George Scott Worthen, MD

Selected Publications

• Yehya N, Fazelinia H, Taylor DM, Lawrence GG. Spruce LA, Thompson JM, Margulies SS, Seeholzer SH, Worthen GS : Differentiating children withsepsis with and without acute respiratory distress syndrome using proteomics Am. J. Physiol. Lung Cell Mol. Physiol. 322(3) : L365-372, Mar 2022
• Rubey KR, Mukhitov AR, Nong J, Krymskaya VP, Myerson JW, Worthen, GS, Brenner JS : Nanoparticle-induced augmentation of neutrophil phagocytosis of bacteria Front. Pharmacol. In Press 2022
• Guo L, Li N, Yang Z, Li H, Zheng H, Yang J, Chen Y, Zhao X, Mei J, Shi H, Worthen GS, Liu L. : Role of CXCL5 in regulating chemotaxis of innate and adaptive leukocytes in infected lungs upon pulmonary Influenza infection Front Immunol 12 : 785, Nov 2021
• Lam LKM, Sophia Murphy, Dimitra Kokkinaki, Alessandro Venosa, Scott Sherrill-Mix, Meghan J. Hotz, Carla Casu, Peggy Zhang, Dorothy E. Loy, Caroline A.G. Ittner, Nuala J. Meyer, Stefano Rivella, Beatrice H. Hahn, G. Scott Worthen, Nilam S. Mangalmurti. : DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia Science Translational Medicine 13 : 616, Oct 2021
• Nadir Yehya, Hossein Fazelinia, Gladys G Lawrence, Lynn A Spruce, Mark V Mai, G Scott Worthen, Jason D Christie. : Plasma Nucleosomes Are Associated with Mortality in Pediatric Acute Respiratory Distress Syndrome Crit Care Med 2021 Notes: online ahead of print
• Paris, AJ, Oved, JH, Wang, P, Dai, N, Worthen, GS : Neutrophils degrade nucleic acids to improve lung repair after injury Blood 30 : 392-93, 2021
• Jacob W. Myerson, Priyal N. Patel, Kate Rubey, Nahal Habibi, Landis R, Walsh, Yi-Wei Lee, David C. Luther, Laura T. Ferguson, Michael H. Zaleski, Marco E. Zamora, Oscar A. Marcos-Contreras, Patrick M. Glassman, Ian Johnson, Elizabeth D. Hood, Tea Shuvaeva, Jason V. Gregory, Raisa Y. Kiseleva, Jia Nong, Colin Greineder, Samir Mitragotri, G. Scott Worthen, Vincent M. Rotello, Joerg Lahann, Vladimir R. Muzykantov, Jacob S. Brenner : Supramolecular Organization Predicts Protein Nanoparticle Delivery to Neutrophils for Acute Lung Inflammation Diagnosis and Treatment. 2021 In Press Nature Nanotechnology 2021 Notes: In Press
• Yasmine Issah, Amruta Naik, Soon Y Tang, Kaitlyn Forrest, Thomas G Brooks, Nicholas Lahens, Katherine N Theken, Mara Mermigos, Amita Sehgal , George S Worthen, Garret A FitzGerald, Shaon Sengupta. : Loss of circadian protection against influenza infection in adult mice exposed to hyperoxia as neonates Elife 10 : e61241, 2021
• Bellissimo DC, Chen CH, Zhu Q, Bagga S, Lee CT, He B, Wertheim GB, Jordan M, Tan K, Worthen GS, Gilliland DG, Speck NA : Runx1 negatively regulates inflammatory cytokine production by neutrophils in response to Toll-like receptor signaling. Blood Adv. 24(6) : 1145-115, 2020
• Hudock KM, Collins MS, Imbrogno M, Snowball J, Kramer EL, Brewington JJ, Gollomp K, McCarthy C, Ostmann AJ, Kopras EJ, Davidson CR, Srdiharan A, Arumugam P, Sengupta S, Xu Y, Worthen GS, Trapnell BC, Clancy JP : Neutrophil extracellular traps activate IL-8 and IL-1 expression in human bronchial epithelia. Am J Physiol Lung Cell Mol Physiol. 319 : L137-L147, 2020