Our Models and Approaches
Our Approach
Murine Disease Modeling:
We generated and work with mice expressing clinical Surfactant Protein C (Sftpc) mutations to study the development and epithelial contribution to pediatric interstitial lung disease and adult lung fibrosis.
Precision Cut Lung Slices:
We work with explanted fibrotic lung tissues and are positioned at one of the largest lung transplant centers in the country. This resource is readily available to us and allows us to decipher the multicellular orchestration of lung fibrosis.
Patient Derived Cell Modeling:
We work with Drs. Darrell Kotton and Kostas Alysandratos at the Boston University Center for Regenerative Medicine to develop and characterize patient-derived iPSC models of lung fibrosis.
Our Funding:
NIH / NHLBI
Pulmonary Fibrosis Foundation
Industry Collaborators
