Robert Bradley Lindell, MD
Assistant Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
- Faculty Member, Systems Immunology and Genomics, Institute for Immunology & Immune Health, University of Pennsylvania Perelman School of Medicine
- Faculty Member, Institute for Translational Medicine & Therapeutics, University of Pennsylvania Perelman School of Medicine
- Faculty Member, Institute for Immunology & Immune Health, University of Pennsylvania Perelman School of Medicine
- Attending Physician, Division of Critical Care Medicine, Children's Hospital of Philadelphia
- Faculty Member, Immunology and Infectious Disease Research Initiative, Children's Hospital of Philadelphia Research Institute
- Faculty Member, Immune Dysregulation Program, Children's Hospital of Philadelphia Research Institute
- Faculty Member, Pediatric Sepsis Program, Children's Hospital of Philadelphia Research Institute
- Faculty Member, Protective Immunity and Immunopathology Affinity Group, Children’s Hospital of Philadelphia Research Institute
Department: Anesthesiology and Critical Care
Contact Information
Children’s Hospital of Philadelphia
Department of Anesthesiology and Critical Care Medicine
3401 Civic Center Boulevard
Philadelphia, PA 19104
Email: lindellr@chop.edu
I3H Keywords
- Precision Immunology and Measuring Immune Health
- Systems Immunology and Genomics
Publications
Links
Education
-
BS (Microbiology)
University of Georgia, 2007 -
BA (Religion)
University of Georgia, 2007 -
MD (Medicine)
Vanderbilt University School of Medicine, 2012
Post-Graduate Training
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Resident, General Pediatrics
Children's Hospital of Philadelphia, 2012 - 2015 -
Fellow, Pediatric Critical Care Medicine
Children's Hospital of Philadelphia, 2016 - 2019
Certifications
- American Board of Pediatrics, General Pediatrics, 2015
- Basic Life Support (BLS), 2022
- Pediatric Advanced Life Support (PALS), 2022
- Advanced Cardiac Life Support (ACLS), 2022
- Advanced Trauma Life Support (ATLS), 2020
- American Board of Pediatrics, Pediatric Critical Care Medicine, 2020
Description of Clinical Expertise
As a pediatric intensivist, I provide care for critically ill children across a broad range of diagnoses. I have specific clinical expertise in managing sepsis, cytokine storm syndromes, and organ support technologies such as extracorporeal membrane oxygenation (ECMO) and therapeutic plasma exchange. I also serve as a clinical resource for evaluating patients with immune dysregulation as a member of the Dysregulated Immune Response Team.
Description of Research Expertise
I lead a translational research program focused on the immunobiology of pediatric sepsis and multi-organ dysfunction syndrome (MODS). My work integrates high-dimensional immune profiling—including proteomics, phospho-flow cytometry, and single-cell RNA sequencing—to identify immune endotypes that inform risk stratification and targeted therapies. Learn more at LindellLab.org.
Description of ITMAT Expertise
As a pediatric intensivist, I care for critically ill children across a wide spectrum of ages and underlying pathologies. My clinical and translational research efforts are focused on enhancing our understanding of the immunobiology of pediatric sepsis, particularly in immunocompromised children.
Selected Publications
- Ham SD, Famularo ST, Arroyo T, Fitzgerald JC, Lindell RB : Defining thrombocytopenia-associated multiple organ dysfunction in the plasma proteome Shock Society 2025 Annual Conference on Shock June 2025 Notes: Oral Presentation
- Sheetz SA, Sayed S, Campos JS, Arroyo T, Famularo ST, Meyer NJ, Henrickson SE, Lindell RB : Dysregulated STAT3 phosphorylation and CD8+ T cell activation in hyperinflammatory pediatric sepsis Shock Society 2025 Annual Conference on Shock June 2025 Notes: Poster Presentation
- Shraim R, Diorio C, Canna SW, Macdonald-Dunlop E, Bassiri H, Martinez Z, Mälarstig A, Abbaspour A, Teachey DT, Lindell RB, Behrens EM : A Method for Comparing Proteins Measured in Serum and Plasma by Olink® Proximity Extension Assay Mol Cell Proteomics May 2025 Notes: In Press
- Lindell RB, Sayed S, Campos JS, Sheetz SA, Babu A, Knight MS, Mauracher AA, Hay CA, Conrey PE, Fitzgerald JC, Yehya N, Famularo ST, Arroyo T, Tustin R, Fazelinia H, Behrens EM, Teachey DT, Freeman AF, Bergerson JRE, Holland SM, Leiding JW, Weiss SL, Hall MW, Taylor D, Feng R, Wherry EJ, Meyer NJ, Henrickson SE : Aberrant STAT signaling drives T cell dysregulation in a targetable pediatric sepsis endotype medRxiv May 2025 Notes: In Press
- Ham SD, Shraim R, Diorio C, Babu A, Behrens EM, Henrickson SE, Lindell RB : Proteomic profiling identifies shared inflammatory pathways in pediatric sepsis, MIS-C, and cytokine release syndrome American Thoracic Society 2025 International Conference May 2025 Notes: Poster Presentation
- Ham SD, Famularo ST, Arroyo T, Fitzgerald JC, Lindell RB : Defining thrombocytopenia-associated multiple organ dysfunction in the plasma proteome CHOP Research Institute Scientific Symposium May 2025 Notes: Poster Presentation
- Arroyo T, Kirchner V, Sheetz SA, Dickey S, Alcamo AM, Lindell RB : Computational Screening for Pediatric Sepsis using the Phoenix Sepsis Score CHOP Research Institute Scientific Symposium May 2025 Notes: Poster Presentation
- Sheetz SA, Sayed S, Campos JS, Babu A, Arroyo T, Famularo ST, Meyer NJ, Henrickson SE, Lindell RB : Functional Deficits in STAT3 Phosphorylation and Cytokine Signaling in CD8+ T Cells from Children with Sepsis CHOP Research Institute Scientific Symposium May 2025 Notes: Poster Presentation
- Lindell RB, Sayed S, Campos JS, Babu A, Ham SD, Sheetz SA, Famularo ST, Arroyo T, Fitzgerald JC, Yehya N, Weiss SL, Hall MW, Wherry EJ, Meyer NJ, Henrickson SE : Defining a new pediatric sepsis endotype associated with bystander T cell activation, dysregulated STAT3 signaling, and poor prognosis American Thoracic Society 2025 International Conference May 2025 Notes: Poster Presentation
- Sheetz SA, Sayed S, Campos JS, Babu A, Arroyo T, Famularo ST, Meyer NJ, Henrickson SE, Lindell RB : Dysregulated T cell cytokine responses characterize a high-risk pediatric sepsis subphenotype Clinical Immunology Society 2025 Annual Meeting May 2025 Notes: Poster Presentation