Mohammad Haj Dezfulian, PhD
Assistant Professor of Pathology and Laboratory Medicine
- Member, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
- Member, The Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania
- Member, Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania
Department: Pathology and Laboratory Medicine
Contact Information
Email: mohammad.hajdezfulian@pennmedicine.upenn.edu
I3H Keywords
- Array
Publications
Links
Education
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B.Sc. (Molecular Biology and Genetics)
Tehran University & Chamran University, 2006 -
PhD (Molecular Biology and Genetics)
University of Windsor, 2014
Post-Graduate Training
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Postdoctoral Fellow
Harvard Medical School/ Birgham and Women's Hospital, 2015 - 2022
Description of Research Expertise
Our laboratory investigates the molecular drivers of immune recognition across autoimmunity, malignancy, and infectious disease. We combine systems immunology with functional genomics and protein engineering to develop high-throughput technologies capable of mapping T cell specificity within patient samples. This engineering-driven approach enables us to elucidate the governing principles of immune specificity and tolerance, ultimately guiding the design of novel immunotherapeutic modalities.
Selected Publications
- Kohlgruber AC, Dezfulian MH, Sie B, Wang CI, Kula T, Laserson U, Larman HB, Elledge SJ. : High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits Nat Biotechnol no volume(no issue) July 2024 Notes: https://doi.org/10.1038/s41587-024-02248-6
- Dezfulian MH, Kula T, Pranzatelli T, Kamitaki N, Meng Q, Khatri B, Perez P, Xu Q, Chang A, Kohlgruber AC, Leng Y, Jupudi AA, Joachims ML, Chiorini JA, Lessard CJ, Farris AD, Muthuswamy SK, Warner BM, Elledge SJ. : TScan-II: A genome-scale platform for the de novo identification of CD4+ T cell epitopes Cell 186(25) : 5569-5586.e21, December 2023 Notes: doi: 10.1016/j.cell.2023.10.024. Epub 2023 Nov 27.
- Kula T, Dezfulian MH, Wang CI, Abdelfattah NS, Hartman ZC, Wucherpfennig KW, Lyerly HK, Elledge SJ. : T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. Cell. 178(4) : 1016-1028.e13, August 2019 Notes: doi: 10.1016/j.cell.2019.07.009.