Publications

• Generation of tumor neoantigens by RNA splicing perturbation.
  Trends in cancer. 2025 Jan;11(1):12-24 Epub 2024 Nov 22; Authors: Rosenberg-Mogilevsky A, Siegfried Z, Karni R

• Inhibition of nonsense-mediated mRNA decay may improve stop codon read-through therapy for Duchenne muscular dystrophy.
  Human molecular genetics. 2023 Jul 20;32(15):2455-2463; Authors: Amar-Schwartz A, Cohen Y, Elhaj A, Ben-Hur V, Siegfried Z, Karni R, Dor T

• RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer.
  Nature. 2023 May;617(7959):147-153 Epub 2023 Mar 22; Authors: Jbara A, Lin KT, Stossel C, Siegfried Z, Shqerat H, Amar-Schwartz A, Elyada E, Mogilevsky M, Raitses-Gurevich M, Johnson JL, Yaron TM, Ovadia O, Jang GH, Danan-Gotthold M, Cantley LC, Levanon EY, Gallinger S, Krainer AR, Golan T, Karni R

• Targeting splicing factors for cancer therapy.
  RNA (New York, N.Y.). 2023 Apr;29(4):506-515 Epub 2023 Jan 25; Authors: Bashari A, Siegfried Z, Karni R

• Retraction Notice to "Generalized verrucosis and abnormal T cell activation due to homozygous TAOK2 mutation".
  Journal of dermatological science. 2022 Nov;108(2):116; Authors: Molho-Pessach V, Ramot Y, Mogilevsky M, Cohen-Daniel L, Eisenstein EM, Abu-Libdeh A, Siam I, Berger M, Karni R, Zlotogorski A

• S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair.
  eLife. 2022 Oct 3;11; Authors: Amar-Schwartz A, Ben Hur V, Jbara A, Cohen Y, Barnabas GD, Arbib E, Siegfried Z, Mashahreh B, Hassouna F, Shilo A, Abu-Odeh M, Berger M, Wiener R, Aqeilan R, Geiger T, Karni R

• Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer.
  Nature communications. 2021 Sep 2;12(1):5238; Authors: Schachter NF, Adams JR, Skowron P, Kozma KJ, Lee CA, Raghuram N, Yang J, Loch AJ, Wang W, Kucharczuk A, Wright KL, Quintana RM, An Y, Dotzko D, Gorman JL, Wojtal D, Shah JS, Leon-Gomez P, Pellecchia G, Dupuy AJ, Perou CM, Ben-Porath I, Karni R, Zacksenhaus E, Woodgett JR, Done SJ, Garzia L, Sorana Morrissy A, Reimand J, Taylor MD, Egan SE

• Splice-switching as cancer therapy.
  Current opinion in pharmacology. 2021 Aug;59:140-148 Epub 2021 Jul 1; Authors: Jbara A, Siegfried Z, Karni R

• Alternative Splicing of the Inhibitory Immune Checkpoint Receptor SLAMF6 Generates a Dominant Positive Form, Boosting T-cell Effector Functions.
  Cancer immunology research. 2021 Jun;9(6):637-650 Epub 2021 Mar 24; Authors: Hajaj E, Zisman E, Tzaban S, Merims S, Cohen J, Klein S, Frankenburg S, Sade-Feldman M, Tabach Y, Yizhak K, Navon A, Stepensky P, Hacohen N, Peretz T, Veillette A, Karni R, Eisenberg G, Lotem M

• Trophoblast lineage specific expression of the alternative splicing factor RBFOX2 suggests a role in placental development.
  Placenta. 2020 Oct;100:142-149 Epub 2020 Jul 7; Authors: Goldman-Wohl D, Greenfield C, Eisenberg-Loebl I, Denichenko P, Jbara A, Karni R, Ariel I, Yagel S

• Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy.
  Nature communications. 2020 Mar 11;11(1):1304; Authors: Mahameed M, Boukeileh S, Obiedat A, Darawshi O, Dipta P, Rimon A, McLennan G, Fassler R, Reichmann D, Karni R, Preisinger C, Wilhelm T, Huber M, Tirosh B

• Dissecting the role of crosstalk between glioblastoma subpopulations in tumor cell spreading.
  Oncogenesis. 2020 Feb 5;9(2):11; Authors: Jubran MR, Rubinstein AM, Cojocari I, Adejumobi IA, Mogilevsky M, Tibi S, Sionov RV, Verreault M, Idbaih A, Karni R, Kravchenko-Balasha N

• 2-APB and CBD-Mediated Targeting of Charged Cytotoxic Compounds Into Tumor Cells Suggests the Involvement of TRPV2 Channels.
  Frontiers in pharmacology. 2019;10:1198 Epub 2019 Oct 15; Authors: Neumann-Raizel H, Shilo A, Lev S, Mogilevsky M, Katz B, Shneor D, Shaul YD, Leffler A, Gabizon A, Karni R, Honigman A, Binshtok AM

