V., Xompero, F., Lappe-Siefke, C., Hermans-Borgmeyer, I., Kuhl, D., Schweizer, M., et al. (2016). The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory. Cell Rep 15, 968-977.

Nirschl, J.J., Ghiretti, A.E., and Holzbaur, E.L. (2016). Lipid Rafts Assemble Dynein Ensembles. Trends Biochem Sci 41, 393-394.

Nirschl, J.J., Magiera, M.M., Lazarus, J.E., Janke, C., and Holzbaur, E.L. (2016). alpha-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons. Cell Rep 14, 2637-2652.

Klinman, E., and Holzbaur, E.L. (2016). Comparative analysis of axonal transport markers in primary mammalian neurons. Methods Cell Biol 131, 409-424.

Nirschl, J.J., and Holzbaur, E.L. (2016). Live-cell imaging of retrograde transport initiation in primary neurons. Methods Cell Biol 131, 269-276.



Klinman, E., and Holzbaur, E.L. (2015). Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein. Cell Rep 12, 462-473.

Kast, D.J., Zajac, A.L., Holzbaur, E.L., Ostap, E.M., and Dominguez, R. (2015). WHAMM Directs the Arp2/3 Complex to the ER for Autophagosome Biogenesis through an Actin Comet Tail Mechanism. Curr Biol 25, 1791-1797.

Ayloo, S., and Holzbaur, E.L. (2015). Reconstitution of microtubule-based motility using cell extracts. Methods Cell Biol 128, 57-68.

Ballister, E.R., Ayloo, S., Chenoweth, D.M., Lampson, M.A., and Holzbaur, E.L. (2015). Optogenetic control of organelle transport using a photocaged chemical inducer of dimerization. Curr Biol 25, R407-408.

Wong, Y.C., and Holzbaur, E.L. (2015). Autophagosome dynamics in neurodegeneration at a glance. J Cell Sci 128, 1259-1267.

Wong, Y.C., and Holzbaur, E.L. (2015). Temporal dynamics of PARK2/parkin and OPTN/optineurin recruitment during the mitophagy of damaged mitochondria. Autophagy 11, 422-424.

McIntosh, B.B., Holzbaur, E.L., and Ostap, E.M. (2015). Control of the initiation and termination of kinesin-1-driven transport by myosin-Ic and nonmuscle tropomyosin. Curr Biol 25, 523-529.

Ballister, E. R., Ayloo, S., Chenoweth, D. M., Lampson, M. A., and Holzbaur, E. L. (2015) Optogenetic control of organelle transport using a photocaged chemical inducer of dimerization.Curr. Biol 25, R407-8.

Wong, Y. C., and Holzbaur, E. L. (2015) Autophagosome dynamics in neurodegeneration at a glance.J. Cell Sci. 128:1259-67.

Wong, Y. C. and Holzbaur, E. L. (2015) Temporal dynamics of PARK2/parkin and OPTN/optineurin recruitment during the mitophagy of damaged mitochondria.Autophagy 11:422-4.

McIntosh, B. B., Holzbaur, E. L., and Ostap, E. M. (2015) Control of the initiation and termination of kinesin-1-driven transport by myosin-Ic and nonmuscle tropomyosin.Curr. Biol. 25:523-9.

Wilson, M. H., and Holzbaur, E. L. (2015) Nesprins achor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.Development 142:218-28.



Wong, Y.C. and Holzbaur, E.L. (2014) Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation.Proc. Natl. Acad. Sci. USA 111: E4439-48.

Ayloo, S., Lazaru, J.E., Dodda, A., Tokito, M., Ostap, E.M., and Holzbaur, E.L. (2014) Dynactin functions as both a dynamic tether and brake during dynein-driven motility. Nat. Commun. 5, 4807.

Maday, S. and Holzbaur, E. L. (2014) Autophagosome biogenesis in primary neurons follows an ordered and spatially regulated pathway.Dev. Cell 30, 71-85.

Fu, M.-M. and Holzbaur, E. L. (2014) Integrated regulation of motor-driven organelle transport by scaffolding proteins. Trends in Cell Biology 24, 564-74.

Fu, M.-M., Nirschl, J. J., and Holzbaur, E. L. (2014) LC3 binding to the scaffolding protein JIP1 regulates processive dynein-driven transport of autophagosomes.Dev. Cell 29:577-90.

Wong, Y. C., and Holzbaur, E. L. (2014) The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.J. Neurosci. 34:1293-305.

Castle, M. J., Perlson, E., Holzbaur, E. L., and Wolfe, J. H. (2014) Long-distance axonal transport of AAV9 is driven by dynein and kinesin-2 and is trafficked in a highly motile Rab7-positive compartment.Mol. Ther. 22:554-66.

Castle, M. J., Gershenson, Z. T., Giles, A. R., Holzbaur, E. L., and Wolfe, J. H. (2014) Adeno-associated virus serotypes 1, 8, and 9 share conserved mechanisms for anterograde and retrograde transport.Hum. Gene Therapy 25, 705-20.

Fu, M.M., and Holzbaur, E.L. (2014) MAPK8IP1/JIP1 regulates the trafficking of autophagosomes in neurons. Autophagy 10, 2079-81.

Maday, S., Twelvetrees, A.E., Moughamian, AJ., and Holzbaur, E.L. (2014) Axonal transport: cargo-specific mechanisms of motility and regulation. Neuron 84, 292-309.

Mategazza, A.R., Zajac, A.L., Twelvetrees, A., Holzbaur, E.L., Amigorena, S., and Marks, M.S. (2014) TLR-dependent phagosome tubulation in dendritic cells promotes phagosome cross-talk to optimize MHC-II antigen presentation. Proc. Natl. Acad. Sci. USA 111, 15508-13.

Thom, C.S., Traxler, E.A., Khandros, E., Nickas, J.M., Zhou, O.Y., Lazarus, J.E., Silva, A.P., Prabhu, D., Yao, Y., Aribeana, C., Fuchs, S.Y., Mackay, J.P., Holzbaur, E.L., and Weiss, M.J. (2014) Trim58 degrades dynein and regulates terminal erythropoiesis. Dev. Cell 30, 688-700.

De La Cruz, E.M., and Holzbaur, E.L. (2014) Navigating the cell: how motors function in vivo. J Cell Sci 127:2997-8.

Hendricks, A.G., Goldman, Y.E., and Holzbaur, E.L. (2014) Reconstituting the motility of isolated intracellular cargoes. Methods Enzymol. 540, 249-62.