Jennifer L Orthmann-Murphy, MD/PhD
Assistant Professor of Neurology
- Co-Director of Age Span Fellowship in MS/Neuroinflammatory Disorders, University of Pennsylvania
- Faculty, Mahoney Institute for Neurosciences
Department: Neurology
Graduate Group Affiliations
Contact Information
Department of Neurology
Hospital of the University of Pennsylvania
3 Gates
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3606
Lab Phone: 215-898-8282
Email: jennifer.orthmann-murphy@pennmedicine.upenn.edu
I3H Keywords
- Autoimmunity
- Neuroimmunology
Links
Education
-
B.A. (Biological Basis of Behavior with distinction (History minor))
University of Pennsylvania, 2001 -
Ph.D. (Neuroscience)
University of Pennsylvania Perelman School of Medicine, 2007 -
M.D. (Combined Degree Program)
University of Pennsylvania Perelman School of Medicine, 2010
Post-Graduate Training
-
Researcher in laboratory of Steven Scherer
University of Pennsylvania, 2008 - 2008 -
Intern, Internal Medicine
University of Pennsylvania, 2010 - 2011 -
Resident, Neurology
University of Pennsylvania, 2011 - 2014 -
R25 Trainee, Neuroscience
University of Pennsylvania, 2013 - 2014 -
Clinical Neuroimmunology and Postdoctoral Research Fellow
Johns Hopkins School of Medicine, Departments of Neuroscience and Neurology, 2014 - 2018 -
Postdoctoral fellow
Solomon Snyder Department of Neuroscience, Johns Hopkins School of Medicine, 2014 - 2018 -
Elective clinic work
Neurogenetics clinic (KKI); Neurogenetics/Hereditary Spastic Paraplegia clinic (NIH) 2016; Leukodystrophy clinic (CHOP) 2017, 2016 - 2018
Certifications
- Board Certification in Neurology, American Board of Psychiatry and Neurology Specialty, 2014
Description of Clinical Expertise
Multiple Sclerosis, Neuroimmunology, Inherited White Matter Disorders
Description of Research Expertise
Research Interests: The Orthmann-Murphy laboratory studies the dynamic role of glial cells in acquired and inherited demyelinating disease.
Key Words: glia, myelin, multiple sclerosis, demyelination, remyelination
Techniques: multiphoton imaging
Description of ITMAT Expertise
Role of glia in remyelination using multiphoton imaging of the intact brain in mouse models of acquired and inherited myelin disease
Selected Publications
- Kornbluh AB, Baldwin A, Fatemi A, Vanderver A, Adang LA, Van Haren K, Sampson J, Eichler FS, Sadjadi R, Engelen M, Orthmann-Murphy JL : Practical Approach to Longitudinal Neurologic Care of Adults With X-Linked Adrenoleukodystrophy and Adrenomyeloneuropathy. Neurology Genetics 10(5) October 2024
- Laura A Adang, Joshua L Bonkowsky, Jaap Jan Boelens, Eric Mallack, Rebecca Ahrens-Nicklas, John A Bernat, Annette Bley, Barbara Burton, Alejandra Darling, Florian Eichler, Erik Eklund, Lisa Emrick, Maria Escolar, Ali Fatemi, Jamie L Fraser, Amy Gaviglio, Stephanie Keller, Marc C Patterson, Paul Orchard, Jennifer Orthmann-Murphy, Jonathan D Santoro, Ludger Schöls, Caroline Sevin, Isha N Srivastava, Deepa Rajan, Jennifer P Rubin, Keith Van Haren, Melissa Wasserstein, Ayelet Zerem, Francesca Fumagalli, Lucia Laugwitz, Adeline Vanderver : Consensus guidelines for the monitoring and management of metachromatic leukodystrophy in the United States Cytotherapy 26 (7) : 739-748, July 2024
