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Taku Kambayashi, MD/PhD

Professor of Pathology and Laboratory Medicine

  • Attending Physician, Hospital of the University of Pennsylvania (8 weeks/year)
  • Director, Institute for Immunology Clinical Fellows Training Program, PSOM
  • Program Advisor, Medical Scientist Training Program, PSOM
  • Member, Pathology Residency Steering Committee, HUP
  • Associate Vice Chair of Research, Department of Pathology, PSOM

Department: Pathology and Laboratory Medicine


Graduate Group Affiliations


Contact Information

288 JMB, 3620 Hamilton Walk
Philadelphia, PA 19104
Office: 215-746-7610
Fax: 215-573-9261
Email: taku.kambayashi@uphs.upenn.edu


I3H Keywords

  • Allergy, Asthma, and Other Inflammatory Diseases
  • Autoimmunity
  • Transplantation Immunity

Publications

Pubmed Link


Links


Education

  • B.S. (Biomedical Engineering)
    Johns Hopkins University, Baltimore, MD, 1993
  • Ph.D. (Immunology)
    Emory University, Atlanta, GA, 2002
  • M.D. (Medicine)
    Emory University, Atlanta, GA, 2004

Post-Graduate Training

  • Resident in Pathology and Laboratory Medicine
    Hospital of the University of Pennsylvania, Philadelphia, PA, 2004 - 2007
  • Transfusion Medicine Fellow
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, 2007 - 2008
  • Post-doctoral Fellow in Pathology and Laboratory Medicine
    University of Pennsylvania School of Medicine, Philadelphia, PA, 2005 - 2008

Certifications

  • Clinical Pathology - American Board of Pathology, 2008
  • Transfusion Medicine - American Board of Pathology, 2008

Description of Clinical Expertise

Transfusion Medicine

Description of Research Expertise

https://kambayashilab.com/

Research interests:
Regulation of T cell responses; Signal transduction; Regulation of skin barrier function; Skin commensals; Transgenerational epigenetic inheritance

Specific Projects:

1) TSLP-mediated regulation of systemic lipid metabolism by T cells.

2) Regulation of skin barrier function and sebum secretion by Vitamin D3.

3) Regulation of systemic lipid metabolism by skin and skin commensals.

4) Mouse models of Idiopathic Multicentric Castleman Disease (iMCD)

5) Regulation of the epigenome of gametes (sperm and egg) by T cells and microbes. The impact of parental T cells and microbes on progeny phenotypes.


Lab personnel:
Wei Du, MD, PhD, Postdoctoral Fellow
Bruk Goshu, PhD Student
Tetsuya Ikawa, MD, PhD, Postdoctoral Fellow
Dorottya Laczko, MD, PhD, Postdoctoral Fellow
Mariko Okumura, Research Specialist
Lillian Sun, MD/PhD Student
Saba Tegegne, MD/PhD Student
Yuichi Yokoyama, MD, PhD, Postdoctoral Fellow
Simon Zhou, PhD Student

Description of ITMAT Expertise

Cell signaling in immune cells and the impact of these pathways on inflammatory diseases.