Key Publications
Michael Cancro (1949–2025)
Mark J. Shlomchik and David Allman - Immunity 58, April 8, 2025 PMID is: 40203802
Read Moreabout Michael Cancro (1949–2025)Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity
Weissenrieder JS, Peura J, Paudel U, Bhalerao N, Weinmann N, Johnson C, Wengyn M, Drager R, Furth EE, Simin K, Ruscetti M, Stanger BZ, Rustgi AK, Pitarresi JR, Foskett JK. Cell Rep. 2025 Apr 24;44(5):115627. PMID: 40286270
Read Moreabout Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticitySIRT1-based therapy targets a gene program involved in mitochondrial turnover in a model of retinal neurodegeneration
Chaqour B, Rossman JB, Meng M, Dine KE, Ross AG, Shindler KS. Sci Rep. 2025 Apr 19;15(1):13585. PMID: 40253451
Read Moreabout SIRT1-based therapy targets a gene program involved in mitochondrial turnover in a model of retinal neurodegenerationTransient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection
Broomfield BJ, Tan CW, Qin RZ, Abberger H, Duckworth BC, Alvarado C, Dalit L, Lee CL, Shandre Mugan R, Mazrad ZAI, Muramatsu H, Mackiewicz L, Williams BE, Chen J, Takanashi A, Fabb S, Pellegrini M, Rogers KL, Moon WJ, Pouton...
Read Moreabout Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protectionA genotype-first approach identifies high incidence of NF1 pathogenic variants with distinct disease associations
Safonov A, Nomakuchi TT, Chao E, Horton C, Dolinsky JS, Yussuf A, Richardson M, Speare V, Li S, Bogus ZC, Bonanni M, Raper A, Odia T, Wubbenhorst BS, Faulders E, Schuth EM, Loranger K, Zhang J, Scalise CB, ElNaggar A,...
Read Moreabout A genotype-first approach identifies high incidence of NF1 pathogenic variants with distinct disease associationsA Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis.
Blockmans D, Penn SK, Setty AR, Schmidt WA, Rubbert-Roth A, Hauge EM, Keen HI, Ishii T, Khalidi N, Dejaco C, Cid MC, Hellmich B, Liu M, Zhao W, Lagunes I, Romero AB, Wung PK, Merkel PA; SELECT-GCA Study Group. N...
Read Moreabout A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis.Type I interferon exposure of an implantation-on-a-chip device alters invasive extravillous trophoblast function.
Michael K. Simoni, Seble G. Negatu, Ju Young Park, Sneha Mani, Montserrat C. Arreguin, Kevin R. Amses, Dan Dongeun Huh, Monica Mainigi, Kellie A. Jurado. Cell Rep Med. 2025 Mar 18; 6(3): 101991. PMCID: PMC11970386 PMID: 40054459
Read Moreabout Type I interferon exposure of an implantation-on-a-chip device alters invasive extravillous trophoblast function.Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate.
Huang YJ, Ngiow SF, Baxter AE, Manne S, Park SL, Wu JE, Khan O, Giles JR, Wherry EJ. Sci Immunol. 2025 Mar 7;10(105):eado3032. doi: 10.1126/sciimmunol.ado3032. Epub 2025 Mar 7. PMID: 40053604
Read Moreabout Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate.Tick feeding or vaccination with tick antigens elicits immunity to the Ixodes scapularis exoproteome in guinea pigs and humans.
Hart TM, Cui Y, Telford SR, Marín-López A, Calloway K, Dai Y, Matias J, DePonte K, Jaycox J, DeBlasio M, Hoornstra D, Belperron AA, Cibichakravarthy B, Johnson EE, Alameh MG, Dwivedi G, Hovius JWR, Bockenstedt LK, Weissman D, Ring...
Read Moreabout Tick feeding or vaccination with tick antigens elicits immunity to the Ixodes scapularis exoproteome in guinea pigs and humans.Assessing the oncogenic risk: the long-term safety of autologous chimeric antigen receptor T cells.
Baker DJ, Levine BL, June CH. Lancet. 2025 Mar 1;405(10480):751-754. doi: 10.1016/S0140-6736(25)00039-X. PMID: 40023653
Read Moreabout Assessing the oncogenic risk: the long-term safety of autologous chimeric antigen receptor T cells.Immune targeting and host-protective effects of the latent stage of Toxoplasma gondii.
