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Saar I Gill, MD/PhD

Professor of Medicine (Hematology-Oncology) at the Hospital of the University of Pennsylvania

  • Attending, Hospital of the University of Pennsylvania
  • Member, Abramson Cancer Center
  • Member, Institute for Immunology
  • Scientific Director, University of Pennsylvania Cell Therapy and Transplant group
  • Director of the TCE in Gene-Edited Hematopoietic Stem Cell Transplantation , University of Pennsylvania

Department: Medicine
Division: Hematology-Oncology


Graduate Group Affiliations


Contact Information

Room 8-101
Smilow Translational Research Center
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: 650 213 6249
Lab Phone: (215) 573-4015
Email: saargill@pennmedicine.upenn.edu


I3H Keywords

  • Array

Education

  • MBBS (medicine)
    University of Melbourne, 1999
  • PhD (immunology)
    University of Melbourne, 2011

Post-Graduate Training

  • Resident, Internal Medicine
    St Vincent's Hospital, Melbourne, 2000 - 2004
  • Fellow, Hematology
    Peter MacCallum Cancer Centre, Melbourne, 2005 - 2007
  • Natural killer cell immunotherapy, GVHD
    Stanford University, 2008 - 2011
  • Fellow, BMT
    University of Pennsylvania, 2011 - 2012

Certifications

  • Royal Australasian College of Physicians, 2008

Description of Clinical Expertise

Blood and Marrow Transplantation
Leukemia
Myelodysplastic Syndromes
Myeloproliferative Neoplasms
Lymphoproliferative Neoplasms
Bone Marrow Failure

Description of Research Expertise

Tumor Immunology
Chimeric Antigen Receptor T cells
Mouse Models of Human Leukemia
Murine Xenografts
Adoptive Cellular Therapy
Genetic Engineering of T cells
Flow Cytometry

