Key Publications
Safety and efficacy of fenebrutinib in relapsing multiple sclerosis (FENopta): a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial and open-label extension study
Bar-Or A, Dufek M, Budincevic H, Drulovic J, Habek M, Hua LH, Weber MS, Thomas P, Napieralski J, Mitzner MC, Ratchford JN, Clayton D, Harp CT, Kuruvilla D, Qi Q, Chen YF, Xu Y, Goodyear A, Oh J; FENopta...
Read Moreabout Safety and efficacy of fenebrutinib in relapsing multiple sclerosis (FENopta): a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial and open-label extension studyEnvironmental stress drives clearance of a persistent enteric virus in mice
Herrmann C, Zaldana K, Lustig AM, Bee GCW, Agostino EL, Koralov SB, Cadwell K. Nat Microbiol. 2025 Aug;10(8):1975-1988. doi: 10.1038/s41564-025-02046-z. Epub 2025 Jun 25. PMID: 40562879
Read Moreabout Environmental stress drives clearance of a persistent enteric virus in miceGiardia helps the immune system pick its battles
Howard CA, Hunter CA. Nat Immunol. 2025 Aug;26(8):1217-1218. doi: 10.1038/s41590-025-02229-0. PMID: 40691328 No abstract available.
Read Moreabout Giardia helps the immune system pick its battlesProbing condensate microenvironments with a micropeptide killswitch
Zhang Y, Stöppelkamp I, Fernandez-Pernas P, Allram M, Charman M, Magalhaes AP, Piedavent-Salomon M, Sommer G, Sung YC, Meyer K, Grams N, Halko E, Dongre S, Meierhofer D, Malszycki M, Ilik IA, Aktas T, Kraushar ML, Vastenhouw N, Weitzman MD...
Read Moreabout Probing condensate microenvironments with a micropeptide killswitchImpaired AMPK control of alveolar epithelial cell metabolism promotes pulmonary fibrosis
Rodríguez LR, Alysandratos KD, Katzen J, Murthy A, Roque Barboza W, Tomer Y, Bui S, Acín-Pérez R, Petcherski A, Minakin K, Carson P, Iyer S, Chavez K, Cooper CH, Babu A, Weiner AI, Vaughan AE, Arany Z, Shirihai OS,...
Read Moreabout Impaired AMPK control of alveolar epithelial cell metabolism promotes pulmonary fibrosisSpatial and single cell mapping of castleman disease reveals key stromal cell types and cytokine pathways
Smith D, Eichinger A, Fennell É, Xu-Monette ZY, Rech A, Wang J, Esteva E, Seyedian A, Yang X, Zhang M, Martinez D, Tan K, Luo M, Young KJ, Murray PG, Park C, Reizis B, Pillai V. Nat Commun....
Read Moreabout Spatial and single cell mapping of castleman disease reveals key stromal cell types and cytokine pathwaysA percolation phase transition controls complement protein coating of surfaces
Wang Z, Kulkarni S, Nong J, Zamora M, Ebrahimimojarad A, Hood E, Shuvaeva T, Zaleski M, Gullipalli D, Wolfe E, Espy C, Arguiri E, Wu J, Wang Y, Marcos-Contreras OA, Song W, Muzykantov VR, Fu J, Radhakrishnan R, Myerson...
Read Moreabout A percolation phase transition controls complement protein coating of surfacesCAR-T cell therapy and reconstructive oncologic surgery in peripheral solid tumors-A narrative review
Knoedler L, Herfeld K, Schaefer DA, Diatta F, Clune J, Evans B, Seu M, Kim BS, Alfertshofer M, Schaschinger T, Iske J, Knoedler S, Lellouch AG, Jeljeli M, Carturan A, Ruella M, Heiland M, Poeck H, Perl M, Pomahac...
Read Moreabout CAR-T cell therapy and reconstructive oncologic surgery in peripheral solid tumors-A narrative reviewTargeting triglyceride-rich lipoproteins in cardiovascular disease
Bajaj A, Rader DJ. Nat Med. 2025 Jul 24. doi: 10.1038/s41591-025-03845-x. Online ahead of print. PMID: 40707611
Read Moreabout Targeting triglyceride-rich lipoproteins in cardiovascular diseaseAutomated characterization of abdominal MRI exams using deep learning
Kim J, Chae A, Duda J, Borthakur A, Rader DJ, Gee JC, Kahn CE Jr; Penn Medicine BioBank; Witschey WR, Sagreiya H. Sci Rep. 2025 Jul 25;15(1):27044. doi: 10.1038/s41598-025-11985-w. PMID: 40715356 PMCID: PMC12297695
Read Moreabout Automated characterization of abdominal MRI exams using deep learningMyeloid cell networks govern re-establishment of original immune landscapes in recurrent ovarian cancer
Ghisoni E, Benedetti F, Minasyan A, Desbuisson M, Cunnea P, Grimm AJ, Fahr N, Capt C, Rayroux N, De Carlo F, Gulhan DC, Dagher J, Barras D, Morotti M, Marín-Jiménez JA, Chap BS, Santoro T, Spagnol G, Fleury M, Fortis...
