Douglas B. Cines, MD
Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Contact Information
Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104
Office: 215-662-3966
Fax: 215-573-2012
Email: dcines@pennmedicine.upenn.edu
I3H Keywords
- Allergy, Asthma, and Other Inflammatory Diseases
- Vaccines
Publications
Links
Education
-
A.B. (History, PreMed)
New York University, 1968 -
M.D. (Medicine)
New York University School of Medicine, 1972
Post-Graduate Training
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Resident in Medicine, N.C
Memorial Hospital, Chapel Hill, NC, 1973 - 1975 -
Fellow, Hematology-Oncology
Hospital of the University of Pennsylvania, 1975 - 1978 -
Intern in Medicine, N.C.
Memorial Hospital, Chapel Hill, NC, 1972 - 1973
Certifications
- American Board of Internal Medicine , 1975
- American Board of Internal Medicine (Hematology), 1980
Description of Clinical Expertise
Coagulation. Immune hematological disorders
Description of Research Expertise
Thormbosis, fibrinolysis, vascular biology, immunohematology
Description of ITMAT Expertise
Dr. Cines works on the delivery of plasminogen activators, among other therapeutics, for the prevention and treatment of thrombotic disorders.
Selected Publications
- Sarkar A, Yadav SK, Field CO, Gollomp K, McCrae KM, Ortel T, Gruel Y, Rollen J, Arepally GM, Rauova L, Cines DB, Poncz M. : Anti-phospholipid syndrome (APS) antibody (Ab)-induced thrombosis can be blocked by platelet factor 4 (PF4)-directed Abs: A novel therapeutic for APS? ASH 2024
- Myoung S, Francis SJ, Chen J, Lee G, Rauova L, Poncz M, Cines DB, Kuchibhatla M, Khandelwal S, Arepally GM. : Complement Activation as a biomarker for platelet activating HIT antibodies. ASH 2024. ASH 2024
- Field CO, Sarkar A, Bdeir Kh, McRae KR, Ortel TL, Kowalska MA, Rauova L, Cines DB, Gollomp K, Poncz M. : Antiphospholipid syndrome (APS) is a platelet factor 4 (PF4)-centric immunothrombotic disorder. ASH 2024
- Rauova L, Oberg J, Gilbert S, Cines DB, Poncz M. : A murine model of vaccine-induced immune thrombotic thrombocytopenia (VITT) leads to anti-NAP2 and anti-PF4 antibodies and may involve TLR9 activation. ISTH 2024
- Ngo ATP, Skidmore A, Yarovoi I, Sarkar A, Levine ND, Bochenek V, Zhao G, Rauova L, Kowalska MA, Eckart K, Mangalmurti NS, Rux A, Cines DB, Poncz M, Gollomp K. : Platelet factor 4 limits neutrophil extracellular trap- and cell-free DNA-induced thrombogenicity and endothelial injury. JCI-Insight. 8(22) November 2023
- Bussel JM, Hou M, Cines DB. : Management of primary ITP in pregnancy. New Eng J Med. 389(6) : 540, August 2023
- Sarkar A, Khandelwal S, Koma G, Kim H, Gruel Y, Rollin J, Passam FH, Wool GD, Arepally GM, Cines DB, Rauova L, Poncz M. : Prevention of thrombocytopenia and thrombosis in HIT using deglycosylated KKO: a novel therapeutic? Blood Adv May 2023
- Cines DB, Greinacher A. : Vaccine-induced immune thrombotic thrombocytopenia Blood 141 : 1659-1665, Apr 2023
- Cai Z, Bdeir K, Yarovoi SV, Rauova L, Arepally GM, Khandelwal S, Rollin J, Gruel Y, Zaitsev S, Poncz M, Greene MI, Cines DB. : Modulation of ultralarge immune complexes in heparin-induced thrombocytopenia J Thromb Haemost 2023
- Rauova L, Oberg J, Field C, Levine N, Arepally HM, Cines DB, Cohen T, Poncz M : ChadOx exposure-induced neutrophil-activating peptide 2 (NAP2) antibodies: Murine-based insights into the pathgenesis of vaccine-induced immune thrombotic thrombocytopenia (VITT). ISTH 2023