• Intra-Tumoral Metabolic Zonation and Resultant Phenotypic Diversification Are Dictated by Blood Vessel Proximity.
  Cell metabolism. 2019 Jul 2;30(1):201-211.e6 Epub 2019 May 2; Authors: Kumar S, Sharife H, Kreisel T, Mogilevsky M, Bar-Lev L, Grunewald M, Aizenshtein E, Karni R, Paldor I, Shlomi T, Keshet E

• Long Noncoding RNA MALAT1 Regulates Cancer Glucose Metabolism by Enhancing mTOR-Mediated Translation of TCF7L2.
  Cancer research. 2019 May 15;79(10):2480-2493 Epub 2019 Mar 26; Authors: Malakar P, Stein I, Saragovi A, Winkler R, Stern-Ginossar N, Berger M, Pikarsky E, Karni R

• Specific inhibition of splicing factor activity by decoy RNA oligonucleotides.
  Nature communications. 2019 Apr 8;10(1):1590; Authors: Denichenko P, Mogilevsky M, Cléry A, Welte T, Biran J, Shimshon O, Barnabas GD, Danan-Gotthold M, Kumar S, Yavin E, Levanon EY, Allain FH, Geiger T, Levkowitz G, Karni R

• Modulation of MKNK2 alternative splicing by splice-switching oligonucleotides as a novel approach for glioblastoma treatment.
  Nucleic acids research. 2018 Nov 30;46(21):11396-11404; Authors: Mogilevsky M, Shimshon O, Kumar S, Mogilevsky A, Keshet E, Yavin E, Heyd F, Karni R

• Recapitulating the clinical scenario of BRCA-associated pancreatic cancer in pre-clinical models.
  International journal of cancer. 2018 Jul 1;143(1):179-183 Epub 2018 Feb 23; Authors: Golan T, Stossel C, Atias D, Buzhor E, Halperin S, Cohen K, Raitses-Gurevich M, Glick Y, Raskin S, Yehuda D, Feldman A, Schvimer M, Friedman E, Karni R, Wilson JM, Denroche RE, Lungu I, Bartlett JMS, Mbabaali F, Gallinger S, Berger R

• TRPM2 Mediates Neutrophil Killing of Disseminated Tumor Cells.
  Cancer research. 2018 May 15;78(10):2680-2690 Epub 2018 Feb 28; Authors: Gershkovitz M, Caspi Y, Fainsod-Levi T, Katz B, Michaeli J, Khawaled S, Lev S, Polyansky L, Shaul ME, Sionov RV, Cohen-Daniel L, Aqeilan RI, Shaul YD, Mori Y, Karni R, Fridlender ZG, Binshtok AM, Granot Z

• The role of alternative splicing in cancer drug resistance.
  Current opinion in genetics & development. 2018 Feb;48:16-21 Epub 2017 Nov 5; Authors: Siegfried Z, Karni R

• CLIP6-PNA-Peptide Conjugates: Non-Endosomal Delivery of Splice Switching Oligonucleotides.
  Bioconjugate chemistry. 2017 Dec 20;28(12):3036-3042 Epub 2017 Dec 6; Authors: Soudah T, Mogilevsky M, Karni R, Yavin E

• The role of RNA alternative splicing in regulating cancer metabolism.
  Human genetics. 2017 Sep;136(9):1113-1127 Epub 2017 Apr 20; Authors: Kozlovski I, Siegfried Z, Amar-Schwartz A, Karni R

• RETRACTED: Generalized verrucosis and abnormal T cell activation due to homozygous TAOK2 mutation.
  Journal of dermatological science. 2017 Aug;87(2):123-129 Epub 2017 Mar 27; Authors: Molho-Pessach V, Ramot Y, Mogilevsky M, Cohen-Daniel L, Eisenstein EM, Abu-Libdeh A, Siam I, Berger M, Karni R, Zlotogorski A

• Activation-Dependent TRAF3 Exon 8 Alternative Splicing Is Controlled by CELF2 and hnRNP C Binding to an Upstream Intronic Element.
  Molecular and cellular biology. 2017 Apr 1;37(7) Epub 2017 Mar 17; Authors: Schultz AS, Preussner M, Bunse M, Karni R, Heyd F

• Long Noncoding RNA MALAT1 Promotes Hepatocellular Carcinoma Development by SRSF1 Upregulation and mTOR Activation.
  Cancer research. 2017 Mar 1;77(5):1155-1167 Epub 2016 Dec 19; Authors: Malakar P, Shilo A, Mogilevsky A, Stein I, Pikarsky E, Nevo Y, Benyamini H, Elgavish S, Zong X, Prasanth KV, Karni R

• Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival.
  Scientific reports. 2016 Aug 16;6:31222; Authors: Malakar P, Chartarifsky L, Hija A, Leibowitz G, Glaser B, Dor Y, Karni R

• Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer.
  Oncotarget. 2016 Jun 28;7(26):40418-40436; Authors: Jadaliha M, Zong X, Malakar P, Ray T, Singh DK, Freier SM, Jensen T, Prasanth SG, Karni R, Ray PS, Prasanth KV

• Heterogeneous nuclear ribonucleoproteins A1 and A2 modulate expression of Tid1 isoforms and EGFR signaling in non-small cell lung cancer.
  Oncotarget. 2016 Mar 29;7(13):16760-72; Authors: Chen CY, Jan CI, Pi WC, Wang WL, Yang PC, Wang TH, Karni R, Wang TC

• Folate levels modulate oncogene-induced replication stress and tumorigenicity.
  EMBO molecular medicine. 2015 Sep;7(9):1138-52; Authors: Lamm N, Maoz K, Bester AC, Im MM, Shewach DS, Karni R, Kerem B

• PfSR1 controls alternative splicing and steady-state RNA levels in Plasmodium falciparum through preferential recognition of specific RNA motifs.
  Molecular microbiology. 2015 Jun;96(6):1283-97 Epub 2015 Apr 16; Authors: Eshar S, Altenhofen L, Rabner A, Ross P, Fastman Y, Mandel-Gutfreund Y, Karni R, Llinás M, Dzikowski R

• Identification of recurrent regulated alternative splicing events across human solid tumors.
  Nucleic acids research. 2015 May 26;43(10):5130-44 Epub 2015 Apr 23; Authors: Danan-Gotthold M, Golan-Gerstl R, Eisenberg E, Meir K, Karni R, Levanon EY

• The role of splicing factors in deregulation of alternative splicing during oncogenesis and tumor progression.
  Molecular & cellular oncology. 2015 Jan-Mar;2(1):e970955 Epub 2014 Dec 1; Authors: Shilo A, Siegfried Z, Karni R

• Mnk2 alternative splicing modulates the p38-MAPK pathway and impacts Ras-induced transformation.
  Cell reports. 2014 Apr 24;7(2):501-513 Epub 2014 Apr 13; Authors: Maimon A, Mogilevsky M, Shilo A, Golan-Gerstl R, Obiedat A, Ben-Hur V, Lebenthal-Loinger I, Stein I, Reich R, Beenstock J, Zehorai E, Andersen CL, Thorsen K, Ørntoft TF, Davis RJ, Davidson B, Mu D, Karni R

• Splicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development.
  RNA (New York, N.Y.). 2014 Apr;20(4):505-15 Epub 2014 Feb 26; Authors: Shilo A, Ben Hur V, Denichenko P, Stein I, Pikarsky E, Rauch J, Kolch W, Zender L, Karni R

• RRM1 domain of the splicing oncoprotein SRSF1 is required for MEK1-MAPK-ERK activation and cellular transformation.
  Carcinogenesis. 2013 Nov;34(11):2498-504 Epub 2013 Jul 10; Authors: Shimoni-Sebag A, Lebenthal-Loinger I, Zender L, Karni R

• Insulin-like growth factor-binding protein-7 (IGFBP7) transcript: A-to-I editing events in normal and cancerous human keratinocytes.
  Archives of dermatological research. 2013 Aug;305(6):519-28 Epub 2013 Mar 30; Authors: Hochberg M, Gilead L, Markel G, Nemlich Y, Feiler Y, Enk CD, Denichenko P, Karni R, Ingber A

• The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers.
  The Journal of pathology. 2013 Mar;229(4):630-9; Authors: Cohen-Eliav M, Golan-Gerstl R, Siegfried Z, Andersen CL, Thorsen K, Ørntoft TF, Mu D, Karni R

• S6K1 alternative splicing modulates its oncogenic activity and regulates mTORC1.
  Cell reports. 2013 Jan 31;3(1):103-15 Epub 2012 Dec 27; Authors: Ben-Hur V, Denichenko P, Siegfried Z, Maimon A, Krainer A, Davidson B, Karni R

• Alternatively spliced lysyl oxidase-like 4 isoforms have a pro-metastatic role in cancer.
  Clinical & experimental metastasis. 2013 Jan;30(1):103-17 Epub 2012 Jul 18; Authors: Sebban S, Golan-Gerstl R, Karni R, Vaksman O, Davidson B, Reich R

