Current Projects

  1. Identification and characterization of splicing changes that occur during cancer progression and their contribution to the metastatic process.
  2. Development of new RNA-based therapies for neurodevelopmental genetic diseases caused by mutations in the splicing factor HNRNPH2 and PCDH19.
  3. Development of specific splicing factor inhibitors (decoy oligonucleotides) as novel anti-cancer therapy for AML and breast cancer.
  4. Enhancing immunotherapy by splicing modulation.
  5. Modulation of m6A RNA modification to inhibit mRNA degradation in genetic diseases and cancer.