Description of ITMAT Expertise

Chimeric antigen receptor T cells for the treatment of hematologic malignancy

Selected Publications

  • McFarland AG, Ooi SK, Tafuri D, Kamali E, Cooper N, Cook EJ, Reddy S, Jarocha D, Wellhausen N, Gill SI, Roche AM, Fraietta JA, Bushman FD, Herbst F. : An integrated enzymatic and computational pipeline for quantifying off-target base-editing bioRxiv Aug 2025
  • Naik S, Aplenc R, Baumeister SHC, Becilli M, Bhagwat AS, Bonifant CL, Budde LE, Chien CD, Curran KJ, Daniyan AF, Dreyzin A, Gardner RA, Ghorashian S, Gottschalk S, Hill LC, Kohler ME, Lamble AJ, Locatelli F, Mamonkin M, Omer B, Park JH, Quintarelli C, Rambaldi B, Richards RM, Sallman DA, Sauer T, Shah NN, Subklewe M, Summers C, Tasian SK, Taylor N, Tettamanti S, Verneris MR, Velasquez MP, Gill SI. : International Consensus Guidelines for the Conduct and Reporting of CAR T-Cell Clinical Trials in AML Blood Adv Aug 2025
  • Mellors PW, Lange AN, Casino Remondo B, Shestov M, Planer JD, Peterson AR, Ying Y, Zhou S, Christie JD, Diamond JM, Cantu E, Basil MC, Gill S. : Shared roles of immune and stromal cells in the pathogenesis of human bronchiolitis obliterans syndrome JCI Insight 10 : e176596, Apr 2025
  • Sande CM, Chen S, Mitchell DV, Lin P, Abraham DM, Cheng JM, Gebhard T, Deolikar RJ, Freeman C, Zhou M, Kumar S, Bowman M, Bowman RL, Zheng S, Munkhbileg B, Chen Q, Stanley NL, Guo K, Lapite A, Hausler R, Taylor DM, Corines J, Morrissette JJ, Lieberman DB, Yang G, Shestova O, Gill S, Zheng J, Smith-Simmer K, Banaszak LG, Shoger KN, Reinig EF, Peterson M, Nicholas P, Walne AJ, Dokal I, Rosenheck JP, Oetjen KA, Link DC, Gelman AE, Reilly CR, Dutta R, Lindsley RC, Brundige KJ, Agarwal S, Bertuch AA, Churpek JE, Tague LK, Johnson FB, Olson TS, Babushok DV. : ATM-dependent DNA damage response constrains cell growth and drives clonal hematopoiesis in telomere biology disorders J Clin Invest 135 : e181659, Apr 2025
  • Pierini S, Gabbasov R, Oliveira-Nunes MC, Qureshi R, Worth A, Huang S, Nagar K, Griffin C, Lian L, Yashiro-Ohtani Y, Ross K, Sloas C, Ball M, Schott B, Sonawane P, Cornell L, Blumenthal D, Chhum S, Minutolo N, Ciccaglione K, Shaw L, Zentner I, Levitsky H, Shestova O, Gill S, Varghese B, Cushing D, Ceeraz DeLong S, Abramson S, Condamine T, Klichinsky M. : Author Correction: Chimeric antigen receptor macrophages (CAR-M) sensitize HER2+ solid tumors to PD1 blockade in pre-clinical models Nat Commun 16 : 2692, Mar 2025
  • Wang X, Gimotty PA, Matthews AH, Mamtani R, Luger SM, Hexner EO, Babushok DV, McCurdy SR, Frey NV, Bruno XJ, Gill S, Martin ME, Paralkar VR, Maillard I, Porter DL, Loren AW, Perl AE, Pratz KW, Getz KD, Lai C. : Evolving racial/ethnic disparities in AML survival in the novel therapy era Blood Adv 9 : 533-544, Feb 2025
  • Pierini S, Gabbasov R, Oliveira-Nunes MC, Qureshi R, Worth A, Huang S, Nagar K, Griffin C, Lian L, Yashiro-Ohtani Y, Ross K, Sloas C, Ball M, Schott B, Sonawane P, Cornell L, Blumenthal D, Chhum S, Minutolo N, Ciccaglione K, Shaw L, Zentner I, Levitsky H, Shestova O, Gill S, Varghese B, Cushing D, Ceeraz DeLong S, Abramson S, Condamine T, Klichinsky M. : Chimeric antigen receptor macrophages (CAR-M) sensitize HER2+ solid tumors to PD1 blockade in pre-clinical models Nat Commun 16 : 706, Jan 2025
  • Reiss KA, Angelos MG, Dees EC, Yuan Y, Ueno NT, Pohlmann PR, Johnson ML, Chao J, Shestova O, Serody JS, Schmierer M, Kremp M, Ball M, Qureshi R, Schott BH, Sonawane P, DeLong SC, Christiano M, Swaby RF, Abramson S, Locke K, Barton D, Kennedy E, Gill S, Cushing D, Klichinsky M, Condamine T, Abdou Y. : CAR-macrophage therapy for HER2-overexpressing advanced solid tumors: a phase 1 trial Nat Med 2025
  • Jadlowsky JK, Hexner EO, Marshall A, Grupp SA, Frey NV, Riley JL, Veloso E, McConville H, Rogal W, Czuczman C, Hwang WT, Li Y, Leskowitz RM, Farrelly O, Karar J, Christensen S, Barber-Rotenberg J, Gaymon A, Aronson N, Bernstein W, Melenhorst JJ, Roche AM, Everett JK, Zolnoski SA, McFarland AG, Reddy S, Petrichenko A, Cook EJ, Lee C, Gonzalez VE, Alexander K, Kulikovskaya I, Ramírez-Fernández Á, Minehart JC, Ruella M, Gill SI, Schuster SJ, Cohen AD, Garfall AL, Shah PD, Porter DL, Maude SL, Levine BL, Siegel DL, Chew A, McKenna S, Lledo L, Davis MM, Plesa G, Herbst F, Stadtmauer EA, Tebas P, DiNofia A, Haas A, Haas NB, Myers R, O'Rourke DM, Svoboda J, Tanyi JL, Aplenc R, Jacobson JM, Ko AH, Cohen RB, June CH, Bushman FD, Fraietta JA. : Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies Nat Med 2025
  • Maillie L, Nasta SD, Svoboda J, Barta SK, Chong EA, Garfall AL, Gill SI, Porter DL, Schuster SJ, Catania C, Frey NV, Landsburg DJ. : Prolonged Neurologic Symptoms Following Immune Effector Cell-Associated Neurotoxicity Syndrome in Patients With Large B-cell Lymphoma Treated With Chimeric Antigen Receptor-Modified T Cell Therapy Transplant Cell Ther 2025