• Regulation of the Ras-MAPK and PI3K-mTOR Signalling Pathways by Alternative Splicing in Cancer.
  International journal of cell biology. 2013;2013:568931 Epub 2013 Sep 3; Authors: Siegfried Z, Bonomi S, Ghigna C, Karni R

• Identification of key regulatory pathways of myeloid differentiation using an mESC-based karyotypically normal cell model.
  Blood. 2012 Dec 6;120(24):4712-9 Epub 2012 Oct 18; Authors: Li D, Yang H, Nan H, Liu P, Pang S, Zhao Q, Karni R, Kamps MP, Xu Y, Zhou J, Wiedmer T, Sims PJ, Wang F

• A novel Plasmodium falciparum SR protein is an alternative splicing factor required for the parasites' proliferation in human erythrocytes.
  Nucleic acids research. 2012 Oct;40(19):9903-16 Epub 2012 Aug 9; Authors: Eshar S, Allemand E, Sebag A, Glaser F, Muchardt C, Mandel-Gutfreund Y, Karni R, Dzikowski R

• The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation.
  Nature structural & molecular biology. 2012 Jan 15;19(2):220-8; Authors: Anczuków O, Rosenberg AZ, Akerman M, Das S, Zhan L, Karni R, Muthuswamy SK, Krainer AR

• Splicing factor hnRNP A2/B1 regulates tumor suppressor gene splicing and is an oncogenic driver in glioblastoma.
  Cancer research. 2011 Jul 1;71(13):4464-72 Epub 2011 May 17; Authors: Golan-Gerstl R, Cohen M, Shilo A, Suh SS, Bakàcs A, Coppola L, Karni R

• Control of pancreatic β cell regeneration by glucose metabolism.
  Cell metabolism. 2011 Apr 6;13(4):440-449; Authors: Porat S, Weinberg-Corem N, Tornovsky-Babaey S, Schyr-Ben-Haroush R, Hija A, Stolovich-Rain M, Dadon D, Granot Z, Ben-Hur V, White P, Girard CA, Karni R, Kaestner KH, Ashcroft FM, Magnuson MA, Saada A, Grimsby J, Glaser B, Dor Y

• Alternative splicing of SLC39A14 in colorectal cancer is regulated by the Wnt pathway.
  Molecular & cellular proteomics : MCP. 2011 Jan;10(1):M110.002998 Epub 2010 Oct 11; Authors: Thorsen K, Mansilla F, Schepeler T, Øster B, Rasmussen MH, Dyrskjøt L, Karni R, Akerman M, Krainer AR, Laurberg S, Andersen CL, Ørntoft TF

• Arginine methylation controls the subcellular localization and functions of the oncoprotein splicing factor SF2/ASF.
  Molecular and cellular biology. 2010 Jun;30(11):2762-74 Epub 2010 Mar 22; Authors: Sinha R, Allemand E, Zhang Z, Karni R, Myers MP, Krainer AR

• SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control.
  Nature structural & molecular biology. 2010 Mar;17(3):306-12 Epub 2010 Feb 7; Authors: Sun S, Zhang Z, Sinha R, Karni R, Krainer AR

• The splicing-factor oncoprotein SF2/ASF activates mTORC1.
  Proceedings of the National Academy of Sciences of the United States of America. 2008 Oct 7;105(40):15323-7 Epub 2008 Oct 1; Authors: Karni R, Hippo Y, Lowe SW, Krainer AR

• Subunit S5a of the 26S proteasome is regulated by antiapoptotic signals.
  The FEBS journal. 2007 Jun;274(11):2815-31 Epub 2007 Apr 25; Authors: Gus Y, Karni R, Levitzki A

• The gene encoding the splicing factor SF2/ASF is a proto-oncogene.
  Nature structural & molecular biology. 2007 Mar;14(3):185-93 Epub 2007 Feb 18; Authors: Karni R, de Stanchina E, Lowe SW, Sinha R, Mu D, Krainer AR

• Active Src elevates the expression of beta-catenin by enhancement of cap-dependent translation.
  Molecular and cellular biology. 2005 Jun;25(12):5031-9; Authors: Karni R, Gus Y, Dor Y, Meyuhas O, Levitzki A

• The pp60c-Src inhibitor PP1 is non-competitive against ATP.
  FEBS letters. 2003 Feb 27;537(1-3):47-52; Authors: Karni R, Mizrachi S, Reiss-Sklan E, Gazit A, Livnah O, Levitzki A

• Activated pp60c-Src leads to elevated hypoxia-inducible factor (HIF)-1alpha expression under normoxia.
  The Journal of biological chemistry. 2002 Nov 8;277(45):42919-25 Epub 2002 Aug 27; Authors: Karni R, Dor Y, Keshet E, Meyuhas O, Levitzki A