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Kathleen Elise O'Neill, MD

Assistant Professor of Obstetrics and Gynecology at the Hospital of the University of Pennsylvania

  • Medical Director, Uterine Transplant Program, University of Pennsylvania
  • Attending, Reproductive Endocrinology & Infertility , Department of Ob/Gyn, Pennsylvania Hospital, Philadelphia, PA
  • Attending, Reproductive Endocrinology & Infertility, Department of Ob/Gyn, Hospital of the University of Pennsylvania, Philadelphia, PA, University of Pennsylvania
  • Attending, Gynecology, Penn Presbyterian Medical Center, Philadelphia, PA

Department: Obstetrics and Gynecology


Contact Information

University of Pennsylvania
Department of Obstetrics and Gynecology
Division of Reproductive Endocrinology and Infertility
421 Curie Blvd, 1353 BRB II/III
Philadelphia, PA 19104
Office: (215) 898-0825
Email: kathleen.o'neill2@pennmedicine.upenn.edu


I3H Keywords

  • Transplantation Immunity

Education

  • BA (Public Policy Studies)
    Duke University, Durham, NC, 2003
  • MD (Medicine)
    University of Michigan, Ann Arbor, MI, 2008
  • MTR (Translational Research)
    University of Pennsylvania, Philadelphia, PA, 2015

Post-Graduate Training

  • Resident, Obstetrics & Gynecology
    Washington University in St. Louis, MO, 2008 - 2012
  • Fellow, Reproductive Endocrinology & Infertility
    University of Pennsylvania, Philadelphia, PA, 2012 - 2015

Certifications

  • Board Certified in Reproductive Endocrinology & Infertility, American Board of Obstetrics & Gynecology, 2019
  • Board Certified in Obstetrics & Gynecology, American Board of Obstetrics & Gynecology, 2014

Description of Clinical Expertise

Mullerian anomalies and Uterus transplant

Description of Research Expertise

Early embryo development, unexplained infertility, endometrium, uterus transplant

Selected Publications

  • Walter JR, Richards EG, Johannesson L, Falcone T, Jungheim E, Testa G, O'Neill KE, Harvie HS : Cost-effectiveness analysis of uterus transplantation vs. gestational carrier for treatment of absolute uterine factor infertility in the United States. Fertil Steril S0015-0282(25) : 00035-4, Jan 2025
  • Yano Maher JC, Zelinski MB, Oktay KH, Duncan FE, Segars JH, Lujan ME, Lou H, Yun BH, Hanfling SN, Schwartz LE, Laronda MM, Halvorson LM, O'Neill KE, Gomez-Lobo V : Classification system of human ovarian follicle morphology: recommendations of the National Institute of Child Health and Human Development - sponsored ovarian nomenclature workshop. Fertil Steril S0015-0282(24)02394-X Nov 2024 Online ahead of print
  • Johannesson L, Humphries LA, Porrett PM, Testa G, Anderson S, Walter JR, Rush M, Ferrando CA, O'Neill K, Richards EG : Classification and treatment of vaginal strictures at the donor-recipient anastomosis after uterus transplant. Fertil Steril 122(3):525-534 Sep 2024
  • Walter JR, Johannesson L, Falcone T, Putnam JM, Testa G, Richards EG, O'Neill KE : In Vitro Fertilization Practice in Patients with Absolute Uterine Factor Undergoing Uterus Transplant in the United States. Fertil Steril 122(3):397-405 Sep 2024
  • Herz C, Vergnet N, Tian S, Aly AH, Jolley MA, Tran N, Arenas G, Lasso A, Schwartz N, O'Neill KE, Yushkevich PA, Pouch AM : Open-source graphical user interface for the creation of synthetic skeletons for medical image analysis. J Med Imaging (Bellingham) 11(3) : 036001, May 2024
  • Johannesson L, Sawinski D, Vock DM, Kristek J, Fronek J, Richards EG, O'Neill KE, Perni U, Porrett PM, Testa G : A Multi-Institutional Report of Intermediate-Term Kidney Outcomes in Uterus Transplant Recipients. Kidney Int Rep 8(10): 2156-2159 Aug 2023
  • Fisher SA, Grijalva M, Guo R, Johnston SA, Laurent LC, Nguyen H, Renz J, Rosario JG, Rudich S, Gregory BD, Kim J, O'Neill K : Systematic Sampling of the Female Reproductive System for Molecular Characterization. Curr Protoc 3(8) : e848, Aug 2023
  • Johannesson L, Testa G, Beshara MM, da Graca B, Walter JR, Quintini C, Latif N, Hashimoto K, Richards EG, O'Neill K : Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US. J Clin Med 12(13) : 4201, Jun 2023
  • O'Neill KE, Maher JY, Laronda MM, Duncan FE, LeDuc RD, Lujan ME, Oktay KH, Pouch AM, Segars JH, Tsui EL, Zelinski MB, Halvorson LM, Gomez-Lobo V : Anatomic nomenclature and 3-dimensional regional model of the human ovary: call for a new paradigm. Am J Obstet Gynecol 228(3):270-275 Mar 2023
  • Sawinski D, Ralston SJ, Coscia L, Klein CL, Wang EY, Porret P, O’Neill K, Iltis AS : Counselling, Research Gaps, and Ethical Considerations Surrounding Pregnancy in Solid Organ Transplant Recipients. J Bioeth Inq 20(1):89-99 Mar 2023