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Bruce J Shenker

  • Director, SDM Flow Cytometry Core Facility

Contact Information


Email: shenker@upenn.edu


I3H Keywords

  • Allergy, Asthma, and Other Inflammatory Diseases
  • Innate and Adaptive Immunity to Pathogens

Education

  • B.S.
    Syracuse University, 4
  • Ph.D.
    Georgetown University, 4

Post-Graduate Training

  • Post-doctoral training
    The Johns Hopkins University School of Medicine, Department of Pathology (Immunopathology), 1977 - 1980

Selected Publications

  • Maserejian Nancy N, Shrader Peter, Brown Olivia A, Trachtenberg Felicia L, Soncini Jennifer, Hauser Russ, Shenker Bruce J : Dental sealants and composite restorations and longitudinal changes in immune function markers in children. International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children 24(3) : 215-25, May 2014
  • Shenker Bruce J, Walker Lisa P, Zekavat Ali, Dlakić Mensur, Boesze-Battaglia Kathleen : Blockade of the PI-3K signalling pathway by the Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces macrophages to synthesize and secrete pro-inflammatory cytokines. Cellular microbiology Apr 2014
  • Shenker Bruce J, Ali Hydar, Boesze-Battaglia Kathleen : PIP3 regulation as promising targeted therapy of mast-cell-mediated diseases. Current pharmaceutical design 17(34) : 3815-22, Nov 2011
  • Krummenacher, C., Brown, A., Shenker, B.J., Edrington, V., and Boesze-Battaglia, K. : Mechanisms by which pathogens hijack and utilize membrane domains to mediate cytotoxicity. The structure of biological membrane, 3rd edition. 2011
  • Shenker Bruce J, Boesze-Battaglia Kathleen, Zekavat Ali, Walker Lisa, Besack Dave, Ali Hydar : Inhibition of mast cell degranulation by a chimeric toxin containing a novel phosphatidylinositol-3,4,5-triphosphate phosphatase. Molecular immunology 48(1-3) : 203-10, Nov-Dec 2010
  • Boesze-Battaglia Kathleen, Brown Angela, Walker Lisa, Besack Dave, Zekavat Ali, Wrenn Steve, Krummenacher Claude, Shenker Bruce J : Cytolethal distending toxin-induced cell cycle arrest of lymphocytes is dependent upon recognition and binding to cholesterol. The Journal of biological chemistry 284(16) : 10650-8, Apr 2009
  • Shenker Bruce J, Maserejian Nancy N, Zhang Annie, McKinlay Sonja : Immune function effects of dental amalgam in children: a randomized clinical trial. Journal of the American Dental Association (1939) 139(11) : 1496-505, Nov 2008
  • Shenker Bruce J, Dlakic Mensur, Walker Lisa P, Besack Dave, Jaffe Eileen, LaBelle Ed, Boesze-Battaglia Kathleen : A novel mode of action for a microbial-derived immunotoxin: the cytolethal distending toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity. Journal of immunology (Baltimore, Md. : 1950) 178(8) : 5099-108, Apr 2007
  • Boesze-Battaglia Kathleen, Besack Dave, McKay Terry, Zekavat Ali, Otis Linda, Jordan-Sciutto Kelly, Shenker Bruce J : Cholesterol-rich membrane microdomains mediate cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal-distending toxin. Cellular microbiology 8(5) : 823-36, May 2006
  • Shenker Bruce J, Demuth Donald R, Zekavat Ali : Exposure of lymphocytes to high doses of Actinobacillus actinomycetemcomitans cytolethal distending toxin induces rapid onset of apoptosis-mediated DNA fragmentation. Infection and immunity 74(4) : 2080-92, Apr 2006