Key Publications
Women in STEM becoming independent: People should feel free to be themselves and do great science.
Liu S, Saraiva M, Bartman CR, Saurat N, Rosato PC, Licona-Limon P, Mendoza A, Guthmiller J, Mlynarczyk C, Goldberg E. J Exp Med. 2025 Sep 1;222(9):e20251386. doi: 10.1084/jem.20251386. Epub 2025 Aug 8. PMID: 40778912
Read Moreabout Women in STEM becoming independent: People should feel free to be themselves and do great science.Cell-free DNA methylomics identify tissue injury patterns in pediatric ARDS.
Yehya N, Till JE, Srivastava N, Zhang D, Christie JD, Carpenter EL, Mangalmurti NS, Zhou W. JCI Insight. 2025 Sep 2:e191684. doi: 10.1172/jci.insight.191684. Online ahead of print. PMID: 40892473
Read Moreabout Cell-free DNA methylomics identify tissue injury patterns in pediatric ARDS.Stem Cell-Derived, Fully Differentiated Islets for Type 1 Diabetes.
Reichman TW, Markmann JF, Odorico J, Witkowski P, Fung JJ, Wijkstrom M, Kandeel F, de Koning EJP, Peters AL, Mathieu C, Kean LS, Bruinsma BG, Wang C, Mascia M, Sanna B, Marigowda G, Pagliuca F, Melton D, Ricordi C,...
Read Moreabout Stem Cell-Derived, Fully Differentiated Islets for Type 1 Diabetes.Bezafibrate improves mitochondrial function, blood-brain barrier integrity, and social deficits in models of 22q11.2 deletion syndrome.
Crockett AM, Colόn MCV, Kebir H, Smith FM, Iascone DM, Ciesielski B, Koshkin S, Patterson AD, Rossano AJ, Sehgal A, Anderson SA, Alvarez JI. Sci Transl Med. 2025 Aug 20;17(812):eads2116. doi: 10.1126/scitranslmed.ads2116. Epub 2025 Aug 20.PMID: 40834102
Read Moreabout Bezafibrate improves mitochondrial function, blood-brain barrier integrity, and social deficits in models of 22q11.2 deletion syndrome.Amino acid competition shapes Acinetobacter baumannii gut carriage.
Ren X, Clark RM, Bansah DA, Varner EN, Tiffany CR, Jaswal K, Geary JH, Todd OA, Winkelman JD, Friedman ES, Jarrett RN, Zemel BS, Wu GD, Zackular JP, DePas WH, Behnsen J, Palmer LD. Cell Host Microbe. 2025...
Read Moreabout Amino acid competition shapes Acinetobacter baumannii gut carriage.Deep learning unlocks antimicrobial self-assembling peptides.
Xia X, de la Fuente-Nunez C. Nat Mater. 2025 Aug;24(8):1168-1169. doi: 10.1038/s41563-025-02299-3. PubMed PMID: 40691518.
Read Moreabout Deep learning unlocks antimicrobial self-assembling peptides.New Approaches to Old Techniques in Cell Handling for Microscopy.
Bartosh Z, Aishwarya V, Hancock WW, Akimova T. Cells. 2025 Aug 18;14(16):1271. doi: 10.3390/cells14161271. PMID: 40862751
Read Moreabout New Approaches to Old Techniques in Cell Handling for Microscopy.Dietary saturated fatty acids promote lung myeloid cell inflammasome activation and IL-1β-mediated inflammation in mice and humans.
McCright SJ, Harding O, Chini J, DeMarco N, Hung LY, Pastore CF, Lu W, Rabinowitz J, Henao-Mejia J, Herbert DR, Young LR, Hill DA. Sci Transl Med. 2025 Aug 27;17(813):eadp5653. doi: 10.1126/scitranslmed.adp5653. Epub 2025 Aug 27. PMID: 40864681
Read Moreabout Dietary saturated fatty acids promote lung myeloid cell inflammasome activation and IL-1β-mediated inflammation in mice and humans.Clinical and molecular dissection of CAR T cell resistance in pancreatic cancer.
Aznar MA, Good CR, Barber-Rotenberg JS, Agarwal S, Wilson W, Watts A, Zhang Z, Gonzales D, Donahue G, Hwang WT, Rennels AK, Rech AJ, Kuramitsu S, Huang H, Glastad KM, Alexander KA, Plesa G, Dowd E, Brennan A, Siegel DL,...
Read Moreabout Clinical and molecular dissection of CAR T cell resistance in pancreatic cancer.Enhanced CAR T-Cell Therapy for Relapsed Lymphoma. Reply.
Svoboda J, Hexner E, June CH. N Engl J Med. 2025 Aug 7;393(6):620. doi: 10.1056/NEJMc2507794. PMID: 40768731
Read Moreabout Enhanced CAR T-Cell Therapy for Relapsed Lymphoma. Reply.SAA1/FPR2 signaling between keratinocytes and neutrophils sustains chronic inflammation in Sweet syndrome.