Read Moreabout Myeloid cell networks govern re-establishment of original immune landscapes in recurrent ovarian cancerMutations in the human CSF1R gene impact microglia's maintenance of brain white matter integrity
Du S, Zhou Y, Li D, Lier J, Cella M, Tada M, Hamasaki H, Wu J, Cai Z, Orthmann-Murphy JL, Kakita A, Kipnis J, Bergner CG, Colonna M. Nat Immunol. 2025 Jul;26(7):1198-1211. doi: 10.1038/s41590-025-02195-7. Epub 2025 Jun 26. PMID: 40571738
Read Moreabout Mutations in the human CSF1R gene impact microglia's maintenance of brain white matter integrityIntegrative single-cell multi-omics profiling of human pancreatic islets identifies T1D-associated genes and regulatory signals
D'Oliveira Albanus R, Zhang X, Zhao Z, Taylor HJ, Tang X, Han Y, Orchard P, Varshney A, Zhang T, Manickam N, Erdos MR, Narisu N, Taylor L, Saavedra X, Liu X, Zhong A, Li B, Zhou T, Naji A,...
Read Moreabout Integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D-associated genes and regulatory signalsPPP2R1A mutations portend improved survival after cancer immunotherapy
Dai Y, Knisely A, Yano M, Dang M, Hinchcliff EM, Lee S, Welp A, Chelvanambi M, Lastrapes M, Liu H, Yuan Z, Wang C, Nie H, Jean S, Montaner LJ, Hou J, Patel A, Patel S, Fellman B, Yuan...
Read Moreabout PPP2R1A mutations portend improved survival after cancer immunotherapyFactors associated with resistance of HIV-1 reservoir viruses to neutralization by autologous IgG antibodies
McMyn NF, Varriale J, Wu HWS, Hariharan V, Moskovljevic M, Tan TS, Lai J, Singhal A, Lynn K, Mounzer K, Tebas P, Montaner LJ, Hoh R, Yu XG, Lichterfeld M, Simonetti FR, Kovacs C, Deeks SG, Siliciano JM,...
Read Moreabout Factors associated with resistance of HIV-1 reservoir viruses to neutralization by autologous IgG antibodiesSystemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo
Shuvaev VV, Tam YK, Lee BW, Myerson JW, Herbst A, Kiseleva RY, Glassman PM, Parhiz H, Alameh MG, Pardi N, Muramatsu H, Shuvaeva TI, Arguiri E, Marcos-Contreras OA, Hood ED, Brysgel TV, Nong J, Papp TE, Eaton DM, Riley...
Read Moreabout Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivoA hypoxia-responsive tRNA-derived small RNA confers renal protection through RNA autophagy
Li G, Sun L, Xin C, Hao T, Kharel P, Manning AC, O'Connor CL, Moore H, Lei S, Gokulnath P, Yang X, Sharma R, Garcia-Mansfield K, Pantham P, Xiao C, Wang HY, Chatterjee E, Yim S, Ren LB, Spanos M,...
Read Moreabout A hypoxia-responsive tRNA-derived small RNA confers renal protection through RNA autophagyIgM+IgD- B cells in human gut-associated lymphoid tissue have memory features and give rise to IgM+ and IgA+ antibody-secreting cells
Bukhari AM, Meng W, Rosenfeld AM, Prak ETL, Knight KL. Sci Rep. 2025 Jul 22;15(1):26613. doi: 10.1038/s41598-025-11209-1. PMID: 40695977
Read Moreabout IgM+IgD- B cells in human gut-associated lymphoid tissue have memory features and give rise to IgM+ and IgA+ antibody-secreting cellsTemporal and spatial omics technologies for 4D profiling
Reynolds DE, Roh YH, Oh D, Vallapureddy P, Fan R, Ko J. Nat Methods. 2025 Jul;22(7):1408-1419. doi: 10.1038/s41592-025-02683-6. Epub 2025 Apr 22. PMID: 40263585 Review.
Read Moreabout Temporal and spatial omics technologies for 4D profilingOvercoming extracellular vesicle-mediated fratricide improves CAR T cell treatment against solid tumors
Zhong W, Qin Z, Yu Z, Yang J, Yan D, Engel NW, Sheppard NC, Fan Y, Radhakrishnan R, Xu X, Ma L, Fuchs SY, June CH, Guo W. Nat Cancer. 2025 Jul;6(7):1157-1172. doi: 10.1038/s43018-025-00949-8. Epub 2025 Apr...
Read Moreabout Overcoming extracellular vesicle-mediated fratricide improves CAR T cell treatment against solid tumors