- Anjana Sevagamoorthy, Adeline Vanderver, Jamie L. Fraser, and Jennifer Orthmann-Murphy : Glial Origins of Inherited White Matter Disorders Additional Perspectives on Glia in Cold Spring Harb Perspect Biol in press 2024
- Aaron Baldwin, Juliette Copeland, Meron Azage, Laynie Dratch, Kelsey Johnson, Rachel A Paul, Defne A Amado, Michael Baer, Andres Deik, Lauren B Elman, Michael Guo, Ali G Hamedani, David J Irwin, Aaron Lasker, Jennifer Orthmann-Murphy, Colin C Quinn, Thomas F Tropea, Steven S Scherer, Russell T Shinohara, Roy H Hamilton, Colin A Ellis : Disparities in genetic testing for neurologic disorders Neurology 102 (6) : https://doi.org/10.1212/WNL.000000000020916, March 2024
- Dratch L, Azage M, Baldwin A, Johnson K, Paul RA, Bardakjian TM, Michon SC, Amado DA, Baer M, Deik AF, Elman LB, Gonzalez-Alegre P, Guo MH, Hamedani AG, Irwin DJ, Lasker A, Orthmann-Murphy J, Quinn C, Tropea TF, Scherer SS, Ellis CA. : Genetic testing in adults with neurologic disorders: indications, approach, and clinical impacts. J Neurology 271 (2) : 733-747, Feb 2024
- Rebecca L. Koch, Claudia Soler-Alfonso, Bridget T. Kiely, Akihiro Asai, Ariana L. Smith, Deeksha S. Bali, Peter B. Kang, Andrew P. Landstrom, H. Orhan Akman, T. Andrew Burrow, Jennifer L. Orthmann-Murphy, Deberah S. Goldman, Surekha Pendyal, Areeg H. El-Gharbawy, Stephanie L. Austin, Laura E. Case, Raphael Schiffmann, Michio Hirano, and Priya S. Kishnani : Diagnosis and management of glycogen storage disease type IV, including adult polyglucosan body disease: A clinical practice resource Molecular Genetics and Metabolism March 2023
- Felipe J.S. Jones and Jennifer Orthmann-Murphy : Clinical Reasoning: A 26-year-old woman with chronic progressive gait dysfunction Neurology October 2024
- Helman G, Orthmann-Murphy JL, Vanderver A : Approaches to diagnosis for individuals with a suspected inherited white matter disorder Handb Clin Neurol 2024
- Jones FJ, Elser H, Mendez A, Fraser JL, Orthmann-Murphy J. : Neuroimage: Leukoencephalopathy With Calcifications and Cysts Neurology September 2024
- Papapetropoulos S, Pontius A,Finger E, Karrenbauer V, Lynch DS, Brennan M, Zappia1 S, Koehler W, Schoels L, Hayer SN, Konno T, Ikeuchi T, Lund T, Orthmann-Murphy J, Eichler E and Wszolek ZK : Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia: Review of Clinical Manifestations as Foundations for Therapeutic Development Frontiers in Neurology : https://doi.org/10.3389/fneur.2021.788168, February 2022
- Jennifer Orthmann-Murphy*, Cody L Call*, Gian C Molina-Castro, Yu Chen Hsieh, Matthew N Rasband, Peter A Calabresi, Dwight E Bergles. *Co-first authors : Remyelination alters the pattern of myelin in the cerebral cortex eLife 9 : e56621, May 2020
- Guo MH, ardakjian TM, Brzozowski MR, Scherer SS, Quinn C, Elman L, Orthmann-Murphy JL, Tropea TF, Ellis CA, Gonzalez-Alegre P : Temporal trends and yield of clinical diagnostic genetic testing in adult neurology American Journal of Medical Genetics 185(10) : 2922-2928, Oct 2021 Notes: https://doi.org/10.1002/ajmg.a.62372
- Bloom MS, Orthmann-Murphy J. Grinspan JB : Motor Learning and Physical Exercise in Adaptive Myelination and Remyelination ASN Neuro 14 : doi: 10.1177/17590914221097510, Jan-Dec 2022