Huang J, Sati S, Ahart O, Rapp-Reyes E, Zhou L, Micheletti RG, James WD, Rosenbach M, Leung TH. J Clin Invest. 2025 Aug 19:e193566. doi: 10.1172/JCI193566. Online ahead of print. PMID: 40828601
Read Moreabout SAA1/FPR2 signaling between keratinocytes and neutrophils sustains chronic inflammation in Sweet syndrome.Alternatively spliced isoforms of IRF7 differentially regulate interferon expression to tune response to viral infection.
Panthi A, Ferretti MB, Howard O, Pokharel SM, McCracken R, Boudreault S, Quesnel-Vallieres M, Li Q, Cherry S, Lynch KW. Cell Rep. 2025 Aug 19;44(9):116166. doi: 10.1016/j.celrep.2025.116166. Online ahead of print.PMID: 40833856
Read Moreabout Alternatively spliced isoforms of IRF7 differentially regulate interferon expression to tune response to viral infection.Directed evolution-based discovery of ligands for in vivo restimulation of chimeric antigen receptor T cells.
Grzywa TM, Neeser A, Ramasubramanian R, Romanov A, Tannir R, Mehta NK, Cossette B, Morgan DM, Goncalves B, Sukaj I, Bergaggio E, Kadauke S, Myers RM, Paruzzo L, Ghilardi G, Cozzone A, Schuster SJ, Frey N, Zhang L, Yousefpour P,...
Read Moreabout Directed evolution-based discovery of ligands for in vivo restimulation of chimeric antigen receptor T cells.Transcription factor BACH2 shapes tissue-resident memory T cell programs to promote HIV-1 persistence.
Wei Y, Ma HK, Wong ME, Back H, Papasavvas E, Mounzer K, Aberra F, Morgenstern R, Tebas P, Konnikova L, Montaner LJ, Ho YC. Immunity. 2025 Aug 16;. doi: 10.1016/j.immuni.2025.07.022. [Epub ahead of print] PubMed PMID: 40845842;...
Read Moreabout Transcription factor BACH2 shapes tissue-resident memory T cell programs to promote HIV-1 persistence.Proviruses in CD4+ T cells reactive to autologous antigens contribute to nonsuppressible HIV-1 viremia
Wu F, Moskovljevic M, Dragoni F, Jayaraman S, Board NL, Camilo-Contreras A, Bernal S, Hariharan V, Zhang H, Lai J, Singhal A, Poulin S, Chano F, Chamberland A, Tremblay C, Zoltick M, Hoffmann CJ, Jones JL, Larman HB, Montaner LJ...
Read Moreabout Proviruses in CD4+ T cells reactive to autologous antigens contribute to nonsuppressible HIV-1 viremiaNRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas.
Sehgal P, Naqvi AS, Higgins M, Liu J, Harvey K, Jarroux J, Kim T, Mankaliye B, Mishra P, Watterson G, Fine J, Davis J, Hayer KE, Castro A, Mogbo A, Drummer C 4th, Martinez D, Koptyra MP, Ang Z, Wang...
Read Moreabout NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas.Setting the table for immune tolerance.
Silverman M, Knoop K. Science. 2025 Aug 14;389(6761):684-685. doi: 10.1126/science.adz8687. Epub 2025 Aug 14. PMID: 40811563
Read Moreabout Setting the table for immune tolerance.The transcription factor BATF pioneers the differentiation program of effector CD8+ T cells through the interaction with IRF4.
Fujisawa S, Tanabe Y, Hojo A, Shiga R, Kurachi J, Koura M, Tamai T, Miyanari Y, Wherry EJ, Kurachi M. Cell Rep. 2025 Aug 26;44(8):116129. doi: 10.1016/j.celrep.2025.116129. Epub 2025 Aug 6. PMID: 40773348
Read Moreabout The transcription factor BATF pioneers the differentiation program of effector CD8+ T cells through the interaction with IRF4.Chromatin repression by PRC2 results in reduced gene expression driving key features of CD8 T cell exhaustion.
Samareh P, Agudelo-Garcia P, Zhang Z, Gilbert M, Mendoza M, Huang H, Wu JE, Baxter AE, Chen Z, Alexander K, Wherry EJ, Good CR, Berger SL. J Immunol. 2025 Aug 7:vkaf188. doi: 10.1093/jimmun/vkaf188. Online ahead of print. PMID: 40795221
Read Moreabout Chromatin repression by PRC2 results in reduced gene expression driving key features of CD8 T cell exhaustion.Safety and efficacy of fenebrutinib in relapsing multiple sclerosis (FENopta): a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial and open-label extension study
Bar-Or A, Dufek M, Budincevic H, Drulovic J, Habek M, Hua LH, Weber MS, Thomas P, Napieralski J, Mitzner MC, Ratchford JN, Clayton D, Harp CT, Kuruvilla D, Qi Q, Chen YF, Xu Y, Goodyear A, Oh J; FENopta...
Read Moreabout Safety and efficacy of fenebrutinib in relapsing multiple sclerosis (FENopta): a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial and open-label extension study