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Saar I Gill, MD/PhD

Professor of Medicine (Hematology-Oncology) at the Hospital of the University of Pennsylvania

  • Attending, Hospital of the University of Pennsylvania
  • Member, Abramson Cancer Center
  • Member, Institute for Immunology
  • Scientific Director, University of Pennsylvania Cell Therapy and Transplant group
  • Director of the TCE in Gene-Edited Hematopoietic Stem Cell Transplantation , University of Pennsylvania

Department: Medicine
Division: Hematology-Oncology


Graduate Group Affiliations


Contact Information

Room 8-101
Smilow Translational Research Center
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: 650 213 6249
Lab Phone: (215) 573-4015
Email: saargill@pennmedicine.upenn.edu


I3H Keywords

  • Array

Education

  • MBBS (medicine)
    University of Melbourne, 1999
  • PhD (immunology)
    University of Melbourne, 2011

Post-Graduate Training

  • Resident, Internal Medicine
    St Vincent's Hospital, Melbourne, 2000 - 2004
  • Fellow, Hematology
    Peter MacCallum Cancer Centre, Melbourne, 2005 - 2007
  • Natural killer cell immunotherapy, GVHD
    Stanford University, 2008 - 2011
  • Fellow, BMT
    University of Pennsylvania, 2011 - 2012

Certifications

  • Royal Australasian College of Physicians, 2008

Description of Clinical Expertise

Blood and Marrow Transplantation
Leukemia
Myelodysplastic Syndromes
Myeloproliferative Neoplasms
Lymphoproliferative Neoplasms
Bone Marrow Failure

Description of Research Expertise

Tumor Immunology
Chimeric Antigen Receptor T cells
Mouse Models of Human Leukemia
Murine Xenografts
Adoptive Cellular Therapy
Genetic Engineering of T cells
Flow Cytometry

Description of ITMAT Expertise

Chimeric antigen receptor T cells for the treatment of hematologic malignancy

Selected Publications

  • Blumenberg V, Diorio C, Gauthier J, Agrusa JE, Dreyzin A, Hänel G, Espinoza-Gutarra MR, Geer M, Perales MA, Ramakrishna S, Jain MD, Gill S, Locke FL, Shouval R, Subklewe M, Komanduri KV, Chapuis AG, Paczesny S, Rejeski K, Shah NN. : Expert Panel Review and Practical Guidance on Biomarker Testing with Engineered Immune Effector Cells Transplant Cell Ther May 2026
  • Durgin JS, Seo SH, Kazmi S, Valentić B, Leff C, Markovska M, Jin X, Shen F, Berjis A, Mukherjee N, Sannecy A, Plesa G, Gabunia K, Scholler J, Gill SI, O'Connor RS, June CH, Ghassemi S. : Single-day nonactivated IL-18-armed CAR T cells establish a durable, stemlike state with enhanced persistence Blood Apr 2026
  • Chen GM, Jain A, Gering DT, Satulovsky J, Datta S, Lai P, Karar J, Gonzalez VE, Alexander K, Chew A, Jadlowsky JK, Ruella M, Paruzzo L, Amses KR, Rech AJ, Stadtmauer EA, Frey NV, Hexner EO, Porter DL, Cohen AD, Gill SI, Garfall AL, Schuster SJ, Mo KC, Liang SI, Spasic M, Levine BL, Siegel DL, Ramírez-Fernández A, Cabanski CR, Yang E, Mackall CL, Bushman FD, Good Z, John Wherry E, June CH, Fraietta JA. : Predictive biomarkers of response to chimeric antigen receptor (CAR) T-cell therapy for pan-haematologic cancer Nat Biomed Eng 2026
  • Altun B, Zhao G, Wang B, Mao X, Manfredo-Vieira S, Willis E, Radaelli E, Goodman EE, Boesteanu AC, Gill SI, Patel DR, Wong S, Cottman-Thomas E, Hogan JJ, Payne AS. : Preclinical evaluation of antigen-specific B-cell depletion for phospholipase A2 receptor membranous nephropathy with chimeric autoantibody receptor T cells Kidney Int 2026
  • Bot A, Stephan MT, Gill S. : The dawn of in vivo immune cell engineering in oncology Nat Biotechnol 2026
  • Bowman M, Gounder S, Singh V, Shestova O, Robinson T, Zhang A, Gandhi A, Bandopadhyay R, Cai SF, Levine RL, Gill SI, Miles LA, Bowman RL. : scDNA: Single Cell DNA analysis software toolkit for subclonality discovery and assessment bioRxiv Dec 2025
  • McFarland AG, Ooi SK, Tafuri D, Kamali E, Cooper N, Cook EJ, Reddy S, Jarocha D, Wellhausen N, Gill SI, Roche AM, Fraietta JA, Bushman FD, Herbst F. : An integrated enzymatic and computational pipeline for quantifying off-target base-editing bioRxiv Aug 2025
  • Naik S, Aplenc R, Baumeister SHC, Becilli M, Bhagwat AS, Bonifant CL, Budde LE, Chien CD, Curran KJ, Daniyan AF, Dreyzin A, Gardner RA, Ghorashian S, Gottschalk S, Hill LC, Kohler ME, Lamble AJ, Locatelli F, Mamonkin M, Omer B, Park JH, Quintarelli C, Rambaldi B, Richards RM, Sallman DA, Sauer T, Shah NN, Subklewe M, Summers C, Tasian SK, Taylor N, Tettamanti S, Verneris MR, Velasquez MP, Gill SI. : International Consensus Guidelines for the Conduct and Reporting of CAR T-Cell Clinical Trials in AML Blood Adv 9 : 6047-6058, Aug 2025
  • Mellors PW, Lange AN, Casino Remondo B, Shestov M, Planer JD, Peterson AR, Ying Y, Zhou S, Christie JD, Diamond JM, Cantu E, Basil MC, Gill S. : Shared roles of immune and stromal cells in the pathogenesis of human bronchiolitis obliterans syndrome JCI Insight 10 : e176596, Apr 2025
  • Sande CM, Chen S, Mitchell DV, Lin P, Abraham DM, Cheng JM, Gebhard T, Deolikar RJ, Freeman C, Zhou M, Kumar S, Bowman M, Bowman RL, Zheng S, Munkhbileg B, Chen Q, Stanley NL, Guo K, Lapite A, Hausler R, Taylor DM, Corines J, Morrissette JJ, Lieberman DB, Yang G, Shestova O, Gill S, Zheng J, Smith-Simmer K, Banaszak LG, Shoger KN, Reinig EF, Peterson M, Nicholas P, Walne AJ, Dokal I, Rosenheck JP, Oetjen KA, Link DC, Gelman AE, Reilly CR, Dutta R, Lindsley RC, Brundige KJ, Agarwal S, Bertuch AA, Churpek JE, Tague LK, Johnson FB, Olson TS, Babushok DV. : ATM-dependent DNA damage response constrains cell growth and drives clonal hematopoiesis in telomere biology disorders J Clin Invest 135 : e181659, Apr 2025