Eberhard JN, Shallberg LA, Winn A, Chandrasekaran S, Giuliano CJ, Merritt EF, Willis E, Konradt C, Christian DA, Aldridge DL, Bunkofske ME, Jacquet M, Dzierszinski F, Katifori E, Lourido S, Koshy AA, Hunter CA. Nat Microbiol. 2025 Mar 27. doi:...
Read Moreabout Immune targeting and host-protective effects of the latent stage of Toxoplasma gondii.Immune history shapes human antibody responses to H5N1 influenza viruses.
Garretson TA, Liu J, Li SH, Scher G, Santos JJS, Hogan G, Vieira MC, Furey C, Atkinson RK, Ye N, Ort JT, Kim K, Hernandez KA, Eilola T, Schultz DC, Cherry S, Cobey S, Hensley SE. Nat Med...
Read Moreabout Immune history shapes human antibody responses to H5N1 influenza viruses.Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity.
Tursi NJ, Tiwari S, Bedanova N, Kannan T, Parzych E, Okba N, Liaw K, Sárközy A, Livingston C, Trullen MI, Gary EN, Vadovics M, Laenger N, Londregan J, Khan MS, Omo-Lamai S, Muramatsu H, Blatney K, Hojecki C, Machado V,...
Read Moreabout Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity.The epigenetic landscape of fate decisions in T cells.
Jay A, Pondevida CM, Vahedi G. Nat Immunol. 2025 Mar 19. doi: 10.1038/s41590-025-02113-x. Online ahead of print. PMID: 40108419
Read Moreabout The epigenetic landscape of fate decisions in T cells.B cell stimulation changes the structure and higher-order organization of the inactive X chromosome.
Sierra I, Toothacre NE, van der Weide RH, Lovell CD, Nguyen SC, Barnett RJ, Cook AL, Ryu HS, Pyfrom S, Wang H, Beiting D, Philips-Cremins JE, Joyce EF, Anguera MC. Cell Rep. 2025 Mar 25;44(3):115351. doi: 10.1016/j.celrep.2025.115351. Epub...
Read Moreabout B cell stimulation changes the structure and higher-order organization of the inactive X chromosome.Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant Enterococcus faecium.
Mills EG, Hewlett K, Smith AB, Griffith MP, Pless L, Sundermann AJ, Harrison LH, Zackular JP, Van Tyne D. Nat Microbiol. 2025 Mar 21. doi: 10.1038/s41564-025-01958-0. Online ahead of print. PMID: 40119148
Read Moreabout Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant Enterococcus faecium.A patient-derived T cell lymphoma biorepository uncovers pathogenetic mechanisms and host-related therapeutic vulnerabilities.
Fiore D, Cappelli LV, Zhaoqi L, Kotlov N, Sorokina M, Phillip J, Zumbo P, Yoffe L, Ghione P, Wang A, Han X, Taylor A, Chiu W, Fragliasso V, Tabbo F, Zamponi N, Di Siervi N, Kayembe C, Medico G, Patel...
Read Moreabout A patient-derived T cell lymphoma biorepository uncovers pathogenetic mechanisms and host-related therapeutic vulnerabilities.Targeting pathogenic interferon-stimulated gene RSAD2 improves pregnancy outcomes in systemic lupus erythematosus models.
Negatu SG, Jurado KA. Cell Rep Med. 2025 Mar 18;6(3):102034. doi: 10.1016/j.xcrm.2025.102034. PMID: 40107239
Read Moreabout Targeting pathogenic interferon-stimulated gene RSAD2 improves pregnancy outcomes in systemic lupus erythematosus models.Therapeutic activation of IL-22-producing innate lymphoid cells enhances host defenses to Clostridioides difficile infection.
Mears KS, Denny JE, Maslanka JR, Mdluli NV, Hulit EN, Matsuda R, Furth EE, Buffie CG, Abt MC. Cell Rep. 2025 Mar 25;44(4):115438. doi: 10.1016/j.celrep.2025.115438. Online ahead of print. PMID: 40138315
Read Moreabout Therapeutic activation of IL-22-producing innate lymphoid cells enhances host defenses to Clostridioides difficile infection.CAR-macrophage therapy for HER2-overexpressing advanced solid tumors: a phase 1 trial.
Reiss KA, Angelos MG, Dees EC, Yuan Y, Ueno NT, Pohlmann PR, Johnson ML, Chao J, Shestova O, Serody JS, Schmierer M, Kremp M, Ball M, Qureshi R, Schott BH, Sonawane P, DeLong SC, Christiano M, Swaby RF, Abramson S,...
Read Moreabout CAR-macrophage therapy for HER2-overexpressing advanced solid tumors: a phase 1 trial.