IC-PTE 2024

Location

15th - 18th May 2024

Mario Negri Institute

Milan, Italy

Organization Committee

Program 2024

May 15^th 2024

Opening Reception

Challenges in PTE Research: The Need for Biomarkers and Research Standards
Severn B. Churn, PhD, Program Director of Synapses, Channels and Neural Circuits NIH, USA

May 16^th 2024

Welcome and Opening Remarks

Laura Lubbers, PhD, Chief Scientific Officer, CURE Epilepsy, USA

Elisa Zanier, MD Head of Department, Mario Negri Institute for Pharmacological Research, Italy

Giuseppe Remuzzi, MD, Director of Mario Negri Institute for Pharmacological Research, Italy

Post-Traumatic Epilepsy: The Lived Experience

Jack Somers, Captain, United State Marine Corps, Retired

Moment of Silence & Reflection

Clinical PTE: Recent Advances, Challenges and Solutions

Overview of PTE and Goals of the Conference

Ramon Diaz-Arrastia, MD, PhD, Director TBI Clinical Res. Center, University of Pennsylvania, USA

Mechanistic Targets for PTE Prevention

Wolfgang Löscher, PhD, Professor, Hanover Medical School, Germany

Advances in the Neuropathological Characterization of PTE following TBI

Victoria Johnson, MBChB, PhD, Assistant Professor, University of Pennsylvania, USA

Predicting PTE Risk: The Development of a Risk Tool for PTE

Amy Wagner, MD, Professor, University of Pittsburgh, USA

Synthesis of Concepts and Discussion of Next Steps

1. How will we select the first/best biological mechanisms to test in clinical trials?
2. What supporting data will be required?

Promising Clinical Biomarkers of PTE

Moderator David Brody, MD, PhD

Blood-Based Biomarkers of PTE

Kevin Wang, PhD

Immune-Based Biomarkers: Lessons from TBI

Edward Needham, MD, PhD

EEG Biomarkers: Lessons from Acquired Epilepsy in the ICU

Edilberto Amorim, MD

Innovations in Brain Imaging: Implications for Post-Traumatic Epilepsy

David Brody, MD, PhD

Blood-Borne Protein Biomarkers of Post-Traumatic Epilgenesis; Gaps and Solutions

Denes Agoston, MD, PhD

Synthesis of Concepts and Discsuion of Next Steps

1. What criteria must be met to establish that biomarkers are ready for use?
2. What level of characterization and sensitivity threshold is required?

PTE: The Industry Perspective on Needs for Clinical Trial

Moderator: Douglas H. Smith

Needs for Developing Biomarkers for PTE Clinical Trials

William Haskins, PhD, Gryphon Bio, USA

Challenges in the Oath to a Clinical Trial: The Startup Perspective

Pavel Klein, MD, Mid-Atlantic Epilepsy and Sleep Center

Synthesis of Concepts and Discussion of Next Steps

1. How do we foster collaboration between industry partners and researchers?
2. How do we ensure we address industry needs to move the field forward?

May 17^th 2024

Welcome and Day 1 Recap

Elisa Zanier, MD, Mario Negri Insitute, Italy

Partnering with Lived-Experience PTE Community

Melissa Miller, PhD, US Department of Defense

Preclinical PTE: Advances, Challenges and Solutions

Moderator: David Loane, PhD, Trinity College, Ireland

Neuroinflamation as a Mechanism of Epileptogenesis: Insights from Status Epilepticus Models

Annamaria Vezzani, PhD, Mario Negri, Italy

Determining the Validity of Preclinical Animal Models

Aristea Galanpoulou, MD, PhD, Albert Einstein College of Medicine, USA

Synthesis of Concepts and Discsuion of Next Steps

1. How will we select the first/best biological mechanisms to test in clinical trials?
2. What supporting data will be required?

Promising Preclinical Biomarkers of PTE

Moderator: Kevin Staley, MD, Harvard School of Medicine, USA

Multi-omic Biomarkers of PTE

Firas Kobaissy, PhD, Morehouse School of Medicine, USA

Imaging Biomarkers of PTE

Federico Moro, PhD, Mario Negri, Italy

Preclinical EEG Biomkarkers of PTE

Asla Pitkänen, MD, PhD, University of Easern Finalnad, Finland

Developing Treatments for PTE: The Translational View

Terence O'Brien, MD, Monash University, Australia

Synthesis of Concepts and Discussion of Next Steps

1. When are biomarkers ready for use?
2. What level of characterization and sensitivity threshold is required?

Hot Topics in PTE: Data Blitz Presentations

Moderator, Christopher Dulla, PhD, Tufts University, USA

Early Career Winners

Ilaria Lisi, Mario Negri Institute, Italy

Bin Gu, PhD, Ohio State University, USA

Irma Ngadimon, PhD, Monash University, Malaysia

Oral Presentations

Justin Weppner, MD, Virginia Tech Carilion School of Medicine, USA

Tawfeeq Shekh-Ahmad, PhD, Hebrew University of Jerusalem, Israel

Discussion

May 18^th 2024

Welcome and Recap

Elisa Zanier, PhD, Maria Negri Institute, Italy

Involvement of Affected Individuals and the Public in PTE Clinical Research

Daniel Correa, MD, MS, Albert Einstein College of Medicine, USA

Developing the Data Infrastructure Needed for Progress in PTE

Moderator: Severn "Ben" Churn, NIH, USA

Federated Platforms/Systems for Validation and Optimization of Preclinical Findings

Joost Wagenaar, PhD, University of Pennsylvania, USA

Harnessing the Power of Big Data for PTE Analysis: Next Steps in Multi-Modal Data Analysis and Field-Wide Data Standardization

Dominique Duncan, University of Southern California, USA

Data Sharing and Standardization: Lessons from the Federal Inter-agency TBI Research (FITBIR) Informatics System

Hibah Awwad, PhD, NINDS/NIH, USA

Discussion

1. What considerations must be taken into account, from the researchers’ perspective, to ensure buy-in to federated data ecosystem? 

2. What additional resources or technology are needed to achieve multimodal analysis? 

The Roadmap to an Interventional Trial of PTE

Moderators: Laura Lubbers, CURE Epilepsy, USA, Elisa Zanier, Mario Negri, Italy

Panelists: Daniel Correa, MD, MS, Ramon Diaz-Arrastia, MD, PhD, Christopher Dulla, PhD, Pavel Klein, MD, Mary Jo Pugh, PhD, RN, Douglas Smith, MD