David Peter Cormode, PhD

Professor of Radiology

Member, Institute for Translational Medicine and Therapeutics
Member, Center for Translational Targeted Therapeutics and Nanomedicine
Member, Penn Institute for Immunology
Member, Penn Center for Musculoskeletal Disorders
Member, Nano/Bio Interface Center
Member, Center of Excellence in Environmental Toxicology
Member, Abramson Cancer Center

Department: Radiology

Graduate Group Affiliations

Contact Information

Hospital of the University of Pennsylvania
Department of Radiology
3400 Spruce Street, 1 Silverstein
Philadelphia, PA 19104
Email: david.cormode@pennmedicine.upenn.edu

I3H Keywords

Allergy, Asthma, and Other Inflammatory Diseases
Cancer Immunology and Immunotherapy

Publications

Pubmed Link

Education

BA/MS (Chemistry)
St. Edmund Hall, University of Oxford, 2002
PhD (Chemistry)
Balliol College, University of Oxford, 2006

Post-Graduate Training

Postdoctoral Fellow
NIH ‘Pathway to independence’ K99 fellow, Translational and Molecular Imaging Institute, Mount Sinai School of Medicine , 2010 - 2012
Postdoctoral Fellow
American Heart Association Fellow, Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, 2009 - 2010
Postdoctoral Fellow
Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, 2006 - 2009

Description of Research Expertise

Dr. Cormode's research focuses on the development of novel and multifunctional nanoparticle contrast agents for medical imaging applications. A current major area is the development of gold and bismuth nanoparticles as contrast agents for computed tomography (CT). The nanoparticles can be further modified to have a variety of additional functional properties, such as fluorescence, MRI contrast or therapeutic effects. Related areas of interest are novel computed tomography-based imaging methods, such as dual energy CT, spectral CT and iterative image reconstruction. These technologies are being applied for structural imaging and molecular imaging of the levels of specific cell types and proteins in vivo. These approaches provide enhanced characterization of cardiovascular diseases and cancers, which should allow improved selection of therapies and monitoring of response to treatments.

Undergraduates and master's students, as well as prospective graduate students and postdoctoral fellows are encouraged to email Dr. Cormode if interested in working in our lab.

Description of ITMAT Expertise

Cardiovascular imaging
Cardiovascular therapeutics
Nanomedicine
Contrast agents

Selected Publications

Huang, Yue; Liu, Yuan; Pandey, Nil K.; Shah, Shrey; Simon-Soro, Aurea; Hsu, Jessica, C.; Ren, Zhi; Xiang, Zhenting; Kim, Dongyeop; Ito, Tatsuro; Oh, Min Jun; Buckley, Christine; Alawi, Faizan; Li, Yong; Smeets, Paul J. M.; Boyer, Sarah; Zhao, Xingchen; Joester, Derk; Zero, Domenick T.; Cormode, David P.; Koo, Hyun. : Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention Nature Communications 14(1) : 6087, September 2023 Notes: Co-corresponding author.
Hajfathalian, Maryam; de Vries, Christiaan R.; Hsu, Jessica C.; Amirshaghaghi, Ahmad; Dong, Yuxi C.; Ren, Zhi; Liu, Yuan; Huang, Yue; Li, Yong; Knight, Simon; Jonnalagadda, Pallavi; Zlitni, Aimen; Grice, Elizabeth; Bollyky, Paul L.; Koo, Hyun; Cormode, David P. : Theranostic gold-in-gold cage nanoparticles enable photothermal ablation and photoacoustic imaging in biofilm-associated infection models Journal of Clinical Investigation 133(21) : e168485, August 2023 Notes: Featured on the NIBIB website: https://www.nibib.nih.gov/news-events/newsroom/golden-solution-quickly-eliminates-bacterial-infections-no-antibiotics-required and Newsweek: https://www.newsweek.com/sugar-gold-nanoparticles-phototherapy-bacteria-antibiotics-1879397
Hsu, Jessica C.; Tang, Zhongmin; Eremina, Olga; Sofias, Alexandros; Lammers, Twan; Lovell, Jonathan F.; Zavaleta, Cristina; Cai, Weibo; Cormode, David P. : Nanomaterial-based contrast agents Nature Reviews Methods Primers 3(1) : 30, April 2023
Nieves, Lenitza M.; Dong, Yuxi C.; Rosario-Berríos, Derick N.; Mossburg, Katherine; Hsu, Jessica C.; Cramer, Gwendolyn M.; Busch, Theresa M.; Maidment, Andrew D. A.; Cormode, David P. : Renally excretable silver telluride nanoparticles as contrast agents for x-ray imaging ACS Applied Materials and Interfaces 14(30) : 34354-34364, July 2022
Dong, Yuxi C.; Kumar, Ananyaa; Rosario-Berríos, Derick N.; Si-Mohamed, Salim; Hsu, Jessica C.; Nieves, Lenitza M.; Douek, Philippe; Noël, Peter B.; Cormode, David P. : Ytterbium nanoparticle contrast agents for conventional and spectral-photon counting CT and their applications for hydrogel imaging ACS Applied Materials and Interfaces 14(34) : 39274-39284, August 2022
Kim, Johoon; Hong, Gwanui; Mazaleuskaya, Luda; Hsu, Jessica, C.; Rosario-Berrios, Derick N.; Grosser, Tilo; Cho-Park, Park F.; Cormode, David P. : Ultrasmall antioxidant cerium oxide nanoparticles for regulation of acute inflammation ACS Applied Materials and Interfaces 13(51) : 60852–60864, December 2021
Hsu, Jessica, C.; Du, Yu; Sengupta, Arjun; Dong, Yuxi C.; Mossburg, Katherine J.; Bouché, Mathilde; Maidment, Andrew D. A.; Weljie, Aalim M.; Cormode, David P. : Effect of nanoparticle synthetic conditions on ligand coating integrity and subsequent nano-bio interactions ACS Applied Materials and Interfaces 13(49) : 58401-58410, November 2021
Si-Mohamed, Salim; Sigovan, Monica; Hsu, Jessica C.; Chalabreysse, Lara; Garrivier, Thibaut; Tatard-Leitman, Valérie; Naha, Pratap C.; Carnaru, Miruna; Boussel, Loic; Cormode, David P.; Douek, Philippe. : In vivo molecular K-edge imaging of atherosclerotic plaque using photon-counting CT Radiology 300 : 98–107, July 2021 Notes: Was the subject of an editorial: Leiner, T. Radiology, 2021, 300, 108-109
Bouché, Mathilde; Sheikh, Saad; Dong, Yuxi C.; Taing, Kimberly; Saxena, Deeksha; Hsu, Jessica C.; Chen, Minna. H; Salinas, Ryan D.; Song, Hongjun; Burdick, Jason, A.; Dorsey, Jay; Cormode, David P. : Radiation-responsive hydrogel for imaging and therapeutic delivery for glioblastoma treatment ACS Biomaterials Science & Engineering 7(7) : 3209-3320, July 2021