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Matthew H. Levine, MD/PhD

Associate Professor of Surgery

  • Attending Surgeon, Hospital of the University of Pennsylvania, Philadelphia, PA
  • Attending Surgeon, Children's Hospital of Philadelphia
  • Surgical Director and Primary Surgeon, Kidney Transplantation, Children's Hospital of Philadelphia
  • Surgical Co-Director for the Transplant Center, Children's Hospital of Philadelphia
  • Director, Transplant Fellowship, Department of Surgery, Perelman School of Medicine, Philadelphia, PA

Department: Surgery


Contact Information

Division of Transplant Surgery
Hospital of the University of Pennsylvania
3400 Spruce Street
Ravdin Courtyard, Level 2
Philadelphia, PA 19104
Office: 215-662-7367
Fax: 215-615-4900
Email: matthew.levine@uphs.upenn.edu


I3H Keywords

  • Transplantation Immunity

Education

  • B.S. (Biochemistry)
    Brown University, Providence, RI , 1994
  • M.D.
    Yale University School of Medicine, New Haven, CT, 2001
  • Ph.D. (Immunobiology)
    Yale University School of Medicine, New Haven, CT, 2001

Post-Graduate Training

  • Intern in Surgery
    Massachusetts General Hospital, Boston, MA, 2001 - 2002
  • Resident in Surgery
    Massachusetts General Hospital, Boston, MA, 2002 - 2006
  • Fellowship, Abdominal Organ Transplantation
    University of California Medical Center, San Francisco, CA, 2007 - 2008

Certifications

  • American Board of Surgery , 2006
  • American Society of Transplant Surgeons - Liver Kidney and Pancreas Transplantation, 2009

Description of ITMAT Expertise

Renal injury
Renal ischemia
Liver injury and regeneration
Transplantation, immunology and clinical
Vascularized composite tissue allotransplantation
Lung injury and transplantation
Regulatory T cell biology, translational

Selected Publications

  • Christensen, L, Levine M : Potential nuances in renoprotective properties of estrogen in females Kidney International 2024 (accepted for publication)
  • Cywes C, Banker A, Muñoz N, Levine M, Abu-Gazala S, Bittermann T, Abt P : The potential utilization of machine perfusion to increase transplantation of macrosteatotic livers Transplantation 108(11) : e370-e375, Nov. 1 2024 Notes: Epub May 21, 2024
  • Concors SJ, Hernandez PT, O’Brien C, DePaolo J, Murken DR, Aufhauser DD, Wang Z, Xiong Y, Krumeich L, Ge G, Beier UH, Bhatti TR, Kozikowski AP, Avelar L, Kurz T, Hancock WW, Levine MH : Differential effects of HDAC6 inhibition versus knockout during hepatic ischemia reperfusion injury and the HDAC6 C-terminal zinc-finger ubiquitin-binding domain Transplantation 108(10) : 2084-2092, Oct. 1 2024 Notes: Epub Sept. 24, 2024
  • Huang KB, Wang FY, Lu Y, Yang LM, Long N, Wang SS, Xie Z, Levine M, Zou T, Sessler JL, Liang H : Cu(II) complex that synergistically potentiates cytotoxicity and an antitumor immune response by targeting cellular redox homeostasis Proceedings of the National Academy of Sciences of the United States of America 121(24) : e2404668121, June 11 2024 Notes: Epub June 4, 2024
  • Benson AB, D'Angelica MI, Abrams T, Abbott DE, Ahmed A, Anaya DA, Anders R, Are C, Bachini M, Binder D, Borad M, Bowlus C, Brown D, Burgoyne A, Castellanos J, Chahal P, Cloyd J, Covey AM, Glazer ES, Hawkins WG, Iyer R, Jacob R, Jennings L, Kelley RK, Kim R, Levine M, Palta M, Park JO, Raman S, Reddy S, Ronnekleiv-Kelly S, Sahai V, Singh G, Stein S, Turk A, Vauthey JN, Venook AP, Yopp A, McMillian N, Schonfeld R, Hochstetler C : NCCN Guidelines® Insights: Biliary Tract Cancers, Version 2.2023 Journal of the National Comprehensive Cancer Network 21(7) : 694-704, July 2023
  • Tran BV, Moris D, Markovic D, Zaribafzadeh H, Henao R, Lai Q, Florman SS, Tabrizian P, Haydel B, Ruiz RM, Klintmalm GB, Lee DD, Taner CB, Hoteit M, Levine MH, Cillo U, Vitale A, Verna EC, Halazun KJ, Tevar AD, Humar A, Chapman WC, Vachharajani N, Aucejo F, Lerut J, Ciccarelli O, Nguyen MH, Melcher ML, Viveiros A, Schaefer B, Hoppe-Lotichius M, Mittler J, Nydam TL, Markmann JF, Rossi M, Mobley C, Ghobrial M, Langnas AN, Carney CA, Berumen J, Schnickel GT, Sudan DL, Hong JC, Rana A, Jones CM, Fishbein TM, Busuttil RW, Barbas AS, Agopian VG : Development and validation of a REcurrent Liver cAncer Prediction ScorE (RELAPSE) following liver transplantation in patients with hepatocellular carcinoma: Analysis of the US Multicenter HCC Transplant Consortium Liver Transplantation 29(7) : 683-697, July 1 2023 Notes: Epub Apr. 10, 2023
  • Potluri V, Naqvi F, Goldberg DS, Shah M, Loupy A, Abt P, Blumberg E, Trofe-Clark J, Bloom R, Sawinski D, Chattergoon M, Segev DL, Bair-Marcantoni N, Durand CM, Reddy R, Levine M, Brown N, Mapchan S, Aubert O, Desai N, Reese PP : Longer-term clinical outcomes from the THINKER and EXPANDER trials of transplantation of HCV-RNA+ donor kidneys into hepatitis C virus-negative recipients Kidney International Reports 8(7) : 1460-1463, Apr. 29 2023 Notes: eCollection July 2023
  • Roll GR, Bray RA, Cooper M, Eagar TN, Gebel HM, Vranic GM, Hitchman KMK, Houp J, Kamoun M, Killian J, Kim J, Kumar V, Levine M, Lovasik BP, Lunow-Luke T, Parsons RF, Pattanayak V, Ranch D, Shah A, Stock PG, Timofeeva OA, Trofe-Clark J, Wongjirad C, Yeh H, Yi S, Rajalingam R : COVID-19 infection and vaccination rarely impact HLA antibody profile in waitlisted renal transplant candidates- a multicenter cohort Human Immunology 84(4) : 278-285, Apr. 2023 Notes: Epub Feb. 23, 2023
  • Sonnenberg EM, Hsu JY, Cohen JB, Potluri VS, Geng Z, Levine MH, Abt PL, Reese PP : Acute kidney injury in deceased organ donors and kidney transplant outcomes: A national cohort study using a novel data source Annals of Surgery 276(6) : e982-e990, Dec. 1 2022 Notes: Epub Nov. 13, 2020
  • Hernandez P, O'Brien C, Concors SJ, Wang Z, Ge G, Hancock WW, Levine MH : The selective estrogen receptor modulator, raloxifene, is protective against renal ischemia-reperfusion injury Transplantation 106(11) : 2166-2171, Nov. 1 2022 Notes: Epub Oct. 21, 2022