Perelman School of Medicine at the University of Pennsylvania

Johnson Lab

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Selected Publications (Johnson, VE)

Arena JD, Smith DH, Lee EB, Gibbons GS, Irwin DJ, Robinson JL, Lee V.M-Y, Trojanowski JQ, Stewart W, Johnson VE. (2020) Tau ImmunoPhenotypes in Chronic Traumatic Encephalopathy Recapitulate those of Aging and Alzheimer’s Disease. Brain. 1;143(5):1572-1587. 

Weber MT, Arena JD, Xiao R, Wolf JA, Johnson VE. (2018) CLARITY Reveals a More Protracted Temporal Course of Axon Swelling and Disconnection than Previously Described Following Traumatic Brain Injury. Brain Pathol. Vol.29(3), p.437-450.

Johnson VE, Weber MT, Xiao R, Cullen DK, Meaney DF, Stewart W, Smith DH. (2018) Mechanical disruption of the blood-brain barrier following experimental concussion. Acta Neuropathologica. 135(5):711-726.

Wolf JA, Johnson BN, Johnson VE, Putt ME, Browne KD, Mietus CJ, Brown DP, Wofford KL, Smith DH, Grady MS, Cohen AS, Cullen DK. (2018). Concussion Induced Hippocampal Circuitry Disruption in Swine. 15;34(14):2303-2314

Ulyanova AV, Koch PF, Cottone C, Grovola MR, Adam CD, Browne KD, Weber MT, Russo RJ, Gagnon KG, Smith DH, Isaac Chen H, Johnson VE, Kacy Cullen D, Wolf JA. (2018) Electrophysiological Signature Reveals Laminar Structure of Porcine Hippocampus. eNeuro, 18;5(5).

Kovacs GG1, Xie SX1, Lee EB1, Robinson JL1, Caswell C1, Irwin DJ1,Toledo JB, Johnson VE, Smith DH, Alafuzov I,  et al. (2017).  Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG). J Neuropathol Exp Neurol. 2017 Jul 1;76(7):605-619.

Johnson VE, Stewart W, Weber MT, Cullen DK, Siman R, Smith DH.  (2016)  SNTF Immunostaining Reveals Previously Undetected Axonal Pathology in Traumatic Brain Injury. Acta Neuropathologica. 131(1):115-35.

Hay JR, Johnson VE, Young AMH, Smith DH, Stewart W. (2015) Blood-Brain Barrier Disruption Is an Early Event That May Persist for Many Years After Traumatic Brain Injury in Humans JNEN 74(12):1147-57. 

Smith DH, Hicks R, Johnson VE, Bergstrom D, Cummings D, Noble-Haeusslein L, Hovda D, Whalen M, Ahlers S, LaPlaca M, Tortella F, Duhaime AC, Dixon CE. (2015) Preclinical Traumatic Brain Injury Common Data Elements: Towards a Common Language Across Laboratories. J Neurotrauma. 15;32(22):1725-35

Johnson VE, Stewart JE, Begbie FD, Trojanowski JQ, Smith DH, and Stewart W. (2013) Inflammation and white matter degeneration persist for years after a single traumatic brain injury. Brain, 2013. 136(1): p. 28-42.

Johnson VE, Stewart JE, Stewart W & and Smith, DH (2012) Widespread Tau and Amyloid-Beta Pathology Many Years After a Single Traumatic Brain Injury in Humans. Brain Pathol. Mar;22(2):142-9.

Johnson VE, Stewart W, Trojanowski JQ, and Smith DH. (2011) Acute and chronically increased immunoreactivity to phosphorylation-independent but not pathological TDP-43 after a single traumatic brain injury in humans. Acta neuropathologica, 122(6): p. 715-72

Tang-Schomer MD*, Johnson VE*, Bass PW, Stewart W, & Smith DH. (2011) Partial Interruption of Axonal Transport due to Microtubule Breakage Accounts for the Formation for the Formation of Periodic Varicosities after Traumatic Axonal Injury. Exp Neurol. 2012 Jan;233(1):364-72. (* = Co-lead authorship.)

Johnson VE, Stewart W, Graham DI, Stewart JE, Praestgaard AH and Smith, D (2009). A link between a neprilysin gene polymorphism and the development of amyloid-beta plaques following traumatic brain injury in humans. J Neurotrauma, 26, 1197-1202

Chen XH, Johnson VE, Uryu K, Trojanowski JQ, Smith DH. (2009) A Lack of Amyloid beta Plaques Despite Persistent Accumulation of Amyloid beta in Axons of Long-Term Survivors of Traumatic Brain Injury. Brain Pathol. Apr;19(2):214-23.

Zhang J, Groff RF, Chen H-C, Browne KD, Huang J, Schwartz ED, Meaney DF, Johnson VE, Stein SC, Rojkjaer   R, Smith DH. (2008) Hemostatic and Neuroprotective Effects of Human Recombinant Activated Factor VII Therapy after Traumatic Brain Injury in Pigs. Exp Neurol. Apr;210(2):645-55.

Uryu K, Chen XH, Martinez D, Browne KD, Johnson VE, Graham DI, Lee VM, Trojanowski JQ, Smith DH. (2007) Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans. Exp Neurol. Dec; 208(2):185-92.

Johnson VE, Murray L., Raghupathi R, Stewart J, Nicoll JARN, MacKinnon M-A, McIntosh TK, Graham DI (2006).  There is no evidence that the presence of Apolipoprotein epsilon 4, Interleukin-1a allele 2 and Interleukin-1b allele 2 cause an increase in programmed cell death following traumatic brain injury in humans. Clin Neuropathol. Nov-Dec;25(6):255-64.